ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1101–1120 of 2,807 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis.

Van Der Gucht, Axel, Aoun Sebaiti, Mehdi, Guedj, Eric et al.·Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2017

This study used a special type of brain scan (PET imaging) to look for energy metabolism problems in the brains of people with macrophagic myofascitis, a condition involving immune cell buildup in muscles. Researchers found that MMF patients had lower energy use in multiple brain regions compared to healthy people, and this pattern was especially pronounced in patients who also had thinking and memory problems.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Stress vulnerability in adolescents with chronic fatigue syndrome: experimental study investigating heart rate variability and skin conductance responses.

Rimes, Katharine A, Lievesley, Kate, Chalder, Trudie·Journal of child psychology and psychiatry, and allied disciplines·2017

This study looked at how adolescents with ME/CFS respond to stress compared to young people with asthma and healthy teenagers. Researchers measured physical stress responses (heart rate and skin sweating) while young people gave a speech. Adolescents with ME/CFS showed signs of being more stressed before, during, and after the task, and their bodies took longer to calm down afterward compared to the other groups.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study.

Castro-Marrero, Jesús, Faro, Mónica, Aliste, Luisa et al.·Psychosomatics·2017

This study looked at 1,757 people with ME/CFS in Spain to understand what other health conditions they commonly experience alongside their ME/CFS. Researchers found that more than 80% of patients had at least one additional condition, such as fibromyalgia, thyroid problems, vitamin D deficiency, or ligament issues. The study identified five different groups of ME/CFS patients based on their comorbidities, with some groups experiencing significantly worse fatigue and quality of life than others.

E2 ModerateCohortPEM unclearCross-Sectional

Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Josev, Elisha K, Jackson, Melinda L, Bei, Bei et al.·Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2017

This study examined sleep problems in teenagers with ME/CFS compared to healthy teenagers. Researchers found that teens with ME/CFS took longer to fall asleep, spent more total time in bed, slept longer overall, woke up later, and reported feeling their sleep was of poorer quality. Anxiety levels were also higher in the ME/CFS group and were connected to worse sleep quality in both groups.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue and psychosocial variables in autoimmune rheumatic disease and chronic fatigue syndrome: A cross-sectional comparison.

Ali, Sheila, Matcham, Faith, Irving, Katherine et al.·Journal of psychosomatic research·2017

This study compared how people with ME/CFS and people with autoimmune rheumatic diseases (like rheumatoid arthritis) experience fatigue and cope with their symptoms. The researchers found that people with ME/CFS were more fatigued, had worse sleep, and were more likely to avoid activities and struggle with accepting their illness, while people with rheumatic diseases were more likely to worry about damage to their bodies. This suggests that fatigue in these different conditions may need different treatment approaches.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Nagy-Szakal, Dorottya, Williams, Brent L, Mishra, Nischay et al.·Microbiome·2017

This study looked at the bacteria living in the gut of 50 ME/CFS patients and 50 healthy people to see if differences in gut bacteria might explain some ME/CFS symptoms. The researchers found that ME/CFS patients have unusual patterns of gut bacteria, and these patterns are different depending on whether the patient also has irritable bowel syndrome (IBS). Importantly, the type and balance of gut bacteria were linked to how severe patients' fatigue, pain, and other symptoms were.

BiomarkersEnergy Metabolism

E2 ModerateCohortPEM unclearCross-Sectional

Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome.

Shan, Zack Y, Kwiatek, Richard, Burnet, Richard et al.·NMR in biomedicine·2017

This study found that ME/CFS patients with the worst sleep quality had specific structural differences in a brain region called the medial prefrontal cortex compared to healthy people. The researchers used MRI brain scans to measure brain tissue and found that the brain tissue in this area appeared different in ME/CFS patients, especially those reporting unrefreshing sleep. This is important because it provides biological evidence that unrefreshing sleep in ME/CFS is a real physical problem, not just a patient's perception.

E2 ModerateCohortPEM not requiredCross-Sectional

Gross and fine motor function in fibromyalgia and chronic fatigue syndrome.

Rasouli, Omid, Fors, Egil A, Borchgrevink, Petter Chr et al.·Journal of pain research·2017

This study compared how quickly people with ME/CFS and fibromyalgia could start moving when they heard a sound, and how well they could do precise hand movements compared to healthy people. Both ME/CFS and fibromyalgia groups were slower to start walking in response to the sound, though their fine hand movements were similar to healthy controls. The results suggest that ME/CFS and fibromyalgia may affect the speed of starting movement, but not the precision of hand tasks.

