ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

637 studies

221–240 of 637 studies

E0 ConsensusReviewPEM unclearMeta-Analysis

Alteration of Postural Balance in Patients with Fibromyalgia Syndrome-A Systematic Review and Meta-Analysis.

Núñez-Fuentes, David, Obrero-Gaitán, Esteban, Zagalaz-Anula, Noelia et al.·Diagnostics (Basel, Switzerland)·2021

This study reviewed 19 research papers involving 2,347 people (mostly women) to understand balance problems in fibromyalgia syndrome (FMS). The researchers found that FMS patients have significantly worse balance than healthy people, with particular difficulty standing still, moving around, and relying on their inner ear and vision for balance. The findings suggest that people with FMS may depend too heavily on feeling where their body is in space rather than using normal balance cues.

E0 ConsensusReviewPEM not requiredSystematic-Review

Review: How has cognitive behaviour therapy been adapted for adolescents with comorbid depression and chronic illness? A scoping review.

Morey, Alice, Loades, Maria E·Child and adolescent mental health·2021

This review looked at how therapy called cognitive behaviour therapy (CBT) has been modified to help teenagers with both depression and long-term illnesses like diabetes, chronic fatigue syndrome, and inflammatory bowel disease. The researchers found that CBT is often adapted by helping young people think differently about their illness, do activities they enjoy while managing their condition, and involving their family. However, there is still limited research showing how well these adapted treatments actually work for this group.

Cognitive Impairment

E0 ConsensusReviewPEM unclearReview-Narrative

The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection.

Moghimi, Narges, Di Napoli, Mario, Biller, José et al.·Current neurology and neuroscience reports·2021

This review examined what we know about how COVID-19 can affect the nervous system in people who experience long-term symptoms after infection (called PASC or long COVID). The researchers looked at published studies to understand how common these neurological problems are, who is most at risk, why they happen, and how they might be treated. They found that long COVID can range from mild to severely disabling symptoms that last weeks or longer, and that multiple factors—including lingering inflammation, immune system problems, and possible viral effects on the brain—may play a role.

NeuroinflammationImmune System

E0 ConsensusReviewPEM not requiredMeta-Analysis

Adverse outcomes in trials of graded exercise therapy for adult patients with chronic fatigue syndrome.

White, P D, Etherington, J·Journal of psychosomatic research·2021

This study reviewed 10 previous trials involving 1,279 people to examine whether graded exercise therapy (GET) causes harm in ME/CFS patients. Researchers compared how many people reported feeling much worse, stopped treatment, or dropped out of follow-up appointments between those doing GET and those receiving other treatments. The study found no clear evidence that GET caused more people to report feeling worse than other treatments, though more GET participants did drop out of follow-up appointments.

E0 ConsensusReviewPEM requiredReview-Narrative

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome.

Paul, Bindu D, Lemle, Marian D, Komaroff, Anthony L et al.·Proceedings of the National Academy of Sciences of the United States of America·2021

This review examines how COVID-19 and ME/CFS may share similar biological problems, particularly an imbalance in how the body handles harmful molecules called free radicals. Both conditions appear to involve problems with inflammation, energy production in cells, and a slowed metabolism. While this research shows these biological abnormalities exist in both illnesses, more studies are needed to understand exactly how they work together and how to treat them.

NeuroinflammationPost-Exertional Malaise

E0 ConsensusReviewPEM unclearReview-Narrative

New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice.

Froghi, Saied, Grant, Charlotte R, Tandon, Radhika et al.·Clinical reviews in allergy & immunology·2021

This review examines how calcium moves into cells through special channels called TRP channels, and how this process affects the immune system. The authors explain that TRP channels play important roles in helping immune cells fight infections and respond to threats. They discuss evidence that problems with these calcium channels may be involved in several diseases, including ME/CFS.

Immune System

E0 ConsensusReviewPEM requiredReview-Narrative

The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications.

Varesi, Angelica, Deumer, Undine-Sophie, Ananth, Sanjana et al.·Journal of clinical medicine·2021

Many people with ME/CFS experience stomach and digestive problems alongside their fatigue and pain. This review explores how the bacteria living in our gut might be different in ME/CFS patients and could be contributing to symptoms. The researchers found that people with ME/CFS tend to have fewer types of gut bacteria compared to healthy people, and they discuss how treating the gut microbiome might help reduce ME/CFS symptoms overall.

