ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1121–1140 of 2,768 studies

E2 ModerateCohortPEM not requiredCase-Control

A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Johnston, Samantha, Staines, Donald, Klein, Anne et al.·BMC medical genetics·2016

Researchers looked at specific genes that control how nerves and muscles communicate in people with ME/CFS compared to healthy people. They found that people with ME/CFS were more likely to carry a particular genetic variation in a gene called ADRA1A, which is involved in how the body responds to stress. This discovery suggests that differences in how the nervous system is wired genetically may play a role in ME/CFS.

E2 ModerateCohortPEM requiredCross-Sectional

Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients.

Johnston, Samantha C, Staines, Donald R, Marshall-Gradisnik, Sonya M·Clinical epidemiology·2016

This study looked at 535 Australian patients with ME/CFS to understand who gets the disease and what symptoms they experience. Researchers found that ME/CFS mainly affects middle-aged women who are well-educated, and often starts after infections like the flu or gut illnesses, or during stressful periods. The most common symptoms included extreme fatigue, brain fog, poor sleep, headaches, muscle and joint pain, and sensitivity to temperature changes.

Diagnostics

E2 ModerateBehavioralPEM unclearLongitudinal

Enhanced psychological flexibility and improved quality of life in chronic fatigue syndrome/myalgic encephalomyelitis.

Densham, Sarah, Williams, Deborah, Johnson, Anne et al.·Journal of psychosomatic research·2016

This study tested whether learning to accept and adapt to difficult experiences—a skill called psychological flexibility—could help ME/CFS patients improve their quality of life. Over 165 patients attended a six-week group treatment program and were measured before, immediately after, and six months later. The program helped improve both psychological flexibility and quality of life, with the benefits lasting at least six months.

E2 ModerateBehavioralPEM unclear

Group Cognitive Behaviour Therapy for Chronic Fatigue Syndrome.

Illegems, Jela, Moorkens, Greta, Van Den Eede, Filip·Psychotherapy and psychosomatics·2016

This study looked at whether group cognitive behaviour therapy (a type of talk therapy that helps people change unhelpful thinking patterns) could help people with ME/CFS. The researchers observed patients receiving this therapy together in groups. The study provides insights into how this type of psychological treatment is delivered and received by ME/CFS patients in a clinical setting.

Interventions

E2 ModerateCohortPEM unclearLongitudinal

Neurocognitive complaints and functional status among patients with chronic fatigue syndrome and fibromyalgia.

Schmaling, Karen B, Betterton, Karran L·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2016

This study followed 93 patients with ME/CFS over 18 months to understand how cognitive problems (like memory and perception difficulties) and physical function change over time. Patients who had both ME/CFS and fibromyalgia reported more pain, worse physical function, and more cognitive difficulties than those with ME/CFS alone. Interestingly, pain improved over time only for the ME/CFS-only group, suggesting that having both conditions may make recovery slower and more complicated.

Cognitive Impairment

E2 ModerateCohortPEM not requiredLongitudinal

Chronic Fatigue Syndrome at Age 16 Years.

Collin, Simon M, Norris, Tom, Nuevo, Roberto et al.·Pediatrics·2016

This study found that about 1.9% of 16-year-olds in the UK experience chronic fatigue syndrome (CFS)—a condition causing severe, long-lasting tiredness that lasts at least 6 months and cannot be explained by other illnesses. Girls were nearly twice as likely as boys to have CFS at this age, and young people experiencing more family stress or difficulties were at higher risk. Children with CFS missed significantly more school than their peers.

E2 ModerateCohortPEM unclearCross-Sectional

Factors facilitating patient satisfaction among women with medically unexplained long-term fatigue: A relational perspective.

Lian, Olaug S, Hansen, Anne Helen·Health (London, England : 1997)·2016

This study surveyed 431 women with ME/CFS about their experiences with doctors in Norway. The researchers found that patients were most satisfied when their doctor understood their illness, saw them regularly, and referred them to specialists. The most important factor was feeling like an equal partner with their doctor rather than just being told what to do.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Subgroup Analysis in Burnout: Relations Between Fatigue, Anxiety, and Depression.

van Dam, Arno·Frontiers in psychology·2016

This study looked at 113 people diagnosed with burnout to see if they fall into different subgroups based on their fatigue, depression, and anxiety levels. Researchers found two distinct groups that differed mainly in how severe their symptoms were, with depression being the strongest factor that separated them. The study raises important questions about whether burnout is truly a separate condition from depression or chronic fatigue.

