ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

1101–1120 of 2,784 studies

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Establishing Clinically Relevant Severity Levels for the Central Sensitization Inventory.

Neblett, Randy, Hartzell, Meredith M, Mayer, Tom G et al.·Pain practice : the official journal of World Institute of Pain·2017

Researchers created and tested a scoring system called the Central Sensitization Inventory (CSI) to help doctors identify when someone's symptoms may be caused by their nervous system being overly sensitive to pain signals. The study divided CSI scores into five levels—from subclinical to extreme—and confirmed that higher scores are associated with having more chronic conditions like fibromyalgia and ME/CFS, as well as higher levels of depression, sleep problems, and disability.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women.

Milrad, Sara F, Hall, Daniel L, Jutagir, Devika R et al.·Journal of neuroimmunology·2017

This study looked at 60 women with ME/CFS to understand how sleep quality affects their symptoms and inflammation levels. Researchers found that women who slept poorly had higher levels of inflammatory substances in their blood and experienced more severe fatigue and ME/CFS symptoms. The findings suggest that improving sleep quality might help reduce both inflammation and symptom severity in people living with ME/CFS.

Immune System

E2 ModerateBehavioralPEM unclearCross-Sectional

Anxiety and depression in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): Examining the incidence of health anxiety in CFS/ME.

Daniels, Jo, Brigden, Amberly, Kacorova, Adela·Psychology and psychotherapy·2017

This study looked at how many people with ME/CFS also experience health anxiety—worry about physical symptoms and their meaning. Researchers surveyed 45 ME/CFS patients and found that most had elevated worry about their health, and many had clinically significant health anxiety. The findings suggest that health anxiety is common in ME/CFS and may be worth screening for and treating.

E2 ModerateCohortPEM unclearCross-Sectional

Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism.

Germain, Arnaud, Ruppert, David, Levine, Susan M et al.·Molecular bioSystems·2017

This study examined the chemicals in the blood of 17 ME/CFS patients and compared them to 15 healthy people. Researchers found 74 different chemicals at abnormal levels in ME/CFS patients, with 35 showing significant differences. Many of these chemicals are important for producing energy in the body, which could help explain why ME/CFS patients feel so exhausted.

BiomarkersEnergy Metabolism

E2 ModerateCohortPEM not requiredCase-Control

Impact of Rantes from jawbone on Chronic Fatigue Syndrome.

Lechner, J, Huesker, K, Von Baehr, V·Journal of biological regulators and homeostatic agents·2017

This study investigated whether inflammation in the jawbone might contribute to ME/CFS. Researchers compared jawbone tissue from 21 ME/CFS patients with tissue from 19 healthy people and found that ME/CFS patients had significantly higher levels of inflammatory proteins (RANTES and FGF-2) in areas of jawbone that had undergone incomplete healing. The authors suggest that this hidden jawbone inflammation might be a previously unknown trigger for ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Stress vulnerability in adolescents with chronic fatigue syndrome: experimental study investigating heart rate variability and skin conductance responses.

Rimes, Katharine A, Lievesley, Kate, Chalder, Trudie·Journal of child psychology and psychiatry, and allied disciplines·2017

This study looked at how adolescents with ME/CFS respond to stress compared to young people with asthma and healthy teenagers. Researchers measured physical stress responses (heart rate and skin sweating) while young people gave a speech. Adolescents with ME/CFS showed signs of being more stressed before, during, and after the task, and their bodies took longer to calm down afterward compared to the other groups.

Autonomic Nervous System

E2 ModerateDiagnosticPEM not requiredMethods-Paper

The assessment of fatigue: Psychometric qualities and norms for the Checklist individual strength.

Worm-Smeitink, M, Gielissen, M, Bloot, L et al.·Journal of psychosomatic research·2017

This study tested a questionnaire called the Checklist Individual Strength (CIS) that measures different types of fatigue, including how tired people feel, difficulty concentrating, lack of motivation, and reduced activity levels. Researchers gave this questionnaire to nearly 2,300 healthy people and over 5,000 patients with chronic fatigue to see if it accurately identifies severe fatigue. They found the CIS works well for measuring fatigue and recommended adjusting the score that indicates 'severe fatigue' from 35 to 40 points for ME/CFS research.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway.

