Yiu, Yan-mun, Ng, Siu-man, Tsui, Yin-ling et al. · Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine · 2007 · DOI
Researchers in Hong Kong tested whether acupuncture could help people with chronic fatigue syndrome. They compared real acupuncture to fake acupuncture (needles that didn't pierce the skin) in 99 patients over 4 weeks. Both groups improved, but the real acupuncture group showed larger improvements in fatigue and quality of life, with no serious side effects reported.
This study provides evidence that acupuncture may be a safe, non-pharmacological intervention for CFS symptoms, addressing a key need for treatment options with minimal adverse effects. The use of rigorous RCT methodology with validated fatigue scales contributes to the limited body of acupuncture research in CFS populations.
This study does not prove acupuncture is more effective than standard medical treatments for CFS, nor does it establish the mechanism by which acupuncture produces benefit. Single-blinding (rather than double-blinding) means patients knew which group they were in, allowing expectancy bias to influence symptom reporting. The results may not generalize to populations outside Hong Kong or to different CFS case definitions.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Yiu, Yan-mun, Ng, Siu-man, Tsui, Yin-ling, & Chan, Yat-lung (2007). [A clinical trial of acupuncture for treating chronic fatigue syndrome in Hong Kong].. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. https://doi.org/10.3736/jcim20070606
BibTeX
@article{mecfsatlas-yiu-2007-clinical-trial,
author = {Yiu, Yan-mun and Ng, Siu-man and Tsui, Yin-ling and Chan, Yat-lung},
title = {[A clinical trial of acupuncture for treating chronic fatigue syndrome in Hong Kong].},
journal = {Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine},
year = {2007},
doi = {10.3736/jcim20070606},
note = {PubMed: 17997936},
url = {https://www.mecfsatlas.com/evidence/yiu-2007-clinical-trial},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/yiu-2007-clinical-trial
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