E2 ModerateCohortPEM unclearCross-Sectional

Can physical assessment techniques aid diagnosis in people with chronic fatigue syndrome/myalgic encephalomyelitis? A diagnostic accuracy study.

Hives, Lucy, Bradley, Alice, Richards, Jim et al.·BMJ open·2017

Researchers tested whether five simple physical examination techniques could help doctors quickly identify ME/CFS. They examined 52 people with ME/CFS and 42 people without the condition, using trained practitioners to check for specific physical signs like spine problems and tender points. The study found that two of these physical signs were reliable and accurate enough to potentially help with diagnosis, suggesting that quick physical checks might be a useful screening tool.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Trends in the incidence of chronic fatigue syndrome and fibromyalgia in the UK, 2001-2013: a Clinical Practice Research Datalink study.

Collin, Simon M, Bakken, Inger J, Nazareth, Irwin et al.·Journal of the Royal Society of Medicine·2017

This study looked at how often ME/CFS and fibromyalgia were diagnosed in UK general practices between 2001 and 2013 using medical records. The researchers found that ME/CFS diagnoses decreased over time, while fibromyalgia diagnoses increased. Interestingly, people in poorer areas were less likely to be diagnosed with ME/CFS but more likely to be diagnosed with fibromyalgia compared to people in wealthier areas.

E2 ModerateCohortPEM unclearCross-Sectional

Heterogeneity in chronic fatigue syndrome - empirically defined subgroups from the PACE trial.

Williams, T E, Chalder, T, Sharpe, M et al.·Psychological medicine·2017

This study found that ME/CFS is not one single condition but rather five distinct subtypes that affect people differently. Researchers analyzed data from 541 patients and identified groups characterized by: low overall symptoms, mood disorders, overlapping conditions like fibromyalgia, combined multiple symptoms, or avoidance behaviors with fear of activity. Understanding these differences could help doctors tailor treatments to what works best for each person's specific type.

E2 ModerateCohortPEM not requiredCase-Control

Cytokine responses to exercise and activity in patients with chronic fatigue syndrome: case-control study.

Clark, L V, Buckland, M, Murphy, G et al.·Clinical and experimental immunology·2017

This study examined whether people with ME/CFS have abnormal immune protein levels (cytokines) in their blood, especially after physical activity. Researchers compared 24 ME/CFS patients with 21 healthy controls and measured multiple immune markers at rest and after exercise. The study found no significant differences in immune protein levels between the two groups, and no link between post-exertional symptoms and increased cytokine levels.

Immune SystemPost-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Differential effects of childhood trauma subtypes on fatigue and physical functioning in chronic fatigue syndrome.

De Venter, Maud, Illegems, Jela, Van Royen, Rita et al.·Comprehensive psychiatry·2017

This study looked at whether different types of childhood trauma are linked to fatigue and physical disability in ME/CFS patients. Researchers found that childhood sexual harassment was strongly associated with worse fatigue and lower physical functioning, while other types of trauma (emotional neglect, emotional abuse, physical threat, and sexual abuse) showed no significant connection. The findings suggest that the specific type of childhood trauma may matter when understanding how trauma relates to ME/CFS symptoms.

E2 ModerateCohortPEM unclearObservational

Down-regulation of renin-aldosterone and antidiuretic hormone systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Miwa, Kunihisa·Journal of cardiology·2017

This study found that ME/CFS patients have smaller hearts and lower levels of certain hormones that control blood volume and fluid balance compared to healthy people. When researchers gave half the ME/CFS patients a synthetic hormone called desmopressin for five days, about half of them felt better, with less dizziness when standing and improved ability to do daily activities.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Subtyping Patients with Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS) By Course of Illness.

Stoothoff, Jamie, Gleason, Kristen, McManimen, Stephanie et al.·Journal of biosensors, biomarkers and diagnostics·2017

This study looked at how ME/CFS progresses differently in different people. Researchers asked 541 patients to describe how their illness changed over time—whether it stayed the same, got worse, got better, or went up and down. They found that patients with different illness patterns had different symptom severity and ability to function, suggesting that grouping patients by how their illness progresses could help doctors better understand and treat the condition.

E2 ModerateCohortPEM unclearLongitudinal

HPV vaccination and risk of chronic fatigue syndrome/myalgic encephalomyelitis: A nationwide register-based study from Norway.

