ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1541–1560 of 2,807 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis.

Sakudo, Akikazu, Kuratsune, Hirohiko, Kato, Yukiko Hakariya et al.·Clinica chimica acta; international journal of clinical chemistry·2012

Researchers used a special light-based scanner on patients' thumbs to see if they could tell the difference between people with ME/CFS and healthy people. The scanner detected subtle changes in how light passes through the skin in a specific wavelength range. When they analyzed the results using computer models, they were able to correctly identify about 70% of ME/CFS patients and 83% of healthy people, suggesting this method might someday help doctors diagnose ME/CFS more objectively.

Biomarkers

E2 ModerateBehavioralPEM not requiredCross-Sectional

Kinesiophobia, catastrophizing and anticipated symptoms before stair climbing in chronic fatigue syndrome: an experimental study.

Nijs, Jo, Meeus, Mira, Heins, Marianne et al.·Disability and rehabilitation·2012

This study looked at whether fear of movement and worried thoughts about symptoms affect how well people with ME/CFS can climb stairs. Researchers found that people with higher fear of movement and catastrophic thinking took longer to complete the stair task. However, these fears did not predict how much physical activity people did in their daily lives over the following week.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCase-Control

Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis/chronic fatigue syndrome than in depression.

Maes, Michael, Twisk, Frank N M, Ringel, Karl·Psychotherapy and psychosomatics·2012

This study found that people with ME/CFS have higher levels of inflammatory markers (immune chemicals) in their blood compared to people with depression, even though both conditions can cause fatigue and other similar symptoms. The researchers measured specific immune proteins and found that while both ME/CFS and depression involve some immune system changes, ME/CFS shows a distinctly different immune profile that helps distinguish it from depression.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression.

Maes, Michael, Mihaylova, Ivana, Kubera, Marta et al.·Progress in neuro-psychopharmacology & biological psychiatry·2012

This study looked at immune system markers in people with depression, comparing them to healthy controls. Researchers measured chemicals called neopterin and inflammatory proteins in the blood and found they were higher in depressed patients, especially those with melancholia (severe depression with physical symptoms). These same markers were also linked to chronic fatigue symptoms, suggesting that immune system activation may play a role in both depression and fatigue.

Immune System

E2 ModerateCohortPEM requiredLongitudinal

Adolescent chronic fatigue syndrome; a follow-up study displays concurrent improvement of circulatory abnormalities and clinical symptoms.

Sulheim, Dag, Hurum, Harald, Helland, Ingrid B et al.·BioPsychoSocial medicine·2012

This study followed 47 teenagers with ME/CFS over several months to see how they changed over time. Researchers found that most teens improved in their symptoms—including fatigue, pain, and brain fog—and these improvements happened at the same time their heart and nervous system function also improved. This suggests that problems with how the body regulates heart rate and blood pressure may be connected to ME/CFS symptoms.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Temporal ordering of interstitial cystitis/bladder pain syndrome and non-bladder conditions.

Clemens, J Quentin, Elliott, Marc N, Suttorp, Marika et al.·Urology·2012

This study looked at nearly 3,400 women with bladder pain syndrome (IC/BPS) to see how often they also had other long-term conditions like fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, migraines, panic attacks, and depression. The researchers found that most of these conditions commonly occur together, but the symptoms don't follow a predictable order—sometimes the bladder symptoms came first, sometimes the other conditions came first, and sometimes they started around the same time.

E2 ModerateCohortPEM unclearCross-Sectional

Xenotropic murine leukaemia virus-related virus is not found in peripheral blood cells from treatment-naive human immunodeficiency virus-positive patients.

Maggi, F, Focosi, D, Lanini, L et al.·Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2012

Researchers tested whether a virus called XMRV could be found in the blood of 124 people with HIV who had not yet started treatment. Using two sensitive tests designed to detect this virus, they found no evidence of XMRV in any of the participants. This adds to growing doubts about whether XMRV actually causes chronic fatigue syndrome or other diseases in humans.

E2 ModerateCohortPEM unclearCross-Sectional

Functional somatic syndromes: sensitivities and specificities of self-reports of physician diagnosis.

