Trinidad, E E, Ramírez-Ronda, C · Boletin de la Asociacion Medica de Puerto Rico · 1994
Chronic Fatigue Syndrome (ME/CFS) is a long-lasting illness that causes extreme tiredness and affects an estimated 24% of people. It was officially defined as a medical condition in 1988 after doctors recognized increasing numbers of patients with similar symptoms. The condition is more common in women aged 20-50 and is currently treated with supportive care to help manage symptoms.
This early clinical overview helped establish ME/CFS as a recognized medical condition and documented its prevalence and demographic patterns. Understanding the historical context and official recognition of ME/CFS is important for patients seeking validation of their illness and for clinicians learning about the disease's characteristics.
This review does not establish the cause of ME/CFS, nor does it present new research data on treatment efficacy. The prevalence estimate of 24% is presented without methodological detail, and the article does not prove what distinguishes ME/CFS from other conditions or explain why women are more frequently affected.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Trinidad, E E & Ramírez-Ronda, C (1994). [Chronic fatigue syndrome].. Boletin de la Asociacion Medica de Puerto Rico. https://pubmed.ncbi.nlm.nih.gov/7945654/
BibTeX
@article{mecfsatlas-trinidad-1994-chronic-fatigue,
author = {Trinidad, E E and Ramírez-Ronda, C},
title = {[Chronic fatigue syndrome].},
journal = {Boletin de la Asociacion Medica de Puerto Rico},
year = {1994},
note = {PubMed: 7945654},
url = {https://www.mecfsatlas.com/evidence/trinidad-1994-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/trinidad-1994-chronic-fatigue
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