Zheng, Yuan, Ren, Xueyang, Qi, Xiaodan et al. · Journal of ethnopharmacology · 2024 · DOI
This study tested a traditional Chinese herbal medicine called Baoyuan Decoction (BYD) to see if it could reduce fatigue in zebrafish models. The researchers found that BYD contains 114 active compounds and appeared to reduce fatigue, inflammation, and oxidative stress by activating specific cellular pathways related to energy metabolism and the body's internal clock.
This research provides mechanistic insights into how energy metabolism and circadian rhythm dysregulation might contribute to fatigue, two processes implicated in ME/CFS pathophysiology. The identification of specific molecular pathways (AMPK/circadian clock interaction) offers a potential biological framework for understanding fatigue and could inform future therapeutic development for ME/CFS, though clinical translation remains uncertain.
This study does not demonstrate that Baoyuan Decoction is effective in treating human ME/CFS or any human fatigue condition—only that it produces measurable biochemical changes in zebrafish. The findings do not establish whether circadian/AMPK dysregulation is a primary cause of ME/CFS fatigue versus a secondary consequence, and do not rule out confounding effects from other pathways identified (IL-17 signaling). Animal model efficacy does not guarantee human clinical benefit.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Zheng, Yuan, Ren, Xueyang, Qi, Xiaodan, Song, Ruolan, Zhao, Chongjun, Ma, Jiamu, et al. (2024). Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK/CRY2/PER1 signaling pathway.. Journal of ethnopharmacology. https://doi.org/10.1016/j.jep.2024.118058
BibTeX
@article{mecfsatlas-zheng-2024-bao-yuan,
author = {Zheng, Yuan and Ren, Xueyang and Qi, Xiaodan and Song, Ruolan and Zhao, Chongjun and Ma, Jiamu and Li, Xianxian and Deng, Qingyue and He, Yingyu and Kong, Lingmei and Qian, Liyan and Zhang, Feng and Li, Mingxia and Sun, Mengyu and Liu, Wei and Liu, Haibin and She, Gaimei},
title = {Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK/CRY2/PER1 signaling pathway.},
journal = {Journal of ethnopharmacology},
year = {2024},
doi = {10.1016/j.jep.2024.118058},
note = {PubMed: 38513778},
url = {https://www.mecfsatlas.com/evidence/zheng-2024-bao-yuan},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/zheng-2024-bao-yuan
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