Warren, John W, Clauw, Daniel J·Psychosomatic medicine·2012

This study found that when doctors ask patients "Have you been diagnosed with ME/CFS or fibromyalgia?" they miss many people who actually have these conditions based on their symptoms. For example, doctors missed 90% of people who truly had ME/CFS by symptom criteria, and 77% of those with fibromyalgia. The researchers showed that asking about symptoms directly, rather than relying on patients to report a doctor's diagnosis, is much more accurate for identifying these conditions.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Humoral and cellular immune responses after influenza vaccination in patients with chronic fatigue syndrome.

Prinsen, Hetty, de Vries, I Jolanda M, Torensma, Ruurd et al.·BMC immunology·2012

This study tested how well people with ME/CFS respond to the flu vaccine compared to healthy people. Researchers measured both antibody production (humoral immunity) and T cell activity (cellular immunity) before and after vaccination. The results showed that people with ME/CFS had immune responses to the flu vaccine that were similar to healthy controls, suggesting their immune systems can respond normally to this vaccine.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Attention-deficit hyperactivity disorder in chronic fatigue syndrome patients.

Sáez-Francàs, Naia, Alegre, José, Calvo, Natalia et al.·Psychiatry research·2012

This study looked at whether people with ME/CFS also have ADHD (attention-deficit hyperactivity disorder), a condition that affects focus and attention. Researchers found that about 30% of ME/CFS patients had ADHD as children, and about 21% still had it as adults. People with ME/CFS who also had ADHD experienced worse depression and anxiety, more severe fatigue, and higher suicide risk than those without ADHD.

Cognitive Impairment

E2 ModerateCohortPEM unclearCase-Control

Responses to exercise differ for chronic fatigue syndrome patients with fibromyalgia.

Cook, Dane B, Stegner, Aaron J, Nagelkirk, Paul R et al.·Medicine and science in sports and exercise·2012

This study compared how the bodies of ME/CFS patients respond to moderate exercise on a stationary bike. Researchers found that patients who have both ME/CFS and fibromyalgia (a condition causing widespread pain) showed different heart and breathing responses during exercise compared to healthy people, including higher perceived effort and different blood pressure patterns.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Characteristics of chronic fatigue syndrome in a Japanese community population : chronic fatigue syndrome in Japan.

Hamaguchi, Masahide, Kawahito, Yutaka, Takeda, Noriyuki et al.·Clinical rheumatology·2011

This Japanese study looked at how many people have ME/CFS in the general population and what their daily habits are like. Researchers found that about 1 in 100 people in Japan have ME/CFS, and people with the condition slept significantly less (about 5.5 hours per night) compared to people without it (about 6.3 hours). The symptom of unrefreshing sleep was particularly useful for identifying who has ME/CFS.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses.

Satterfield, Brent C, Garcia, Rebecca A, Jia, Hongwei et al.·Retrovirology·2011

In 2009, researchers reported finding a virus called XMRV in most people with ME/CFS, which sparked hope for a potential cause. This study tested blood samples from 45 ME/CFS patients and 42 healthy people from across the United States using sensitive laboratory methods to look for XMRV and related viruses. The researchers found no evidence of these viruses in any of the samples, suggesting that XMRV is not present in most ME/CFS cases.

E2 ModeratePEM not requiredRegistry-Resource

A Disease Register for ME/CFS: Report of a Pilot Study.

Pheby, Derek, Lacerda, Eliana, Nacul, Luis et al.·BMC research notes·2011

Researchers created a disease register (a database) to identify and track people with ME/CFS in a fair and systematic way. They searched GP records in three regions of England and found 510 patients with unexplained chronic fatigue, of which 160 agreed to join the register. By following these patients over time, researchers can better understand how ME/CFS progresses and use this group for future studies.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care.

Nacul, Luis C, Lacerda, Eliana M, Pheby, Derek et al.·BMC medicine·2011

This study looked at how many people in three regions of England have ME/CFS by checking medical records and asking doctors directly about their patients. Depending on which diagnostic criteria they used, between 0.03% and 0.2% of adults had ME/CFS—meaning roughly 1 in 500 to 1 in 3,300 people. The study shows ME/CFS is a real and significant health problem affecting many people who need better support and care.

Diagnostics

E2 ModerateBehavioralPEM not requiredObservational

Does the heterogeneity of chronic fatigue syndrome moderate the response to cognitive behaviour therapy? An exploratory study.

