Vu, Luyen Tien, Ahmed, Faraz, Zhu, Hongya et al. · Cell reports. Medicine · 2024 · DOI
Researchers used advanced technology to examine immune cells from ME/CFS patients and healthy controls, both at rest and after exercise. They found that ME/CFS patients have problems with a type of immune cell called monocytes that appear abnormal and may be moving into tissues inappropriately. After exercise, patients showed additional problems with platelets (cells involved in blood clotting), suggesting the disease involves multiple layers of immune system dysfunction.
This study provides molecular-level evidence that ME/CFS involves specific, measurable immune system abnormalities rather than being psychosomatic. Understanding monocyte and platelet dysfunction may eventually lead to diagnostic biomarkers and targeted treatments. The findings suggest immune dysregulation is both constitutive and exercise-inducible, validating the post-exertional malaise symptom that characterizes the disease.
This study does not prove that monocyte and platelet dysregulation cause ME/CFS symptoms—only that these abnormalities are associated with the disease. It does not establish whether these immune changes are primary disease mechanisms or secondary consequences of another underlying process. The findings in blood cells may not fully represent what is happening in tissues, and results require validation in independent cohorts and functional studies.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Vu, Luyen Tien, Ahmed, Faraz, Zhu, Hongya, Iu, David Shing Huk, Fogarty, Elizabeth A, Kwak, Yeonui, et al. (2024). Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation.. Cell reports. Medicine. https://doi.org/10.1016/j.xcrm.2023.101373
BibTeX
@article{mecfsatlas-vu-2024-single-cell,
author = {Vu, Luyen Tien and Ahmed, Faraz and Zhu, Hongya and Iu, David Shing Huk and Fogarty, Elizabeth A and Kwak, Yeonui and Chen, Weizhong and Franconi, Carl J and Munn, Paul R and Tate, Ann E and Levine, Susan M and Stevens, Jared and Mao, Xiangling and Shungu, Dikoma C and Moore, Geoffrey E and Keller, Betsy A and Hanson, Maureen R and Grenier, Jennifer K and Grimson, Andrew},
title = {Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation.},
journal = {Cell reports. Medicine},
year = {2024},
doi = {10.1016/j.xcrm.2023.101373},
note = {PubMed: 38232699},
url = {https://www.mecfsatlas.com/evidence/vu-2024-single-cell},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/vu-2024-single-cell
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