ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1121–1140 of 2,807 studies

E2 ModerateDiagnosticPEM not requiredMethods-Paper

The assessment of fatigue: Psychometric qualities and norms for the Checklist individual strength.

Worm-Smeitink, M, Gielissen, M, Bloot, L et al.·Journal of psychosomatic research·2017

This study tested a questionnaire called the Checklist Individual Strength (CIS) that measures different types of fatigue, including how tired people feel, difficulty concentrating, lack of motivation, and reduced activity levels. Researchers gave this questionnaire to nearly 2,300 healthy people and over 5,000 patients with chronic fatigue to see if it accurately identifies severe fatigue. They found the CIS works well for measuring fatigue and recommended adjusting the score that indicates 'severe fatigue' from 35 to 40 points for ME/CFS research.

Diagnostics

E2 ModerateCohortPEM not required

Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Nehrke, Pamela I, Fox, Pamela A, Jason, Leonard A·Neurology (E-Cronicon)·2017

This study looked at whether learning about ME/CFS reduces negative stereotypes about the illness. College students who volunteered for ME/CFS research projects showed less stigmatizing attitudes compared to students working on unrelated projects. The findings suggest that education and accurate information about ME/CFS can help reduce the harmful misconceptions many people hold about this serious medical condition.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Patterns of control beliefs in chronic fatigue syndrome: results of a population-based survey.

Doerr, Johanna M, Jopp, Daniela S, Chajewski, Michael et al.·BMC psychology·2017

This study looked at how ME/CFS patients think about their ability to solve problems and manage their condition. Researchers surveyed 113 people with ME/CFS, 264 with severe fatigue that didn't quite meet CFS criteria, and 124 healthy people. They found that people who didn't feel confident in their problem-solving skills were much more likely to have ME/CFS or severe fatigue. Interestingly, some healthy people also had low confidence, suggesting that mindset alone doesn't determine who gets ME/CFS.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Establishing Clinically Relevant Severity Levels for the Central Sensitization Inventory.

Neblett, Randy, Hartzell, Meredith M, Mayer, Tom G et al.·Pain practice : the official journal of World Institute of Pain·2017

Researchers created and tested a scoring system called the Central Sensitization Inventory (CSI) to help doctors identify when someone's symptoms may be caused by their nervous system being overly sensitive to pain signals. The study divided CSI scores into five levels—from subclinical to extreme—and confirmed that higher scores are associated with having more chronic conditions like fibromyalgia and ME/CFS, as well as higher levels of depression, sleep problems, and disability.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray.

Loebel, Madlen, Eckey, Maren, Sotzny, Franziska et al.·PloS one·2017

This study examined whether ME/CFS patients have different immune responses to Epstein-Barr virus (EBV), a common virus that can cause mononucleosis. Researchers compared antibody patterns in 92 ME/CFS patients versus 50 healthy people and found that ME/CFS patients had slightly higher antibody levels against a specific EBV protein called EBNA-6. This suggests that some ME/CFS patients may have an altered immune response to EBV, though most antibody patterns were similar between patients and healthy controls.

Immune System

E2 ModerateBehavioralPEM unclearCross-Sectional

Anxiety and depression in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): Examining the incidence of health anxiety in CFS/ME.

Daniels, Jo, Brigden, Amberly, Kacorova, Adela·Psychology and psychotherapy·2017

This study looked at how many people with ME/CFS also experience health anxiety—worry about physical symptoms and their meaning. Researchers surveyed 45 ME/CFS patients and found that most had elevated worry about their health, and many had clinically significant health anxiety. The findings suggest that health anxiety is common in ME/CFS and may be worth screening for and treating.

E2 ModerateCohortPEM not requiredCross-Sectional

Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway.

Kanchanatawan, Buranee, Sirivichayakul, Sunee, Thika, Supaksorn et al.·Metabolic brain disease·2017

This study looked at physical symptoms like fatigue, muscle pain, and flu-like feelings in people with schizophrenia. Researchers found that more than half of schizophrenia patients experienced these symptoms, which were linked to depression, anxiety, and problems with memory and attention. The symptoms appeared to be connected to changes in how the body processes tryptophan, an amino acid, and how the immune system responds to these breakdown products.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women.

