ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

649 studies

181–200 of 649 studies

E0 ConsensusReviewPEM not requiredReview-Narrative

Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review.

Mahmoudi, Hassan, Hossainpour, Hadi·Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2023

This review examines how fecal microbiota transplantation (FMT)—transferring healthy bacteria from a donor's stool to a patient's gut—can treat various diseases. While FMT is very effective for serious C. difficile infections, researchers are exploring whether it might help other conditions including chronic fatigue syndrome, inflammatory bowel disease, and irritable bowel syndrome by restoring a healthy balance of gut bacteria.

Immune System

E0 ConsensusReviewPEM unclearSystematic-Review

Effects of traditional Chinese exercise on sleep quality: A systematic review and meta-analysis of randomized controlled trials.

Liu, Haoyu, Liu, Siling, Xiong, Lu et al.·Medicine·2023

This review examined whether traditional Chinese exercises like Tai Chi and Qigong can help improve sleep quality. Researchers analyzed 20 studies and found that these exercises did help people sleep better, especially those with fibromyalgia, chronic fatigue-like illness, and insomnia. However, the benefit wasn't seen in all groups studied, such as stroke patients or college students.

Sleep

E0 ConsensusReviewPEM unclearReview-Narrative

The microbiome in post-acute infection syndrome (PAIS).

Guo, Cheng, Yi, Boyang, Wu, Jianyong et al.·Computational and structural biotechnology journal·2023

This review examined how the bacteria and other microorganisms living in our bodies—particularly in the gut and mouth—may be altered in patients with prolonged illnesses following infections, including ME/CFS and long COVID. The researchers looked at existing studies to understand whether changes in these microbial communities might contribute to why some people develop long-lasting symptoms after being sick. They explored possible explanations for how these microbial changes could trigger or worsen symptoms in post-infection syndromes.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Persistent SARS-CoV-2 Infection, EBV, HHV-6 and Other Factors May Contribute to Inflammation and Autoimmunity in Long COVID.

Vojdani, Aristo, Vojdani, Elroy, Saidara, Evan et al.·Viruses·2023

This review examines how long COVID—a condition where symptoms persist months after a coronavirus infection—may develop through similar mechanisms to ME/CFS. The authors suggest that viral persistence, reactivation of old herpes viruses (like Epstein-Barr virus), immune system dysfunction, and gut microbiome changes may all contribute to ongoing inflammation and autoimmune problems. They propose testing for antibodies and other markers to better identify and treat long COVID.

Gut MicrobiomeImmune SystemLong COVID Overlap

E0 ConsensusReviewPEM unclearReview-Narrative

Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Grach, Stephanie L, Seltzer, Jaime, Chon, Tony Y et al.·Mayo Clinic proceedings·2023

This review explains how doctors can diagnose and manage ME/CFS, a serious illness that causes extreme tiredness and other symptoms, often starting after an infection. The authors note that ME/CFS shares many similarities with long COVID, the condition some people experience after having COVID-19. They provide practical guidance to help healthcare providers recognize and treat this condition.

Long COVID OverlapPost-Exertional Malaise

E0 ConsensusReviewPEM unclear

No Causal Effects Detected in COVID-19 and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two Sample Mendelian Randomization Study.

Xu, Wangzi, Cao, Yu, Wu, Lin·International journal of environmental research and public health·2023

This study investigated whether COVID-19 infection actually causes ME/CFS or if the illnesses just happen to occur together. Researchers analyzed genetic data from thousands of people to look for a direct causal link between COVID-19 and ME/CFS. They found no significant connection, suggesting that while some people may develop ME/CFS-like symptoms after COVID-19, the virus itself may not be a direct cause of ME/CFS.

E0 ConsensusReviewPEM not requiredSystematic-Review

DNA Methylation Signatures of Functional Somatic Syndromes: Systematic Review.

Fischer, Susanne, Kleinstäuber, Maria, Fiori, Laura M et al.·Psychosomatic medicine·2023

This review looked at research on DNA changes in people with ME/CFS, fibromyalgia, and irritable bowel syndrome. Scientists found that people with these conditions have different patterns of chemical switches on their genes compared to healthy people, particularly in genes that control immune function and stress response. These differences may help explain why people with ME/CFS experience fatigue, pain, and other symptoms.

Immune System

E0 ConsensusReviewPEM requiredReview-Narrative

Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2: More in Common Than Not?

