Wyller, Vegard Bruun, Godang, Kristin, Mørkrid, Lars et al. · Pediatrics · 2007 · DOI
This study looked at how the body controls temperature in adolescents with ME/CFS compared to healthy teenagers. Researchers found that people with ME/CFS have abnormal responses to temperature changes, with their bodies struggling to regulate heat and cold properly. The study suggests this problem may be related to dysfunction in the nervous system's control of stress hormones like adrenaline.
Abnormal temperature regulation and excessive sweating/shivering are common but poorly understood symptoms in ME/CFS. This study provides mechanistic evidence linking these symptoms to sympathetic nervous system dysfunction, potentially opening new avenues for understanding and treating these distressing thermoregulatory symptoms.
This study does not prove that sympathetic dysfunction is the primary cause of ME/CFS—only that it is associated with the condition. It does not establish whether thermoregulatory abnormalities are disease-causing or a secondary consequence of ME/CFS. The small sample size limits generalizability to the broader ME/CFS population.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Wyller, Vegard Bruun, Godang, Kristin, Mørkrid, Lars, Saul, Jerome Philip, Thaulow, Erik, & Walløe, Lars (2007). Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: relation to clinical symptoms.. Pediatrics. https://doi.org/10.1542/peds.2006-2759
BibTeX
@article{mecfsatlas-wyller-2007-abnormal-thermoregulatory,
author = {Wyller, Vegard Bruun and Godang, Kristin and Mørkrid, Lars and Saul, Jerome Philip and Thaulow, Erik and Walløe, Lars},
title = {Abnormal thermoregulatory responses in adolescents with chronic fatigue syndrome: relation to clinical symptoms.},
journal = {Pediatrics},
year = {2007},
doi = {10.1542/peds.2006-2759},
note = {PubMed: 17606539},
url = {https://www.mecfsatlas.com/evidence/wyller-2007-abnormal-thermoregulatory},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/wyller-2007-abnormal-thermoregulatory
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