Van Den Houte, Maaike, Van Oudenhove, Lukas, Bogaerts, Katleen et al. · Psychosomatic medicine · 2019 · DOI
This study tested whether people with ME/CFS and fibromyalgia show a consistent pattern of reporting symptoms that don't match what's actually happening in their bodies. Researchers used two different experiments—one involving controlled breathing challenges and another using emotional pictures—to see if the same people would show symptom distortion in both tests. They found that symptom distortion in one test did not predict symptom distortion in the other, suggesting that how symptoms are perceived depends heavily on the specific situation rather than being a stable trait.
Understanding whether symptom perception distortions are stable traits or context-dependent has important implications for ME/CFS treatment and research. If distortions vary by situation, interventions and diagnostic criteria may need to be tailored to specific contexts rather than targeting a single underlying mechanism. This study provides evidence that symptom reporting in ME/CFS is more nuanced than previously thought, potentially redirecting research toward context-specific factors.
This study does not prove that symptom perception distortions do not exist in ME/CFS—only that they may not manifest consistently across different experimental paradigms. The findings do not establish what mechanisms cause context-dependent symptom reporting, nor do they explain whether distortions reflect neurobiological, psychological, or mixed processes. The lack of correlation between two paradigms does not rule out that other laboratory tasks or real-world situations might show relationships.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Van Den Houte, Maaike, Van Oudenhove, Lukas, Bogaerts, Katleen, Van Diest, Ilse, De Bie, Jozef, Persoons, Philippe, et al. (2019). Relationship Between Different Experimental Measures of Distorted Symptom Perception in Functional Syndrome Patients.. Psychosomatic medicine. https://doi.org/10.1097/PSY.0000000000000692
BibTeX
@article{mecfsatlas-van-den-houte-2019-relationship-between,
author = {Van Den Houte, Maaike and Van Oudenhove, Lukas and Bogaerts, Katleen and Van Diest, Ilse and De Bie, Jozef and Persoons, Philippe and Van den Bergh, Omer},
title = {Relationship Between Different Experimental Measures of Distorted Symptom Perception in Functional Syndrome Patients.},
journal = {Psychosomatic medicine},
year = {2019},
doi = {10.1097/PSY.0000000000000692},
note = {PubMed: 30920465},
url = {https://www.mecfsatlas.com/evidence/van-den-houte-2019-relationship-between},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/van-den-houte-2019-relationship-between
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