Tajima, Seiki, Kuratsune, Hirohiko, Yamaguti, Kouzi et al. · Nihon rinsho. Japanese journal of clinical medicine · 2007
This study measured activity levels and sleep patterns in people with ME/CFS using wearable devices and heart rate analysis. Researchers found that ME/CFS patients had lower activity during waking hours, slept longer, experienced more frequent sleep disruptions, and showed abnormal nervous system activity during sleep compared to healthy people.
This research provides objective physiological markers of ME/CFS-related sleep disturbance and autonomic nervous system dysfunction, which could help validate patient symptoms and advance understanding of how these biological abnormalities contribute to fatigue and disability.
This cross-sectional study cannot establish causation or determine whether the observed autonomic and sleep abnormalities are causes or consequences of ME/CFS. The study does not establish whether these findings are unique to CFS or occur in other fatiguing conditions, nor does it demonstrate whether correcting these abnormalities would improve symptoms.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Tajima, Seiki, Kuratsune, Hirohiko, Yamaguti, Kouzi, Takahashi, Ayumi, Takashima, Shoko, Watanabe, Yasuyoshi, et al. (2007). [Estimation of fatigue state in patient with CFS using actigraph and R-R interval power spectrum analysis].. Nihon rinsho. Japanese journal of clinical medicine. https://pubmed.ncbi.nlm.nih.gov/17561697/
BibTeX
@article{mecfsatlas-tajima-2007-estimation-fatigue,
author = {Tajima, Seiki and Kuratsune, Hirohiko and Yamaguti, Kouzi and Takahashi, Ayumi and Takashima, Shoko and Watanabe, Yasuyoshi and Nishizawa, Yoshiki},
title = {[Estimation of fatigue state in patient with CFS using actigraph and R-R interval power spectrum analysis].},
journal = {Nihon rinsho. Japanese journal of clinical medicine},
year = {2007},
note = {PubMed: 17561697},
url = {https://www.mecfsatlas.com/evidence/tajima-2007-estimation-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/tajima-2007-estimation-fatigue
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