ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1621–1640 of 2,768 studies

E2 ModerateBehavioralPEM not requiredObservational

Therapist effects in routine psychotherapy practice: an account from chronic fatigue syndrome.

Cella, Matteo, Stahl, Daniel, Reme, Silje Endresen et al.·Psychotherapy research : journal of the Society for Psychotherapy Research·2011

This study looked at whether it matters which therapist treats patients with ME/CFS when they receive cognitive behavioral therapy (CBT). Researchers tracked 374 ME/CFS patients treated by 12 different therapists in a specialized clinic and measured changes in fatigue and disability. They found that while patients improved overall, the individual therapist made almost no difference in outcomes—the patients' improvements were similar regardless of which qualified therapist treated them.

Interventions

E2 ModerateDiagnosticPEM unclearMethods-Paper

Measuring disability in patients with chronic fatigue syndrome: reliability and validity of the Work and Social Adjustment Scale.

Cella, Matteo, Sharpe, Michael, Chalder, Trudie·Journal of psychosomatic research·2011

This study tested whether a simple questionnaire called the Work and Social Adjustment Scale (WSAS) accurately measures how much ME/CFS affects a person's daily life and ability to work. Researchers gave this questionnaire to over 1,000 ME/CFS patients and found it was reliable and valid—meaning it consistently measured disability and actually reflected real-world functioning.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome.

Eglinton, Rebekah, Chung, Man Cheung·Psychiatry research·2011

This study looked at whether people with ME/CFS have higher rates of PTSD (post-traumatic stress disorder) and whether trauma-related stress affects fatigue levels. Researchers found that ME/CFS patients did experience more PTSD symptoms and traumatic life events than healthy controls, but surprisingly, the severity of PTSD symptoms did not directly predict how severe their fatigue was. Instead, a sense of helplessness was more strongly linked to both fatigue and mental health problems.

E2 ModerateCohortPEM unclearCross-Sectional

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Maes, Michael, Kubera, Marta, Uytterhoeven, Marc et al.·Medical science monitor : international medical journal of experimental and clinical research·2011

This study measured two markers of oxidative stress (damage caused by harmful molecules in the body) in people with ME/CFS compared to healthy people. Researchers found that ME/CFS patients had significantly higher levels of plasma peroxides—harmful molecules that damage cells. These findings suggest that oxidative stress may play a role in ME/CFS, which could help explain some of the illness's symptoms.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

[The role of depression in cognitive impairment in patients with chronic fatigue syndrome].

Santamarina-Pérez, Pilar, Freniche, Verónica, Eiroa-Orosa, Francisco Jose et al.·Medicina clinica·2011

This study tested whether depression explains the thinking and memory problems that people with ME/CFS experience. Researchers gave 57 women with ME/CFS a variety of cognitive tests measuring attention, memory, and processing speed, then compared results between those with and without depression. The findings showed that cognitive problems were present in ME/CFS patients regardless of whether they had depression, suggesting that the brain fog and thinking difficulties are part of ME/CFS itself, not caused by depression.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: labels, meanings and consequences.

Wojcik, Wojtek, Armstrong, David, Kanaan, Richard·Journal of psychosomatic research·2011

This study surveyed British neurologists to understand how they view ME/CFS and whether they consider it a neurological condition. The results revealed that 84% of neurologists did not view ME/CFS as a neurological disorder, even though it is officially classified as one in the ICD-10 medical coding system. The researchers discuss how the way we label and classify ME/CFS affects how doctors treat patients and how patients understand their own illness.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort.

van Kuppeveld, Frank J M, de Jong, Arjan S, Lanke, Kjerstin H et al.·BMJ (Clinical research ed.)·2010

Researchers in the Netherlands tested whether a virus called XMRV, which had been reported in ME/CFS patients in other studies, was present in blood samples from Dutch ME/CFS patients. Using sensitive laboratory tests, they found no trace of this virus in any of the patients or healthy control participants. This challenges earlier claims that XMRV might be connected to ME/CFS.

