Krueger, G R, Klueppelberg, U, Hoffmann, A et al. · In vivo (Athens, Greece) · 1994
This review examines connections between human herpesvirus-6 (HHV-6), a common virus most people catch as infants, and various illnesses including ME/CFS. The virus usually stays dormant in the body after infection, but in some people it may reactivate and be linked to several health conditions. The authors reviewed existing knowledge about which diseases show signs of active HHV-6 infection.
This early literature review established HHV-6 as a potential pathogenic factor in ME/CFS, helping motivate subsequent viral investigations in the condition. It provided an important foundation for researchers exploring whether viral reactivation contributes to post-infectious illnesses and immune dysregulation in ME/CFS populations.
This review does not establish that HHV-6 causes ME/CFS or determine the prevalence of active HHV-6 infection in ME/CFS patients compared to controls. It identifies associations and presence of viral antibodies but cannot distinguish between causation, reactivation secondary to immune dysfunction, or incidental co-infection. The methodology does not allow causal claims about HHV-6's role in disease pathogenesis.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Krueger, G R, Klueppelberg, U, Hoffmann, A, & Ablashi, D V (1994). Clinical correlates of infection with human herpesvirus-6.. In vivo (Athens, Greece). https://pubmed.ncbi.nlm.nih.gov/7893974/
BibTeX
@article{mecfsatlas-krueger-1994-clinical-correlates,
author = {Krueger, G R and Klueppelberg, U and Hoffmann, A and Ablashi, D V},
title = {Clinical correlates of infection with human herpesvirus-6.},
journal = {In vivo (Athens, Greece)},
year = {1994},
note = {PubMed: 7893974},
url = {https://www.mecfsatlas.com/evidence/krueger-1994-clinical-correlates},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/krueger-1994-clinical-correlates
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