Joseph, Phillip, Singh, Inderjit, Oliveira, Rudolf et al.·Chest·2023

This review compares how the body responds to exercise in people with long COVID (PASC) and ME/CFS, two conditions that share similar symptoms like extreme tiredness and worsening symptoms after activity. Researchers found that both conditions show similar abnormalities in heart function, blood flow, and breathing during exercise that go beyond simple deconditioning or being out of shape. These shared patterns suggest both conditions may involve similar underlying biological problems, which could help doctors develop better tests and treatments.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

SARS-CoV-2 Reinfections and Long COVID in the Post-Omicron Phase of the Pandemic.

Boufidou, Fotini, Medić, Snežana, Lampropoulou, Vicky et al.·International journal of molecular sciences·2023

This review examined how repeated COVID-19 infections might be connected to long COVID—the persistent symptoms some people experience after infection. The researchers found that the risk of developing long COVID and related health problems increases with each infection someone has, particularly in older adults. While vaccination appears protective, more research is needed to understand how to best prevent long COVID after reinfection.

E0 ConsensusReviewPEM unclearSystematic-Review

A systematic review and meta-analysis of urinary biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Taccori, Asher, Maksoud, Rebekah, Eaton-Fitch, Natalie et al.·Journal of translational medicine·2023

Researchers looked at 21 studies examining urine samples from ME/CFS patients to find markers that could help diagnose the condition. They focused especially on a substance called cortisol (a stress hormone) in urine. While they found some differences in urine samples between people with ME/CFS and healthy people, the results were too inconsistent to identify a reliable single marker for diagnosis.

Biomarkers

E0 ConsensusGuidelinePEM requiredGuideline

[Tiredness/Fatigue-S3 guideline update].

Kornder, Nele, Baum, Erika, Maisel, Peter et al.·ZFA. Zeitschrift fur Allgemeinmedizin·2023

This guideline helps family doctors diagnose and treat fatigue by providing a systematic approach. When fatigue has no clear cause, doctors should ask about sleep, mood, medications, and life stressors, and perform basic blood tests. The guideline emphasizes that fatigue often has multiple causes working together, and recommends checking specifically for post-exertional malaise (PEM)—a key feature of ME/CFS—so patients can receive appropriate specialized care.

Post-Exertional Malaise

E0 ConsensusReviewPEM requiredSystematic-Review

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.

Maksoud, Rebekah, Magawa, Chandi, Eaton-Fitch, Natalie et al.·BMC medicine·2023

Researchers reviewed 101 studies looking for biological markers (biomarkers) that could help diagnose ME/CFS. A biomarker is something measurable in your blood or body that shows a disease is present. While scientists found many potential biomarkers affecting the immune system, energy production, circulation, and other body functions, none have been proven reliable enough to use as a diagnostic test yet.

BiomarkersImmune System

E0 ConsensusReviewPEM unclearMeta-Analysis

Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis.

Mohamed, Abdalla Z, Andersen, Thu, Radovic, Sanja et al.·Sleep medicine reviews·2023

This study looked at 24 research papers that measured sleep objectively (using devices and tests, not just patient reports) in people with ME/CFS. The researchers found that ME/CFS patients do indeed have real, measurable sleep problems—they take longer to fall asleep, wake up more during the night, and don't get good-quality sleep. Interestingly, these sleep problems looked slightly different in teenagers compared to adults with ME/CFS.

SleepAutonomic Nervous System

E0 ConsensusReviewPEM not requiredSystematic-Review

Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.

Lepri, Beatrice, Romani, Daniele, Storari, Lorenzo et al.·International journal of environmental research and public health·2023

This review looked at 15 studies testing whether pain neuroscience education—teaching patients how pain works in the nervous system—helps people with chronic muscle and joint pain, including those with conditions like fibromyalgia and chronic fatigue syndrome. The research found that this type of education does appear to reduce pain and improve disability and mood, especially when delivered one-on-one and combined with other treatments like physical therapy.

Pain and Sensitization

E0 ConsensusReviewPEM unclearReview-Narrative

Female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: a literature review.

Pollack, Beth, von Saltza, Emelia, McCorkell, Lisa et al.·Frontiers in rehabilitation sciences·2023

This review examined how Long COVID and related illnesses like ME/CFS affect women's reproductive health, including menstrual cycles, fertility, and pregnancy. The researchers found that women with these conditions experience more problems with their periods, difficulty getting pregnant, and symptom flare-ups around their menstrual cycle. The study highlights that we need much more research to understand these reproductive health issues and to help doctors better support women with these conditions.

