Tomoda, A, Miike, T, Yamada, E et al. · Brain & development · 2000 · DOI
This study looked at three children (ages 11-13) with ME/CFS and used special brain imaging scans to measure blood flow and chemical activity in their brains. The scans showed differences in brain blood flow and metabolism compared to healthy children, suggesting that ME/CFS may involve changes in how the brain is functioning, not just a psychological problem.
This early neuroimaging study provides evidence that ME/CFS in children involves objective brain abnormalities rather than being purely psychological or functional in origin. Such findings are important for establishing ME/CFS as a biomedical condition and may eventually help identify diagnostic markers and guide treatment development.
This case series cannot establish whether brain blood flow and metabolic changes are a cause of ME/CFS symptoms, a consequence of the illness, or an epiphenomenon. The small sample size and heterogeneous findings across cases limit conclusions about what is typical in pediatric ME/CFS. The study also does not prove these findings are specific to ME/CFS or explain the mechanism underlying symptom development.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Tomoda, A, Miike, T, Yamada, E, Honda, H, Moroi, T, Ogawa, M, et al. (2000). Chronic fatigue syndrome in childhood.. Brain & development. https://doi.org/10.1016/s0387-7604(99)00111-4
BibTeX
@article{mecfsatlas-tomoda-2000-chronic-fatigue,
author = {Tomoda, A and Miike, T and Yamada, E and Honda, H and Moroi, T and Ogawa, M and Ohtani, Y and Morishita, S},
title = {Chronic fatigue syndrome in childhood.},
journal = {Brain & development},
year = {2000},
doi = {10.1016/s0387-7604(99)00111-4},
note = {PubMed: 10761837},
url = {https://www.mecfsatlas.com/evidence/tomoda-2000-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/tomoda-2000-chronic-fatigue
Contribute
Private, reviewed by a human. Not a public comment thread.