Tamura, Yasuhisa, Yamato, Masanori, Kataoka, Yosky · Frontiers in neurology · 2022 · DOI
This review looked at how ME/CFS may be caused by inflammation in the brain and examined animal studies testing anti-inflammatory treatments. Researchers found that brain inflammation is connected to how severe ME/CFS symptoms are, and that certain compounds with anti-inflammatory properties showed promise in reducing these inflammatory responses in animal models. This suggests that anti-inflammatory medicines might help improve symptoms in ME/CFS patients.
This review is important because it identifies a potential biological mechanism—neuroinflammation—underlying ME/CFS symptoms and suggests testable therapeutic targets. For patients, this work could lead to new treatment options if anti-inflammatory approaches are validated in human trials. For researchers, it provides a framework connecting animal model findings to clinical symptom severity.
This review does not prove that anti-inflammatory treatments will be safe or effective in ME/CFS patients, as animal models do not fully replicate human disease complexity. It establishes correlation between neuroinflammation and symptom severity, not definitive causation. The findings are preliminary and require human clinical trials before any treatment recommendations can be made.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Tamura, Yasuhisa, Yamato, Masanori, & Kataoka, Yosky (2022). Animal Models for Neuroinflammation and Potential Treatment Methods.. Frontiers in neurology. https://doi.org/10.3389/fneur.2022.890217
BibTeX
@article{mecfsatlas-tamura-2022-animal-models,
author = {Tamura, Yasuhisa and Yamato, Masanori and Kataoka, Yosky},
title = {Animal Models for Neuroinflammation and Potential Treatment Methods.},
journal = {Frontiers in neurology},
year = {2022},
doi = {10.3389/fneur.2022.890217},
note = {PubMed: 35832182},
url = {https://www.mecfsatlas.com/evidence/tamura-2022-animal-models},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/tamura-2022-animal-models
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