ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1381–1400 of 2,795 studies

E2 ModerateCohortPEM unclearCross-Sectional

Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.

Elfaitouri, Amal, Herrmann, Björn, Bölin-Wiener, Agnes et al.·PloS one·2013

This study looked at whether ME/CFS patients have different immune responses to heat shock protein 60 (HSP60), a protein found in both human cells and bacteria. Researchers tested blood samples from ME/CFS patients and healthy people, finding that some ME/CFS patients had specific antibodies against a bacterial version of this protein. This suggests that a past infection might trigger the immune system to attack proteins in the body, which could contribute to ME/CFS.

Immune System

E2 ModerateCohortPEM unclearObservational

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Rezaei, Simin D, Hearps, Anna C, Mills, John et al.·Virology journal·2013

Researchers tested tissue samples from 35 Australian prostate cancer patients to see if they contained XMRV or related viruses, which had been claimed to cause both prostate cancer and ME/CFS. Using sensitive laboratory tests, they found no evidence of these viruses in any of the samples. This study adds to growing evidence that XMRV is not actually involved in prostate cancer and was likely a laboratory contamination rather than a real virus.

E2 ModerateCohortPEM not requiredCase-Control

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Chung, Shiu-Dong, Liu, Shih-Ping, Lin, Ching-Chun et al.·PloS one·2013

This study found that women with bladder pain syndrome/interstitial cystitis (BPS/IC) are more than twice as likely to have had hyperthyroidism (an overactive thyroid) compared to women without bladder pain. The researchers reviewed medical records from Taiwan and suggest that doctors treating women with thyroid problems should ask about urinary symptoms.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK.

Donegan, Katherine, Beau-Lejdstrom, Raphaelle, King, Bridget et al.·Vaccine·2013

This study examined whether the cervical cancer vaccine (Cervarix) given to girls in the UK was linked to chronic fatigue syndrome or other fatigue conditions. Researchers compared how often fatigue-related conditions were reported after the vaccine was introduced in 2008 to how often they were expected to occur naturally. They found no evidence that the vaccine increased the risk of developing these fatigue syndromes.

E2 ModerateCohortPEM not requiredCross-Sectional

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Gotts, Zoe M, Deary, Vincent, Newton, Julia et al.·BMJ open·2013

This study looked at sleep patterns in 343 people with chronic fatigue syndrome using overnight sleep monitoring machines. Researchers found that about 30% of patients had a separate sleep disorder, and the remaining patients fell into four different groups based on their sleep problems—some had trouble falling asleep, some had frequent sleep interruptions, some slept longer than average, and some had very short sleep with lots of waking. The findings suggest that people with ME/CFS have different types of sleep problems and may benefit from different sleep treatments based on their specific pattern.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue and personality: a twin study of causal pathways and shared liabilities.

Poeschla, Brian, Strachan, Eric, Dansie, Elizabeth et al.·Annals of behavioral medicine : a publication of the Society of Behavioral Medicine·2013

This study looked at whether personality traits like emotional stability and sociability are connected to chronic fatigue and ME/CFS. Researchers studied 245 pairs of twins and found that people who are more emotionally unstable tend to have more chronic fatigue, while people who are less outgoing also experience more fatigue. Interestingly, emotional instability and fatigue appear to be linked through shared genes, but low sociability may actually contribute to fatigue in a way that works both directions.

E2 ModerateBehavioralPEM not requiredLongitudinal

The process of cognitive behaviour therapy for chronic fatigue syndrome: which changes in perpetuating cognitions and behaviour are related to a reduction in fatigue?

Heins, Marianne J, Knoop, Hans, Burk, William J et al.·Journal of psychosomatic research·2013

This study looked at how cognitive behaviour therapy (CBT) helps reduce fatigue in ME/CFS patients by tracking what changes during treatment. Researchers followed 183 patients over 18 weeks, measuring fatigue and factors like sense of control, symptom focus, activity levels, and physical functioning. They found that gaining a better sense of control over fatigue, doing more activity, improving physical functioning, and thinking less about symptoms were linked to fatigue improvement—explaining about 20-46% of the fatigue reduction.

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of mycotoxins in patients with chronic fatigue syndrome.

