ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

654 studies

541–560 of 654 studies

E0 ConsensusReviewPEM unclearReview-Narrative

Approved and investigational uses of modafinil : an evidence-based review.

Kumar, Raminder·Drugs·2008

This review looked at studies testing modafinil, a medication that promotes wakefulness, in different conditions including sleep disorders and fatigue-related illnesses. The authors found that modafinil works well for approved conditions like narcolepsy and sleep apnea, but studies testing it for chronic fatigue syndrome were very small and gave unclear results. The medication can cause side effects like insomnia, headaches, and appetite loss, and may interact with other drugs.

SleepCognitive Impairment

E0 ConsensusReviewPEM not requiredSystematic-Review

Cognitive behaviour therapy for chronic fatigue syndrome in adults.

Price, Jonathan R, Mitchell, Edward, Tidy, Elizabeth et al.·The Cochrane database of systematic reviews·2008

This review looked at 15 studies involving over 1,000 people with ME/CFS to see if cognitive behaviour therapy (CBT)—a type of talk therapy focused on thoughts and behaviors—could help reduce fatigue. Compared to usual care, CBT showed modest improvements in fatigue at the end of treatment, with 40% of people in CBT improving versus 26% in usual care. However, the benefits were less clear when researchers checked on people months later.

Interventions

E0 ConsensusGuidelinePEM not requiredGuideline

EULAR evidence-based recommendations for the management of fibromyalgia syndrome.

Carville, S F, Arendt-Nielsen, L, Bliddal, H et al.·Annals of the rheumatic diseases·2008

European medical experts reviewed research on how to treat fibromyalgia, a condition causing widespread pain and fatigue. They looked at studies of different treatments—medicines and therapies like exercise and counseling—to see which ones worked best. Based on the strongest evidence available, they created 9 recommendations to help doctors manage fibromyalgia.

E0 ConsensusReviewPEM not requiredSystematic-Review

Chronic fatigue syndrome.

Reid, Steven F, Chalder, Trudie, Cleare, Anthony et al.·BMJ clinical evidence·2008

This review looked at all available research on treatments for ME/CFS up to September 2007, examining 45 studies to see which treatments work and which are safe. The researchers studied many different treatments including therapy, exercise programs, supplements, and medications. They found that the quality and strength of evidence varies considerably depending on which treatment is being examined.

E0 ConsensusReviewPEM not requiredReview-Narrative

Neuroaetiology of chronic fatigue syndrome: an overview.

Sanders, Patricia, Korf, Jakob·The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2008

This review examines several competing theories about what causes ME/CFS. The authors found that while viral infections, brain hormone imbalances, immune problems, and psychological factors are all proposed as causes, none has been definitively proven. The authors suggest that ME/CFS may not be one single disease, but rather several different conditions that produce similar symptoms, which could explain why treatments like cognitive behavioral therapy work for some patients but not others.

Immune System

E0 ConsensusReviewPEM not requiredSystematic-Review

Somatic comorbidities of irritable bowel syndrome: a systematic analysis.

Riedl, Andrea, Schmidtmann, Marco, Stengel, Andreas et al.·Journal of psychosomatic research·2008

This study looked at other health conditions that commonly occur alongside irritable bowel syndrome (IBS). Researchers found that people with IBS are twice as likely to have other physical health problems compared to people without IBS. Conditions like fibromyalgia, chronic fatigue syndrome, and chronic pelvic pain appear in up to 65% of IBS patients, and digestive problems occur in about half of them.

E0 ConsensusReviewPEM not requiredEditorial

Central nervous system abnormalities in fibromyalgia and chronic fatigue syndrome: new concepts in treatment.

Gur, Ali, Oktayoglu, Pelin·Current pharmaceutical design·2008

This review examines how ME/CFS and fibromyalgia may both involve problems in the nervous system—specifically in how the brain processes pain, manages stress hormones, and controls automatic body functions. The authors discuss why current treatments are limited and explore new medication approaches that target brain chemicals involved in pain and fatigue.

SleepAutonomic Nervous SystemCognitive Impairment

E0 ConsensusGuidelinePEM requiredGuideline

Diagnosis and management of chronic fatigue syndrome or myalgic encephalomyelitis (or encephalopathy): summary of NICE guidance.

