Wallis, Amy, Butt, Henry, Ball, Michelle et al. · Gut microbes · 2017 · DOI
This study looked at how gut bacteria, sex hormones, and the immune system interact differently in men and women with ME/CFS. The researchers found that the relationship between specific types of bacteria in the gut and ME/CFS symptoms varies between males and females. This suggests that biological sex may play an important role in how the microbiome affects ME/CFS symptoms.
Understanding sex differences in how gut bacteria relate to ME/CFS symptoms could lead to personalized treatment approaches for men and women. This research highlights that biological sex is an important variable in microbiome studies and may explain why ME/CFS affects and manifests differently across sexes, potentially informing future therapeutic interventions.
This study does not prove that specific bacteria cause ME/CFS symptoms, only that associations differ between sexes. The observational design cannot establish causation or rule out confounding factors. The findings are preliminary and require validation in larger, prospective studies with functional analyses before clinical recommendations can be made.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Wallis, Amy, Butt, Henry, Ball, Michelle, Lewis, Donald P, & Bruck, Dorothy (2017). Support for the microgenderome invites enquiry into sex differences.. Gut microbes. https://doi.org/10.1080/19490976.2016.1256524
BibTeX
@article{mecfsatlas-wallis-2017-support-microgenderome,
author = {Wallis, Amy and Butt, Henry and Ball, Michelle and Lewis, Donald P and Bruck, Dorothy},
title = {Support for the microgenderome invites enquiry into sex differences.},
journal = {Gut microbes},
year = {2017},
doi = {10.1080/19490976.2016.1256524},
note = {PubMed: 27808584},
url = {https://www.mecfsatlas.com/evidence/wallis-2017-support-microgenderome},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/wallis-2017-support-microgenderome
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