ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1381–1400 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Medically unexplained conditions considered by patients in general practice.

Tschudi-Madsen, Hedda, Kjeldsberg, Mona, Natvig, Bård et al.·Family practice·2014

This study looked at why patients in general practice often worry they might have conditions like chronic fatigue syndrome, fibromyalgia, or food intolerance. Researchers asked over 900 patients about eight unexplained conditions and found that about 40% of them were concerned they might have one or more of these. The main finding was that patients with more symptoms and more stress in their lives were more likely to think they had one of these conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

[A chronic fatigue syndrome and blood platelet serotonin levels in patients with multiple sclerosis].

Baĭdina, T V, Akintseva, Iu V, Trushnikova, T N·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2014

This study looked at fatigue in 60 people with multiple sclerosis (MS) and compared them to 12 healthy people. Researchers measured fatigue using a standardized scale and checked levels of serotonin (a chemical messenger) in blood platelets. They found that nearly 58% of MS patients experienced severe fatigue, and these patients had lower serotonin levels that seemed connected to their MS symptoms.

E2 ModerateCohortPEM not requiredObservational

Short-term effect of aerobic exercise on symptoms in multiple sclerosis and chronic fatigue syndrome: a pilot study.

Learmonth, Yvonne C, Paul, Lorna, McFadyen, Angus K et al.·International journal of MS care·2014

Researchers wanted to see if 15 minutes of moderate cycling exercise would worsen symptoms in people with ME/CFS or MS. They compared 8 people with each condition to 8 healthy volunteers, measuring pain, fatigue, and physical function before exercise and at several time points up to 24 hours after. The good news: a single 15-minute cycling session did not cause lasting increases in pain or worsening of physical function in either patient group.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Irritable bowel syndrome may be associated with maternal inheritance and mitochondrial DNA control region sequence variants.

van Tilburg, Miranda A L, Zaki, Essam A, Venkatesan, Thangam et al.·Digestive diseases and sciences·2014

This study looked at whether irritable bowel syndrome (IBS) runs in families through the mother's side, and whether this pattern is linked to variations in mitochondrial DNA (the energy-producing structures in our cells). Researchers found that about 1 in 6 IBS patients had a family history suggesting maternal inheritance, and certain DNA variations were more common in these patients. This suggests that mitochondrial dysfunction may explain IBS symptoms in some people.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Postural tachycardia syndrome is associated with significant symptoms and functional impairment predominantly affecting young women: a UK perspective.

McDonald, Claire, Koshi, Sharon, Busner, Lorna et al.·BMJ open·2014

This study looked at 136 people in the UK with postural tachycardia syndrome (PoTS)—a condition where your heart rate increases too much when you stand up—and found that it causes serious tiredness and functional problems, especially in young women. The researchers compared two groups of PoTS patients and found their symptoms and quality-of-life impacts were similar to those in people with chronic fatigue syndrome (ME/CFS). Importantly, there was no consistent treatment approach across patients, with some taking no medication and others on different drug combinations.

Autonomic Nervous SystemCognitive Impairment

E2 ModerateCohortPEM not requiredLongitudinal

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology.

Stringer, Elizabeth Ann, Baker, Katharine Susanne, Carroll, Ian R et al.·Journal of translational medicine·2013

This study tracked blood samples and fatigue reports from 10 people with ME/CFS and 10 healthy people over 25 days. Researchers found that a hormone called leptin—which controls hunger and immune function—was linked to daily changes in fatigue severity in people with ME/CFS. A computer program analyzing all measured immune markers could correctly identify high fatigue days versus low fatigue days about 78% of the time, suggesting the immune system plays a real role in ME/CFS symptoms.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Mental illness in metropolitan, urban and rural Georgia populations.

Reeves, William C, Lin, Jin-Mann S, Nater, Urs M·BMC public health·2013

This study looked at how common mental health conditions like anxiety and depression are in people living in different areas of Georgia (cities, towns, and rural areas). Researchers found that people with ME/CFS-like illness had higher rates of anxiety and depression than people without the condition. Women, people with less education, and those living in rural areas were more likely to experience these mental health conditions.

E2 ModerateBehavioralPEM unclearObservational

Cognitive behavior therapy in patients with chronic fatigue syndrome: the role of illness acceptance and neuroticism.

