ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

643 studies

181–200 of 643 studies

E0 ConsensusReviewPEM unclearSystematic-Review

A systematic review and meta-analysis of urinary biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Taccori, Asher, Maksoud, Rebekah, Eaton-Fitch, Natalie et al.·Journal of translational medicine·2023

Researchers looked at 21 studies examining urine samples from ME/CFS patients to find markers that could help diagnose the condition. They focused especially on a substance called cortisol (a stress hormone) in urine. While they found some differences in urine samples between people with ME/CFS and healthy people, the results were too inconsistent to identify a reliable single marker for diagnosis.

Biomarkers

E0 ConsensusReviewPEM unclearReview-Narrative

Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Grach, Stephanie L, Seltzer, Jaime, Chon, Tony Y et al.·Mayo Clinic proceedings·2023

This review explains how doctors can diagnose and manage ME/CFS, a serious illness that causes extreme tiredness and other symptoms, often starting after an infection. The authors note that ME/CFS shares many similarities with long COVID, the condition some people experience after having COVID-19. They provide practical guidance to help healthcare providers recognize and treat this condition.

Long COVID OverlapPost-Exertional Malaise

E0 ConsensusReviewPEM not requiredReview-Narrative

Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review.

Mahmoudi, Hassan, Hossainpour, Hadi·Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2023

This review examines how fecal microbiota transplantation (FMT)—transferring healthy bacteria from a donor's stool to a patient's gut—can treat various diseases. While FMT is very effective for serious C. difficile infections, researchers are exploring whether it might help other conditions including chronic fatigue syndrome, inflammatory bowel disease, and irritable bowel syndrome by restoring a healthy balance of gut bacteria.

Immune System

E0 ConsensusGuidelinePEM requiredGuideline

[Tiredness/Fatigue-S3 guideline update].

Kornder, Nele, Baum, Erika, Maisel, Peter et al.·ZFA. Zeitschrift fur Allgemeinmedizin·2023

This guideline helps family doctors diagnose and treat fatigue by providing a systematic approach. When fatigue has no clear cause, doctors should ask about sleep, mood, medications, and life stressors, and perform basic blood tests. The guideline emphasizes that fatigue often has multiple causes working together, and recommends checking specifically for post-exertional malaise (PEM)—a key feature of ME/CFS—so patients can receive appropriate specialized care.

Post-Exertional Malaise

E0 ConsensusReviewPEM requiredSystematic-Review

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.

Maksoud, Rebekah, Magawa, Chandi, Eaton-Fitch, Natalie et al.·BMC medicine·2023

Researchers reviewed 101 studies looking for biological markers (biomarkers) that could help diagnose ME/CFS. A biomarker is something measurable in your blood or body that shows a disease is present. While scientists found many potential biomarkers affecting the immune system, energy production, circulation, and other body functions, none have been proven reliable enough to use as a diagnostic test yet.

BiomarkersImmune System

E0 ConsensusReviewPEM unclearMeta-Analysis

Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis.

Mohamed, Abdalla Z, Andersen, Thu, Radovic, Sanja et al.·Sleep medicine reviews·2023

This study looked at 24 research papers that measured sleep objectively (using devices and tests, not just patient reports) in people with ME/CFS. The researchers found that ME/CFS patients do indeed have real, measurable sleep problems—they take longer to fall asleep, wake up more during the night, and don't get good-quality sleep. Interestingly, these sleep problems looked slightly different in teenagers compared to adults with ME/CFS.

SleepAutonomic Nervous System

E0 ConsensusReviewPEM not requiredSystematic-Review

Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.

Lepri, Beatrice, Romani, Daniele, Storari, Lorenzo et al.·International journal of environmental research and public health·2023

This review looked at 15 studies testing whether pain neuroscience education—teaching patients how pain works in the nervous system—helps people with chronic muscle and joint pain, including those with conditions like fibromyalgia and chronic fatigue syndrome. The research found that this type of education does appear to reduce pain and improve disability and mood, especially when delivered one-on-one and combined with other treatments like physical therapy.

Pain and Sensitization

E0 ConsensusReviewPEM unclearReview-Narrative

Female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: a literature review.

