van der Werf, Sieberen P, de Vree, Berna, van Der Meer, Jos W M et al. · Neuropsychiatry, neuropsychology, and behavioral neurology · 2002
This study looked at whether paying too much attention to bodily sensations and reporting many physical symptoms might slow down how quickly people with ME/CFS can process information and react to tasks. Researchers measured how fast patients could respond to simple tests and found that people who were highly aware of their body sensations reported more symptoms and performed more slowly on reaction time tests. The study suggests that increased attention to the body may be partly responsible for the cognitive slowing that people with ME/CFS experience.
Understanding the mechanisms underlying cognitive slowing in ME/CFS is crucial for developing targeted interventions. This study suggests that cognitive dysfunction in ME/CFS may partly involve how patients attend to and interpret bodily sensations, which could inform psychological and rehabilitative approaches. The findings may help explain why cognitive symptoms fluctuate and why some patients experience worse cognitive performance during periods of heightened symptom awareness.
This study cannot establish causality—it cannot prove that body consciousness causes slowed processing, only that they are associated. The cross-sectional design means we cannot determine the temporal sequence of these relationships or whether they are bidirectional. The study does not rule out direct neurobiological causes of cognitive slowing; rather, it suggests attentional processes may be an additional contributing factor.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
van der Werf, Sieberen P, de Vree, Berna, van Der Meer, Jos W M, & Bleijenberg, Gijs (2002). The relations among body consciousness, somatic symptom report, and information processing speed in chronic fatigue syndrome.. Neuropsychiatry, neuropsychology, and behavioral neurology. https://pubmed.ncbi.nlm.nih.gov/11877546/
BibTeX
@article{mecfsatlas-van-der-werf-2002-relations-among,
author = {van der Werf, Sieberen P and de Vree, Berna and van Der Meer, Jos W M and Bleijenberg, Gijs},
title = {The relations among body consciousness, somatic symptom report, and information processing speed in chronic fatigue syndrome.},
journal = {Neuropsychiatry, neuropsychology, and behavioral neurology},
year = {2002},
note = {PubMed: 11877546},
url = {https://www.mecfsatlas.com/evidence/van-der-werf-2002-relations-among},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/van-der-werf-2002-relations-among
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