ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1241–1260 of 2,795 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic multisymptom illness among female Veterans deployed to Iraq and Afghanistan.

Mohanty, April F, Muthukutty, Anusha, Carter, Marjorie E et al.·Medical care·2015

This study looked at how common chronic multisymptom illnesses—including chronic fatigue syndrome, fibromyalgia, and irritable bowel syndrome—are among female veterans who deployed to Iraq and Afghanistan. Researchers found that these conditions were more than twice as common in this group compared to other female veterans. The study suggests that deployment experiences may play a role in developing these illnesses.

E2 ModerateCohortPEM not requiredCross-Sectional

Endogenous event-related potentials in patients with primary Sjögren's syndrome without central nervous system involvement.

Dziadkowiak, E, Sebastian, A, Wiland, P et al.·Scandinavian journal of rheumatology·2015

This study looked at brain electrical activity in patients with Sjögren's syndrome (an autoimmune disease affecting moisture-producing glands) to see if they had subtle thinking or processing problems. Researchers found that patients showed slightly delayed brain responses to cognitive tasks, and these delays were linked to how long they'd had the disease and how inflamed their salivary glands were. Patients with both Sjögren's syndrome and chronic fatigue syndrome showed different patterns than those with Sjögren's syndrome alone.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Perceived Fatigue Interference and Depressed Mood: Comparison of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Fatigued Breast Cancer Survivors.

Hall, Daniel L, Antoni, Michael H, Lattie, Emily G et al.·Fatigue : biomedicine, health & behavior·2015

This study compared how fatigue affects daily life in people with ME/CFS versus breast cancer survivors who experience fatigue. The researchers found that ME/CFS patients reported more severe fatigue and more depression than the cancer survivors. Importantly, in ME/CFS patients, higher depression was closely tied to greater fatigue-related problems in daily activities, suggesting that mood and fatigue interference may be connected in ways worth exploring for treatment.

E2 ModerateCohortPEM not requiredCase-Control

Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.

Lau, Chi-ieong, Lin, Che-Chen, Chen, Wei-Hung et al.·Journal of psychosomatic research·2015

This study found that people with migraine headaches are 1.5 times more likely to develop ME/CFS than people without migraine. The risk was even higher in older adults (age 65+), who were more than twice as likely to develop ME/CFS if they had migraines. The more frequently someone had migraines, the higher their risk of developing ME/CFS appeared to be.

E2 ModerateCohortPEM not requiredCross-Sectional

Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.

Hardcastle, Sharni Lee, Brenu, Ekua Weba, Johnston, Samantha et al.·International journal of medical sciences·2015

This study looked at immune system proteins in the blood of people with ME/CFS, comparing those with moderate and severe illness to healthy people. Researchers found that different immune markers were present at different levels depending on how severe someone's illness was. This suggests that ME/CFS may actually involve different immune patterns in different people, which could help researchers better understand why treatments don't work the same way for everyone.

Immune System

E2 ModerateCohortPEM requiredCross-Sectional

Unintended Consequences of not Specifying Exclusionary Illnesses for Systemic Exertion Intolerance Disease.

Jason, Leonard A, Sunnquist, Madison, Kot, Bobby et al.·Diagnostics (Basel, Switzerland)·2015

Researchers studied a new proposed name and definition for ME/CFS called SEID (Systemic Exertion Intolerance Disease). They found that the new definition was much looser than the old one and incorrectly labeled people with depression and other illnesses as having SEID when they didn't actually have ME/CFS. This means the new definition could overestimate how many people have ME/CFS.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Measuring substantial reductions in activity.

Schafer, Charles, Evans, Meredyth, Jason, Leonard A et al.·Journal of prevention & intervention in the community·2015

ME/CFS diagnosis requires showing a significant drop in daily activities, but doctors have struggled to measure this fairly. This study looked at different ways to measure activity levels—including work, quality of life surveys, and activity trackers—to find which method works best. The researchers found that tracking current work activities was the most useful way to show the substantial reduction in functioning that ME/CFS patients experience.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Effects of early childhood trauma on hypothalamic-pituitary-adrenal (HPA) axis function in patients with Chronic Fatigue Syndrome.