Cella, Matteo, Chalder, Trudie, White, Peter D·Psychotherapy and psychosomatics·2011

This study looked at whether ME/CFS patients are different from each other in ways that predict how well they respond to cognitive behaviour therapy (CBT), a type of talking therapy. Researchers analyzed data from 236 patients and found that most patients improved with CBT regardless of their characteristics, but they identified a smaller group with certain traits—including weight changes, tremors, anxiety, and pain—who were less likely to benefit. The findings suggest CBT can help most people with ME/CFS, though a minority may need different approaches.

Interventions

E2 ModerateCohortPEM unclearCross-Sectional

Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome.

Schutzer, Steven E, Angel, Thomas E, Liu, Tao et al.·PloS one·2011

This study examined spinal fluid from people with post-treatment Lyme disease and ME/CFS to see if these two conditions are different. Using advanced laboratory techniques, researchers found that each condition has a unique pattern of proteins in the spinal fluid, meaning they appear to be distinct diseases rather than the same illness. This discovery could eventually help doctors tell these conditions apart and develop better treatments for each.

Neuroinflammation

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome in an ethnically diverse population: the influence of psychosocial adversity and physical inactivity.

Bhui, Kamaldeep S, Dinos, Sokratis, Ashby, Deborah et al.·BMC medicine·2011

This study looked at how common ME/CFS is in different ethnic groups in England and found that people from ethnic minority backgrounds had higher rates of the illness than White British people. The researchers discovered that anxiety, depression, lack of physical activity, stress in relationships, and poor social support were all linked to higher rates of ME/CFS, and together these factors explained why some ethnic groups had more cases.

E2 ModerateCohortPEM unclearCross-Sectional

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients.

Delviks-Frankenberry, Krista A, Chaipan, Chawaree, Bagni, Rachel et al.·Advances in virology·2011

Researchers tested whether a virus called XMRV, which had been proposed as a possible cause of ME/CFS, was present in HIV-positive patients who developed lymphoma (a type of cancer). They checked blood samples from 26 patients using three different detection methods, but did not find any evidence of XMRV. This suggests that XMRV is not associated with lymphomas that develop in people with HIV.

E2 ModerateCohortPEM not requiredCase-Control

Sleep-wake behavior in chronic fatigue syndrome.

Rahman, Khairunnessa, Burton, Alexander, Galbraith, Sally et al.·Sleep·2011

Researchers wanted to know if ME/CFS is caused by problems with the body's internal biological clock. They studied 15 people with ME/CFS and 15 healthy controls for 5 days, measuring sleep patterns, daily activity, stress hormone levels, and heart function. While people with ME/CFS reported worse fatigue, sleep problems, and pain, the researchers found no differences in actual sleep patterns or biological rhythms between the groups.

Autonomic Nervous System

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Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis.

Kinesiophobia, catastrophizing and anticipated symptoms before stair climbing in chronic fatigue syndrome: an experimental study.

Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis/chronic fatigue syndrome than in depression.

Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression.

Adolescent chronic fatigue syndrome; a follow-up study displays concurrent improvement of circulatory abnormalities and clinical symptoms.

Temporal ordering of interstitial cystitis/bladder pain syndrome and non-bladder conditions.

Xenotropic murine leukaemia virus-related virus is not found in peripheral blood cells from treatment-naive human immunodeficiency virus-positive patients.

Functional somatic syndromes: sensitivities and specificities of self-reports of physician diagnosis.

Humoral and cellular immune responses after influenza vaccination in patients with chronic fatigue syndrome.

Attention-deficit hyperactivity disorder in chronic fatigue syndrome patients.

Responses to exercise differ for chronic fatigue syndrome patients with fibromyalgia.

Characteristics of chronic fatigue syndrome in a Japanese community population : chronic fatigue syndrome in Japan.

Serologic and PCR testing of persons with chronic fatigue syndrome in the United States shows no association with xenotropic or polytropic murine leukemia virus-related viruses.

A Disease Register for ME/CFS: Report of a Pilot Study.

Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care.

Does the heterogeneity of chronic fatigue syndrome moderate the response to cognitive behaviour therapy? An exploratory study.

Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome.

Chronic fatigue syndrome in an ethnically diverse population: the influence of psychosocial adversity and physical inactivity.

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients.

Sleep-wake behavior in chronic fatigue syndrome.

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