Poppe, Carine, Petrovic, Mirko, Vogelaers, Dirk et al.·Journal of psychosomatic research·2013

This study tested whether cognitive behavior therapy (CBT)—a talking treatment that helps change thought patterns and behaviors—improves quality of life in ME/CFS patients. Eighty patients received CBT and reported on their mental health, physical wellbeing, fatigue, and personality traits before and after treatment. While patients did improve, the gains were modest, and the study found that personality traits like neuroticism and how much patients accept their illness affected who benefited most.

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome.

Lewis, I, Pairman, J, Spickett, G et al.·Journal of internal medicine·2013

Some ME/CFS patients also have POTS (a condition where the heart rate and blood pressure don't adjust properly when standing up). This study found that ME/CFS patients with POTS are younger, experience less severe fatigue and depression, and have different patterns of daytime sleepiness compared to ME/CFS patients without POTS. A simple combination of two questionnaires can accurately identify which ME/CFS patients have POTS, potentially helping doctors decide who needs additional testing and treatment.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Influence of symptom expectancies on stair-climbing performance in chronic fatigue syndrome: effect of study context.

Heins, Marianne, Knoop, Hans, Nijs, Jo et al.·International journal of behavioral medicine·2013

This study looked at how ME/CFS patients' expectations about getting worse after physical activity affect how they actually perform during that activity. Researchers had 49 patients climb stairs while measuring how long it took and how their heart rate changed. They found that patients who expected to feel more fatigued after climbing took longer to complete the task, even after accounting for their initial fatigue level. Worry about symptoms and catastrophic thinking about their condition appeared to play a role in these expectations.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

CFS in Children and Adolescent: Ten Years of Retrospective Clinical Evaluation.

Elgen, Irene, Hikmat, Omar, Aspevik, Tora N et al.·International journal of pediatrics·2013

This study looked at 27 children and adolescents diagnosed with ME/CFS over a 10-year period in one clinic. Almost all of them developed fatigue after an infection and showed evidence of past viral infections. About 44% were underweight. The researchers concluded that diagnosing ME/CFS in young people requires careful evaluation by multiple specialists and attention to nutrition and mental health.

E2 ModerateCohortPEM not requiredObservational

Fatigue heralding multiple sclerosis.

Berger, Joseph R, Pocoski, Jennifer, Preblick, Ronald et al.·Multiple sclerosis (Houndmills, Basingstoke, England)·2013

This study looked at medical records to see how often fatigue appears before someone is diagnosed with multiple sclerosis (MS). Researchers found that about 29% of newly diagnosed MS patients had been labeled with fatigue in the 3 years before their MS diagnosis, often 1–2 years earlier. The findings suggest that persistent fatigue might be an early warning sign of MS, and doctors should carefully evaluate people with unexplained fatigue for possible neurological causes.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder.

Post, Robert M, Altshuler, Lori L, Leverich, Gabriele S et al.·Journal of affective disorders·2013

This study looked at whether difficult experiences in childhood (such as abuse or having parents with mental health problems) are connected to physical health problems in adults with bipolar disorder. Over 900 adults answered questions about their childhood and their current medical conditions. The researchers found that people who experienced more childhood adversity tended to have more medical problems as adults, including chronic fatigue syndrome, fibromyalgia, and several other conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of mycotoxins in patients with chronic fatigue syndrome.

Brewer, Joseph H, Thrasher, Jack D, Straus, David C et al.·Toxins·2013

Researchers tested urine samples from 112 ME/CFS patients to see if they had been exposed to mycotoxins—toxic substances produced by mold found in water-damaged buildings. They found that 93% of patients had detectable mycotoxins in their urine, with most patients having been exposed to moldy buildings. When they tested urine from 55 healthy people with no mold exposure, none showed mycotoxins at detectable levels.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis.

Fuchs, Coralie E, van Geelen, Stefan M, van Geel, Rolf et al.·Clinical child psychology and psychiatry·2013

This study looked at how teenagers with ME/CFS and teenagers with juvenile arthritis see themselves and their health. Researchers found that teenagers with ME/CFS tend to view themselves more negatively—focusing on being tired and unwell—while teenagers with arthritis tend to see themselves as strong and healthy despite physical problems. The study suggests that how young people think about themselves during this important developmental period may affect their long-term wellbeing.

E2 ModerateCohortPEM not requiredCross-Sectional

Multiscale analysis of heart rate variability in non-stationary environments.

Gao, Jianbo, Gurbaxani, Brian M, Hu, Jing et al.·Frontiers in physiology·2013

This study looked at how the heart rate patterns of people with ME/CFS differ from healthy people, especially when they're under stress. Researchers used advanced computer methods to analyze heart rate data collected during a social stress test. They found that before the stress test, people with ME/CFS had noticeably different heart rate patterns than healthy controls, but these differences became smaller during the stress test itself.