Milrad, Sara F, Hall, Daniel L, Jutagir, Devika R et al.·Journal of neuroimmunology·2017

This study looked at 60 women with ME/CFS to understand how sleep quality affects their symptoms and inflammation levels. Researchers found that women who slept poorly had higher levels of inflammatory substances in their blood and experienced more severe fatigue and ME/CFS symptoms. The findings suggest that improving sleep quality might help reduce both inflammation and symptom severity in people living with ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Are current chronic fatigue syndrome criteria diagnosing different disease phenotypes?

Maclachlan, Laura, Watson, Stuart, Gallagher, Peter et al.·PloS one·2017

This study looked at whether different diagnostic criteria for ME/CFS are actually identifying the same disease or different versions of it. Researchers tested 49 ME/CFS patients and 10 healthy controls using questionnaires and objective tests of heart function and thinking ability. They found that patients reported more autonomic and cognitive symptoms than controls, but objective heart tests didn't show clear differences—though different patient subgroups did show different levels of impairment on cognitive testing.

Autonomic Nervous SystemDiagnosticsCognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase®.

Chandler, Rebecca E, Juhlin, Kristina, Fransson, Jonas et al.·Drug safety·2017

Researchers analyzed thousands of reports from a global database of side effects following HPV vaccination. They found that certain combinations of symptoms—headaches, dizziness, fatigue, and fainting—were reported more often after HPV vaccination than with other vaccines, particularly in young women. These symptom clusters resemble conditions like POTS, CRPS, and chronic fatigue syndrome, though most reports did not include an official diagnosis.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Gross and fine motor function in fibromyalgia and chronic fatigue syndrome.

Rasouli, Omid, Fors, Egil A, Borchgrevink, Petter Chr et al.·Journal of pain research·2017

This study compared how quickly people with ME/CFS and fibromyalgia could start moving when they heard a sound, and how well they could do precise hand movements compared to healthy people. Both ME/CFS and fibromyalgia groups were slower to start walking in response to the sound, though their fine hand movements were similar to healthy controls. The results suggest that ME/CFS and fibromyalgia may affect the speed of starting movement, but not the precision of hand tasks.

E2 ModerateBehavioralPEM unclearCross-Sectional

Activity Pacing is Associated With Better and Worse Symptoms for Patients With Long-term Conditions.

Antcliff, Deborah, Campbell, Malcolm, Woby, Steve et al.·The Clinical journal of pain·2017

This study looked at different ways people with chronic fatigue, fibromyalgia, and chronic pain manage their activities day-to-day. Researchers found that some pacing strategies work better than others: spreading activities consistently throughout the day helped, but drastically cutting back activities was linked to feeling worse. The study suggests that how you pace your activities matters—not all pacing strategies are equally helpful.

Pain and Sensitization

E2 ModerateBehavioralPEM not requiredObservational

Activity patterns in response to symptoms in patients being treated for chronic fatigue syndrome: An experience sampling methodology study.

Band, Rebecca, Barrowclough, Christine, Caldwell, Kim et al.·Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2017

This study looked at how 23 people with ME/CFS change their activity levels in response to their symptoms throughout the day. Researchers had participants use an app on their phones to report their fatigue, pain, mood, and activity patterns 10 times per day for 6 days. They found that when symptoms got worse, people tended to either do less activity or swing between doing too much and then crashing—patterns that may keep the illness going.

E2 ModerateCohortPEM not requiredCross-Sectional

Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome.

van der Schaaf, Marieke E, De Lange, Floris P, Schmits, Iris C et al.·Biological psychiatry·2017

This study examined brain structure in 89 women with ME/CFS using brain imaging. Researchers found that the amount of pain a patient experiences—not fatigue—was the strongest predictor of changes in a specific brain region called the dorsolateral prefrontal cortex. People with more pain showed smaller brain volume and lower levels of brain chemicals in this region, even after accounting for fatigue, depression, and physical activity.

Pain and Sensitization

E2 ModerateCohortPEM requiredObservational

Incidence rates of Guillain Barré (GBS), chronic fatigue/systemic exertion intolerance disease (CFS/SEID) and postural orthostatic tachycardia syndrome (POTS) prior to introduction of human papilloma virus (HPV) vaccination among adolescent girls in Finland, 2002-2012.

