ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

1381–1400 of 2,784 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome.

Curriu, Marta, Carrillo, Jorge, Massanella, Marta et al.·Journal of translational medicine·2013

This study examined the immune cells in the blood of 22 people with ME/CFS and 30 healthy controls using a technique called flow cytometry. Researchers found that people with ME/CFS had some notable differences in their T cells and NK cells—types of white blood cells that help fight infections—while B cells appeared largely normal. These immune cell differences may help doctors identify ME/CFS and might explain why people with the condition get frequent viral infections.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Depression in paediatric chronic fatigue syndrome.

Bould, Helen, Collin, Simon M, Lewis, Glyn et al.·Archives of disease in childhood·2013

This study looked at how many young people with ME/CFS also experience depression. Researchers surveyed 542 children aged 12-18 and found that about 29% had depression—much higher than in the general population. Depression was more common in those with worse physical symptoms, higher disability, more pain, and poorer school attendance.

E2 ModerateCohortPEM not requiredCross-Sectional

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

Neblett, Randy, Cohen, Howard, Choi, YunHee et al.·The journal of pain·2013

This study tested a questionnaire called the Central Sensitization Inventory (CSI) to see if it could help doctors identify patients with conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome. Researchers believe these conditions may share a common cause: the nervous system becoming overly sensitive to pain and other stimuli. The study found that a CSI score of 40 or higher was a good way to identify patients with these central sensitivity syndromes.

Pain and Sensitization

E2 ModerateCohortPEM not requiredObservational

Fatigue heralding multiple sclerosis.

Berger, Joseph R, Pocoski, Jennifer, Preblick, Ronald et al.·Multiple sclerosis (Houndmills, Basingstoke, England)·2013

This study looked at medical records to see how often fatigue appears before someone is diagnosed with multiple sclerosis (MS). Researchers found that about 29% of newly diagnosed MS patients had been labeled with fatigue in the 3 years before their MS diagnosis, often 1–2 years earlier. The findings suggest that persistent fatigue might be an early warning sign of MS, and doctors should carefully evaluate people with unexplained fatigue for possible neurological causes.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Multiscale analysis of heart rate variability in non-stationary environments.

Gao, Jianbo, Gurbaxani, Brian M, Hu, Jing et al.·Frontiers in physiology·2013

This study looked at how the heart rate patterns of people with ME/CFS differ from healthy people, especially when they're under stress. Researchers used advanced computer methods to analyze heart rate data collected during a social stress test. They found that before the stress test, people with ME/CFS had noticeably different heart rate patterns than healthy controls, but these differences became smaller during the stress test itself.

Biomarkers

E2 ModerateCohortPEM not requiredObservational

Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK.

Donegan, Katherine, Beau-Lejdstrom, Raphaelle, King, Bridget et al.·Vaccine·2013

This study examined whether the cervical cancer vaccine (Cervarix) given to girls in the UK was linked to chronic fatigue syndrome or other fatigue conditions. Researchers compared how often fatigue-related conditions were reported after the vaccine was introduced in 2008 to how often they were expected to occur naturally. They found no evidence that the vaccine increased the risk of developing these fatigue syndromes.

E2 ModerateBehavioralPEM not requiredLongitudinal

Internet-based therapy for adolescents with chronic fatigue syndrome: long-term follow-up.

Nijhof, Sanne L, Priesterbach, Loudy P, Uiterwaal, Cuno S P M et al.·Pediatrics·2013

This study followed adolescents with ME/CFS for nearly 3 years after they completed an internet-based cognitive behavioral therapy program called FITNET. About 59% of teenagers had recovered from their illness by the end of the follow-up period, and most of those who improved right after treatment stayed better. Interestingly, teens who received standard care also recovered at similar rates over time, though it took longer.

E2 ModerateCohortPEM not requiredCase-Control

Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially.

