ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1401–1420 of 2,795 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Attributions, distress and behavioural responses in the significant others of people with chronic fatigue syndrome.

Brooks, Joanna M, Daglish, Julie, Wearden, Alison J·Journal of health psychology·2013

This study looked at how family members and close friends of people with ME/CFS think about the illness and how those beliefs affect their emotions and behavior toward the patient. Researchers interviewed 30 family members and found that when they blamed the patient personally for their symptoms—rather than understanding it as a medical condition—they experienced more stress and were more likely to respond negatively to the patient. Understanding these beliefs could help develop better family-based support programs.

E2 ModerateBehavioralPEM unclearCross-Sectional

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.

Lattie, Emily G, Antoni, Michael H, Fletcher, Mary Ann et al.·Fatigue : biomedicine, health & behavior·2013

This study examined whether learning to manage stress could help people with ME/CFS feel less burdened by their illness, even if their symptoms don't improve. Researchers found that people who felt they had better stress management skills reported lower emotional distress and felt less limited in their daily activities and social life. Importantly, this benefit existed independently of how severe their ME/CFS symptoms were.

E2 ModerateCohortPEM unclearLongitudinal

Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database.

Crawley, E, Collin, S M, White, P D et al.·QJM : monthly journal of the Association of Physicians·2013

This study tracked over 800 people with ME/CFS who received care at NHS specialist services in England for 8-20 months. Patients showed meaningful improvements in fatigue, physical function, anxiety, depression, and pain. The study found that patients who started with more severe fatigue, disability, or pain tended to have less improvement, suggesting baseline severity is an important predictor of how well someone will improve with specialist care.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Smorgick, Noam, Marsh, Courtney A, As-Sanie, Sawsan et al.·Journal of pediatric and adolescent gynecology·2013

This study looked at young women (under age 24) with endometriosis to see how often they also experienced other pain conditions, mood problems, and asthma. Researchers found that more than half had multiple pain syndromes (like chronic fatigue syndrome, fibromyalgia, or irritable bowel syndrome), about half had depression or anxiety, and about a quarter had asthma. The study suggests these conditions often occur together in young women with endometriosis.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue and personality: a twin study of causal pathways and shared liabilities.

Poeschla, Brian, Strachan, Eric, Dansie, Elizabeth et al.·Annals of behavioral medicine : a publication of the Society of Behavioral Medicine·2013

This study looked at whether personality traits like emotional stability and sociability are connected to chronic fatigue and ME/CFS. Researchers studied 245 pairs of twins and found that people who are more emotionally unstable tend to have more chronic fatigue, while people who are less outgoing also experience more fatigue. Interestingly, emotional instability and fatigue appear to be linked through shared genes, but low sociability may actually contribute to fatigue in a way that works both directions.

E2 ModerateCohortPEM unclearCross-Sectional

Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?

Castro-Marrero, Jesús, Cordero, Mario D, Sáez-Francas, Naia et al.·Antioxidants & redox signaling·2013

This study looked at whether problems in the energy-producing parts of cells (mitochondria) might be different between ME/CFS and fibromyalgia, two conditions that cause fatigue and are often confused with each other. Researchers tested blood cells from people with ME/CFS, fibromyalgia, and healthy people, measuring energy-related markers and signs of cellular damage. They found that both conditions showed some mitochondrial problems, but the patterns were different—suggesting mitochondrial dysfunction might help doctors tell these two conditions apart.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

HIV-associated fatigue in the era of highly active antiretroviral therapy: novel biological mechanisms?

Payne, B A I, Hateley, C L, Ong, E L C et al.·HIV medicine·2013

This study looked at fatigue in people living with HIV who were taking modern HIV medications and had their virus under control. Surprisingly, about half of these patients still reported significant fatigue, even though their HIV was suppressed and their immune systems were recovering. The researchers found that fatigue was often linked to problems with blood pressure control (orthostatic intolerance) and previous exposure to certain older HIV medications.

Energy Metabolism

E2 ModerateBehavioralPEM not requiredCase-Control

The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs.

Warren, John W, Langenberg, Patricia, Clauw, Daniel J·Journal of psychosomatic research·2013

This study found that people who have multiple overlapping illnesses like fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and others are more likely to develop additional new conditions over time. The more conditions someone already had, the higher their risk of developing a new one. This suggests these conditions may share common underlying causes rather than being completely separate diseases.

E2 ModerateCohortPEM not requiredCross-Sectional

Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls.

Bradley, A S, Ford, B, Bansal, A S·Clinical and experimental immunology·2013

This study looked at different types of B cells (immune cells that help fight infection) in people with ME/CFS compared to healthy people. Researchers found that ME/CFS patients had more immature B cells and fewer fully developed B cells than healthy controls, suggesting their immune system might not be developing B cells normally. This finding is interesting because a drug that removes B cells helped some ME/CFS patients improve.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.

Schüttrumpf, Jörg, Hourfar, M Kai, Alesci, Sonja et al.·Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie·2013

Researchers tested whether XMRV, a virus that had been suggested as a possible cause of ME/CFS, was present in the blood of people with hemophilia who received frequent blood products. Using sensitive testing methods, they found no trace of XMRV in any of the 127 people tested, even in those who had received many blood transfusions and factor treatments over time.

E2 ModerateCohortPEM not requiredCase-Control

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Chung, Shiu-Dong, Liu, Shih-Ping, Lin, Ching-Chun et al.·PloS one·2013

This study found that women with bladder pain syndrome/interstitial cystitis (BPS/IC) are more than twice as likely to have had hyperthyroidism (an overactive thyroid) compared to women without bladder pain. The researchers reviewed medical records from Taiwan and suggest that doctors treating women with thyroid problems should ask about urinary symptoms.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCase-Control

Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome.

