Yang, De Gang, Gu, Rui, Kubo, Jin et al. · The International journal of neuroscience · 2020 · DOI
Researchers tested whether a brain stimulation treatment called repetitive transcranial magnetic stimulation (rTMS) could help ME/CFS patients with fatigue. They treated 22 patients with 6-8 sessions of rTMS and measured fatigue levels before and after treatment. The study found that rTMS improved fatigue symptoms in all patients, whether they started with severe or mild fatigue.
This study suggests that rTMS may be an effective therapeutic option for ME/CFS patients regardless of disease severity, potentially expanding treatment accessibility. Understanding that treatment efficacy is not dependent on baseline fatigue severity helps clinicians identify which patients might benefit and sets the stage for larger clinical trials.
This small study does not establish optimal rTMS protocols for ME/CFS or prove long-term durability of benefits beyond 2 weeks. The lack of a control group means we cannot determine whether improvements result from rTMS specifically or from other factors like hospitalization, placebo effects, or natural symptom variation. Results from 22 patients may not generalize to all ME/CFS populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Yang, De Gang, Gu, Rui, Kubo, Jin, & Kakuda, Wataru (2020). Is the efficacy of repetitive transcranial magnetic stimulation influenced by baseline severity of fatigue symptom in patients with myalgic encephalomyelitis.. The International journal of neuroscience. https://doi.org/10.1080/00207454.2019.1663189
BibTeX
@article{mecfsatlas-yang-2020-efficacy-repetitive,
author = {Yang, De Gang and Gu, Rui and Kubo, Jin and Kakuda, Wataru},
title = {Is the efficacy of repetitive transcranial magnetic stimulation influenced by baseline severity of fatigue symptom in patients with myalgic encephalomyelitis.},
journal = {The International journal of neuroscience},
year = {2020},
doi = {10.1080/00207454.2019.1663189},
note = {PubMed: 31483181},
url = {https://www.mecfsatlas.com/evidence/yang-2020-efficacy-repetitive},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/yang-2020-efficacy-repetitive
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