Hughes, A-M, Lucas, R M, McMichael, A J et al.·Clinical and experimental immunology·2013

This study looked at whether early childhood experiences—like having siblings and attending childcare—affect the risk of developing central nervous system demyelination (a condition where the protective coating around nerve fibers becomes damaged). Researchers compared adults with demyelination to healthy controls and found that having younger siblings appeared to protect against demyelination, while the number of older siblings affected asthma risk differently. Interestingly, people with demyelination were more likely to also have chronic fatigue syndrome.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

Chan, Winnie, Bosch, Jos A, Jones, David et al.·Transplantation·2013

This study looked at tiredness in people who have received kidney transplants and are doing well medically. Researchers found that nearly 6 out of 10 kidney transplant patients experience significant fatigue that affects their daily life and quality of life, yet most doctors weren't documenting this problem in their medical records. The fatigue levels were similar to those seen in chronic fatigue syndrome, and it was linked to factors like inflammation, kidney function decline, poor sleep, anxiety, and depression.

Sleep

E2 ModerateCohortPEM unclearObservational

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Rezaei, Simin D, Hearps, Anna C, Mills, John et al.·Virology journal·2013

Researchers tested tissue samples from 35 Australian prostate cancer patients to see if they contained XMRV or related viruses, which had been claimed to cause both prostate cancer and ME/CFS. Using sensitive laboratory tests, they found no evidence of these viruses in any of the samples. This study adds to growing evidence that XMRV is not actually involved in prostate cancer and was likely a laboratory contamination rather than a real virus.

E2 ModerateCohortPEM not requiredLongitudinal

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology.

Stringer, Elizabeth Ann, Baker, Katharine Susanne, Carroll, Ian R et al.·Journal of translational medicine·2013

This study tracked blood samples and fatigue reports from 10 people with ME/CFS and 10 healthy people over 25 days. Researchers found that a hormone called leptin—which controls hunger and immune function—was linked to daily changes in fatigue severity in people with ME/CFS. A computer program analyzing all measured immune markers could correctly identify high fatigue days versus low fatigue days about 78% of the time, suggesting the immune system plays a real role in ME/CFS symptoms.

Immune System

E2 ModerateBehavioralPEM not requiredLongitudinal

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Kempke, S, Luyten, P, Claes, S et al.·Psychological medicine·2013

This study looked at whether a personality trait called self-critical perfectionism—the tendency to be harshly self-critical and set unrealistic standards—might be linked to daily fatigue and pain in ME/CFS patients. Over 14 days, 90 patients recorded their fatigue and pain levels each day. The researchers found that patients who scored higher on self-critical perfectionism did experience more fatigue and pain during the study period, even after accounting for mood differences.

Pain and Sensitization

E2 ModerateCohortPEM unclearObservational

Lack of evidence for retroviral infections formerly related to chronic fatigue in Spanish fibromyalgia patients.

Oltra, Elisa, García-Escudero, María, Mena-Durán, Armando Vicente et al.·Virology journal·2013

Researchers tested whether two viruses previously thought to be linked to ME/CFS and fibromyalgia were actually present in Spanish patients with these conditions. They found no reliable evidence that either virus was present in patient samples, and concluded that earlier positive results were likely due to contamination in the laboratory rather than genuine infections.

E2 ModerateCohortPEM not requiredLongitudinal

Examining the impact of obesity on individuals with chronic fatigue syndrome.

Flores, Samantha, Brown, Abigail, Adeoye, Samuel et al.·Workplace health & safety·2013

This study looked at how weight affects people with ME/CFS compared to healthy people of similar weight. Researchers found that people with ME/CFS who were overweight or obese had worse health and functioning than healthy people carrying the same amount of weight. The findings suggest that having ME/CFS makes weight-related health challenges even more difficult.

E2 ModerateBehavioralPEM not requiredLongitudinal

The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome.

Heins, Marianne J, Knoop, Hans, Bleijenberg, Gijs·Behaviour research and therapy·2013

This study looked at whether the quality of the relationship between patients and their CBT therapist affects how much CBT helps reduce fatigue in ME/CFS. Researchers followed 217 patients through CBT treatment and measured both the therapeutic relationship (like whether patients felt heard and had confidence in treatment) and changes in fatigue-related thoughts and behaviors. They found that when patients started therapy with positive expectations and felt they understood what the therapy aimed to do, they experienced better improvements in fatigue by the end of treatment.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Health-related quality of life in patients with interstitial cystitis/bladder pain syndrome and frequently associated comorbidities.

