Zhang, Ziteng, Ma, Xiujuan, Xia, Zhenna et al. · Neuroscience · 2017 · DOI
This study explored whether a specific immune system protein called NLRP3 might be involved in causing fatigue in mice. Researchers stressed mice with repeated swimming tests and found that stressed mice had higher levels of an inflammatory chemical (IL-1β) in their brains and showed fatigue-like behaviors. When they removed the NLRP3 protein in mice, the fatigue behaviors were reduced and inflammatory levels decreased, suggesting this protein may play a role in fatigue.
This study identifies a specific immune mechanism (NLRP3 inflammasome) that may contribute to fatigue generation, offering a potential therapeutic target. Understanding the neuroinflammatory basis of fatigue could lead to new treatments for ME/CFS patients, a condition currently lacking approved disease-modifying therapies.
This study does not prove that NLRP3 activation causes fatigue in humans with ME/CFS—it demonstrates correlation in a mouse stress model. The acute swim stress protocol differs fundamentally from the chronic, post-exertional malaise pattern in ME/CFS, and findings in mice do not automatically translate to human disease. It also does not establish whether NLRP3 is the primary cause of CFS or merely one contributing factor among many.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Zhang, Ziteng, Ma, Xiujuan, Xia, Zhenna, Chen, Jikuai, Liu, Yangang, Chen, Yongchun, et al. (2017). NLRP3 inflammasome activation mediates fatigue-like behaviors in mice via neuroinflammation.. Neuroscience. https://doi.org/10.1016/j.neuroscience.2017.06.048
BibTeX
@article{mecfsatlas-zhang-2017-nlrp3-inflammasome,
author = {Zhang, Ziteng and Ma, Xiujuan and Xia, Zhenna and Chen, Jikuai and Liu, Yangang and Chen, Yongchun and Zhu, Jiangbo and Li, Jinfeng and Yu, Huaiyu and Zong, Ying and Lu, Guocai},
title = {NLRP3 inflammasome activation mediates fatigue-like behaviors in mice via neuroinflammation.},
journal = {Neuroscience},
year = {2017},
doi = {10.1016/j.neuroscience.2017.06.048},
note = {PubMed: 28684277},
url = {https://www.mecfsatlas.com/evidence/zhang-2017-nlrp3-inflammasome},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/zhang-2017-nlrp3-inflammasome
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