ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1621–1640 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome.

Eglinton, Rebekah, Chung, Man Cheung·Psychiatry research·2011

This study looked at whether people with ME/CFS have higher rates of PTSD (post-traumatic stress disorder) and whether trauma-related stress affects fatigue levels. Researchers found that ME/CFS patients did experience more PTSD symptoms and traumatic life events than healthy controls, but surprisingly, the severity of PTSD symptoms did not directly predict how severe their fatigue was. Instead, a sense of helplessness was more strongly linked to both fatigue and mental health problems.

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: labels, meanings and consequences.

Wojcik, Wojtek, Armstrong, David, Kanaan, Richard·Journal of psychosomatic research·2011

This study surveyed British neurologists to understand how they view ME/CFS and whether they consider it a neurological condition. The results revealed that 84% of neurologists did not view ME/CFS as a neurological disorder, even though it is officially classified as one in the ICD-10 medical coding system. The researchers discuss how the way we label and classify ME/CFS affects how doctors treat patients and how patients understand their own illness.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome.

Smits, Bart, van den Heuvel, Lambert, Knoop, Hans et al.·Mitochondrion·2011

This study looked at whether measurements of mitochondria (the energy-producing parts of cells) can help distinguish ME/CFS from true mitochondrial diseases. The researchers found that while people with ME/CFS have fewer mitochondria overall, the mitochondria that are present work normally. In contrast, people with actual mitochondrial disorders have mitochondria that don't function well, even when mitochondrial numbers are considered.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Up-regulation of TGF-β1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

Zhang, Hai-Ying, Liu, Zhan-Dong, Hu, Chao-Jun et al.·Journal of the Formosan Medical Association = Taiwan yi zhi·2011

Researchers measured levels of a immune signaling molecule called TGF-β1 in blood cells from ME/CFS patients and compared them to healthy people and patients with other illnesses. They found that ME/CFS patients had significantly higher levels of TGF-β1 than both groups, suggesting this molecule may play a role in ME/CFS disease development.

Immune System

E2 ModerateCohortPEM not requiredObservational

No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population.

Robinson, Mark James, Tuke, Philip William, Erlwein, Otto et al.·Advances in virology·2011

This study tested whether XMRV (a virus that was claimed to cause ME/CFS) could be found in prostate cancer patients, lymphoma patients, and healthy blood donors in the UK. Researchers looked for genetic traces of the virus using sensitive laboratory tests. They found no evidence that XMRV or related viruses were actually infecting these groups of people.

E2 ModerateCohortPEM not requiredCase-Control

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.

Moldofsky, Harvey, Patcai, John·BMC neurology·2011

This study looked at people who had severe SARS infection and were unable to return to work for over a year afterward. These patients experienced long-lasting fatigue, widespread muscle pain, weakness, depression, and poor sleep quality. Researchers found that their sleep patterns and symptoms were very similar to those seen in fibromyalgia and chronic fatigue syndrome.

Pain and SensitizationSleep

E2 ModerateCohortPEM unclearCase-Control

Increased tenderness in the left third intercostal space in adult patients with myalgic encephalomyelitis: a controlled study.

Puri, B K, Gunatilake, K D R, Fernando, K A C et al.·The Journal of international medical research·2011

Researchers examined the chests of 42 people with ME/CFS and 20 healthy people to look for physical signs. They found that 81% of people with ME/CFS had tenderness (pain when touched) in a specific area on the left side of their rib cage, while none of the healthy people had this tenderness. This suggests there may be a consistent physical finding that doctors could potentially use to help identify ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis.

Williams, Allison M, Kitchen, Peter, Eby, Jeanette·BMC complementary and alternative medicine·2011

This study looked at how many people in Ontario, Canada visited alternative health care providers like massage therapists, acupuncturists, and naturopaths in 2005. Researchers found that about 13% of adults (over 1.2 million people) used these services. People with chronic conditions, including chronic fatigue syndrome, were more likely to visit alternative providers, especially if they felt their regular doctors weren't meeting their health needs.