Baker, R, Shaw, E J·BMJ (Clinical research ed.)·2007

This document summarizes official guidance from NICE (the UK's National Institute for Health and Care Excellence) on how to diagnose and manage ME/CFS. It provides recommendations for healthcare professionals on recognizing the condition, running appropriate tests, and treating patients with practical advice on activity management, rehabilitation, and when to refer patients to specialists.

Diagnostics

E0 ConsensusGuidelinePEM requiredGuideline

Chronic fatigue syndrome and myalgic encephalomyelitis: the 2007 guidelines from the National Institute of Clinical Excellence.

Nye, Fred·The Journal of infection·2007

The National Institute of Clinical Excellence (NICE) published official guidelines in 2007 for diagnosing and managing ME/CFS. These guidelines were developed to help doctors recognize the condition and provide consistent care to patients across the UK. The guidelines cover how to identify ME/CFS, what tests to use, and what treatments are recommended.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredReview-Narrative

The chronic fatigue syndrome--an update.

Wyller, Vegard Bruun·Acta neurologica Scandinavica. Supplementum·2007

ME/CFS is a serious condition where extreme fatigue is the main symptom and gets worse with activity rather than better with rest. This review of scientific research shows that ME/CFS affects more women than men, likely involves problems with the immune system and muscles, and that certain talk therapies and exercise programs have shown benefit in clinical trials. Most patients improve over time, though complete recovery is rare, especially in adults.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredEditorial

[Chronic fatigue syndrome--a functional somatic syndrome].

Linde, Andreas·Therapeutische Umschau. Revue therapeutique·2007

This review suggests that ME/CFS is a condition involving multiple body systems rather than a single cause, and that it shares features with other similar illnesses affecting the mind and body. The authors found that treatments involving gradual increases in activity and cognitive behavioral therapy show the most promise, while antidepressants may help as an add-on treatment.

Endocrine Disruption

E0 ConsensusReviewPEM not requiredReview-Narrative

The cognitive behavioural model of medically unexplained symptoms: a theoretical and empirical review.

Deary, V, Chalder, T, Sharpe, M·Clinical psychology review·2007

This review examines the theory that ME/CFS and similar conditions involve interactions between thinking patterns, stress responses, and behavior that keep symptoms going. Researchers looked at decades of research to see if cognitive behavioral therapy (a type of talking therapy focused on thoughts and behaviors) works for these conditions. The review suggests that multiple factors—including genetics, immune function, personality traits, and how people interpret their symptoms—likely work together in ways that current treatments may not fully address.

E0 ConsensusReviewPEM not requiredReview-Narrative

[Overlap between atypical depression, seasonal affective disorder and chronic fatigue syndrome].

Juruena, Mario Francisco, Cleare, Anthony James·Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)·2007

This review article examines whether ME/CFS, atypical depression, and seasonal affective disorder share common biological roots. The researchers found that all three conditions may involve underactivity in the body's stress-response system (particularly a part of the brain called the hypothalamic-pituitary-adrenal axis), rather than overactivity as seen in other types of depression. This suggests these conditions might be more closely related than previously thought, which could help explain why patients sometimes experience overlapping symptoms.

Endocrine Disruption

E0 ConsensusReviewPEM not requiredReview-Narrative

[Viral infections in chronic fatigue syndrome].

Sairenji, Takeshi, Nagata, Keiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review looked at research on whether viruses and other infections might trigger ME/CFS. Most people with ME/CFS report having a flu-like illness before their symptoms started, which led researchers to investigate if infections could cause long-term immune system problems. The authors summarized what scientists have learned about different viruses, bacteria-like organisms, and other microbes that might be involved in ME/CFS development.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

[Chronic fatigue syndrome: biochemical examination of blood].