Kanchanatawan, Buranee, Sirivichayakul, Sunee, Thika, Supaksorn et al.·Metabolic brain disease·2017

This study looked at physical symptoms like fatigue, muscle pain, and flu-like feelings in people with schizophrenia. Researchers found that more than half of schizophrenia patients experienced these symptoms, which were linked to depression, anxiety, and problems with memory and attention. The symptoms appeared to be connected to changes in how the body processes tryptophan, an amino acid, and how the immune system responds to these breakdown products.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Gross and fine motor function in fibromyalgia and chronic fatigue syndrome.

Rasouli, Omid, Fors, Egil A, Borchgrevink, Petter Chr et al.·Journal of pain research·2017

This study compared how quickly people with ME/CFS and fibromyalgia could start moving when they heard a sound, and how well they could do precise hand movements compared to healthy people. Both ME/CFS and fibromyalgia groups were slower to start walking in response to the sound, though their fine hand movements were similar to healthy controls. The results suggest that ME/CFS and fibromyalgia may affect the speed of starting movement, but not the precision of hand tasks.

E2 ModerateBehavioralPEM unclearCross-Sectional

Activity Pacing is Associated With Better and Worse Symptoms for Patients With Long-term Conditions.

Antcliff, Deborah, Campbell, Malcolm, Woby, Steve et al.·The Clinical journal of pain·2017

This study looked at different ways people with chronic fatigue, fibromyalgia, and chronic pain manage their activities day-to-day. Researchers found that some pacing strategies work better than others: spreading activities consistently throughout the day helped, but drastically cutting back activities was linked to feeling worse. The study suggests that how you pace your activities matters—not all pacing strategies are equally helpful.

Pain and Sensitization

E2 ModeratePEM unclearBiobank-Resource

The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis.

Lacerda, Eliana M, Bowman, Erinna W, Cliff, Jacqueline M et al.·Open journal of bioresources·2017

The UK ME/CFS Biobank is a collection of blood samples and health information from 284 people with ME/CFS, 60 people with multiple sclerosis, and 135 healthy volunteers. Researchers created this resource to help scientists study what causes ME/CFS and find better ways to diagnose and treat it. The samples and detailed patient information can be used by researchers worldwide to search for biological markers of the disease.

BiomarkersImmune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue in an adult attention deficit hyperactivity disorder population: A trans-diagnostic approach.

Rogers, Denise C, Dittner, Antonia J, Rimes, Katharine A et al.·The British journal of clinical psychology·2017

This study looked at fatigue in adults with ADHD and compared it to fatigue in people with ME/CFS and healthy people. Researchers found that adults with ADHD experience significantly more fatigue than healthy controls, with about 62% meeting criteria for clinically significant fatigue. Importantly, they discovered that people with ME/CFS and people with ADHD share many similar challenges, including low mood, anxiety, and reduced confidence in their abilities.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

Activity patterns in response to symptoms in patients being treated for chronic fatigue syndrome: An experience sampling methodology study.

Band, Rebecca, Barrowclough, Christine, Caldwell, Kim et al.·Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2017

This study looked at how 23 people with ME/CFS change their activity levels in response to their symptoms throughout the day. Researchers had participants use an app on their phones to report their fatigue, pain, mood, and activity patterns 10 times per day for 6 days. They found that when symptoms got worse, people tended to either do less activity or swing between doing too much and then crashing—patterns that may keep the illness going.

E2 ModerateCohortPEM not requiredCross-Sectional

Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome.

van der Schaaf, Marieke E, De Lange, Floris P, Schmits, Iris C et al.·Biological psychiatry·2017

This study examined brain structure in 89 women with ME/CFS using brain imaging. Researchers found that the amount of pain a patient experiences—not fatigue—was the strongest predictor of changes in a specific brain region called the dorsolateral prefrontal cortex. People with more pain showed smaller brain volume and lower levels of brain chemicals in this region, even after accounting for fatigue, depression, and physical activity.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Familiality and Heritability of Fatigue in an Australian Twin Sample.

Corfield, Elizabeth C, Martin, Nicholas G, Nyholt, Dale R·Twin research and human genetics : the official journal of the International Society for Twin Studies·2017

This study looked at whether fatigue runs in families and whether genetics plays a role. Researchers compared identical twins (who share all genes) with fraternal twins (who share about half) and found that when one twin had fatigue, their identical twin was more likely to also have fatigue than fraternal twins were. The results suggest that about 40% of fatigue differences between people are due to genetics, while the remaining 60% comes from environmental factors or lifestyle.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic Fatigue Syndrome: Cognitive, Behavioural and Emotional Processing Vulnerability Factors.