Light, Kathleen C, Agarwal, Neeraj, Iacob, Eli et al.·Psychoneuroendocrinology·2013

This study compared how certain genes are turned 'on' and 'off' differently in blood cells from people with ME/CFS, men with prostate cancer receiving hormone therapy, and healthy people. The researchers found that while both patient groups experience severe fatigue, they show different patterns of gene activity, suggesting that fatigue in these conditions may arise from different biological mechanisms. One gene related to calming the nervous system (DBI) was linked to fatigue severity in both patient groups, offering a potential target for future treatments.

Immune System

E2 ModerateBehavioralPEM not requiredLongitudinal

The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome.

Heins, Marianne J, Knoop, Hans, Bleijenberg, Gijs·Behaviour research and therapy·2013

This study looked at whether the quality of the relationship between patients and their CBT therapist affects how much CBT helps reduce fatigue in ME/CFS. Researchers followed 217 patients through CBT treatment and measured both the therapeutic relationship (like whether patients felt heard and had confidence in treatment) and changes in fatigue-related thoughts and behaviors. They found that when patients started therapy with positive expectations and felt they understood what the therapy aimed to do, they experienced better improvements in fatigue by the end of treatment.

Interventions

E2 ModerateCohortPEM not requiredLongitudinal

Examining the impact of obesity on individuals with chronic fatigue syndrome.

Flores, Samantha, Brown, Abigail, Adeoye, Samuel et al.·Workplace health & safety·2013

This study looked at how weight affects people with ME/CFS compared to healthy people of similar weight. Researchers found that people with ME/CFS who were overweight or obese had worse health and functioning than healthy people carrying the same amount of weight. The findings suggest that having ME/CFS makes weight-related health challenges even more difficult.

E2 ModerateCohortPEM not requiredCross-Sectional

Association between cognitive performance, physical fitness, and physical activity level in women with chronic fatigue syndrome.

Ickmans, Kelly, Clarys, Peter, Nijs, Jo et al.·Journal of rehabilitation research and development·2013

This study looked at whether people with ME/CFS who have better thinking skills (like memory and reaction time) also tend to be more physically fit or active. Researchers tested 31 women with ME/CFS and 13 healthy women on thinking tasks and physical fitness measures. They found that physical fitness—especially heart and muscle function—was linked to thinking speed, but daily activity levels were not.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredLongitudinal

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Kempke, S, Luyten, P, Claes, S et al.·Psychological medicine·2013

This study looked at whether a personality trait called self-critical perfectionism—the tendency to be harshly self-critical and set unrealistic standards—might be linked to daily fatigue and pain in ME/CFS patients. Over 14 days, 90 patients recorded their fatigue and pain levels each day. The researchers found that patients who scored higher on self-critical perfectionism did experience more fatigue and pain during the study period, even after accounting for mood differences.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

Chan, Winnie, Bosch, Jos A, Jones, David et al.·Transplantation·2013

This study looked at tiredness in people who have received kidney transplants and are doing well medically. Researchers found that nearly 6 out of 10 kidney transplant patients experience significant fatigue that affects their daily life and quality of life, yet most doctors weren't documenting this problem in their medical records. The fatigue levels were similar to those seen in chronic fatigue syndrome, and it was linked to factors like inflammation, kidney function decline, poor sleep, anxiety, and depression.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Frémont, Marc, Coomans, Danny, Massart, Sebastien et al.·Anaerobe·2013

This study examined bacteria in the gut of ME/CFS patients compared to healthy people. Researchers found that ME/CFS patients have different types and amounts of gut bacteria than healthy controls, particularly an overgrowth of certain bacteria and a decrease in others. These differences suggest that gut bacteria imbalance may be linked to ME/CFS, and testing for these specific bacteria changes might help diagnose the condition or guide new treatments like probiotics.

E2 ModerateCohortPEM not requiredCross-Sectional

Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients.

Oakes, Brendan, Hoagland-Henefield, Matthias, Komaroff, Anthony L et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2013

Researchers tested whether two common viruses (HHV-6 and HHV-7) and a genetic element called HERV-K18 were present at higher levels in people with ME/CFS compared to healthy controls. They measured these in blood and saliva samples from 39 ME/CFS patients and 9 healthy people. They found no significant differences between the two groups, and these markers did not correlate with how severe patients' symptoms were.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Patterns of abnormal visual attention in myalgic encephalomyelitis.

Hutchinson, Claire V, Badham, Stephen P·Optometry and vision science : official publication of the American Academy of Optometry·2013

This study tested whether people with ME/CFS have difficulty with visual attention—the ability to focus on and track things they see. Researchers compared 29 patients with ME/CFS to 29 healthy people using eye-tracking tests. The results showed that ME/CFS patients did struggle more with certain types of visual attention tasks, particularly when they had to focus on specific things or search for objects, supporting what many patients report experiencing.

Cognitive Impairment

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Attributions, distress and behavioural responses in the significant others of people with chronic fatigue syndrome.

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.

Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database.

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Chronic fatigue and personality: a twin study of causal pathways and shared liabilities.

Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?

HIV-associated fatigue in the era of highly active antiretroviral therapy: novel biological mechanisms?

The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs.

Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls.

No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome.

The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome.

Examining the impact of obesity on individuals with chronic fatigue syndrome.

Association between cognitive performance, physical fitness, and physical activity level in women with chronic fatigue syndrome.

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Human endogenous retrovirus-K18 superantigen expression and human herpesvirus-6 and human herpesvirus-7 viral loads in chronic fatigue patients.

Patterns of abnormal visual attention in myalgic encephalomyelitis.

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