Sternon, J, Decaux, G, Hoffmann, G · Revue medicale de Bruxelles · 1994
This paper describes how doctors can diagnose ME/CFS using specific criteria and discusses what might cause the condition. The authors note that viral infections may trigger ME/CFS, and that anxiety or depression can make symptoms worse. Importantly, they found that some patients improve on their own after a few years, though most don't respond well to available treatments.
Understanding the diagnostic criteria and natural history of ME/CFS helps patients and clinicians recognize the condition and set realistic expectations about disease trajectory. The discussion of potential viral triggers and psychiatric comorbidities remains relevant to current research exploring ME/CFS etiology and the relationship between physical illness and psychological symptoms.
This review does not establish causal mechanisms for ME/CFS or prove that viral infections definitively cause the syndrome—it only notes this as a possibility. The observation that psychiatric symptoms may increase somatic complaints does not demonstrate that ME/CFS is primarily psychological or that anxiety causes the underlying illness. The study does not provide data on actual remission rates, treatment efficacy, or the specific features that distinguish ME/CFS from other conditions.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Sternon, J, Decaux, G, & Hoffmann, G (1994). [Chronic fatigue syndrome].. Revue medicale de Bruxelles. https://pubmed.ncbi.nlm.nih.gov/7984848/
BibTeX
@article{mecfsatlas-sternon-1994-chronic-fatigue,
author = {Sternon, J and Decaux, G and Hoffmann, G},
title = {[Chronic fatigue syndrome].},
journal = {Revue medicale de Bruxelles},
year = {1994},
note = {PubMed: 7984848},
url = {https://www.mecfsatlas.com/evidence/sternon-1994-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/sternon-1994-chronic-fatigue
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