ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1541–1560 of 2,795 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays.

Oakes, Brendan, Qiu, Xiaoxing, Levine, Susan et al.·Advances in virology·2011

In 2009, researchers claimed they found a virus called XMRV in most ME/CFS patients' blood. This study tested whether that finding was real by looking for antibodies (immune system markers) to XMRV in blood samples from ME/CFS patients and healthy people. The researchers found no evidence of XMRV antibodies in any of the samples, suggesting the original finding may not have been accurate.

Biomarkers

E2 ModerateCohortPEM unclearCross-Sectional

Chronic fatigue syndrome in the media: a content analysis of newspaper articles.

Knudsen, Ann Kristen, Omenås, Anne Nagelgaard, Harvey, Samuel B et al.·JRSM short reports·2011

Researchers analyzed Norwegian newspaper articles about ME/CFS published between 2008-2009 to see how they described treatments. They found that newspapers were much more likely to write positively about alternative treatments (like the Lightning Process) and negatively about evidence-based treatments (like cognitive behavioral therapy and graded exercise) than the scientific evidence supports. This matters because many people get health information from newspapers, so unbalanced reporting could influence patient choices.

E2 ModerateCohortPEM not requiredCross-Sectional

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology.

Maes, Michael, Mihaylova, Ivana, Kubera, Marta et al.·Journal of affective disorders·2011

This study looked at whether depression involves the immune system attacking the body's own molecules that have been damaged by stress and inflammation. Researchers compared antibody levels in 26 depressed patients and 17 healthy controls, finding that depressed patients had significantly higher levels of immune proteins attacking several molecular targets. These autoimmune responses were linked to fatigue and flu-like symptoms, suggesting a biological pathway that may connect depression, immune dysfunction, and physical exhaustion.

Immune System

E2 ModerateCohortPEM unclearObservational

No evidence of XMRV in prostate cancer cohorts in the Midwestern United States.

Sakuma, Toshie, Hué, Stéphane, Squillace, Karen A et al.·Retrovirology·2011

Researchers tested prostate tissue and blood samples from men with and without prostate cancer to see if a virus called XMRV was present. They found a few samples that tested positive, but further investigation showed these were likely contaminated with mouse DNA from the laboratory rather than real virus. The study found no strong evidence that XMRV is actually infecting people's prostate tissue or blood.

E2 ModerateCohortPEM unclearCross-Sectional

The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers.

Nacul, Luis C, Lacerda, Eliana M, Campion, Peter et al.·BMC public health·2011

This study measured how ME/CFS affects daily life and well-being in 170 patients and 44 family caregivers. Using a standard health questionnaire, researchers found that ME/CFS causes severe disability—worse than many other chronic illnesses like cancer—affecting both physical abilities and mental health. The emotional burden also significantly impacts the family members and caregivers who support people with ME/CFS.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Self-critical perfectionism, stress generation, and stress sensitivity in patients with chronic fatigue syndrome: relationship with severity of depression.

Luyten, Patrick, Kempke, Stefan, Van Wambeke, Peter et al.·Psychiatry·2011

This study looked at whether people with ME/CFS who are hard on themselves and set very high standards tend to create more stressful situations in daily life, and whether they react more strongly to stress. The researchers found that this pattern of self-criticism was linked to more daily hassles and greater sensitivity to stress, which in turn was connected to higher levels of depression. Understanding these patterns may help doctors develop better psychological treatments for ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

[The role of depression in cognitive impairment in patients with chronic fatigue syndrome].

Santamarina-Pérez, Pilar, Freniche, Verónica, Eiroa-Orosa, Francisco Jose et al.·Medicina clinica·2011

This study tested whether depression explains the thinking and memory problems that people with ME/CFS experience. Researchers gave 57 women with ME/CFS a variety of cognitive tests measuring attention, memory, and processing speed, then compared results between those with and without depression. The findings showed that cognitive problems were present in ME/CFS patients regardless of whether they had depression, suggesting that the brain fog and thinking difficulties are part of ME/CFS itself, not caused by depression.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Symptom fluctuations and daily physical activity in patients with chronic fatigue syndrome: a case-control study.

Meeus, Mira, van Eupen, Inge, van Baarle, Ellen et al.·Archives of physical medicine and rehabilitation·2011

This study tracked physical activity and daily symptoms in 67 women with ME/CFS compared to healthy women who were not very active. Researchers found that ME/CFS patients were generally less active overall, but surprisingly, on days when patients were more active, they experienced more symptoms and greater symptom fluctuations the same day and the next day. Conversely, patients had fewer symptom changes on days when they stayed more sedentary and spread their limited activity throughout the day.