Hakariya, Yukiko, Kuratsune, Hirohiko·Nihon rinsho. Japanese journal of clinical medicine·2007

This review examined blood test abnormalities in ME/CFS patients. While standard blood tests often appear normal in CFS patients despite their many symptoms, specialized blood tests have found problems in the systems that control stress, hormones, and immune function. The authors suggest that ME/CFS may result from brain dysfunction caused by immune chemicals called cytokines or antibodies that attack the body's own cells.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Personality and chronic fatigue syndrome: methodological and conceptual issues.

van Geelen, Stefan M, Sinnema, Gerben, Hermans, Hubert J M et al.·Clinical psychology review·2007

This review looked at studies examining whether ME/CFS patients have particular personality traits, such as being perfectionistic or hardworking. The researchers found that different studies gave very different answers—some found no personality differences between ME/CFS patients and healthy people, while others reported more serious psychological problems. The authors concluded that more careful research is needed, particularly looking at how patients understand and tell their own life stories.

E0 ConsensusReviewPEM not requiredSystematic-Review

Identity and coping experiences in Chronic Fatigue Syndrome: a synthesis of qualitative studies.

Larun, Lillebeth, Malterud, Kirsti·Patient education and counseling·2007

This study looked at 20 earlier research projects to understand how ME/CFS affects patients' sense of self and how they cope. Patients often feel very sick but are not believed by others, including doctors, which makes their experience even harder. Patients want answers and a diagnosis to help them recover, while doctors often doubt the illness is real. When patients feel dismissed, they may withdraw and stop trying to engage with others.

E0 ConsensusReviewPEM not requiredReview-Narrative

Hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome.

Van Den Eede, Filip, Moorkens, Greta, Van Houdenhove, Boudewijn et al.·Neuropsychobiology·2007

This review examined research on the stress-response system (called the HPA axis) in ME/CFS patients. Scientists found that many people with ME/CFS have lower-than-normal stress hormone levels and don't respond typically to stress. While it's unclear whether this hormone imbalance causes ME/CFS or develops because of it, the authors suggest it likely plays a role in how symptoms develop and persist.

Endocrine Disruption

E0 ConsensusReviewPEM not requiredReview-Narrative

Benefits of physical training in fibromyalgia and related syndromes.

Maquet, D, Demoulin, C, Croisier, J-L et al.·Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique·2007

This review looked at studies on whether physical exercise and training help people with fibromyalgia and related conditions like ME/CFS. Most studies found that gradual, carefully planned exercise programs did help reduce pain and fatigue, though some reviews were less certain. The authors recommend that exercise should be part of a broader treatment approach that includes other therapies.

E0 ConsensusReviewPEM not requiredSystematic-Review

Dental amalgam and multiple sclerosis: a systematic review and meta-analysis.

Aminzadeh, Kevin K, Etminan, Mahyar·Journal of public health dentistry·2007

This study looked at whether dental fillings containing mercury (amalgam) might be linked to multiple sclerosis (MS). Researchers reviewed all available studies on this topic and combined the results. They found only a very small, statistically insignificant increase in MS risk among people with amalgam fillings, meaning the evidence does not support a strong connection between these fillings and MS development.

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Evidence Atlas

Evidence browser

Approved and investigational uses of modafinil : an evidence-based review.

Cognitive behaviour therapy for chronic fatigue syndrome in adults.

EULAR evidence-based recommendations for the management of fibromyalgia syndrome.

Chronic fatigue syndrome.

Neuroaetiology of chronic fatigue syndrome: an overview.

Somatic comorbidities of irritable bowel syndrome: a systematic analysis.

Central nervous system abnormalities in fibromyalgia and chronic fatigue syndrome: new concepts in treatment.

Diagnosis and management of chronic fatigue syndrome or myalgic encephalomyelitis (or encephalopathy): summary of NICE guidance.

Chronic fatigue syndrome and myalgic encephalomyelitis: the 2007 guidelines from the National Institute of Clinical Excellence.

The chronic fatigue syndrome--an update.

[Chronic fatigue syndrome--a functional somatic syndrome].

The cognitive behavioural model of medically unexplained symptoms: a theoretical and empirical review.

[Overlap between atypical depression, seasonal affective disorder and chronic fatigue syndrome].

[Viral infections in chronic fatigue syndrome].

[Chronic fatigue syndrome: biochemical examination of blood].

Personality and chronic fatigue syndrome: methodological and conceptual issues.

Identity and coping experiences in Chronic Fatigue Syndrome: a synthesis of qualitative studies.

Hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome.

Benefits of physical training in fibromyalgia and related syndromes.

Dental amalgam and multiple sclerosis: a systematic review and meta-analysis.

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