Skufca, J, Ollgren, J, Ruokokoski, E et al.·Papillomavirus research (Amsterdam, Netherlands)·2017

This Finnish study looked at how often three conditions—ME/CFS, Guillain-Barré syndrome (GBS), and POTS—were diagnosed in teenage girls between 2002 and 2012, before the HPV vaccine program started. Researchers wanted to establish baseline numbers to help evaluate vaccine safety in the future. They found these conditions were relatively rare, though ME/CFS and POTS diagnoses increased over the decade studied.

Diagnostics

E2 ModeratePEM unclearBiobank-Resource

The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis.

Lacerda, Eliana M, Bowman, Erinna W, Cliff, Jacqueline M et al.·Open journal of bioresources·2017

The UK ME/CFS Biobank is a collection of blood samples and health information from 284 people with ME/CFS, 60 people with multiple sclerosis, and 135 healthy volunteers. Researchers created this resource to help scientists study what causes ME/CFS and find better ways to diagnose and treat it. The samples and detailed patient information can be used by researchers worldwide to search for biological markers of the disease.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis.

Van Der Gucht, Axel, Aoun Sebaiti, Mehdi, Guedj, Eric et al.·Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2017

This study used a special type of brain scan (PET imaging) to look for energy metabolism problems in the brains of people with macrophagic myofascitis, a condition involving immune cell buildup in muscles. Researchers found that MMF patients had lower energy use in multiple brain regions compared to healthy people, and this pattern was especially pronounced in patients who also had thinking and memory problems.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

[Sleep disturbances - an important factor in combination 'minor' symptoms of multiple sclerosis].

Yakupov, E Z, Troshina, Yu V·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2017

This study looked at sleep problems in 54 people with multiple sclerosis (MS) compared to 54 healthy people. Researchers found that people with MS had much more trouble sleeping, and that poor sleep was connected to anxiety, depression, and fatigue. The study suggests that sleep disturbances may play an important role in how MS affects quality of life and fatigue symptoms.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Stress vulnerability in adolescents with chronic fatigue syndrome: experimental study investigating heart rate variability and skin conductance responses.

Rimes, Katharine A, Lievesley, Kate, Chalder, Trudie·Journal of child psychology and psychiatry, and allied disciplines·2017

This study looked at how adolescents with ME/CFS respond to stress compared to young people with asthma and healthy teenagers. Researchers measured physical stress responses (heart rate and skin sweating) while young people gave a speech. Adolescents with ME/CFS showed signs of being more stressed before, during, and after the task, and their bodies took longer to calm down afterward compared to the other groups.

Autonomic Nervous System

E2 ModerateCohortPEM unclearObservational

Down-regulation of renin-aldosterone and antidiuretic hormone systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

Miwa, Kunihisa·Journal of cardiology·2017

This study found that ME/CFS patients have smaller hearts and lower levels of certain hormones that control blood volume and fluid balance compared to healthy people. When researchers gave half the ME/CFS patients a synthetic hormone called desmopressin for five days, about half of them felt better, with less dizziness when standing and improved ability to do daily activities.

Autonomic Nervous System

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The assessment of fatigue: Psychometric qualities and norms for the Checklist individual strength.

Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

Patterns of control beliefs in chronic fatigue syndrome: results of a population-based survey.

Establishing Clinically Relevant Severity Levels for the Central Sensitization Inventory.

Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray.

Anxiety and depression in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): Examining the incidence of health anxiety in CFS/ME.

Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway.

Poor sleep quality is associated with greater circulating pro-inflammatory cytokines and severity and frequency of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) symptoms in women.

Are current chronic fatigue syndrome criteria diagnosing different disease phenotypes?

Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase®.

Gross and fine motor function in fibromyalgia and chronic fatigue syndrome.

Activity Pacing is Associated With Better and Worse Symptoms for Patients With Long-term Conditions.

Activity patterns in response to symptoms in patients being treated for chronic fatigue syndrome: An experience sampling methodology study.

Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome.

Incidence rates of Guillain Barré (GBS), chronic fatigue/systemic exertion intolerance disease (CFS/SEID) and postural orthostatic tachycardia syndrome (POTS) prior to introduction of human papilloma virus (HPV) vaccination among adolescent girls in Finland, 2002-2012.

The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis.

Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis.

[Sleep disturbances - an important factor in combination 'minor' symptoms of multiple sclerosis].

Stress vulnerability in adolescents with chronic fatigue syndrome: experimental study investigating heart rate variability and skin conductance responses.

Down-regulation of renin-aldosterone and antidiuretic hormone systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

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