E2 ModerateCohortPEM unclearCross-Sectional

No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan.

Furuta, Rika A, Miyazawa, Takayuki, Sugiyama, Takeki et al.·Retrovirology·2011

Researchers tested blood samples from 500 healthy people, 67 prostate cancer patients, and 100 ME/CFS patients in Japan to see if a virus called XMRV was linked to these conditions. They found some antibodies to XMRV in a small number of people (1.6-3.0%), but no clear evidence of active infection in any group, suggesting XMRV is not a cause of ME/CFS in Japan.

E2 ModerateCohortPEM unclearCross-Sectional

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients.

Delviks-Frankenberry, Krista A, Chaipan, Chawaree, Bagni, Rachel et al.·Advances in virology·2011

Researchers tested whether a virus called XMRV, which had been proposed as a possible cause of ME/CFS, was present in HIV-positive patients who developed lymphoma (a type of cancer). They checked blood samples from 26 patients using three different detection methods, but did not find any evidence of XMRV. This suggests that XMRV is not associated with lymphomas that develop in people with HIV.

E2 ModerateGuidelinePEM not requiredGuideline

How to explain central sensitization to patients with 'unexplained' chronic musculoskeletal pain: practice guidelines.

Nijs, Jo, Paul van Wilgen, C, Van Oosterwijck, Jessica et al.·Manual therapy·2011

Central sensitization is a condition where the nervous system becomes overly sensitive to pain signals, making people feel pain from things that normally wouldn't hurt. This guideline explains that teaching patients about how their nervous system works—called pain physiology education—can help them understand their pain and feel better. The education works best when delivered in face-to-face sessions with written materials, and it has helped people with fibromyalgia, chronic fatigue syndrome, and other long-term pain conditions.

Pain and Sensitization

E2 ModerateCohortPEM unclearObservational

What stops children with a chronic illness accessing health care: a mixed methods study in children with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Webb, Carly M, Collin, Simon M, Deave, Toity et al.·BMC health services research·2011

Children with ME/CFS are waiting much longer than recommended to see a specialist—the typical wait is 18 months, while guidelines suggest assessment should happen within 3-6 months. This study found that many GPs and other doctors don't know enough about ME/CFS or how to refer children properly, and some had negative attitudes toward the condition. Parents also found it hard to explain an 'invisible' illness to healthcare providers, which delayed their children from getting the specialist care they needed.

E2 ModerateCohortPEM not requiredCross-Sectional

Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature.

Lombardi, Vincent C, Hagen, Kathryn S, Hunter, Kenneth W et al.·In vivo (Athens, Greece)·2011

This 2011 study looked for a specific virus (XMRV) in the blood of ME/CFS patients and measured immune system chemicals called cytokines and chemokines. Researchers found a distinctive pattern of 10 immune chemicals that could identify XMRV-positive patients with very high accuracy (93-96%), suggesting that this virus may trigger a particular type of immune response in some people with ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic conditions and major depression in community-dwelling older adults.

Fiest, Kirsten M, Currie, Shawn R, Williams, Jeanne V A et al.·Journal of affective disorders·2011

This study looked at how common chronic illnesses and depression are together in older adults in Canada. Researchers found that people over 50 with long-term health conditions are much more likely to also have depression. Interestingly, conditions like Chronic Fatigue Syndrome, fibromyalgia, and migraines showed the strongest link with depression in seniors.

E2 ModerateCohortPEM unclearCross-Sectional

An Italian study on health-related quality of life and fatigue in patients with chronic fatigue syndrome and patients with chronic HCV virus infection: similarities and differences.

Racciatti, Delia, Gorgoretti, V, Sepede, G et al.·International journal of immunopathology and pharmacology·2011

This Italian study compared fatigue and quality of life in 39 ME/CFS patients versus 49 people with chronic hepatitis C. Using standard questionnaires, researchers found that ME/CFS patients experienced significantly more severe fatigue and lower quality of life than hepatitis C patients. The study concludes that managing fatigue should be a priority for ME/CFS patients to help improve their overall well-being.

