ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

654 studies

561–580 of 654 studies

E0 ConsensusGuidelinePEM unclearGuideline

NICE guidance on managing chronic fatigue syndrome/ME.

Hairon, Nerys, NICE·Nursing times·2007

This document provides official guidance from NICE (the UK's health authority) on how doctors should manage ME/CFS. It offers recommendations for diagnosing the condition, treating symptoms, and supporting patients in their daily lives. The guidance is based on the best evidence available and aims to help healthcare providers give consistent, appropriate care to people with ME/CFS.

Diagnostics

E0 ConsensusReviewPEM requiredSystematic-Review

Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: a systematic review.

Meeus, Mira, Nijs, Jo, Meirleir, Kenny De·European journal of pain (London, England)·2007

This review looked at 25 scientific studies about chronic pain in ME/CFS patients. Most people with ME/CFS experience widespread pain along with fatigue, but there is no clear agreement on how to define or measure this pain. The review found that pain is common and disabling, but we still don't know exactly what causes it or how to treat it effectively.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

Evidence for prescribing exercise as therapy in chronic disease.

Pedersen, B K, Saltin, B·Scandinavian journal of medicine & science in sports·2006

This review examined whether exercise therapy helps treat many different diseases, including chronic fatigue syndrome (ME/CFS). The authors looked at evidence showing how exercise affects disease causes, symptoms, fitness, and quality of life across multiple conditions. They also discussed how much exercise is safe and effective for each disease.

E0 ConsensusReviewPEM not requiredReview-Narrative

Autoantibodies associated with psychiatric disorders.

Margutti, Paola, Delunardo, Federica, Ortona, Elena·Current neurovascular research·2006

This review examines evidence that the immune system can sometimes produce antibodies that attack the brain and blood vessels, potentially causing psychiatric symptoms like depression, anxiety, and psychosis. The authors discuss how this autoimmune mechanism may occur in several conditions, including chronic fatigue syndrome, and review what we know about antibodies in psychiatric disorders including schizophrenia and autism.

Neuroinflammation

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome.

Prins, Judith B, van der Meer, Jos W M, Bleijenberg, Gijs·Lancet (London, England)·2006

This review examines the major debates and disagreements about ME/CFS that have occurred over the past 20 years among doctors, researchers, and patients. The authors discuss questions about how ME/CFS is defined, how it is diagnosed, what causes it, and what treatments work best. They suggest that future research should study ME/CFS alongside other similar conditions and use new tools from neuroscience and genetics to better understand the illness.

E0 ConsensusReviewPEM not requiredSystematic-Review

Chronic fatigue syndrome: a systematic review.

Maquet, D, Demoulin, C, Crielaard, J M·Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique·2006

This review examined all available research about ME/CFS to understand what we know about the condition. Researchers found that ME/CFS affects between 0.2% and 0.7% of people and that despite decades of research into possible causes like infections, immune problems, and hormonal imbalances, we still don't fully understand what causes the illness. Treatment should combine physical rehabilitation with psychological support to address the whole person.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology.

Cho, Hyong Jin, Skowera, Anna, Cleare, Anthony et al.·Current opinion in psychiatry·2006

This review examines what ME/CFS is and how it works in the body. The research shows that ME/CFS is a real condition separate from depression or anxiety, though the official way doctors diagnose it may need updating. Scientists have found signs that the nervous system, immune system, and genetics all play a role, but they still don't fully understand how these pieces fit together.

Immune System

E0 ConsensusReviewPEM not requiredSystematic-Review

Antidepressants and cognitive-behavioral therapy for symptom syndromes.

Jackson, Jeffrey L, O'Malley, Patrick G, Kroenke, Kurt·CNS spectrums·2006

This review looked at research on whether antidepressant medications and talking therapy (cognitive-behavioral therapy or CBT) help with long-lasting physical symptoms like pain and fatigue. The researchers examined studies on 11 different conditions, including chronic fatigue syndrome. They found that CBT was the most consistently helpful treatment, while antidepressants showed mixed results depending on the specific condition.