Post-Exertional Malaise

E0 ConsensusReviewPEM requiredSystematic-Review

The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis.

Wormgoor, Marjon E A, Rodenburg, Sanne C·Journal of translational medicine·2021

This review looked at 18 studies testing physiotherapy (physical therapy) for ME/CFS, paying special attention to post-exertional malaise (PEM)—the worsening of symptoms after activity that defines ME. The researchers found that treatments appearing to help patients with general chronic fatigue showed less benefit when studied in patients with stricter ME/CFS definitions that include PEM, and may actually cause harm in ME patients. The study warns that physical therapy approaches effective for milder conditions should not be used for ME patients with prominent PEM.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearSystematic-Review

Brainstem Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Scoping Review and Evaluation of Magnetic Resonance Imaging Findings.

Nelson, Todd, Zhang, Lan-Xin, Guo, Hui et al.·Frontiers in neurology·2021

This review examined brain imaging studies to understand how ME/CFS affects the brainstem, which is the part of the brain that controls vital functions like heart rate, breathing, and sleep. Researchers found that people with ME/CFS often show changes in the brain's structure and how different brain regions communicate with each other. These findings suggest that problems in the brainstem might explain many ME/CFS symptoms, though more research is needed to fully understand the connections.

Neuroinflammation

E0 ConsensusReviewPEM unclearReview-Narrative

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms.

Proal, Amy D, VanElzakker, Michael B·Frontiers in microbiology·2021

Some people who recover from COVID-19 infection continue to experience symptoms for months afterward, a condition called Long COVID or PASC. This review examines multiple biological explanations for why this happens, including organ damage, lingering virus in the body, reactivation of dormant viruses, immune system dysfunction, blood clotting problems, and the body's own immune cells attacking healthy tissues. The authors suggest that different patients likely have different underlying causes, which means different treatments may work best for different people.

Immune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

The Quality of Methodological and Reporting in Network Meta-Analysis of Acupuncture and Moxibustion: A Cross-Sectional Survey.

Yuan, Ting, Xiong, Jun, Wang, Xue et al.·Evidence-based complementary and alternative medicine : eCAM·2021

This study reviewed 29 research papers that used a statistical method called network meta-analysis to compare different acupuncture and moxibustion treatments. The researchers assessed how well these papers were designed and reported their findings. They found that most papers had medium quality, with some having significant gaps in how they explained their methods and results.

E0 ConsensusReviewPEM unclearReview-Narrative

Induced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome.

Monzón-Nomdedeu, María B, Morten, Karl J, Oltra, Elisa·World journal of stem cells·2021

This review examines whether special laboratory cells called induced pluripotent stem cells (iPSCs) could be used as 'sensors' to detect ME/CFS and fibromyalgia. The researchers found that patients with these conditions have unusual chemicals in their blood and body fluids that differ from healthy people. They propose that iPSCs could be grown in patient samples to detect these abnormal chemicals, potentially helping diagnose these diseases and predict how patients might respond to future treatments.

BiomarkersEnergy Metabolism

E0 ConsensusReviewPEM unclearReview-Narrative

Back to the Future? Immunoglobulin Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Brownlie, Helen, Speight, Nigel·Healthcare (Basel, Switzerland)·2021

This review examined past studies on intravenous immunoglobulin (IV IgG), a blood-based treatment, for ME/CFS. The authors found that while results were previously thought to be mixed, a closer look suggests IV IgG may actually help a meaningful group of patients—particularly those with severe ME/CFS who have specific immune system markers. Some patients experienced temporary worsening of symptoms like headaches during treatment, which may actually indicate the treatment was working rather than causing harm.

Immune System

E0 ConsensusReviewPEM unclearSystematic-Review

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Comparison of Clinical Presentation and Symptomatology.

Wong, Timothy L, Weitzer, Danielle J·Medicina (Kaunas, Lithuania)·2021

Researchers reviewed 21 studies about Long COVID (symptoms lasting months after COVID-19 infection) and compared them to ME/CFS symptoms. They found that Long COVID patients reported 25 out of 29 known ME/CFS symptoms, suggesting these two conditions share many similarities. The study highlights the need for better monitoring and treatment of patients with Long COVID, and calls for more standardized research methods to understand both conditions better.

