ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

1401–1420 of 2,784 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis.

Fuchs, Coralie E, van Geelen, Stefan M, van Geel, Rolf et al.·Clinical child psychology and psychiatry·2013

This study looked at how teenagers with ME/CFS and teenagers with juvenile arthritis see themselves and their health. Researchers found that teenagers with ME/CFS tend to view themselves more negatively—focusing on being tired and unwell—while teenagers with arthritis tend to see themselves as strong and healthy despite physical problems. The study suggests that how young people think about themselves during this important developmental period may affect their long-term wellbeing.

E2 ModerateCohortPEM unclearCross-Sectional

Views on the nature of chronic fatigue syndrome: content analysis.

Hossenbaccus, Zahra, White, Peter D·JRSM short reports·2013

This study looked at how ME/CFS is described in newspapers, patient websites, and medical textbooks in the UK. Researchers found that patient organizations typically view ME/CFS as a physical illness, while doctors' resources were more likely to describe it as both physical and psychological. This disagreement may explain why some patients and doctors struggle to understand each other.

E2 ModerateCohortPEM unclearCross-Sectional

High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Frémont, Marc, Coomans, Danny, Massart, Sebastien et al.·Anaerobe·2013

This study examined bacteria in the gut of ME/CFS patients compared to healthy people. Researchers found that ME/CFS patients have different types and amounts of gut bacteria than healthy controls, particularly an overgrowth of certain bacteria and a decrease in others. These differences suggest that gut bacteria imbalance may be linked to ME/CFS, and testing for these specific bacteria changes might help diagnose the condition or guide new treatments like probiotics.

E2 ModerateCohortPEM not requiredCross-Sectional

HIV-associated fatigue in the era of highly active antiretroviral therapy: novel biological mechanisms?

Payne, B A I, Hateley, C L, Ong, E L C et al.·HIV medicine·2013

This study looked at fatigue in people living with HIV who were taking modern HIV medications and had their virus under control. Surprisingly, about half of these patients still reported significant fatigue, even though their HIV was suppressed and their immune systems were recovering. The researchers found that fatigue was often linked to problems with blood pressure control (orthostatic intolerance) and previous exposure to certain older HIV medications.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation.

Rayhan, Rakib U, Ravindran, Murugan K, Baraniuk, James N·Frontiers in physiology·2013

This study found that migraines are very common in people with ME/CFS and Gulf War Illness—occurring in about 8 out of 10 ME/CFS patients and 6 out of 10 Gulf War Illness patients, compared to only 1 out of 8 healthy people. The researchers suggest that both conditions may affect how the brain and nervous system process pain, and that doctors should routinely check for and treat migraines in patients with these illnesses.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Patterns of abnormal visual attention in myalgic encephalomyelitis.

Hutchinson, Claire V, Badham, Stephen P·Optometry and vision science : official publication of the American Academy of Optometry·2013

This study tested whether people with ME/CFS have difficulty with visual attention—the ability to focus on and track things they see. Researchers compared 29 patients with ME/CFS to 29 healthy people using eye-tracking tests. The results showed that ME/CFS patients did struggle more with certain types of visual attention tasks, particularly when they had to focus on specific things or search for objects, supporting what many patients report experiencing.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.

Schüttrumpf, Jörg, Hourfar, M Kai, Alesci, Sonja et al.·Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie·2013

Researchers tested whether XMRV, a virus that had been suggested as a possible cause of ME/CFS, was present in the blood of people with hemophilia who received frequent blood products. Using sensitive testing methods, they found no trace of XMRV in any of the 127 people tested, even in those who had received many blood transfusions and factor treatments over time.

E2 ModerateBehavioralPEM not requiredCase-Control

The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs.

Warren, John W, Langenberg, Patricia, Clauw, Daniel J·Journal of psychosomatic research·2013

This study found that people who have multiple overlapping illnesses like fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and others are more likely to develop additional new conditions over time. The more conditions someone already had, the higher their risk of developing a new one. This suggests these conditions may share common underlying causes rather than being completely separate diseases.

E2 ModerateCohortPEM unclearLongitudinal

Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database.

Crawley, E, Collin, S M, White, P D et al.·QJM : monthly journal of the Association of Physicians·2013

This study tracked over 800 people with ME/CFS who received care at NHS specialist services in England for 8-20 months. Patients showed meaningful improvements in fatigue, physical function, anxiety, depression, and pain. The study found that patients who started with more severe fatigue, disability, or pain tended to have less improvement, suggesting baseline severity is an important predictor of how well someone will improve with specialist care.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?

Castro-Marrero, Jesús, Cordero, Mario D, Sáez-Francas, Naia et al.·Antioxidants & redox signaling·2013

This study looked at whether problems in the energy-producing parts of cells (mitochondria) might be different between ME/CFS and fibromyalgia, two conditions that cause fatigue and are often confused with each other. Researchers tested blood cells from people with ME/CFS, fibromyalgia, and healthy people, measuring energy-related markers and signs of cellular damage. They found that both conditions showed some mitochondrial problems, but the patterns were different—suggesting mitochondrial dysfunction might help doctors tell these two conditions apart.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria.

