Zhang, Zhenxian, Cai, Zhixing, Yu, Yonghui et al. · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2015 · DOI
This study tested whether a traditional Chinese herbal medicine (Lixujieyu recipe) combined with specific types of music therapy could help reduce fatigue, depression, and anxiety in people with chronic fatigue syndrome. Researchers assigned 90 patients to different groups: five groups received the herbal medicine plus different types of music therapy, and one group received the herbal medicine alone. After 4 weeks of treatment, patients who received the herbal medicine combined with certain music types (Gong-Tune or Jiao-Tune) showed better improvement in fatigue, depression, and anxiety compared to the herbal medicine alone.
This study offers insights into non-pharmacological and traditional medicine approaches that may complement standard CFS management, particularly for patients with comorbid anxiety and depression. The identification of specific music therapy modalities (Gong-Tune and Jiao-Tune) as potentially more effective suggests that targeted interventions warrant further investigation in ME/CFS research.
This study does not establish that music therapy or herbal medicine are universally effective for all ME/CFS patients, as it examined only one herbal recipe in a specific patient population with defined Traditional Chinese Medicine patterns. The study does not distinguish whether improvements result from the herbal medicine, the music, or their combination, nor does it prove these interventions work for ME/CFS cases outside the liver stagnation/spleen deficiency classification.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Zhang, Zhenxian, Cai, Zhixing, Yu, Yonghui, Wu, Lili, & Zhang, Ye (2015). Effect of Lixujieyu recipe in combination with Five Elements music therapy on chronic fatigue syndrome.. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. https://doi.org/10.1016/s0254-6272(15)30152-7
BibTeX
@article{mecfsatlas-zhang-2015-effect-lixujieyu,
author = {Zhang, Zhenxian and Cai, Zhixing and Yu, Yonghui and Wu, Lili and Zhang, Ye},
title = {Effect of Lixujieyu recipe in combination with Five Elements music therapy on chronic fatigue syndrome.},
journal = {Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan},
year = {2015},
doi = {10.1016/s0254-6272(15)30152-7},
note = {PubMed: 26742307},
url = {https://www.mecfsatlas.com/evidence/zhang-2015-effect-lixujieyu},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/zhang-2015-effect-lixujieyu
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