E2 ModerateCohortPEM not requiredCase-Control

Cognitive impairment in fatigue and sleepiness associated conditions.

Neu, Daniel, Kajosch, Hendrik, Peigneux, Philippe et al.·Psychiatry research·2011

This study compared how fatigue and sleepiness affect thinking and memory. Researchers tested 15 people with ME/CFS, 15 people with sleep apnea, and 16 healthy controls using memory tests, attention tasks, and brain wave measurements. Both patient groups showed cognitive problems, though people with sleep apnea had slightly more difficulty with certain thinking tasks and movement speed.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Physical activity intensity but not sedentary activity is reduced in chronic fatigue syndrome and is associated with autonomic regulation.

Newton, J L, Pairman, J, Hallsworth, K et al.·QJM : monthly journal of the Association of Physicians·2011

This study looked at how much people with ME/CFS move around during the day compared to healthy people. Researchers found that people with ME/CFS do less intense physical activity (like brisk walking or exercise) than healthy controls, even though they spend similar amounts of time sitting. The study also found that reduced physical activity was linked to problems with heart rate regulation in ME/CFS patients.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

The retrovirus XMRV is not directly involved in the pathogenesis of common types of lymphoid malignancy.

Waugh, Elspeth M, Jarrett, Ruth F, Shield, Lesley et al.·Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2011

Researchers tested whether a virus called XMRV, which had been found in some ME/CFS patients, might cause blood cancers like lymphoma and leukemia. They checked blood samples from 368 patients with these cancers and 507 control samples using three different sensitive tests. The virus was not found in any cancer patient samples, suggesting XMRV is not a major cause of these blood cancers.

E2 ModerateCohortPEM not requiredCase-Control

Symptom fluctuations and daily physical activity in patients with chronic fatigue syndrome: a case-control study.

Meeus, Mira, van Eupen, Inge, van Baarle, Ellen et al.·Archives of physical medicine and rehabilitation·2011

This study tracked physical activity and daily symptoms in 67 women with ME/CFS compared to healthy women who were not very active. Researchers found that ME/CFS patients were generally less active overall, but surprisingly, on days when patients were more active, they experienced more symptoms and greater symptom fluctuations the same day and the next day. Conversely, patients had fewer symptom changes on days when they stayed more sedentary and spread their limited activity throughout the day.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression.

Maes, Michael, Mihaylova, Ivanka, Kubera, Marta et al.·Neuro endocrinology letters·2011

This study looked at a protective enzyme called GPX that helps defend cells from damage in people with depression and ME/CFS. The researchers found that people with depression had lower levels of this enzyme compared to healthy people, but people with ME/CFS had normal levels. Both groups showed connections between low enzyme levels and symptoms like mood problems and autonomic nervous system dysfunction.

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The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome.

Chronic fatigue syndrome: labels, meanings and consequences.

Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome.

Up-regulation of TGF-β1 mRNA expression in peripheral blood mononuclear cells of patients with chronic fatigue syndrome.

No Evidence of XMRV or MuLV Sequences in Prostate Cancer, Diffuse Large B-Cell Lymphoma, or the UK Blood Donor Population.

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.

Increased tenderness in the left third intercostal space in adult patients with myalgic encephalomyelitis: a controlled study.

Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis.

No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan.

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients.

How to explain central sensitization to patients with 'unexplained' chronic musculoskeletal pain: practice guidelines.

What stops children with a chronic illness accessing health care: a mixed methods study in children with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature.

Chronic conditions and major depression in community-dwelling older adults.

An Italian study on health-related quality of life and fatigue in patients with chronic fatigue syndrome and patients with chronic HCV virus infection: similarities and differences.

Cognitive impairment in fatigue and sleepiness associated conditions.

Physical activity intensity but not sedentary activity is reduced in chronic fatigue syndrome and is associated with autonomic regulation.

The retrovirus XMRV is not directly involved in the pathogenesis of common types of lymphoid malignancy.

Symptom fluctuations and daily physical activity in patients with chronic fatigue syndrome: a case-control study.

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression.

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