Baraniuk, James N, Adewuyi, Oluwatoyin, Merck, Samantha Jean et al.·American journal of translational research·2013

This study created a scoring system to help doctors better identify and measure ME/CFS severity by combining eight common symptoms (fatigue, pain, cognitive problems, sleep issues, and post-exertion exhaustion). Researchers found that a total symptom score of 14 or higher, combined with moderate-to-severe fatigue, accurately distinguished ME/CFS patients from healthy people. This scoring system was highly consistent and may help match patients to specific disease subtypes.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Chung, Shiu-Dong, Liu, Shih-Ping, Lin, Ching-Chun et al.·PloS one·2013

This study found that women with bladder pain syndrome/interstitial cystitis (BPS/IC) are more than twice as likely to have had hyperthyroidism (an overactive thyroid) compared to women without bladder pain. The researchers reviewed medical records from Taiwan and suggest that doctors treating women with thyroid problems should ask about urinary symptoms.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome.

Badham, Stephen P, Hutchinson, Claire V·Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2013

Many people with ME/CFS report that their eyes feel slow and they struggle to follow moving objects. This was the first study to objectively test these complaints using eye-tracking equipment. Researchers compared eye movements in people with ME/CFS to healthy controls and found that while simple eye movements were similar between groups, people with ME/CFS had significant difficulty smoothly tracking a moving target—a task that requires sustained eye control.

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course.

Mørch, Kristine, Hanevik, Kurt, Rivenes, Ann C et al.·BMC gastroenterology·2013

After a water contamination outbreak in Norway, researchers followed people who developed severe tiredness following a Giardia intestinal infection. Five years after infection, they found that about 41% of patients still had chronic fatigue syndrome, while about 21% had recovered completely. The study also identified other conditions like sleep problems and depression that sometimes occur alongside post-infectious fatigue.

Diagnostics

E2 ModerateCohortPEM not requiredLongitudinal

Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome.

Warren, John W, Clauw, Daniel J, Langenberg, Patricia·BJU international·2013

This study followed 304 women with interstitial cystitis/painful bladder syndrome (IC/PBS)—a condition causing bladder pain, urgency, and frequent urination—for about 3 years after their symptoms started. Researchers found that women who had mild symptoms at the beginning were more likely to stay mild, while women who also had chronic fatigue syndrome (ME/CFS) tended to develop more severe bladder symptoms over time.

E2 ModerateCohortPEM not requiredObservational

Treatment of 741 Italian patients with chronic fatigue syndrome.

Tirelli, U, Lleshi, A, Berretta, M et al.·European review for medical and pharmacological sciences·2013

This study looked at 741 ME/CFS patients treated at an Italian hospital between 2000 and 2005 to see which treatments helped the most. Antiviral and immunoglobulin drugs (which boost the immune system) showed the best results, with about 15% of patients improving. The study also found that patients who received 4 or more different treatments had better outcomes than those who received fewer treatments.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Smorgick, Noam, Marsh, Courtney A, As-Sanie, Sawsan et al.·Journal of pediatric and adolescent gynecology·2013

This study looked at young women (under age 24) with endometriosis to see how often they also experienced other pain conditions, mood problems, and asthma. Researchers found that more than half had multiple pain syndromes (like chronic fatigue syndrome, fibromyalgia, or irritable bowel syndrome), about half had depression or anxiety, and about a quarter had asthma. The study suggests these conditions often occur together in young women with endometriosis.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive deficits in chronic fatigue syndrome and their relationship to psychological status, symptomatology, and everyday functioning.

Cockshell, Susan J, Mathias, Jane L·Neuropsychology·2013

Researchers compared thinking and memory skills between 50 people with ME/CFS and 50 healthy people. They found that people with ME/CFS were slower at processing information (like reaction time), but performed normally on other thinking tasks like memory and attention. Interestingly, this slowness was not explained by depression, anxiety, fatigue, or sleep problems.

Cognitive Impairment

E2 ModerateBehavioralPEM unclearCross-Sectional

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.

Lattie, Emily G, Antoni, Michael H, Fletcher, Mary Ann et al.·Fatigue : biomedicine, health & behavior·2013

This study examined whether learning to manage stress could help people with ME/CFS feel less burdened by their illness, even if their symptoms don't improve. Researchers found that people who felt they had better stress management skills reported lower emotional distress and felt less limited in their daily activities and social life. Importantly, this benefit existed independently of how severe their ME/CFS symptoms were.

E2 ModerateCohortPEM unclearCross-Sectional

Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.

Elfaitouri, Amal, Herrmann, Björn, Bölin-Wiener, Agnes et al.·PloS one·2013

This study looked at whether ME/CFS patients have different immune responses to heat shock protein 60 (HSP60), a protein found in both human cells and bacteria. Researchers tested blood samples from ME/CFS patients and healthy people, finding that some ME/CFS patients had specific antibodies against a bacterial version of this protein. This suggests that a past infection might trigger the immune system to attack proteins in the body, which could contribute to ME/CFS.

Immune System

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Evidence browser

Health and identity: Self-positioning in adolescent chronic fatigue syndrome and juvenile idiopathic arthritis.

Views on the nature of chronic fatigue syndrome: content analysis.

High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients.

HIV-associated fatigue in the era of highly active antiretroviral therapy: novel biological mechanisms?

Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation.

Patterns of abnormal visual attention in myalgic encephalomyelitis.

No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.

The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs.

Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database.

Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?

A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria.

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome.

Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course.

Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome.

Treatment of 741 Italian patients with chronic fatigue syndrome.

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Cognitive deficits in chronic fatigue syndrome and their relationship to psychological status, symptomatology, and everyday functioning.

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.

Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.

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