E2 ModerateCohortPEM not requiredCross-Sectional

The impact of chronic fatigue syndrome on cognitive functioning in adolescents.

Nijhof, Linde N, Nijhof, Sanne L, Bleijenberg, Gijs et al.·European journal of pediatrics·2016

This study looked at how ME/CFS affects thinking and concentration in teenagers. Researchers compared 59 teenagers with ME/CFS to 40 healthy teenagers and found that those with ME/CFS had lower scores on intelligence tests than their school grades would predict. When comparing teenagers' current test scores to their performance before they got sick, the ME/CFS group showed a significant decline, while healthy teens did not.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Factors in Patient Empowerment: A Survey of an Online Patient Research Network.

Chiauzzi, Emil, DasMahapatra, Pronabesh, Cochin, Elisenda et al.·The patient·2016

This study asked nearly 4,000 patients with various chronic illnesses—including ME/CFS—about how involved they feel in managing their own health. Researchers found that patients often struggle to align their treatment goals with their doctors and don't always get enough time with their physicians. The study identified two main factors that help patients feel empowered: having positive interactions with their healthcare providers and feeling knowledgeable and in control of their care.

E2 ModerateCohortPEM not requiredCross-Sectional

Characteristics of hyperacusis in the general population.

Paulin, Johan, Andersson, Linus, Nordin, Steven·Noise & health·2016

This study looked at how common sound sensitivity (hyperacusis) is in the general population and what characteristics people with this condition share. Researchers surveyed thousands of people and found that sound sensitivity often occurs alongside other conditions like ME/CFS, anxiety, depression, and fibromyalgia. People with sound sensitivity tend to avoid loud environments and may seek medical help for their symptoms.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

How do women with chronic fatigue syndrome/myalgic encephalomyelitis rate quality and coordination of healthcare services? A cross-sectional study.

Hansen, Anne Helen, Lian, Olaug S·BMJ open·2016

This study asked 431 Norwegian women with ME/CFS to rate how satisfied they were with their healthcare. Most women (about 60%) said their primary care doctors provided poor quality care, while slightly fewer (about 48%) rated specialist care as poor. Nearly 3 out of 4 women felt that different healthcare services weren't well coordinated with each other. Women who felt sicker overall and those with more severe ME/CFS symptoms were more likely to report poor care quality.

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of serological and molecular test for diagnosis of infectious mononucleosis.

Salehi, Hassan, Salehi, Marziyeh, Roghanian, Rasoul et al.·Advanced biomedical research·2016

This study compared two different tests for diagnosing infectious mononucleosis (IM), a viral infection caused by Epstein-Barr virus (EBV). Researchers tested 100 patients suspected of having IM and 100 healthy people using two methods: a blood test (ELISA) and a genetic test (PCR). The blood test was easier, faster, and cheaper than the genetic test, making it a better choice for initial diagnosis.

E2 ModerateMechanismPEM unclearMechanistic

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome.

Loebel, Madlen, Grabowski, Patricia, Heidecke, Harald et al.·Brain, behavior, and immunity·2016

Researchers tested whether ME/CFS patients have unusually high levels of antibodies (immune proteins) that attack nerve signaling receptors in the body. They found that about 30% of ME/CFS patients had elevated antibodies against certain receptors involved in adrenaline and acetylcholine signaling—chemicals that control heart rate, breathing, and other automatic body functions. Importantly, patients who received rituximab (a treatment that depletes B cells) and improved showed decreases in these antibody levels, suggesting a possible link between these antibodies and disease activity.

BiomarkersImmune System

E2 ModerateCohortPEM requiredCross-Sectional

Housebound versus nonhousebound patients with myalgic encephalomyelitis and chronic fatigue syndrome.

Pendergrast, Tricia, Brown, Abigail, Sunnquist, Madison et al.·Chronic illness·2016

This study compared ME/CFS patients who are severely ill and mostly confined to their homes with those who are less severely affected and can leave home. Researchers found that the housebound group—about 1 in 4 patients—experienced much worse physical functioning, fatigue, pain, brain fog, sleep problems, and other symptoms compared to the less severely ill group. Understanding these differences can help doctors and researchers better tailor treatments for the most severely affected patients.

Post-Exertional Malaise

E2 ModeratePEM unclearRegistry-Resource

Comorbidities treated in primary care in children with chronic fatigue syndrome / myalgic encephalomyelitis: A nationwide registry linkage study from Norway.

