Stulemeijer, Maja, de Jong, Lieke W A M, Fiselier, Theo J W et al. · BMJ (Clinical research ed.) · 2005 · DOI
This study tested whether cognitive behaviour therapy (CBT)—a type of talking therapy that helps people change unhelpful thinking patterns and gradually return to activities—could help teenagers with ME/CFS. Teenagers who received 10 sessions of CBT over five months showed greater improvements in fatigue, ability to do daily activities, and school attendance compared to those who waited for treatment. The therapy was tailored based on whether teenagers were mostly active or inactive.
This is one of the few rigorous randomised controlled trials testing a psychological intervention in adolescent ME/CFS, demonstrating that structured therapy can produce measurable improvements in fatigue and functioning during a critical developmental period. The findings suggest CBT may be a viable treatment option for youth with ME/CFS, offering hope for patients and their families seeking evidence-based interventions.
This study does not prove CBT is curative for ME/CFS or that it works equally well for all patients with different ME/CFS phenotypes. The waiting-list control design does not account for natural recovery or placebo effects, and the short five-month follow-up period does not establish whether improvements are sustained long-term. The study also does not clarify whether CBT works by addressing underlying biological mechanisms or primarily through behavioural adaptation.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Stulemeijer, Maja, de Jong, Lieke W A M, Fiselier, Theo J W, Hoogveld, Sigrid W B, & Bleijenberg, Gijs (2005). Cognitive behaviour therapy for adolescents with chronic fatigue syndrome: randomised controlled trial.. BMJ (Clinical research ed.). https://doi.org/10.1136/bmj.38301.587106.63
BibTeX
@article{mecfsatlas-stulemeijer-2005-cognitive-behaviour,
author = {Stulemeijer, Maja and de Jong, Lieke W A M and Fiselier, Theo J W and Hoogveld, Sigrid W B and Bleijenberg, Gijs},
title = {Cognitive behaviour therapy for adolescents with chronic fatigue syndrome: randomised controlled trial.},
journal = {BMJ (Clinical research ed.)},
year = {2005},
doi = {10.1136/bmj.38301.587106.63},
note = {PubMed: 15585538},
url = {https://www.mecfsatlas.com/evidence/stulemeijer-2005-cognitive-behaviour},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/stulemeijer-2005-cognitive-behaviour
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