E0 ConsensusReviewPEM not requiredReview-Narrative

Mercury amalgam dental fillings: an epidemiologic assessment.

Bates, Michael N·International journal of hygiene and environmental health·2006

This review examined whether mercury from dental fillings causes chronic health problems, including chronic fatigue syndrome. Researchers looked at many studies on this topic and found little scientific evidence that amalgam fillings cause general chronic diseases, fatigue, or other common illnesses in the general population.

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic musculoskeletal pain in chronic fatigue syndrome: recent developments and therapeutic implications.

Nijs, Jo, Meeus, Mira, De Meirleir, Kenny·Manual therapy·2006

Many people with ME/CFS experience muscle and joint pain that can be even more bothersome than the fatigue itself. This review found that while some people with ME/CFS have naturally flexible joints, this doesn't seem to cause their pain. However, the way people think about their pain—such as catastrophizing or assuming the worst—plays a big role in how much pain they feel. The body's response to exercise appears to create extra stress on muscles in ME/CFS patients, which explains why exercise can make pain worse rather than better.

Post-Exertional Malaise

E0 ConsensusReviewPEM unclearSystematic-Review

Interventions for the treatment, management and rehabilitation of patients with chronic fatigue syndrome/myalgic encephalomyelitis: an updated systematic review.

Chambers, Duncan, Bagnall, Anne-Marie, Hempel, Susanne et al.·Journal of the Royal Society of Medicine·2006

This review looked at 70 studies to find out which treatments help people with ME/CFS. The researchers found that two talking therapies—cognitive behaviour therapy and graded exercise therapy—showed the most promise for reducing symptoms and helping people function better. For most other treatments tested, there wasn't enough clear evidence that they worked, and some caused unwanted side effects.

E0 ConsensusReviewPEM unclearSystematic-Review

Systematic review of multi-symptom conditions in Gulf War veterans.

Thomas, Hollie V, Stimpson, Nicola J, Weightman, Alison L et al.·Psychological medicine·2006

This review examined 23 studies comparing health problems in Gulf War veterans to people who were not deployed. Veterans who served in the Gulf War were nearly 4 times more likely to develop chronic fatigue syndrome and about 3.5 times more likely to report multiple chemical sensitivities or other multi-symptom illnesses. The review suggests that deployment to the Gulf War is connected with higher rates of these conditions.

Pain and Sensitization

E0 ConsensusReviewPEM unclearSystematic-Review

Physical activity for secondary prevention of disease. Systematic reviews of randomised clinical trials.

Karmisholt, Katrine, Gøtzsche, Peter C·Danish medical bulletin·2005

This review looked at whether physical activity helps prevent disease in people who already have certain health conditions. The researchers examined 17 high-quality studies published between 1998-2004. Physical activity was helpful for some conditions like heart disease and arthritis, but did not show benefits for chronic fatigue syndrome, depression, or several other conditions.

E0 ConsensusReviewPEM not requiredSystematic-Review

A systematic review describing the prognosis of chronic fatigue syndrome.

Cairns, R, Hotopf, M·Occupational medicine (Oxford, England)·2005

This review looked at 28 studies about how ME/CFS progresses over time. Researchers found that full recovery without treatment is uncommon (about 5%), but roughly 4 out of 10 patients did improve their symptoms. People who had milder fatigue to start with, felt they could control their symptoms, and didn't believe their illness was purely physical tended to have better outcomes.

E0 ConsensusReviewPEM unclearReview-Narrative

Epidemiology of chronic fatigue syndrome.

Ranjith, G·Occupational medicine (Oxford, England)·2005

This review examined research on how common ME/CFS is in different populations and what factors might be linked to it. While fatigue itself is very common, ME/CFS is actually quite rare. Interestingly, some patterns seen in specialist clinics (like who gets sick) don't always match what researchers find when they study the general population.

E0 ConsensusReviewPEM not requiredSystematic-Review

The placebo response in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis.

