van't Leven, Marjolein, Zielhuis, Gerhard A, van der Meer, Jos W et al. · European journal of public health · 2010 · DOI
This study surveyed over 9,000 Dutch adults to understand how common fatigue is in the general population and what factors might be associated with it. Researchers found that about 1% of adults experience fatigue meeting CFS-like criteria, and 30% experience longer-lasting fatigue. People with CFS-like fatigue were more likely to be female, less physically active, obese, and taking painkillers regularly.
This study provides rare population-level prevalence data showing CFS-like conditions affect approximately 1% of adults—much higher than previously estimated from clinical cohorts alone. It highlights that ME/CFS remains largely unrecognized by general practitioners despite significant population burden, and identifies modifiable lifestyle factors that warrant investigation as potential contributors or consequences of fatigue.
This cross-sectional design cannot establish causation; associations between lifestyle factors and fatigue may reflect reverse causality (i.e., fatigue causing inactivity rather than inactivity causing fatigue). The study lacks clinical confirmation of CFS cases and cannot distinguish whether identified associations are causal, correlative, or secondary to underlying disease. The high response rate of only 43% may introduce selection bias affecting prevalence estimates.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
van't Leven, Marjolein, Zielhuis, Gerhard A, van der Meer, Jos W, Verbeek, André L, & Bleijenberg, Gijs (2010). Fatigue and chronic fatigue syndrome-like complaints in the general population.. European journal of public health. https://doi.org/10.1093/eurpub/ckp113
BibTeX
@article{mecfsatlas-vant-leven-2010-fatigue-chronic,
author = {van't Leven, Marjolein and Zielhuis, Gerhard A and van der Meer, Jos W and Verbeek, André L and Bleijenberg, Gijs},
title = {Fatigue and chronic fatigue syndrome-like complaints in the general population.},
journal = {European journal of public health},
year = {2010},
doi = {10.1093/eurpub/ckp113},
note = {PubMed: 19689970},
url = {https://www.mecfsatlas.com/evidence/vant-leven-2010-fatigue-chronic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/vant-leven-2010-fatigue-chronic
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