Zhang, Meng, Liu, Rui, Zhou, Ting et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2025 · DOI
Researchers tested whether ginseng stem and leaf saponins (a compound from ginseng plants) could help treat chronic fatigue syndrome in mice. They found that this compound improved swimming endurance, protected the liver and brain from damage, reduced harmful substances in the body, and restored balance to brain chemicals that are often abnormal in fatigue conditions.
ME/CFS lacks effective pharmacological treatments, and this study identifies a potential multi-target mechanism by which a plant-derived compound might address both physical exhaustion and cognitive dysfunction through neuroprotection and metabolic rebalancing. Understanding how natural compounds affect fatigue pathways at the biochemical level may inform future therapeutic development for human patients.
This study does not prove that ginseng saponins will be effective, safe, or tolerable in humans with ME/CFS—it is a preclinical animal model study only. Animal models of CFS do not fully replicate human ME/CFS pathophysiology, and findings cannot be assumed to translate directly to clinical benefit. The study demonstrates association and mechanism in mice but does not establish causation in human disease.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Zhang, Meng, Liu, Rui, Zhou, Ting, Guo, Yuxin, Li, Hui, & Wu, Wei (2025). Exploring the anti-fatigue properties of ginseng stem and leaf saponins: Using UHPLC-MS metabolomics and neurotransmitter analysis.. Phytomedicine : international journal of phytotherapy and phytopharmacology. https://doi.org/10.1016/j.phymed.2025.156459
BibTeX
@article{mecfsatlas-zhang-2025-exploring-anti,
author = {Zhang, Meng and Liu, Rui and Zhou, Ting and Guo, Yuxin and Li, Hui and Wu, Wei},
title = {Exploring the anti-fatigue properties of ginseng stem and leaf saponins: Using UHPLC-MS metabolomics and neurotransmitter analysis.},
journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
year = {2025},
doi = {10.1016/j.phymed.2025.156459},
note = {PubMed: 39923426},
url = {https://www.mecfsatlas.com/evidence/zhang-2025-exploring-anti},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-27. https://www.mecfsatlas.com/evidence/zhang-2025-exploring-anti
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