E0 ConsensusReviewPEM unclearReview-Narrative

Surveying the Metabolic and Dysfunctional Profiles of T Cells and NK Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Maya, Jessica·International journal of molecular sciences·2023

This review examined research on how immune cells (T cells and NK cells) work differently in ME/CFS patients compared to healthy people. The authors found evidence that these immune cells may be exhausted or damaged, similar to what happens in chronic viral infections. Understanding why these immune cells aren't functioning properly could help explain ME/CFS symptoms and guide development of better treatments.

Immune System

E0 ConsensusReviewPEM not requiredEvidence-Map

Frontiers in chronic fatigue syndrome research: An analysis of the top 100 most influential articles in the field.

Wang, Xingxin, Li, Xuhao, Dong, Tiantian et al.·Medicine·2023

This study analyzed the 100 most-cited scientific papers on ME/CFS to understand what researchers have been focusing on and what directions the field is moving toward. Researchers found that ME/CFS research is a global effort involving hundreds of institutions across many countries, with studies increasingly looking at cognitive behavioral therapy, how to diagnose ME/CFS better, and the biological basis of the condition. The analysis suggests future research will likely focus on finding biological markers, understanding immune system changes, and identifying genetic risk factors.

Biomarkers

E0 ConsensusReviewPEM unclearMeta-Analysis

The relation between cognitive-behavioural responses to symptoms in patients with long term medical conditions and the outcome of cognitive behavioural therapy for fatigue - A secondary analysis of four RCTs.

de Gier, M, Picariello, F, Slot, M et al.·Behaviour research and therapy·2023

This study looked at how people with different long-term illnesses—including ME/CFS—think and behave in response to fatigue, and whether these patterns affect how well cognitive behavioural therapy (CBT) works. Researchers found that certain thought patterns and behaviours, like avoiding activity or believing that fatigue causes damage, were linked to less improvement with CBT. The good news is that when CBT helped patients change these patterns—by reducing fear, worry, and excessive rest—their fatigue improved significantly.

Interventions

E0 ConsensusReviewPEM unclearReview-Narrative

Animal Models for Neuroinflammation and Potential Treatment Methods.

Tamura, Yasuhisa, Yamato, Masanori, Kataoka, Yosky·Frontiers in neurology·2022

This review looked at how ME/CFS may be caused by inflammation in the brain and examined animal studies testing anti-inflammatory treatments. Researchers found that brain inflammation is connected to how severe ME/CFS symptoms are, and that certain compounds with anti-inflammatory properties showed promise in reducing these inflammatory responses in animal models. This suggests that anti-inflammatory medicines might help improve symptoms in ME/CFS patients.

NeuroinflammationImmune System

E0 ConsensusReviewPEM not requiredMeta-Analysis

Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis.

Mozhgani, Sayed-Hamidreza, Rajabi, Farid, Qurbani, Mohsen et al.·Intervirology·2022

This study reviewed and combined the results of 17 different research studies to see if there's a connection between a common virus called HHV-6 and ME/CFS. The researchers found evidence suggesting that HHV-6 infection may be associated with developing ME/CFS, but they emphasize that more research is needed to fully understand this relationship.

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Evidence Atlas

Evidence browser

Application and development of fecal microbiota transplantation in the treatment of gastrointestinal and metabolic diseases: A review.

Effects of traditional Chinese exercise on sleep quality: A systematic review and meta-analysis of randomized controlled trials.

The microbiome in post-acute infection syndrome (PAIS).

Persistent SARS-CoV-2 Infection, EBV, HHV-6 and Other Factors May Contribute to Inflammation and Autoimmunity in Long COVID.

Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

No Causal Effects Detected in COVID-19 and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two Sample Mendelian Randomization Study.

DNA Methylation Signatures of Functional Somatic Syndromes: Systematic Review.

Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2: More in Common Than Not?

SARS-CoV-2 Reinfections and Long COVID in the Post-Omicron Phase of the Pandemic.

A systematic review and meta-analysis of urinary biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

[Tiredness/Fatigue-S3 guideline update].

Biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.

Objective sleep measures in chronic fatigue syndrome patients: A systematic review and meta-analysis.

Effectiveness of Pain Neuroscience Education in Patients with Chronic Musculoskeletal Pain and Central Sensitization: A Systematic Review.

Female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: a literature review.

Surveying the Metabolic and Dysfunctional Profiles of T Cells and NK Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Frontiers in chronic fatigue syndrome research: An analysis of the top 100 most influential articles in the field.

The relation between cognitive-behavioural responses to symptoms in patients with long term medical conditions and the outcome of cognitive behavioural therapy for fatigue - A secondary analysis of four RCTs.

Animal Models for Neuroinflammation and Potential Treatment Methods.

Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research