Pollack, Beth, von Saltza, Emelia, McCorkell, Lisa et al.·Frontiers in rehabilitation sciences·2023

This review examined how Long COVID and related illnesses like ME/CFS affect women's reproductive health, including menstrual cycles, fertility, and pregnancy. The researchers found that women with these conditions experience more problems with their periods, difficulty getting pregnant, and symptom flare-ups around their menstrual cycle. The study highlights that we need much more research to understand these reproductive health issues and to help doctors better support women with these conditions.

E0 ConsensusReviewPEM unclearEvidence-Map

ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Anthony L. Komaroff, W. Ian Lipkin·Frontiers in Medicine·2023

Harvard and Columbia researchers conducted a comprehensive review of biological abnormalities in ME/CFS and Long COVID. They found striking overlaps in immune dysregulation, autonomic dysfunction, metabolic disruption, and neurological features. The paper maps the literature to guide researchers working across both conditions.

Immune SystemLong COVID Overlap

E0 ConsensusReviewPEM unclearReview-Narrative

Surveying the Metabolic and Dysfunctional Profiles of T Cells and NK Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Maya, Jessica·International journal of molecular sciences·2023

This review examined research on how immune cells (T cells and NK cells) work differently in ME/CFS patients compared to healthy people. The authors found evidence that these immune cells may be exhausted or damaged, similar to what happens in chronic viral infections. Understanding why these immune cells aren't functioning properly could help explain ME/CFS symptoms and guide development of better treatments.

Immune System

E0 ConsensusReviewPEM unclearMeta-Analysis

The relation between cognitive-behavioural responses to symptoms in patients with long term medical conditions and the outcome of cognitive behavioural therapy for fatigue - A secondary analysis of four RCTs.

de Gier, M, Picariello, F, Slot, M et al.·Behaviour research and therapy·2023

This study looked at how people with different long-term illnesses—including ME/CFS—think and behave in response to fatigue, and whether these patterns affect how well cognitive behavioural therapy (CBT) works. Researchers found that certain thought patterns and behaviours, like avoiding activity or believing that fatigue causes damage, were linked to less improvement with CBT. The good news is that when CBT helped patients change these patterns—by reducing fear, worry, and excessive rest—their fatigue improved significantly.

Interventions

E0 ConsensusReviewPEM not requiredSystematic-Review

The role of psychiatry in diagnosis and treatment of paediatric chronic fatigue syndrome - a scoping literature review.

Dolp, Reinhard, Wardle, David Pr, Khalid-Khan, Sarosh·International journal of adolescent medicine and health·2023

This review looked at how psychiatry (the medical specialty focused on mental health) is involved in diagnosing and treating ME/CFS in children and teenagers. The researchers searched medical literature and found that psychiatrists are rarely part of the care team for young people with ME/CFS, and when they are involved, their role is often unclear or limited to treating separate mental health problems. The study suggests that psychiatry could potentially play a more defined and helpful role in caring for children and adolescents with ME/CFS.

Diagnostics

E0 ConsensusReviewPEM unclearReview-Narrative

Animal Models for Neuroinflammation and Potential Treatment Methods.

Tamura, Yasuhisa, Yamato, Masanori, Kataoka, Yosky·Frontiers in neurology·2022

This review looked at how ME/CFS may be caused by inflammation in the brain and examined animal studies testing anti-inflammatory treatments. Researchers found that brain inflammation is connected to how severe ME/CFS symptoms are, and that certain compounds with anti-inflammatory properties showed promise in reducing these inflammatory responses in animal models. This suggests that anti-inflammatory medicines might help improve symptoms in ME/CFS patients.

NeuroinflammationImmune System

E0 ConsensusReviewPEM unclearSystematic-Review

Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cognitive, and physical impairment.

Campos, Maria Cristine, Nery, Tatyana, Starke, Ana Carolina et al.·Neuroscience and biobehavioral reviews·2022

This review looked at how doctors and researchers measure fatigue in people who have long-term tiredness after COVID-19. The study found that fatigue after COVID-19 is common and can affect thinking, mood, and physical abilities. The researchers identified different tools—questionnaires and performance tests—that can help measure how tired someone feels and how much their tiredness limits their daily activities.