Kempke, Stefan, Luyten, Patrick, De Coninck, Sarah et al.·Psychoneuroendocrinology·2015

This study looked at whether traumatic experiences in childhood are connected to how the body's stress system (the HPA axis) works in people with ME/CFS. Researchers measured stress hormone levels in 40 women with ME/CFS and tested how their bodies responded to stress. They found that emotional neglect in childhood was linked to a blunted (reduced) stress response, suggesting that some ME/CFS patients may have a stress system that doesn't react normally to challenges.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredObservational

The role of the partner and relationship satisfaction on treatment outcome in patients with chronic fatigue syndrome.

Verspaandonk, J, Coenders, M, Bleijenberg, G et al.·Psychological medicine·2015

This study looked at how a patient's partner and their relationship quality affect how well cognitive behavioural therapy (CBT) works for ME/CFS. Researchers found that when partners were overly helpful or protective (called 'solicitous responses'), patients were less likely to improve significantly from their fatigue and disability. The study suggests that addressing how partners respond to the illness during treatment may be important for better outcomes.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Attention network test: assessment of cognitive function in chronic fatigue syndrome.

Togo, Fumiharu, Lange, Gudrun, Natelson, Benjamin H et al.·Journal of neuropsychology·2015

This study tested whether a computer-based attention test called the Attention Network Task (ANT) could measure thinking and processing speed problems in ME/CFS patients. Researchers compared 41 ME/CFS patients (some with depression, some without) to 29 healthy controls and found that ME/CFS patients took longer to respond to tasks, especially when the tasks were complex, even though they made the same number of mistakes as controls. This suggests that slowed thinking speed, rather than errors, may be the main cognitive problem in ME/CFS.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

The Self beyond Somatic Symptoms: A Narrative Approach to Self-Experience in Adolescent Chronic Fatigue Syndrome.

van Geelen, Stefan M, Fuchs, Coralie E, van Geel, Rolf et al.·Psychopathology·2015

This study looked at how adolescents with ME/CFS experience themselves and their identity, beyond just listing their symptoms. Researchers compared 42 teenagers with ME/CFS to teenagers with arthritis and healthy peers, and found that those with ME/CFS reported feeling more powerless, isolated, and unable to achieve their goals, while also having lower self-esteem and mental health scores. The findings suggest that ME/CFS deeply affects not just the body, but how young people see and value themselves.

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep characteristics, exercise capacity and physical activity in patients with chronic fatigue syndrome.

Aerenhouts, Dirk, Ickmans, Kelly, Clarys, Peter et al.·Disability and rehabilitation·2015

This study looked at how sleep problems and low activity levels are connected in people with ME/CFS. Researchers measured fitness capacity, sleep patterns, and daily activity in 42 women with ME/CFS and compared them to 24 healthy inactive women. People with ME/CFS slept more, spent more time in bed, had difficulty falling asleep and staying asleep, and were less physically active than the control group.

Sleep

E2 ModerateDiagnosticPEM unclearMethods-Paper

Issues in Estimating Rates of Pediatric Chronic Fatigue Syndrome and Myalgic Encephalomyelitis in a Community-based Sample.

Jason, Leonard A, Katz, Ben Z, Mears, Cynthia et al.·Avicenna journal of neuropsychophysiology·2015

This study looked at how common ME/CFS is in children living in regular communities, not just in doctor's offices. Researchers used a two-step approach: first they screened children for ME/CFS-like symptoms, then they did detailed medical and mental health evaluations to confirm diagnoses. The study also compared children with ME/CFS to healthy children without the condition.

Diagnostics

E2 ModerateCohortPEM requiredCross-Sectional

Chronic Fatigue Syndrome versus Systemic Exertion Intolerance Disease.

Jason, Leonard A, Sunnquist, Madison, Brown, Abigail et al.·Fatigue : biomedicine, health & behavior·2015

Researchers compared different ways of diagnosing ME/CFS by testing 796 patients using a new diagnostic system called SEID (Systemic Exertion Intolerance Disease). They found that the new SEID criteria identified about 88% of patients, which is similar to an older diagnostic system but captures a larger group than some other definitions. The study suggests that different diagnostic criteria can identify different sizes and severity levels of patient populations.

Cognitive ImpairmentPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Plasma cytokine expression in adolescent chronic fatigue syndrome.

Wyller, Vegard Bruun, Sørensen, Øystein, Sulheim, Dag et al.·Brain, behavior, and immunity·2015

This study measured inflammation markers called cytokines in the blood of 120 adolescents with ME/CFS and compared them to 68 healthy young people. Despite CFS patients reporting significantly more fatigue and symptoms suggesting inflammation, the researchers found no differences in cytokine levels or inflammation patterns between the two groups. This suggests that the fatigue and symptoms in adolescent ME/CFS may not be caused by the type of low-grade inflammation in the blood that researchers had previously suspected.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Altered resting-state functional connectivity in women with chronic fatigue syndrome.

