ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1401–1420 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring.

Dixit, Ronak, Popescu, Alexandra, Bagić, Anto et al.·Epilepsy & behavior : E&B·2013

This study looked at 280 patients seen at a hospital epilepsy unit to understand what health conditions are more common in people with psychogenic nonepileptic spells (PNES)—seizure-like episodes that aren't caused by epilepsy—compared to those with actual epilepsy. They found that patients with PNES were more likely to be female, have a history of trauma, and experience conditions like fibromyalgia, chronic fatigue syndrome, chronic pain, and irritable bowel syndrome. The researchers suggest these patterns might help doctors identify PNES earlier and order the right tests sooner.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Influence of symptom expectancies on stair-climbing performance in chronic fatigue syndrome: effect of study context.

Heins, Marianne, Knoop, Hans, Nijs, Jo et al.·International journal of behavioral medicine·2013

This study looked at how ME/CFS patients' expectations about getting worse after physical activity affect how they actually perform during that activity. Researchers had 49 patients climb stairs while measuring how long it took and how their heart rate changed. They found that patients who expected to feel more fatigued after climbing took longer to complete the task, even after accounting for their initial fatigue level. Worry about symptoms and catastrophic thinking about their condition appeared to play a role in these expectations.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children.

Kawabata, Minako, Ueno, Taro, Tomita, Jun et al.·BMC psychiatry·2013

This study looked at sleep and rest patterns in healthy children and children with chronic fatigue syndrome (CFS) using wristband activity trackers. The researchers found that when they looked at the patterns of rest and sleep separately—distinguishing between time spent out of bed versus in bed—children with CFS had different patterns compared to healthy children. This suggests that how the body organizes rest and activity may be disrupted in CFS.

Sleep

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course.

Mørch, Kristine, Hanevik, Kurt, Rivenes, Ann C et al.·BMC gastroenterology·2013

After a water contamination outbreak in Norway, researchers followed people who developed severe tiredness following a Giardia intestinal infection. Five years after infection, they found that about 41% of patients still had chronic fatigue syndrome, while about 21% had recovered completely. The study also identified other conditions like sleep problems and depression that sometimes occur alongside post-infectious fatigue.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Long-term parental unemployment in childhood and subsequent chronic fatigue syndrome.

Fuller-Thomson, Esme, Mehta, Rukshan, Sulman, Joanne·ISRN family medicine·2013

This study looked at whether having a parent who was unemployed for a long time during childhood is connected to developing ME/CFS later in life. Researchers surveyed over 7,000 Canadian women and found that those who experienced parental unemployment in childhood were about 3 times more likely to have ME/CFS as adults, even after accounting for other life challenges and health factors.

E2 ModerateCohortPEM unclearCross-Sectional

A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome.

Smylie, Anne Liese, Broderick, Gordon, Fernandes, Henrique et al.·BMC immunology·2013

This study compared immune system markers in blood samples from Gulf War veterans with illness, people with ME/CFS, and healthy controls. Researchers measured immune chemicals (called cytokines) before, during, and after exercise to see if different patterns could identify each group. They found distinct immune fingerprints for each condition, and importantly, these patterns differed between men and women.

Immune System

E2 ModerateBehavioralPEM not requiredCase-Control

Prevalence of DSM-IV personality disorders in patients with chronic fatigue syndrome: a controlled study.

Kempke, Stefan, Van Den Eede, Filip, Schotte, Chris et al.·International journal of behavioral medicine·2013

This study tested whether people with ME/CFS have more personality disorders than the general population. Researchers gave 92 women with ME/CFS and two comparison groups (92 community members and 92 psychiatric patients) a questionnaire about personality traits. The results showed that ME/CFS patients had personality disorder rates similar to healthy people, not higher rates, though they did show some depressive and obsessive-compulsive traits.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

Bossuyt, Xavier, Cooreman, Sarah, De Baere, Heidi et al.·Clinica chimica acta; international journal of clinical chemistry·2013

This study tested an automated machine to detect antinuclear antibodies (ANA)—proteins the immune system sometimes makes that can be seen in blood tests. Researchers compared how well this automated system worked compared to traditional methods, using blood samples from people with autoimmune diseases, healthy donors, people with chronic fatigue syndrome, and other patient groups. The machine was good at collecting images but had difficulty identifying the specific patterns of these antibodies accurately.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome.