E2 ModerateCohortPEM unclearObservational

[Transcranial magnetic stimulation in the chronic fatigue syndrome].

Sholomov, I I, Cherevashchenko, L A, Bolotova, N V et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2010

This study examined whether transcranial magnetic stimulation (TMS)—a non-invasive technique that uses magnetic pulses to stimulate the brain—might help people with ME/CFS. Researchers observed patients receiving TMS treatment and tracked their responses. While the study provides early observations about this treatment approach, more rigorous testing is needed to confirm whether TMS is truly effective for ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same.

Newton, J L, Mabillard, H, Scott, A et al.·The journal of the Royal College of Physicians of Edinburgh·2010

This study looked at patients referred to a specialist fatigue clinic in Newcastle, England to see how many actually had ME/CFS versus other conditions causing tiredness. The researchers found that 60% of referred patients were diagnosed with ME/CFS, while the remaining 40% had other causes of fatigue—most commonly tiredness from other chronic illnesses, sleep problems, or mental health conditions. This suggests many people with fatigue don't fit ME/CFS criteria but still need help managing their symptoms.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Postinfectious and chronic fatigue syndromes: clinical experience from a tertiary-referral centre in Norway.

Naess, Halvor, Sundal, Endre, Myhr, Kjell-Morten et al.·In vivo (Athens, Greece)·2010

This study looked at 873 ME/CFS patients in Norway to see whether their illness started after an infection. About 77% of patients reported having an infection before their fatigue began. Patients who had an infection at the start were more likely to have a sudden onset of fatigue and to show some improvement by the time they were seen at the clinic, compared to those without an infection.

E2 ModerateCohortPEM not requiredLongitudinal

The effects of repeated thermal therapy on quality of life in patients with type II diabetes mellitus.

Beever, Richard·Journal of alternative and complementary medicine (New York, N.Y.)·2010

This study tested whether far-infrared sauna sessions (3 times per week for 3 months) could improve quality of life in people with type II diabetes. Researchers found that participants reported improvements in physical health, general health, stress, and fatigue. The study suggests that saunas might help people with diabetes feel better, and interestingly, more people seemed willing to try saunas compared to other lifestyle changes.

E2 ModerateCohortPEM not requiredCross-Sectional

Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.

Nickel, J Curtis, Tripp, Dean A, Pontari, Michel et al.·The Journal of urology·2010

This study looked at how often bladder pain syndrome occurs alongside other conditions like irritable bowel syndrome, fibromyalgia, and ME/CFS. Researchers found that people with bladder pain syndrome were much more likely to have these other conditions compared to healthy controls. Importantly, people who had multiple overlapping conditions experienced worse pain, sleep problems, depression, and lower quality of life than those with just one condition.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM not requiredObservational

Cognitive behavioural therapy and psycho-education for chronic fatigue syndrome in young people: reflections from the families' perspective.

Dennison, Laura, Stanbrook, Rachel, Moss-Morris, Rona et al.·British journal of health psychology·2010

This study asked 16 young people with ME/CFS and their parents about their experiences with two types of therapy: cognitive behavioural therapy (CBT) and psycho-education (PE). Most families found both treatments helpful and acceptable, particularly the practical parts like setting goals and gradually increasing activity. However, some felt the emotional aspects of the illness weren't fully addressed, and others had mixed feelings about how much family involvement was needed.

E2 ModerateCohortPEM requiredCross-Sectional

Postexertional malaise in women with chronic fatigue syndrome.

VanNess, J Mark, Stevens, Staci R, Bateman, Lucinda et al.·Journal of women's health (2002)·2010

This study looked at how women with ME/CFS recover from exercise compared to healthy women. After a single exercise test, 85% of healthy women felt completely back to normal within 24 hours, but none of the women with ME/CFS did—in fact, most took much longer to recover, experiencing worsening fatigue, pain, cognitive problems, and other symptoms. This research confirms that postexertional malaise is a real and serious condition that makes recovery from physical activity dramatically different for people with ME/CFS.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Biochemical and vascular aspects of pediatric chronic fatigue syndrome.