Long COVID Overlap

E0 ConsensusReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Toogood, Peter L, Clauw, Daniel J, Phadke, Sameer et al.·Pharmacological research·2021

ME/CFS is a serious illness causing extreme fatigue that doesn't improve with rest, along with pain, sleep problems, and difficulty thinking clearly. This review looks at what we currently know about ME/CFS, how doctors diagnose it, and what treatments exist today. The authors examined past research to identify promising targets for new medicines that could help treat ME/CFS in the future.

Immune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM requiredReview-Narrative

A Comprehensive Update of the Current Understanding of Chronic Fatigue Syndrome.

Noor, Nazir, Urits, Ivan, Degueure, Arielle et al.·Anesthesiology and pain medicine·2021

This review summarizes what researchers currently understand about ME/CFS, a complex illness causing severe fatigue and other symptoms. The condition may involve problems with the immune system, stress response, or nervous system, and can be triggered by infections like Epstein-Barr virus, though not always. Diagnosis requires six months of fatigue plus four symptoms like memory problems, sore throat, or post-exertion malaise, and doctors must rule out other conditions first. Treatment options include therapy, medication, and newer approaches like electrical stimulation, though more research is needed to find the best approaches.

SleepImmune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM unclear

Pathomechanisms and possible interventions in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Fluge, Øystein, Tronstad, Karl J, Mella, Olav·The Journal of clinical investigation·2021

This review article examines what we know about how ME/CFS damages the body and discusses possible treatments. Researchers looked at existing scientific evidence to understand the disease mechanisms—the biological processes that cause ME/CFS symptoms—and evaluated various interventions that might help patients. The goal was to create a comprehensive overview of current scientific understanding to guide future research and treatment development.

BiomarkersImmune System

E0 ConsensusReviewPEM unclearEditorial

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

Ariza, Maria Eugenia·Biomolecules·2021

This review examines whether certain viruses, particularly Epstein-Barr virus (EBV), may play a role in ME/CFS. Earlier research on this topic produced mixed results, leading some scientists to think viruses weren't involved. However, newer research methods have found that specific proteins made by EBV could contribute to immune system and nervous system problems in some ME/CFS patients.

BiomarkersImmune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Epidemiology, pathophysiology, and classification of the neurological symptoms of post-COVID-19 syndrome.

Carod-Artal, F J, García-Moncó, J C·Neurology perspectives·2021

This review examines long-term symptoms people experience after COVID-19 infection, particularly neurological (brain and nerve-related) symptoms like brain fog, memory problems, headaches, and sleep issues. The authors found that post-COVID-19 syndrome is complex and variable—affecting different people in different ways—and likely involves multiple causes including immune system changes, nerve dysfunction, and possibly persistent viral effects. Because the definition and criteria for post-COVID-19 syndrome remain unclear, reported rates of occurrence vary dramatically, ranging from 2% to 85% depending on the study.

Cognitive Impairment

E0 ConsensusReviewPEM unclearSystematic-Review

A systematic review of nutraceutical interventions for mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome.

Maksoud, Rebekah, Balinas, Cassandra, Holden, Sean et al.·Journal of translational medicine·2021

This review looked at whether special supplements that target the energy-producing parts of cells (mitochondria) might help ME/CFS patients feel less fatigued. The researchers searched for published studies testing these supplements in ME/CFS patients and found 9 studies. About two-thirds of these studies showed some improvement in fatigue, but the overall evidence isn't strong enough yet to say these supplements definitely work.

Energy Metabolism

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Alteration of Postural Balance in Patients with Fibromyalgia Syndrome-A Systematic Review and Meta-Analysis.

Review: How has cognitive behaviour therapy been adapted for adolescents with comorbid depression and chronic illness? A scoping review.

The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection.

Adverse outcomes in trials of graded exercise therapy for adult patients with chronic fatigue syndrome.

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome.

New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice.

The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Current Evidence and Potential Therapeutic Applications.

The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis.

Brainstem Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Scoping Review and Evaluation of Magnetic Resonance Imaging Findings.

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms.

The Quality of Methodological and Reporting in Network Meta-Analysis of Acupuncture and Moxibustion: A Cross-Sectional Survey.

Induced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome.

Back to the Future? Immunoglobulin Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)-A Systemic Review and Comparison of Clinical Presentation and Symptomatology.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

A Comprehensive Update of the Current Understanding of Chronic Fatigue Syndrome.

Pathomechanisms and possible interventions in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

Epidemiology, pathophysiology, and classification of the neurological symptoms of post-COVID-19 syndrome.

A systematic review of nutraceutical interventions for mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome.

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