Venables, P J · Best practice & research. Clinical rheumatology · 2006 · DOI
Sjögren's syndrome is an autoimmune disease where the body attacks its own glands that produce tears and saliva, causing dry eyes and mouth. This article explains how doctors diagnose and treat Sjögren's syndrome, emphasizing that most patients do well with local treatments (like eye drops) and a medication called hydroxychloroquine, while stronger drugs are reserved for patients with more serious complications.
While this is a Sjögren's syndrome guideline rather than ME/CFS research, it is relevant because fatigue and dry eyes/mouth are sometimes reported by ME/CFS patients, and the differential diagnosis section explicitly mentions chronic fatigue syndrome. Understanding how rheumatologists distinguish Sjögren's from CFS may help clarify whether some ME/CFS patients have concurrent autoimmune disease.
This guideline does not provide evidence that ME/CFS and Sjögren's syndrome are related conditions, nor does it establish prevalence of Sjögren's in ME/CFS populations. It is a management review for a specific autoimmune condition and does not investigate the relationship between these two syndromes. The guideline's mention of chronic fatigue syndrome as a differential diagnosis reflects clinical practice but does not constitute comparative research.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Venables, P J (2006). Management of patients presenting with Sjogren's syndrome.. Best practice & research. Clinical rheumatology. https://doi.org/10.1016/j.berh.2006.05.003
BibTeX
@article{mecfsatlas-venables-2006-management-patients,
author = {Venables, P J},
title = {Management of patients presenting with Sjogren's syndrome.},
journal = {Best practice & research. Clinical rheumatology},
year = {2006},
doi = {10.1016/j.berh.2006.05.003},
note = {PubMed: 16979538},
url = {https://www.mecfsatlas.com/evidence/venables-2006-management-patients},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/venables-2006-management-patients
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