Mariman, An, Delesie, Liesbeth, Tobback, Els et al.·Journal of psychosomatic research·2013

Researchers studied nearly 280 patients who came to a specialized clinic thinking they had ME/CFS, and gave them thorough medical, sleep, and mental health assessments. They found that only about 23% actually had clear-cut ME/CFS; most others had sleep problems like sleep apnea, depression or anxiety, or a combination of these conditions. This suggests that when people feel persistently exhausted, many different medical and mental health issues could be the real cause.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

Neblett, Randy, Cohen, Howard, Choi, YunHee et al.·The journal of pain·2013

This study tested a questionnaire called the Central Sensitization Inventory (CSI) to see if it could help doctors identify patients with conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome. Researchers believe these conditions may share a common cause: the nervous system becoming overly sensitive to pain and other stimuli. The study found that a CSI score of 40 or higher was a good way to identify patients with these central sensitivity syndromes.

Pain and Sensitization

E2 ModerateBehavioralPEM not requiredCross-Sectional

A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample.

Marques, M, De Gucht, V, Leal, I et al.·International journal of behavioral medicine·2013

This study compared ME/CFS patients from Portugal and the Netherlands to see how their experiences with fatigue, physical symptoms, and quality of life were similar or different. Researchers found that while both groups experienced worse quality of life when fatigue was more severe, the psychological and behavioral factors that made fatigue worse were somewhat different between the two countries.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive performance is of clinical importance, but is unrelated to pain severity in women with chronic fatigue syndrome.

Ickmans, Kelly, Meeus, Mira, Kos, Daphne et al.·Clinical rheumatology·2013

This study looked at whether cognitive problems (thinking, memory, attention) in women with ME/CFS are related to pain severity. Researchers gave cognitive tests and questionnaires to 29 women with ME/CFS and 17 healthy women. They found that cognitive problems were NOT linked to pain levels, but were connected to fatigue and mental health, suggesting that cognitive difficulties in ME/CFS may work differently than in other chronic pain conditions.

Pain and SensitizationCognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Mental illness in metropolitan, urban and rural Georgia populations.

Reeves, William C, Lin, Jin-Mann S, Nater, Urs M·BMC public health·2013

This study looked at how common mental health conditions like anxiety and depression are in people living in different areas of Georgia (cities, towns, and rural areas). Researchers found that people with ME/CFS-like illness had higher rates of anxiety and depression than people without the condition. Women, people with less education, and those living in rural areas were more likely to experience these mental health conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

Multiscale analysis of heart rate variability in non-stationary environments.

Gao, Jianbo, Gurbaxani, Brian M, Hu, Jing et al.·Frontiers in physiology·2013

This study looked at how the heart rate patterns of people with ME/CFS differ from healthy people, especially when they're under stress. Researchers used advanced computer methods to analyze heart rate data collected during a social stress test. They found that before the stress test, people with ME/CFS had noticeably different heart rate patterns than healthy controls, but these differences became smaller during the stress test itself.

Biomarkers

E2 ModerateCohortPEM unclearCross-Sectional

Depression in paediatric chronic fatigue syndrome.

Bould, Helen, Collin, Simon M, Lewis, Glyn et al.·Archives of disease in childhood·2013

This study looked at how many young people with ME/CFS also experience depression. Researchers surveyed 542 children aged 12-18 and found that about 29% had depression—much higher than in the general population. Depression was more common in those with worse physical symptoms, higher disability, more pain, and poorer school attendance.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue and personality: a twin study of causal pathways and shared liabilities.