Brewer, Joseph H, Thrasher, Jack D, Straus, David C et al.·Toxins·2013

Researchers tested urine samples from 112 ME/CFS patients to see if they had been exposed to mycotoxins—toxic substances produced by mold found in water-damaged buildings. They found that 93% of patients had detectable mycotoxins in their urine, with most patients having been exposed to moldy buildings. When they tested urine from 55 healthy people with no mold exposure, none showed mycotoxins at detectable levels.

E2 ModerateCohortPEM not requiredCross-Sectional

Health-related quality of life in patients with interstitial cystitis/bladder pain syndrome and frequently associated comorbidities.

Suskind, Anne M, Berry, Sandra H, Suttorp, Marika J et al.·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2013

This study looked at how chronic conditions—including fibromyalgia, ME/CFS, and irritable bowel syndrome—affect quality of life in women with bladder pain syndrome (IC/BPS). Researchers surveyed 276 women and found that fibromyalgia and IBS were linked to significantly worse physical and mental health outcomes, while ME/CFS showed no significant association. The findings suggest that treating bladder pain syndrome effectively requires addressing other conditions a patient may have.

E2 ModerateCohortPEM unclearCross-Sectional

A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome.

Smylie, Anne Liese, Broderick, Gordon, Fernandes, Henrique et al.·BMC immunology·2013

This study compared immune system markers in blood samples from Gulf War veterans with illness, people with ME/CFS, and healthy controls. Researchers measured immune chemicals (called cytokines) before, during, and after exercise to see if different patterns could identify each group. They found distinct immune fingerprints for each condition, and importantly, these patterns differed between men and women.

Immune System

E2 ModerateCohortPEM not requiredObservational

Fatigue heralding multiple sclerosis.

Berger, Joseph R, Pocoski, Jennifer, Preblick, Ronald et al.·Multiple sclerosis (Houndmills, Basingstoke, England)·2013

This study looked at medical records to see how often fatigue appears before someone is diagnosed with multiple sclerosis (MS). Researchers found that about 29% of newly diagnosed MS patients had been labeled with fatigue in the 3 years before their MS diagnosis, often 1–2 years earlier. The findings suggest that persistent fatigue might be an early warning sign of MS, and doctors should carefully evaluate people with unexplained fatigue for possible neurological causes.

Diagnostics

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

Bossuyt, Xavier, Cooreman, Sarah, De Baere, Heidi et al.·Clinica chimica acta; international journal of clinical chemistry·2013

This study tested an automated machine to detect antinuclear antibodies (ANA)—proteins the immune system sometimes makes that can be seen in blood tests. Researchers compared how well this automated system worked compared to traditional methods, using blood samples from people with autoimmune diseases, healthy donors, people with chronic fatigue syndrome, and other patient groups. The machine was good at collecting images but had difficulty identifying the specific patterns of these antibodies accurately.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

The role of neuroticism, perfectionism and depression in chronic fatigue syndrome. A structural equation modeling approach.

Valero, Sergi, Sáez-Francàs, Naia, Calvo, Natalia et al.·Comprehensive psychiatry·2013

This study examined whether personality traits and depression influence how severe ME/CFS symptoms are in patients. Researchers looked at 229 ME/CFS patients and tested whether neuroticism (a tendency toward negative emotions) and perfectionism affect fatigue severity, and whether depression acts as a connecting link between these traits and fatigue. They found that neuroticism appears to influence fatigue severity primarily through depression—meaning people with high neuroticism tend to develop depression, which then worsens fatigue.

E2 ModerateCohortPEM not requiredCross-Sectional

Sub-typing daily fatigue progression in chronic fatigue syndrome.

Jason, Leonard A, Brown, Molly M·Journal of mental health (Abingdon, England)·2013

Researchers asked 90 people with chronic fatigue syndrome to rate their fatigue levels every 30 minutes throughout one day. Using these daily patterns, they found three different groups of patients: some had constantly high fatigue that stayed the same all day, others had moderate fatigue that went up and down but got better over time, and a third group had moderate fatigue that went up and down but got worse over time. This suggests that ME/CFS affects people differently, and tracking fatigue patterns throughout the day could help doctors better understand each person's condition.