Cognitive Impairment

E0 ConsensusReviewPEM unclearReview-Narrative

Fatigue in ANCA-associated vasculitis (AAV) and systemic sclerosis (SSc): similarities with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A critical review of the literature.

van Eeden, Charmaine, Osman, Mohammed S, Cohen Tervaert, Jan Willem·Expert review of clinical immunology·2022

This review examined severe, long-lasting fatigue in patients with certain autoimmune diseases and compared it to ME/CFS. The researchers found that fatigue in these autoimmune diseases shares similarities with ME/CFS, including common immune and metabolic problems. Importantly, this fatigue often persists even after the main disease is brought under control, suggesting it may need different treatment approaches than the underlying condition.

Severe MEImmune System

E0 ConsensusReviewPEM unclearEvidence-Map

Fatigue, post-exertional malaise and orthostatic intolerance: a map of Cochrane evidence relevant to rehabilitation for people with post COVID-19 condition.

Arienti, Chiara, Cordani, Claudio, Lazzarini, Stefano G et al.·European journal of physical and rehabilitation medicine·2022

This study looked at what treatments have helped people with fatigue and exercise problems in other conditions to understand what might help people with long COVID. Researchers found that exercise programs, telehealth rehabilitation, and educational interventions showed promise for fatigue, while combined aerobic and anaerobic training helped with exercise intolerance. However, they found very little research specifically on post-exertional malaise (feeling much worse after activity) or orthostatic intolerance (dizziness when standing), which are key symptoms in post-COVID and ME/CFS.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle?

Kavyani, Bahar, Lidbury, Brett A, Schloeffel, Richard et al.·Cellular and molecular life sciences : CMLS·2022

This review explores whether problems with how your body processes an amino acid called tryptophan might explain ME/CFS symptoms. The kynurenine pathway is a biochemical process that helps your cells make energy and affects immune function and brain inflammation. The authors suggest that abnormalities in this pathway could be a missing piece in understanding why ME/CFS develops.

NeuroinflammationBiomarkers

E0 ConsensusReviewPEM unclearSystematic-Review

Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review.

Tziastoudi, Maria, Cholevas, Christos, Stefanidis, Ioannis et al.·Annals of clinical and translational neurology·2022

This study looked at genetic research on both COVID-19 and ME/CFS to see if they share common genetic factors that might explain why both conditions cause extreme fatigue. Researchers reviewed 71 studies on COVID-19 genetics and 26 studies on ME/CFS genetics, then identified six genes that appear in both conditions. The findings suggest that immune system dysfunction—specifically problems with inflammation and how immune cells communicate—may play a role in both illnesses.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Breast Implant-Associated Immunological Disorders.

Suh, Lily J, Khan, Imran, Kelley-Patteson, Christine et al.·Journal of immunology research·2022

This review examined reports of illness associated with breast implants, which can cause fatigue, joint pain, difficulty concentrating, and other symptoms similar to those in ME/CFS. Researchers found evidence that breast implants may trigger autoimmune problems in some people, and that removing implants improved symptoms in over half of patients studied. The review suggests that bacterial infections around implants, rather than the implant material itself, might be responsible for these problems.

Immune System

E0 ConsensusReviewPEM not requiredSystematic-Review

Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies.

Yang, Juan, Shin, Kyung-Min, Abu Dabrh, Abd Moain et al.·Global advances in health and medicine·2022

Researchers looked at whether ginseng, a plant supplement used for fatigue in other conditions, might help people with ME/CFS. They found only 2 small studies with a total of 68 patients. While the results suggest ginseng might be helpful, there isn't enough evidence yet to say for certain whether it works or is safe for ME/CFS patients.

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A systematic review and meta-analysis of urinary biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review.

[Tiredness/Fatigue-S3 guideline update].

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.

Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis.

Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.

Female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: a literature review.

ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Surveying the Metabolic and Dysfunctional Profiles of T Cells and NK Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

The relation between cognitive-behavioural responses to symptoms in patients with long term medical conditions and the outcome of cognitive behavioural therapy for fatigue - A secondary analysis of four RCTs.

The role of psychiatry in diagnosis and treatment of paediatric chronic fatigue syndrome - a scoping literature review.

Animal Models for Neuroinflammation and Potential Treatment Methods.

Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cognitive, and physical impairment.

Fatigue in ANCA-associated vasculitis (AAV) and systemic sclerosis (SSc): similarities with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A critical review of the literature.

Fatigue, post-exertional malaise and orthostatic intolerance: a map of Cochrane evidence relevant to rehabilitation for people with post COVID-19 condition.

Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle?

Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review.

Breast Implant-Associated Immunological Disorders.

Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies.

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