Post-Exertional Malaise

E2 ModerateGuidelinePEM not requiredGuideline

How to explain central sensitization to patients with 'unexplained' chronic musculoskeletal pain: practice guidelines.

Nijs, Jo, Paul van Wilgen, C, Van Oosterwijck, Jessica et al.·Manual therapy·2011

Central sensitization is a condition where the nervous system becomes overly sensitive to pain signals, making people feel pain from things that normally wouldn't hurt. This guideline explains that teaching patients about how their nervous system works—called pain physiology education—can help them understand their pain and feel better. The education works best when delivered in face-to-face sessions with written materials, and it has helped people with fibromyalgia, chronic fatigue syndrome, and other long-term pain conditions.

Pain and Sensitization

E2 ModeratePEM not requiredRegistry-Resource

A Disease Register for ME/CFS: Report of a Pilot Study.

Pheby, Derek, Lacerda, Eliana, Nacul, Luis et al.·BMC research notes·2011

Researchers created a disease register (a database) to identify and track people with ME/CFS in a fair and systematic way. They searched GP records in three regions of England and found 510 patients with unexplained chronic fatigue, of which 160 agreed to join the register. By following these patients over time, researchers can better understand how ME/CFS progresses and use this group for future studies.

Diagnostics

E2 ModerateDiagnosticPEM not requiredCross-Sectional

Is the International Physical Activity Questionnaire-short form (IPAQ-SF) valid for assessing physical activity in Chronic Fatigue Syndrome?

Meeus, Mira, Van Eupen, Inge, Willems, Joke et al.·Disability and rehabilitation·2011

Researchers tested whether a common activity questionnaire (IPAQ-SF) could accurately measure physical activity in people with ME/CFS. Fifty-six patients filled out the questionnaire, wore activity monitors for a week, and kept activity diaries. The questionnaire's measurements didn't match what the activity monitors and diaries showed, and it wasn't good at capturing the low activity levels typical of ME/CFS patients.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychophysical distress and alexithymic traits in chronic fatigue syndrome with and without comorbid depression.

Sepede, G, Racciatti, D, Gorgoretti, V et al.·International journal of immunopathology and pharmacology·2011

This study compared people with ME/CFS to healthy people and looked at two things: emotional distress and difficulty recognizing their own feelings. They found that ME/CFS patients had more physical symptoms and emotional complaints than healthy people, especially those who also had depression. Interestingly, even ME/CFS patients without depression had some difficulty identifying their emotions, though less than those with depression.

E2 ModerateCohortPEM not requiredCross-Sectional

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression.

Maes, Michael, Mihaylova, Ivanka, Kubera, Marta et al.·Neuro endocrinology letters·2011

This study looked at a protective enzyme called GPX that helps defend cells from damage in people with depression and ME/CFS. The researchers found that people with depression had lower levels of this enzyme compared to healthy people, but people with ME/CFS had normal levels. Both groups showed connections between low enzyme levels and symptoms like mood problems and autonomic nervous system dysfunction.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Characteristics of chronic fatigue syndrome in a Japanese community population : chronic fatigue syndrome in Japan.

Hamaguchi, Masahide, Kawahito, Yutaka, Takeda, Noriyuki et al.·Clinical rheumatology·2011

This Japanese study looked at how many people have ME/CFS in the general population and what their daily habits are like. Researchers found that about 1 in 100 people in Japan have ME/CFS, and people with the condition slept significantly less (about 5.5 hours per night) compared to people without it (about 6.3 hours). The symptom of unrefreshing sleep was particularly useful for identifying who has ME/CFS.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

The retrovirus XMRV is not directly involved in the pathogenesis of common types of lymphoid malignancy.

Waugh, Elspeth M, Jarrett, Ruth F, Shield, Lesley et al.·Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2011

Researchers tested whether a virus called XMRV, which had been found in some ME/CFS patients, might cause blood cancers like lymphoma and leukemia. They checked blood samples from 368 patients with these cancers and 507 control samples using three different sensitive tests. The virus was not found in any cancer patient samples, suggesting XMRV is not a major cause of these blood cancers.

E2 ModerateCohortPEM not requiredObservational

Xenotropic murine leukemia virus-related virus (XMRV) in patients with systemic lupus erythematosus.