Kim, Byung-Hoon, Namkoong, Kee, Kim, Jae-Jin et al.·Psychiatry research·2015

This study used brain scans to examine how different regions of the brain communicate with each other in women with ME/CFS compared to healthy women. Researchers found that certain brain areas involved in attention and emotion showed increased communication in ME/CFS patients, and this increased activity was linked to symptom severity. Interestingly, the overall efficiency of brain network communication was reduced in people with ME/CFS, suggesting the brain may be working harder to accomplish its tasks.

E2 ModerateCohortPEM not requiredCross-Sectional

The association between daytime napping and cognitive functioning in chronic fatigue syndrome.

Gotts, Zoe M, Ellis, Jason G, Deary, Vincent et al.·PloS one·2015

This study looked at how sleep patterns, especially daytime napping, affect fatigue, sleepiness, and thinking ability in people with ME/CFS. Researchers asked 118 patients to keep a sleep diary for two weeks and complete daily assessments of their symptoms. They found that afternoon napping was linked to worse cognitive problems and increased daytime sleepiness, suggesting that when and how much patients nap may influence how well they can think and function.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Right arcuate fasciculus abnormality in chronic fatigue syndrome.

Zeineh, Michael M, Kang, James, Atlas, Scott W et al.·Radiology·2015

This study used advanced brain imaging to compare 15 ME/CFS patients with 14 healthy controls. Researchers found that ME/CFS patients had less white matter (the brain's communication pathways) overall, and specific changes in fiber structure on the right side of the brain. The severity of these brain changes correlated with how sick patients felt, suggesting this could be a measurable biological marker of the illness.

E2 ModerateCohortPEM unclearCross-Sectional

Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis.

Khaiboullina, Svetlana F, DeMeirleir, Kenny L, Rawat, Shanti et al.·Cytokine·2015

This study looked at chemical messengers in the blood called cytokines to understand Gulf War illness (GWI) and ME/CFS better. Researchers found that certain cytokines could identify ME/CFS patients very well, but were less reliable for GWI patients. The findings suggest that while GWI and ME/CFS share many similar symptoms, they may have different underlying immune system problems.

BiomarkersImmune System

E2 ModerateCohortPEM unclearObservational

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine.

Magnus, Per, Gunnes, Nina, Tveito, Kari et al.·Vaccine·2015

This large study of the Norwegian population during the 2009 flu pandemic found that people who caught the H1N1 influenza virus were more than twice as likely to develop ME/CFS afterward. However, people who received the pandemic flu vaccine did not show an increased risk of developing ME/CFS. This suggests that actually getting infected with the flu virus itself, rather than the vaccine, may trigger ME/CFS in some people.

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Chronic multisymptom illness among female Veterans deployed to Iraq and Afghanistan.

Endogenous event-related potentials in patients with primary Sjögren's syndrome without central nervous system involvement.

Perceived Fatigue Interference and Depressed Mood: Comparison of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Fatigued Breast Cancer Survivors.

Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.

Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients.

Unintended Consequences of not Specifying Exclusionary Illnesses for Systemic Exertion Intolerance Disease.

Measuring substantial reductions in activity.

Effects of early childhood trauma on hypothalamic-pituitary-adrenal (HPA) axis function in patients with Chronic Fatigue Syndrome.

The role of the partner and relationship satisfaction on treatment outcome in patients with chronic fatigue syndrome.

Attention network test: assessment of cognitive function in chronic fatigue syndrome.

The Self beyond Somatic Symptoms: A Narrative Approach to Self-Experience in Adolescent Chronic Fatigue Syndrome.

Sleep characteristics, exercise capacity and physical activity in patients with chronic fatigue syndrome.

Issues in Estimating Rates of Pediatric Chronic Fatigue Syndrome and Myalgic Encephalomyelitis in a Community-based Sample.

Chronic Fatigue Syndrome versus Systemic Exertion Intolerance Disease.

Plasma cytokine expression in adolescent chronic fatigue syndrome.

Altered resting-state functional connectivity in women with chronic fatigue syndrome.

The association between daytime napping and cognitive functioning in chronic fatigue syndrome.

Right arcuate fasciculus abnormality in chronic fatigue syndrome.

Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis.

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine.

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