Brooks, Samantha K, Chalder, Trudie, Rimes, Katharine A·Behavioural and cognitive psychotherapy·2017

This study looked at whether certain personality traits and thinking patterns might make someone more vulnerable to developing ME/CFS. Researchers compared 67 people with ME/CFS to 73 healthy people, asking about their personalities both now and before they became ill. They found that people who later developed ME/CFS tended to be perfectionists, were very self-sacrificing, and had unhelpful beliefs about emotions—especially before they got sick.

E2 ModerateCohortPEM not requiredObservational

Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase®.

Chandler, Rebecca E, Juhlin, Kristina, Fransson, Jonas et al.·Drug safety·2017

Researchers analyzed thousands of reports from a global database of side effects following HPV vaccination. They found that certain combinations of symptoms—headaches, dizziness, fatigue, and fainting—were reported more often after HPV vaccination than with other vaccines, particularly in young women. These symptom clusters resemble conditions like POTS, CRPS, and chronic fatigue syndrome, though most reports did not include an official diagnosis.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Effect of melatonin supplementation on plasma lipid hydroperoxides, homocysteine concentration and chronic fatigue syndrome in multiple sclerosis patients treated with interferons-beta and mitoxantrone.

Adamczyk-Sowa, M, Sowa, P, Adamczyk, J et al.·Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2016

This study looked at whether melatonin (a natural hormone that helps regulate sleep) could help reduce fatigue in people with multiple sclerosis. The researchers measured certain markers in the blood related to oxidative stress (cellular damage) and found that melatonin supplementation for 90 days lowered these harmful markers in all MS patient groups studied.

E2 ModerateBehavioralPEM not requiredObservational

Significant other behavioural responses and patient chronic fatigue syndrome symptom fluctuations in the context of daily life: An experience sampling study.

Band, Rebecca, Barrowclough, Christine, Emsley, Richard et al.·British journal of health psychology·2016

This study looked at how the way family members and partners respond to ME/CFS symptoms affects patients' day-to-day experiences. Researchers asked 23 ME/CFS patients and their loved ones to report on their interactions and symptoms six times daily for a week using smartphones. They found that negative or unhelpful responses from loved ones made symptoms and distress worse in the moment, while overly helpful responses sometimes led to less activity, but these effects were temporary rather than lasting.

E2 ModerateCohortPEM not requiredCross-Sectional

Characteristics of patients contacting a center for undiagnosed and rare diseases.

Mueller, Tobias, Jerrentrup, Andreas, Bauer, Max Jakob et al.·Orphanet journal of rare diseases·2016

This study looked at 522 adults who visited a hospital center for help with diseases that hadn't been diagnosed yet. Most patients were women, and their main complaints were general weakness, joint pain, and stomach discomfort. The researchers found that many patients had been given diagnoses like chronic fatigue syndrome, fibromyalgia, or irritable bowel syndrome—conditions where symptoms are real but hard to explain with standard medical tests.

Diagnostics

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Establishing Clinically Relevant Severity Levels for the Central Sensitization Inventory.

Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women.

Anxiety and depression in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): Examining the incidence of health anxiety in CFS/ME.

Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism.

Impact of Rantes from jawbone on Chronic Fatigue Syndrome.

Stress vulnerability in adolescents with chronic fatigue syndrome: experimental study investigating heart rate variability and skin conductance responses.

The assessment of fatigue: Psychometric qualities and norms for the Checklist individual strength.

Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway.

Gross and fine motor function in fibromyalgia and chronic fatigue syndrome.

Activity Pacing is Associated With Better and Worse Symptoms for Patients With Long-term Conditions.

The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis.

Fatigue in an adult attention deficit hyperactivity disorder population: A trans-diagnostic approach.

Activity patterns in response to symptoms in patients being treated for chronic fatigue syndrome: An experience sampling methodology study.

Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome.

Familiality and Heritability of Fatigue in an Australian Twin Sample.

Chronic Fatigue Syndrome: Cognitive, Behavioural and Emotional Processing Vulnerability Factors.

Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase®.

Effect of melatonin supplementation on plasma lipid hydroperoxides, homocysteine concentration and chronic fatigue syndrome in multiple sclerosis patients treated with interferons-beta and mitoxantrone.

Significant other behavioural responses and patient chronic fatigue syndrome symptom fluctuations in the context of daily life: An experience sampling study.

Characteristics of patients contacting a center for undiagnosed and rare diseases.

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