Suskind, Anne M, Berry, Sandra H, Suttorp, Marika J et al.·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2013

This study looked at how chronic conditions—including fibromyalgia, ME/CFS, and irritable bowel syndrome—affect quality of life in women with bladder pain syndrome (IC/BPS). Researchers surveyed 276 women and found that fibromyalgia and IBS were linked to significantly worse physical and mental health outcomes, while ME/CFS showed no significant association. The findings suggest that treating bladder pain syndrome effectively requires addressing other conditions a patient may have.

E2 ModerateCohortPEM not requiredCross-Sectional

Latent class analysis of comorbidity patterns among women with generalized and localized vulvodynia: preliminary findings.

Nguyen, Ruby Hn, Veasley, Christin, Smolenski, Derek·Journal of pain research·2013

This study examined 1,457 women with vulvodynia (chronic vulvar pain) to understand which other pain conditions tend to occur together. Researchers found that women with more severe vulvar pain were much more likely to also have multiple other pain conditions, particularly irritable bowel syndrome and fibromyalgia. The findings suggest that these different pain conditions may share common underlying causes.

Pain and Sensitization

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome.

Cella, M, White, P D, Sharpe, M et al.·Psychological medicine·2013

This study looked at how often certain thought patterns and behaviors occur in ME/CFS patients, and whether these patterns differ when patients also have depression or anxiety. Researchers surveyed 640 ME/CFS patients and found that more than half had ME/CFS alone, while the rest also had depression and/or anxiety. Different thinking patterns appeared in patients with different mental health combinations—for example, patients with anxiety were more likely to focus heavily on their symptoms, while those with depression were more likely to avoid activities.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients.

Oakes, Brendan, Hoagland-Henefield, Matthias, Komaroff, Anthony L et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2013

Researchers tested whether two common viruses (HHV-6 and HHV-7) and a genetic element called HERV-K18 were present at higher levels in people with ME/CFS compared to healthy controls. They measured these in blood and saliva samples from 39 ME/CFS patients and 9 healthy people. They found no significant differences between the two groups, and these markers did not correlate with how severe patients' symptoms were.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

The role of neuroticism, perfectionism and depression in chronic fatigue syndrome. A structural equation modeling approach.

Valero, Sergi, Sáez-Francàs, Naia, Calvo, Natalia et al.·Comprehensive psychiatry·2013

This study examined whether personality traits and depression influence how severe ME/CFS symptoms are in patients. Researchers looked at 229 ME/CFS patients and tested whether neuroticism (a tendency toward negative emotions) and perfectionism affect fatigue severity, and whether depression acts as a connecting link between these traits and fatigue. They found that neuroticism appears to influence fatigue severity primarily through depression—meaning people with high neuroticism tend to develop depression, which then worsens fatigue.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome.

Depression in paediatric chronic fatigue syndrome.

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

Fatigue heralding multiple sclerosis.

Multiscale analysis of heart rate variability in non-stationary environments.

Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK.

Internet-based therapy for adolescents with chronic fatigue syndrome: long-term follow-up.

Early-life hygiene-related factors affect risk of central nervous system demyelination and asthma differentially.

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology.

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Lack of evidence for retroviral infections formerly related to chronic fatigue in Spanish fibromyalgia patients.

Examining the impact of obesity on individuals with chronic fatigue syndrome.

The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome.

Health-related quality of life in patients with interstitial cystitis/bladder pain syndrome and frequently associated comorbidities.

Latent class analysis of comorbidity patterns among women with generalized and localized vulvodynia: preliminary findings.

Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome.

Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients.

The role of neuroticism, perfectionism and depression in chronic fatigue syndrome. A structural equation modeling approach.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research