Bakken, Inger J, Tveito, Kari, Aaberg, Kari M et al.·BMC family practice·2016

This large Norwegian study looked at health problems that children with ME/CFS commonly experience in primary care compared to other children. Children with ME/CFS were much more likely to have records of extreme tiredness, depression, anxiety, migraines, and muscle pain. Interestingly, many children with ME/CFS had a recent infection (especially infectious mononucleosis) before their diagnosis, suggesting infections might play a role in developing the condition.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

[The influence of physical load on the propriate immune and physiological parameters.].

Milicková, M, Zákovská, A, Chlíbková, D·Ceskoslovenska fysiologie·2016

This study looked at how intense physical exercise affects the immune system by measuring antibodies (immune proteins) in ultramarathon runners before and after a race. The researchers found that two types of antibodies—IgA and IgG—increased after the race, suggesting that extreme physical stress temporarily changes how the immune system works. Understanding these changes may help explain why some people develop chronic fatigue after intense exercise.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

Cognitive behaviour therapy for chronic fatigue syndrome: Differences in treatment outcome between a tertiary treatment centre in the United Kingdom and the Netherlands.

Worm-Smeitink, M, Nikolaus, S, Goldsmith, K et al.·Journal of psychosomatic research·2016

This study compared how well cognitive behaviour therapy (CBT) worked for ME/CFS patients at two different treatment centers—one in the Netherlands and one in the UK. Both centers used CBT but with slightly different approaches. The Dutch center saw larger improvements in fatigue, physical functioning, and ability to work or socialize compared to the UK center. The researchers found that differences in how patients were treated, rather than differences in the patients themselves, likely explained why one center had better results.

Interventions

E2 ModerateCohortPEM unclearCross-Sectional

Experiences of general practitioner continuity among women with chronic fatigue syndrome/myalgic encephalomyelitis: a cross-sectional study.

Hansen, Anne Helen, Lian, Olaug S·BMC health services research·2016

This study asked Norwegian women with ME/CFS about their experiences with their general practitioners across three areas: whether doctors shared information with them, whether their care was well-coordinated, and whether they felt their doctor understood them personally. Most women (about two-thirds) reported positive experiences in all three areas, though information-sharing and care coordination could be improved. The study found that longer relationships with the same GP and better communication were linked to more positive experiences.

E2 ModerateCohortPEM unclearCase-Control

Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome.

Hornig, M, Gottschalk, G, Peterson, D L et al.·Molecular psychiatry·2016

Researchers examined fluid from around the spine (cerebrospinal fluid) in ME/CFS patients and compared it to healthy people and those with multiple sclerosis. They found that ME/CFS patients had unusual patterns of immune proteins called cytokines in this fluid, suggesting their immune system in the brain and spinal cord is activated differently. The most notable finding was higher levels of a protein called eotaxin, which typically helps recruit immune cells involved in allergic responses.

Immune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

A targeted genome association study examining transient receptor potential ion channels, acetylcholine receptors, and adrenergic receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients.

Enhanced psychological flexibility and improved quality of life in chronic fatigue syndrome/myalgic encephalomyelitis.

Group Cognitive Behaviour Therapy for Chronic Fatigue Syndrome.

Neurocognitive complaints and functional status among patients with chronic fatigue syndrome and fibromyalgia.

Chronic Fatigue Syndrome at Age 16 Years.

Factors facilitating patient satisfaction among women with medically unexplained long-term fatigue: A relational perspective.

Subgroup Analysis in Burnout: Relations Between Fatigue, Anxiety, and Depression.

The impact of chronic fatigue syndrome on cognitive functioning in adolescents.

Factors in Patient Empowerment: A Survey of an Online Patient Research Network.

Characteristics of hyperacusis in the general population.

How do women with chronic fatigue syndrome/myalgic encephalomyelitis rate quality and coordination of healthcare services? A cross-sectional study.

Comparison of serological and molecular test for diagnosis of infectious mononucleosis.

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome.

Housebound versus nonhousebound patients with myalgic encephalomyelitis and chronic fatigue syndrome.

Comorbidities treated in primary care in children with chronic fatigue syndrome / myalgic encephalomyelitis: A nationwide registry linkage study from Norway.

[The influence of physical load on the propriate immune and physiological parameters.].

Cognitive behaviour therapy for chronic fatigue syndrome: Differences in treatment outcome between a tertiary treatment centre in the United Kingdom and the Netherlands.

Experiences of general practitioner continuity among women with chronic fatigue syndrome/myalgic encephalomyelitis: a cross-sectional study.

Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research