Wortinger, Laura Anne, Endestad, Tor, Melinder, Annika Maria D et al. · PloS one · 2016 · DOI
This study looked at how the brains of teenagers with ME/CFS show different activity patterns compared to healthy teenagers. Researchers used brain imaging to examine a network called the salience network, which helps the brain notice important signals like pain and fatigue. They found that teenagers with ME/CFS had weaker connections in this network, and the strength of these connections was linked to how severe their fatigue and pain symptoms were.
This is among the first brain imaging studies to examine neural networks specifically in adolescent ME/CFS patients, an understudied population. The findings suggest that the brain's salience network—which processes fatigue and pain signals—may be fundamentally altered in ME/CFS, potentially offering a biological mechanism for understanding these core symptoms.
This study cannot prove that salience network dysfunction causes ME/CFS symptoms; it only demonstrates correlation. The small sample size and cross-sectional design limit generalizability and prevent determination of whether these brain changes are primary features of the disease or secondary consequences of chronic illness. The study also does not establish whether these neural changes are specific to ME/CFS or occur in other chronic conditions.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Wortinger, Laura Anne, Endestad, Tor, Melinder, Annika Maria D, Øie, Merete Glenne, Sevenius, Andre, & Bruun Wyller, Vegard (2016). Aberrant Resting-State Functional Connectivity in the Salience Network of Adolescent Chronic Fatigue Syndrome.. PloS one. https://doi.org/10.1371/journal.pone.0159351
BibTeX
@article{mecfsatlas-wortinger-2016-aberrant-resting,
author = {Wortinger, Laura Anne and Endestad, Tor and Melinder, Annika Maria D and Øie, Merete Glenne and Sevenius, Andre and Bruun Wyller, Vegard},
title = {Aberrant Resting-State Functional Connectivity in the Salience Network of Adolescent Chronic Fatigue Syndrome.},
journal = {PloS one},
year = {2016},
doi = {10.1371/journal.pone.0159351},
note = {PubMed: 27414048},
url = {https://www.mecfsatlas.com/evidence/wortinger-2016-aberrant-resting},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/wortinger-2016-aberrant-resting
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