ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

655 studies

641–655 of 655 studies

E0 ConsensusReviewPEM not requiredReview-Narrative

Clinical correlates of infection with human herpesvirus-6.

Krueger, G R, Klueppelberg, U, Hoffmann, A et al.·In vivo (Athens, Greece)·1994

This review examines connections between human herpesvirus-6 (HHV-6), a common virus most people catch as infants, and various illnesses including ME/CFS. The virus usually stays dormant in the body after infection, but in some people it may reactivate and be linked to several health conditions. The authors reviewed existing knowledge about which diseases show signs of active HHV-6 infection.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Pathogenic tracks in fatigue syndromes.

Moutschen, M, Triffaux, J M, Demonty, J et al.·Acta clinica Belgica·1994

This review examined research on ME/CFS and related fatigue conditions that develop after viral infections, looking at five main areas: infectious triggers, immune system problems, muscle function, hormonal imbalances, and psychiatric factors. The authors suggest that abnormalities in the body's stress-hormone system (HPA axis) may be a primary cause, leading to chronic immune activation and reactivation of dormant viruses like those in the herpes family, which then cause muscle weakness and fatigue symptoms.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

The neuropsychiatry of chronic fatigue syndrome.

Wessely, S·Ciba Foundation symposium·1993

This review examines how ME/CFS relates to psychiatric conditions and brain function. Rather than viewing ME/CFS as purely physical or purely psychological, the authors found evidence that brain system problems—particularly in the hypothalamus, a key control center—play an important role in the condition. The paper argues that understanding ME/CFS requires looking at both brain biology and mental health factors together.

E0 ConsensusReviewPEM not requiredSystematic-Review

Psychotropic treatment of chronic fatigue syndrome and related disorders.

Goodnick, P J, Sandoval, R·The Journal of clinical psychiatry·1993

This review examined whether antidepressant medications can help people with ME/CFS and fibromyalgia, since depression often occurs alongside these conditions. Researchers looked at 23 studies and found that certain antidepressants—particularly at lower doses than used for depression alone—may help reduce both fatigue and pain symptoms. Different types of antidepressants appeared to work better for different symptoms: some were better for pain relief, while others were better for mood.

E0 ConsensusReviewPEM not requiredReview-Narrative

Studies of herpesvirus infection in chronic fatigue syndrome.

Straus, S E·Ciba Foundation symposium·1993

This review examined whether common viruses in the herpesvirus family (like Epstein-Barr virus and human herpesvirus 6) cause ME/CFS. Researchers found that while some ME/CFS patients have higher levels of antibodies to these viruses and some cases may start after herpesvirus infection, these viruses are likely not the main cause of the illness for most people.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

The pathophysiology of chronic fatigue syndrome: confirmations, contradictions, and conjectures.

Manu, P, Lane, T J, Matthews, D A·International journal of psychiatry in medicine·1992

This 1992 review examined 32 published studies on ME/CFS to identify what researchers had consistently found, disagreed about, or only reported once. The review confirmed that ME/CFS primarily affects middle-aged white women and is often accompanied by depression, but found conflicting evidence about whether infections cause the illness and whether immune treatments help.

Immune System

E0 ConsensusReviewPEM not requiredEditorial

Fibromyalgia, chronic fatigue, and myofascial pain syndromes.

Goldenberg, D L·Current opinion in rheumatology·1992

This review examined research published on fibromyalgia and chronic fatigue syndrome, looking at what treatments work best and how these conditions are diagnosed. Researchers found that while many studies have been done, no single treatment has proven highly effective for either condition, and the way doctors diagnose chronic fatigue syndrome needs to be improved and made more consistent.

Diagnostics

E0 ConsensusGuidelinePEM unclearGuideline

A report--chronic fatigue syndrome: guidelines for research.

Sharpe, M C, Archard, L C, Banatvala, J E et al.·Journal of the Royal Society of Medicine·1991

This 1991 document provides guidelines for how researchers should study ME/CFS to ensure consistent and reliable findings. Rather than reporting new experimental results, it offers recommendations on how to standardize research methods, study design, and patient definitions. It represents the thinking of leading medical experts who were trying to establish a common framework for ME/CFS research.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

An overview of chronic fatigue syndrome.