Poeschla, Brian, Strachan, Eric, Dansie, Elizabeth et al.·Annals of behavioral medicine : a publication of the Society of Behavioral Medicine·2013

This study looked at whether personality traits like emotional stability and sociability are connected to chronic fatigue and ME/CFS. Researchers studied 245 pairs of twins and found that people who are more emotionally unstable tend to have more chronic fatigue, while people who are less outgoing also experience more fatigue. Interestingly, emotional instability and fatigue appear to be linked through shared genes, but low sociability may actually contribute to fatigue in a way that works both directions.

E2 ModerateCohortPEM unclearCase-Control

Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population.

Caccamo, Daniela, Cesareo, Eleonora, Mariani, Serena et al.·Oxidative medicine and cellular longevity·2013

This study looked at genetic differences in how people's bodies process certain chemicals, comparing patients with multiple chemical sensitivity (MCS), fibromyalgia, and chronic fatigue syndrome to healthy people. Researchers found that specific genetic variations related to chemical processing were more common in patients with these conditions, suggesting that how your body handles toxins may be linked to environmental sensitivity illnesses. These genetic markers could potentially help doctors diagnose these conditions more accurately in the future.

E2 ModerateCohortPEM requiredObservational

Paediatric chronic fatigue syndrome: complex presentations and protracted time to diagnosis.

Knight, Sarah, Harvey, Adrienne, Lubitz, Lionel et al.·Journal of paediatrics and child health·2013

This study looked at 59 young people (average age 15) diagnosed with ME/CFS at a specialist clinic in Australia to understand how the illness affects them and how long it takes to get diagnosed. Researchers found that young people typically wait over a year after their symptoms start before getting a diagnosis, and most experience significant problems with school attendance and daily activities. The most common symptoms included extreme tiredness, sleep problems, pain, and difficulty thinking clearly.

Diagnostics

E2 ModeratePEM not requiredRegistry-Resource

Cholecystectomy and clinical presentations of gastroparesis.

Parkman, Henry P, Yates, Katherine, Hasler, William L et al.·Digestive diseases and sciences·2013

This study looked at 391 patients with gastroparesis (a condition where the stomach empties food slowly) to see if those who had their gallbladder removed had different symptoms than those who hadn't. They found that patients who had gallbladder surgery experienced more severe upper abdominal pain and retching, but less constipation. Interestingly, patients with prior gallbladder removal also had more other health conditions, including chronic fatigue syndrome and fibromyalgia.

E2 ModerateCohortPEM not requiredObservational

Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK.

Donegan, Katherine, Beau-Lejdstrom, Raphaelle, King, Bridget et al.·Vaccine·2013

This study examined whether the cervical cancer vaccine (Cervarix) given to girls in the UK was linked to chronic fatigue syndrome or other fatigue conditions. Researchers compared how often fatigue-related conditions were reported after the vaccine was introduced in 2008 to how often they were expected to occur naturally. They found no evidence that the vaccine increased the risk of developing these fatigue syndromes.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring.

Influence of symptom expectancies on stair-climbing performance in chronic fatigue syndrome: effect of study context.

Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children.

Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course.

Long-term parental unemployment in childhood and subsequent chronic fatigue syndrome.

A comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome.

Prevalence of DSM-IV personality disorders in patients with chronic fatigue syndrome: a controlled study.

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome.

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample.

Cognitive performance is of clinical importance, but is unrelated to pain severity in women with chronic fatigue syndrome.

Mental illness in metropolitan, urban and rural Georgia populations.

Multiscale analysis of heart rate variability in non-stationary environments.

Depression in paediatric chronic fatigue syndrome.

Chronic fatigue and personality: a twin study of causal pathways and shared liabilities.

Xenobiotic sensor- and metabolism-related gene variants in environmental sensitivity-related illnesses: a survey on the Italian population.

Paediatric chronic fatigue syndrome: complex presentations and protracted time to diagnosis.

Cholecystectomy and clinical presentations of gastroparesis.

Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research