Balada, Eva, Castro-Marrero, Jesús, Felip, Lledó et al.·Journal of clinical immunology·2011

Researchers tested whether a virus called XMRV—which had been found in some ME/CFS patients—might also be present in people with lupus (SLE), a different autoimmune disease that also causes severe fatigue. They checked blood samples from 95 lupus patients and 50 healthy people but found no sign of XMRV in any of them. This suggests that XMRV is probably not responsible for the fatigue seen in lupus patients.

E2 ModerateCohortPEM not requiredCase-Control

Immunologic and psychosocial status in chronic fatigue syndrome.

Nas, K, Cevik, R, Batum, S et al.·Bratislavske lekarske listy·2011

Researchers compared immune system markers and psychological health in 25 ME/CFS patients and 20 healthy controls. They found that ME/CFS patients had lower levels of a specific type of immune cell (CD56) and higher levels of an inflammatory marker (IL-6), along with more depression and reduced quality of life. These immune changes appeared connected to sleep problems, social isolation, and physical limitations.

Immune System

E2 ModerateCohortPEM not requiredObservational

No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected.

Knox, Konstance, Carrigan, Donald, Simmons, Graham et al.·Science (New York, N.Y.)·2011

This study tested blood samples from 61 ME/CFS patients to look for viruses called XMRV and related mouse viruses that had been reported in earlier research. The researchers found no evidence of these viruses in the patients' blood, even in 43 patients who had previously tested positive. They concluded that earlier findings were likely due to contamination in the laboratory rather than actual infection.

E2 ModerateCohortPEM unclearCross-Sectional

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Maes, Michael, Kubera, Marta, Uytterhoeven, Marc et al.·Medical science monitor : international medical journal of experimental and clinical research·2011

This study measured two markers of oxidative stress (damage caused by harmful molecules in the body) in people with ME/CFS compared to healthy people. Researchers found that ME/CFS patients had significantly higher levels of plasma peroxides—harmful molecules that damage cells. These findings suggest that oxidative stress may play a role in ME/CFS, which could help explain some of the illness's symptoms.

Biomarkers

E2 ModerateBehavioralPEM not requiredObservational

Therapist effects in routine psychotherapy practice: an account from chronic fatigue syndrome.

Cella, Matteo, Stahl, Daniel, Reme, Silje Endresen et al.·Psychotherapy research : journal of the Society for Psychotherapy Research·2011

This study looked at whether it matters which therapist treats patients with ME/CFS when they receive cognitive behavioral therapy (CBT). Researchers tracked 374 ME/CFS patients treated by 12 different therapists in a specialized clinic and measured changes in fatigue and disability. They found that while patients improved overall, the individual therapist made almost no difference in outcomes—the patients' improvements were similar regardless of which qualified therapist treated them.

Interventions

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Failure to Detect XMRV-Specific Antibodies in the Plasma of CFS Patients Using Highly Sensitive Chemiluminescence Immunoassays.

Chronic fatigue syndrome in the media: a content analysis of newspaper articles.

IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology.

No evidence of XMRV in prostate cancer cohorts in the Midwestern United States.

The functional status and well being of people with myalgic encephalomyelitis/chronic fatigue syndrome and their carers.

Self-critical perfectionism, stress generation, and stress sensitivity in patients with chronic fatigue syndrome: relationship with severity of depression.

[The role of depression in cognitive impairment in patients with chronic fatigue syndrome].

Symptom fluctuations and daily physical activity in patients with chronic fatigue syndrome: a case-control study.

How to explain central sensitization to patients with 'unexplained' chronic musculoskeletal pain: practice guidelines.

A Disease Register for ME/CFS: Report of a Pilot Study.

Is the International Physical Activity Questionnaire-short form (IPAQ-SF) valid for assessing physical activity in Chronic Fatigue Syndrome?

Psychophysical distress and alexithymic traits in chronic fatigue syndrome with and without comorbid depression.

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression.

Characteristics of chronic fatigue syndrome in a Japanese community population : chronic fatigue syndrome in Japan.

The retrovirus XMRV is not directly involved in the pathogenesis of common types of lymphoid malignancy.

Xenotropic murine leukemia virus-related virus (XMRV) in patients with systemic lupus erythematosus.

Immunologic and psychosocial status in chronic fatigue syndrome.

No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected.

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Therapist effects in routine psychotherapy practice: an account from chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research