Krupp, L B, Mendelson, W B, Friedman, R·The Journal of clinical psychiatry·1991

This review examined research on ME/CFS to understand whether the illness is caused by psychological factors, immune system problems, or both. Researchers found that ME/CFS patients experience more disabling fatigue than people with other chronic illnesses, and some have immune system abnormalities. However, many ME/CFS patients have no psychiatric illness, suggesting ME/CFS is a real medical condition separate from depression.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

Post-infectious neuromyasthenia (chronic fatigue syndrome): a summary of ongoing studies.

Salit, I E, Abbey, S E, Moldofsky, H et al.·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This 1991 review examined multiple ongoing studies about ME/CFS (then called post-infectious neuromyasthenia), a condition that causes extreme fatigue and other symptoms following infections. The researchers summarized what different studies were finding about how this illness affects the body and brain. This work helped organize early research efforts to better understand this serious condition.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredReview-Narrative

Cognitive and mood-state changes in patients with chronic fatigue syndrome.

Grafman, J, Johnson, R, Scheffers, M·Reviews of infectious diseases·1991

This review examined whether ME/CFS causes problems with memory, thinking, and mood. The researchers found that while some people with acute mono or EBV infection may have thinking difficulties, they couldn't confirm this happens in ME/CFS patients using objective tests. However, they did notice that people with ME/CFS often have depression or anxiety either before or alongside their illness.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredReview-Narrative

Serologic and immunologic responses in chronic fatigue syndrome with emphasis on the Epstein-Barr virus.

Jones, J F·Reviews of infectious diseases·1991

This review examined whether ME/CFS is connected to Epstein-Barr virus (EBV), the virus that causes mono. Researchers found that people with ME/CFS had higher levels of antibodies to EBV compared to healthy people, but this doesn't prove the virus causes the disease. They also found that immune cells called natural killer cells—which help fight infections—work differently in ME/CFS patients, though the findings varied between studies.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome and depression: cause, effect, or covariate.

Abbey, S E, Garfinkel, P E·Reviews of infectious diseases·1991

Many people with ME/CFS experience depression, but it's unclear why. This review examines four possible explanations: depression might be the main illness with fatigue as a symptom, depression might develop because of having ME/CFS, both conditions might occur together separately, or depression might be incorrectly diagnosed. The authors discuss how depression can affect medical tests used to study ME/CFS, which is important to understand when interpreting research results.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredReview-Narrative

Review of laboratory findings for patients with chronic fatigue syndrome.

Buchwald, D, Komaroff, A L·Reviews of infectious diseases·1991

This review examined blood test results from many ME/CFS patients and found several patterns in how their immune systems function differently. The most common findings included weaker natural killer cells (which normally help fight infections), unusual antibody levels, and signs of past Epstein-Barr virus infection. These patterns appeared across multiple studies, suggesting they may be important features of the condition.

Immune System

E0 ConsensusReviewPEM unclearEditorial

Postviral fatigue syndrome: time for a new approach.

David, A S, Wessely, S, Pelosi, A J·British medical journal (Clinical research ed.)·1988

This 1988 review examined how ME/CFS was being studied and discussed in medical literature, finding significant problems with how research was being conducted. The authors argued that the condition should not be viewed as simply 'all in your head' or 'purely physical,' but rather as involving multiple factors affecting the body and mind. They called for better research methods and clearer definitions before doctors could effectively help patients.

Diagnostics

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Evidence browser

Clinical correlates of infection with human herpesvirus-6.

Pathogenic tracks in fatigue syndromes.

The neuropsychiatry of chronic fatigue syndrome.

Psychotropic treatment of chronic fatigue syndrome and related disorders.

Studies of herpesvirus infection in chronic fatigue syndrome.

The pathophysiology of chronic fatigue syndrome: confirmations, contradictions, and conjectures.

Fibromyalgia, chronic fatigue, and myofascial pain syndromes.

A report--chronic fatigue syndrome: guidelines for research.

An overview of chronic fatigue syndrome.

Post-infectious neuromyasthenia (chronic fatigue syndrome): a summary of ongoing studies.

Cognitive and mood-state changes in patients with chronic fatigue syndrome.

Serologic and immunologic responses in chronic fatigue syndrome with emphasis on the Epstein-Barr virus.

Chronic fatigue syndrome and depression: cause, effect, or covariate.

Review of laboratory findings for patients with chronic fatigue syndrome.

Postviral fatigue syndrome: time for a new approach.

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