Feiring, Berit, Laake, Ida, Bakken, Inger Johanne et al.·Vaccine·2017

This study looked at whether the HPV vaccine (used to prevent cervical cancer) was linked to developing ME/CFS in Norwegian girls and boys between 2009 and 2014. Researchers tracked over 824,000 young people using national health records and found that girls who received the HPV vaccine were not at higher risk of developing ME/CFS compared to those who didn't receive it. The study did find that ME/CFS became slightly more common over time in both vaccinated and unvaccinated young people.

E2 ModerateCohortPEM not requiredCross-Sectional

An assessment of fatigue in patients with postural orthostatic tachycardia syndrome.

Wise, Shelby, Ross, Amanda, Brown, Abigail et al.·Journal of health psychology·2017

This study looked at fatigue in people with POTS (postural orthostatic tachycardia syndrome), a condition that shares many symptoms with ME/CFS. Researchers asked 138 young people with POTS to describe their fatigue and brain fog using questionnaires. They found that fatigue comes in multiple forms and that people with POTS fall into two groups: those with mild symptoms and those with severe symptoms, with the severe group experiencing much worse brain fog and activity limitations.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Differences in alexithymia and emotional awareness in exhaustion syndrome and chronic fatigue syndrome.

Maroti, Daniel, Molander, Peter, Bileviciute-Ljungar, Indre·Scandinavian journal of psychology·2017

This study looked at how people with Exhaustion Syndrome and ME/CFS differ in how they experience and identify their emotions. Researchers tested 31 people with Exhaustion Syndrome, 38 with ME/CFS, and 30 healthy people using emotion-recognition tests and questionnaires about emotional awareness. The results showed that both groups had some difficulty with emotions, but in slightly different ways—people with ME/CFS had more trouble actually identifying what they were feeling in a performance test, while people with Exhaustion Syndrome mainly reported difficulty on a self-assessment questionnaire.

E2 ModerateCohortPEM not requiredCross-Sectional

Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England.

Earl, Kate E, Sakellariou, Giorgos K, Sinclair, Melanie et al.·BMJ open·2017

This study investigated whether low vitamin D levels contribute to the fatigue experienced by people with ME/CFS. Researchers compared 92 ME/CFS patients with 94 healthy controls and found that ME/CFS patients actually had higher vitamin D levels, often because they were taking vitamin D supplements. Importantly, there was no connection between vitamin D levels and how fatigued patients felt, suggesting that vitamin D deficiency is not a cause of ME/CFS fatigue.

E2 ModerateBehavioralPEM not requiredCross-Sectional

An attention and interpretation bias for illness-specific information in chronic fatigue syndrome.

Hughes, A M, Chalder, T, Hirsch, C R et al.·Psychological medicine·2017

This study looked at whether people with ME/CFS notice illness-related information more than healthy people, and whether they tend to interpret unclear situations in a health-focused way. Researchers found that people with ME/CFS do pay more attention to fatigue-related words and are more likely to interpret ambiguous situations negatively related to their health compared to healthy controls. These thought patterns were connected to beliefs about fear and avoidance, suggesting they may help keep ME/CFS symptoms going.

Cognitive Impairment

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Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis.

Stress vulnerability in adolescents with chronic fatigue syndrome: experimental study investigating heart rate variability and skin conductance responses.

Comorbidity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Nationwide Population-Based Cohort Study.

Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Fatigue and psychosocial variables in autoimmune rheumatic disease and chronic fatigue syndrome: A cross-sectional comparison.

Fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome.

Gross and fine motor function in fibromyalgia and chronic fatigue syndrome.

Can physical assessment techniques aid diagnosis in people with chronic fatigue syndrome/myalgic encephalomyelitis? A diagnostic accuracy study.

Trends in the incidence of chronic fatigue syndrome and fibromyalgia in the UK, 2001-2013: a Clinical Practice Research Datalink study.

Heterogeneity in chronic fatigue syndrome - empirically defined subgroups from the PACE trial.

Cytokine responses to exercise and activity in patients with chronic fatigue syndrome: case-control study.

Differential effects of childhood trauma subtypes on fatigue and physical functioning in chronic fatigue syndrome.

Down-regulation of renin-aldosterone and antidiuretic hormone systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Subtyping Patients with Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS) By Course of Illness.

HPV vaccination and risk of chronic fatigue syndrome/myalgic encephalomyelitis: A nationwide register-based study from Norway.

An assessment of fatigue in patients with postural orthostatic tachycardia syndrome.

Differences in alexithymia and emotional awareness in exhaustion syndrome and chronic fatigue syndrome.

Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England.

An attention and interpretation bias for illness-specific information in chronic fatigue syndrome.

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