Cho, Hyong Jin, Hotopf, Matthew, Wessely, Simon·Psychosomatic medicine·2005

This study looked at how often ME/CFS patients improve simply from believing they will improve (the placebo effect) in clinical trials. Researchers found that the placebo response in ME/CFS is actually lower than many people assume—only about 20% of patients improved with placebo. Interestingly, patients were less likely to show placebo improvement when the treatment was psychological or psychiatric in nature, possibly because many ME/CFS patients believe their illness is physical rather than mental.

Interventions

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: the need for subtypes.

Jason, Leonard A, Corradi, Karina, Torres-Harding, Susan et al.·Neuropsychology review·2005

ME/CFS is a complex condition that affects people in different ways, and researchers found that treating it as one single disease may not be helpful. This review shows that patients with ME/CFS have different combinations of symptoms, different levels of disability, and different biological markers (measurable signs in the body), suggesting the condition should be divided into subtypes. Just like how different patients with diabetes or heart disease need different treatment approaches, ME/CFS patients might benefit from being grouped into categories so doctors can provide more targeted care.

Diagnostics

E0 ConsensusReviewPEM not requiredSystematic-Review

Treatments for chronic fatigue syndrome.

Rimes, K A, Chalder, T·Occupational medicine (Oxford, England)·2005

This review looked at different ways to treat chronic fatigue syndrome by examining studies on therapies like cognitive behavioral therapy (talking therapy that helps change thought patterns), graded exercise therapy (gradually increasing physical activity), medications, immune treatments, and supplements. The most helpful treatments found were cognitive behavioral therapy and graded exercise therapy, though many other treatments need more research. Occupational health doctors may be able to help patients manage their symptoms and return to work.

E0 ConsensusReviewPEM not requiredReview-Narrative

Genetic factors in neuromuscular pain.

Buskila, Dan, Neumann, Lily, Press, Joseph·CNS spectrums·2005

This review examined whether ME/CFS, fibromyalgia, and related chronic pain conditions share genetic roots. Researchers looked at recent studies suggesting that genes involved in serotonin and dopamine—brain chemicals that affect mood and pain—may make some people more likely to develop these conditions. The review also highlights that environmental triggers (like infections or stress) likely play a role in people who are genetically predisposed.

Pain and Sensitization

E0 ConsensusReviewPEM not requiredMeta-Analysis

Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms.

Cairns, Victoria, Godwin, Jon·International journal of epidemiology·2005

This study looked at patients who had Lyme disease and found that many experienced long-lasting fatigue, muscle and joint pain, and thinking difficulties even after antibiotic treatment. Researchers combined results from five previous studies comparing Lyme disease patients to healthy controls and found these symptoms were significantly more common in the Lyme disease group. The symptom pattern was notably different from other conditions like fibromyalgia or depression.

Pain and SensitizationCognitive Impairment

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Evidence Atlas

Evidence browser

NICE guidance on managing chronic fatigue syndrome/ME.

Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: a systematic review.

Evidence for prescribing exercise as therapy in chronic disease.

Autoantibodies associated with psychiatric disorders.

Chronic fatigue syndrome.

Chronic fatigue syndrome: a systematic review.

Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology.

Antidepressants and cognitive-behavioral therapy for symptom syndromes.

Mercury amalgam dental fillings: an epidemiologic assessment.

Chronic musculoskeletal pain in chronic fatigue syndrome: recent developments and therapeutic implications.

Interventions for the treatment, management and rehabilitation of patients with chronic fatigue syndrome/myalgic encephalomyelitis: an updated systematic review.

Systematic review of multi-symptom conditions in Gulf War veterans.

Physical activity for secondary prevention of disease. Systematic reviews of randomised clinical trials.

A systematic review describing the prognosis of chronic fatigue syndrome.

Epidemiology of chronic fatigue syndrome.

The placebo response in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis.

Chronic fatigue syndrome: the need for subtypes.

Treatments for chronic fatigue syndrome.

Genetic factors in neuromuscular pain.

Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms.

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