E2 ModerateBehavioralPEM unclearObservational

Cognitive behavior therapy in patients with chronic fatigue syndrome: the role of illness acceptance and neuroticism.

Poppe, Carine, Petrovic, Mirko, Vogelaers, Dirk et al.·Journal of psychosomatic research·2013

This study tested whether cognitive behavior therapy (CBT)—a talking treatment that helps change thought patterns and behaviors—improves quality of life in ME/CFS patients. Eighty patients received CBT and reported on their mental health, physical wellbeing, fatigue, and personality traits before and after treatment. While patients did improve, the gains were modest, and the study found that personality traits like neuroticism and how much patients accept their illness affected who benefited most.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder.

Post, Robert M, Altshuler, Lori L, Leverich, Gabriele S et al.·Journal of affective disorders·2013

This study looked at whether difficult experiences in childhood (such as abuse or having parents with mental health problems) are connected to physical health problems in adults with bipolar disorder. Over 900 adults answered questions about their childhood and their current medical conditions. The researchers found that people who experienced more childhood adversity tended to have more medical problems as adults, including chronic fatigue syndrome, fibromyalgia, and several other conditions.

E2 ModerateBehavioralPEM not requiredCross-Sectional

A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample.

Marques, M, De Gucht, V, Leal, I et al.·International journal of behavioral medicine·2013

This study compared ME/CFS patients from Portugal and the Netherlands to see how their experiences with fatigue, physical symptoms, and quality of life were similar or different. Researchers found that while both groups experienced worse quality of life when fatigue was more severe, the psychological and behavioral factors that made fatigue worse were somewhat different between the two countries.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis.

Fuchs, Coralie E, van Geelen, Stefan M, van Geel, Rolf et al.·Clinical child psychology and psychiatry·2013

This study looked at how teenagers with ME/CFS and teenagers with juvenile arthritis see themselves and their health. Researchers found that teenagers with ME/CFS tend to view themselves more negatively—focusing on being tired and unwell—while teenagers with arthritis tend to see themselves as strong and healthy despite physical problems. The study suggests that how young people think about themselves during this important developmental period may affect their long-term wellbeing.

E2 ModerateCohortPEM unclearCase-Control

A case-control study on the association between rheumatoid arthritis and bladder pain syndrome/interstitial cystitis.

Keller, Joseph J, Liu, Shih-Ping, Lin, Herng-Ching·Neurourology and urodynamics·2013

This study looked at whether people with rheumatoid arthritis (an autoimmune disease that causes joint inflammation) are more likely to have bladder pain syndrome/interstitial cystitis (BPS/IC, a chronic bladder condition). Researchers compared nearly 9,300 people with BPS/IC to over 46,000 people without it, using insurance records from Taiwan. They found that people with BPS/IC were about 1.7 times more likely to have a history of rheumatoid arthritis than those without BPS/IC, even after accounting for other health conditions.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

Neblett, Randy, Cohen, Howard, Choi, YunHee et al.·The journal of pain·2013

This study tested a questionnaire called the Central Sensitization Inventory (CSI) to see if it could help doctors identify patients with conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome. Researchers believe these conditions may share a common cause: the nervous system becoming overly sensitive to pain and other stimuli. The study found that a CSI score of 40 or higher was a good way to identify patients with these central sensitivity syndromes.

Pain and Sensitization

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Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK.

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Chronic fatigue and personality: a twin study of causal pathways and shared liabilities.

The process of cognitive behaviour therapy for chronic fatigue syndrome: which changes in perpetuating cognitions and behaviour are related to a reduction in fatigue?

Detection of mycotoxins in patients with chronic fatigue syndrome.

Health-related quality of life in patients with interstitial cystitis/bladder pain syndrome and frequently associated comorbidities.

A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome.

Fatigue heralding multiple sclerosis.

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

The role of neuroticism, perfectionism and depression in chronic fatigue syndrome. A structural equation modeling approach.

Sub-typing daily fatigue progression in chronic fatigue syndrome.

Cognitive behavior therapy in patients with chronic fatigue syndrome: the role of illness acceptance and neuroticism.

Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder.

A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample.

Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis.

A case-control study on the association between rheumatoid arthritis and bladder pain syndrome/interstitial cystitis.

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

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