Biomarkers

E2 ModerateCohortPEM unclearCross-Sectional

Depression in paediatric chronic fatigue syndrome.

Bould, Helen, Collin, Simon M, Lewis, Glyn et al.·Archives of disease in childhood·2013

This study looked at how many young people with ME/CFS also experience depression. Researchers surveyed 542 children aged 12-18 and found that about 29% had depression—much higher than in the general population. Depression was more common in those with worse physical symptoms, higher disability, more pain, and poorer school attendance.

E2 ModerateCohortPEM not requiredCross-Sectional

Heart rate variability during sleep and subsequent sleepiness in patients with chronic fatigue syndrome.

Togo, Fumiharu, Natelson, Benjamin H·Autonomic neuroscience : basic & clinical·2013

This study looked at how the heart's rhythm changes during sleep in ME/CFS patients compared to healthy people, and whether these changes relate to feeling more or less tired after sleep. Researchers found that some ME/CFS patients who woke up feeling sleepier had different heart rhythm patterns during deep sleep than healthy controls, even though standard sleep measurements looked normal. This suggests the nervous system's control of the heart during sleep might be disrupted in ME/CFS, which could contribute to unrefreshing sleep.

SleepAutonomic Nervous System

E2 ModerateCohortPEM unclearCase-Control

A case-control study on the association between rheumatoid arthritis and bladder pain syndrome/interstitial cystitis.

Keller, Joseph J, Liu, Shih-Ping, Lin, Herng-Ching·Neurourology and urodynamics·2013

This study looked at whether people with rheumatoid arthritis (an autoimmune disease that causes joint inflammation) are more likely to have bladder pain syndrome/interstitial cystitis (BPS/IC, a chronic bladder condition). Researchers compared nearly 9,300 people with BPS/IC to over 46,000 people without it, using insurance records from Taiwan. They found that people with BPS/IC were about 1.7 times more likely to have a history of rheumatoid arthritis than those without BPS/IC, even after accounting for other health conditions.

Immune System

E2 ModerateBehavioralPEM not requiredLongitudinal

The process of cognitive behaviour therapy for chronic fatigue syndrome: which changes in perpetuating cognitions and behaviour are related to a reduction in fatigue?

Heins, Marianne J, Knoop, Hans, Burk, William J et al.·Journal of psychosomatic research·2013

This study looked at how cognitive behaviour therapy (CBT) helps reduce fatigue in ME/CFS patients by tracking what changes during treatment. Researchers followed 183 patients over 18 weeks, measuring fatigue and factors like sense of control, symptom focus, activity levels, and physical functioning. They found that gaining a better sense of control over fatigue, doing more activity, improving physical functioning, and thinking less about symptoms were linked to fatigue improvement—explaining about 20-46% of the fatigue reduction.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Medically unexplained conditions considered by patients in general practice.

[A chronic fatigue syndrome and blood platelet serotonin levels in patients with multiple sclerosis].

Short-term effect of aerobic exercise on symptoms in multiple sclerosis and chronic fatigue syndrome: a pilot study.

Irritable bowel syndrome may be associated with maternal inheritance and mitochondrial DNA control region sequence variants.

Postural tachycardia syndrome is associated with significant symptoms and functional impairment predominantly affecting young women: a UK perspective.

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology.

Mental illness in metropolitan, urban and rural Georgia populations.

Cognitive behavior therapy in patients with chronic fatigue syndrome: the role of illness acceptance and neuroticism.

Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome.

Influence of symptom expectancies on stair-climbing performance in chronic fatigue syndrome: effect of study context.

CFS in Children and Adolescent: Ten Years of Retrospective Clinical Evaluation.

Fatigue heralding multiple sclerosis.

Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder.

Detection of mycotoxins in patients with chronic fatigue syndrome.

Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis.

Multiscale analysis of heart rate variability in non-stationary environments.

Depression in paediatric chronic fatigue syndrome.

Heart rate variability during sleep and subsequent sleepiness in patients with chronic fatigue syndrome.

A case-control study on the association between rheumatoid arthritis and bladder pain syndrome/interstitial cystitis.

The process of cognitive behaviour therapy for chronic fatigue syndrome: which changes in perpetuating cognitions and behaviour are related to a reduction in fatigue?

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research