Kennedy, Gwen, Khan, Faisel, Hill, Alexander et al.·Archives of pediatrics & adolescent medicine·2010

This study compared 25 children with ME/CFS to 23 healthy children to understand what happens in their bodies at a chemical and blood vessel level. The researchers found that children with ME/CFS had signs of increased oxidative stress (cellular damage from harmful molecules) and more dying white blood cells, similar to what has been seen in adults with ME/CFS. However, unlike adults, the children's blood vessel stiffness appeared normal.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Illness duration and coping style in chronic fatigue syndrome.

Brown, Molly M, Brown, Abigail A, Jason, Leonard A·Psychological reports·2010

This study looked at how people with ME/CFS cope with their illness depending on how long they've had it. Researchers found that people who had been sick for longer tended to use more helpful coping strategies—like planning, acceptance, and looking for positive aspects—compared to those who were more recently diagnosed. Interestingly, the severity of symptoms and physical limitations were similar in both groups, but people with longer illness duration were less likely to be working.

E2 ModerateCohortPEM not requiredObservational

Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections.

Barnes, Eleanor, Flanagan, Peter, Brown, Anthony et al.·The Journal of infectious diseases·2010

In 2010, researchers tested 230 people with HIV or hepatitis C to see if they carried a virus called XMRV, which had recently been suggested as a possible cause of chronic fatigue syndrome. They found no trace of XMRV in blood samples or immune cells, and people's immune systems showed no signs of having fought off this virus. This suggested that XMRV was not common in people with these blood-borne infections.

E2 ModerateCohortPEM not requiredCross-Sectional

Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis.

Zhang, Lihan, Gough, John, Christmas, David et al.·Journal of clinical pathology·2010

This study looked at blood samples from ME/CFS patients to identify different genetic subtypes based on how 88 genes were turned on or off. Researchers found that ME/CFS patients had distinct genetic patterns that were different from healthy people and those with depression. They also discovered that different viral infections—particularly Epstein-Barr virus and enterovirus—were linked to different genetic subtypes of ME/CFS.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.

van Hoogmoed, Dewy, Fransen, Jaap, Bleijenberg, Gijs et al.·Rheumatology (Oxford, England)·2010

This study looked at severe fatigue in people with rheumatoid arthritis (RA), a condition that causes joint inflammation. Researchers found that 42% of RA patients experienced severe fatigue that felt frustrating and exhausting. Importantly, this severe fatigue was more closely linked to pain, mood, sleep quality, and how patients thought about their fatigue—rather than to inflammation markers alone.

Pain and SensitizationSleep

E2 ModerateCohortPEM not requiredCase-Control

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

Hong, Ping, Li, Jinming, Li, Yongzhe·Virology journal·2010

Researchers tested 65 people with ME/CFS and 85 healthy controls to see if a virus called XMRV might cause ME/CFS. Using sensitive laboratory tests, they found no evidence of XMRV in any of the study participants' blood cells. This study suggests XMRV is not associated with ME/CFS in Chinese patients.

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Evidence browser

Therapist effects in routine psychotherapy practice: an account from chronic fatigue syndrome.

Measuring disability in patients with chronic fatigue syndrome: reliability and validity of the Work and Social Adjustment Scale.

The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome.

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

[The role of depression in cognitive impairment in patients with chronic fatigue syndrome].

Chronic fatigue syndrome: labels, meanings and consequences.

Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort.

[Transcranial magnetic stimulation in the chronic fatigue syndrome].

The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same.

Postinfectious and chronic fatigue syndromes: clinical experience from a tertiary-referral centre in Norway.

The effects of repeated thermal therapy on quality of life in patients with type II diabetes mellitus.

Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome.

Cognitive behavioural therapy and psycho-education for chronic fatigue syndrome in young people: reflections from the families' perspective.

Postexertional malaise in women with chronic fatigue syndrome.

Biochemical and vascular aspects of pediatric chronic fatigue syndrome.

Illness duration and coping style in chronic fatigue syndrome.

Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections.

Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis.

Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

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