Zinn, M A, Zinn, M L, Valencia, I et al. · Biological psychology · 2018 · DOI
Researchers used a brain-imaging technique called EEG to record electrical activity in the brains of 50 ME/CFS patients and 50 healthy people while they rested quietly. They found that ME/CFS patients had unusual patterns of brain activity in specific regions—particularly in the front and back of the brain—that were linked to reduced motivation and fatigue. These differences suggest that ME/CFS may involve changes in how the brain works, not just tiredness from physical causes.
This study provides objective neurophysiological evidence that ME/CFS involves measurable differences in brain function, supporting the idea that fatigue in this condition has a biological basis in the central nervous system rather than being psychological. Identifying specific brain regions and frequency bands affected by ME/CFS could help validate diagnostic markers and guide future targeted treatments.
This cross-sectional study cannot establish whether the brain activity differences cause fatigue symptoms or result from the illness; it only shows correlation. The findings are descriptive and do not prove that the observed cortical hypoactivation is unique to ME/CFS or stable over time. The study does not assess whether these changes persist, improve, or worsen, or how they relate to post-exertional malaise.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Zinn, M A, Zinn, M L, Valencia, I, Jason, L A, & Montoya, J G (2018). Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome.. Biological psychology. https://doi.org/10.1016/j.biopsycho.2018.05.016
BibTeX
@article{mecfsatlas-zinn-2018-cortical-hypoactivation,
author = {Zinn, M A and Zinn, M L and Valencia, I and Jason, L A and Montoya, J G},
title = {Cortical hypoactivation during resting EEG suggests central nervous system pathology in patients with chronic fatigue syndrome.},
journal = {Biological psychology},
year = {2018},
doi = {10.1016/j.biopsycho.2018.05.016},
note = {PubMed: 29802861},
url = {https://www.mecfsatlas.com/evidence/zinn-2018-cortical-hypoactivation},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/zinn-2018-cortical-hypoactivation
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