ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2785 studies

1661–1680 of 2,785 studies

E2 ModerateCohortPEM not requiredLongitudinal

Longitudinal MRI shows no cerebral abnormality in chronic fatigue syndrome.

Perrin, R, Embleton, K, Pentreath, V W et al.·The British journal of radiology·2010

This study used MRI brain scans to look for physical abnormalities in people with ME/CFS compared to healthy people. Eighteen patients with ME/CFS and nine healthy volunteers were scanned twice, one year apart. The researchers found no significant differences between the two groups in brain size, fluid levels, blood flow, or white matter lesions, and these measurements remained stable over the year.

Biomarkers

E2 ModerateCohortPEM unclearCross-Sectional

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Satterfield, Brent C, Garcia, Rebecca A, Gurrieri, Fiorella et al.·Molecular autism·2010

This study tested whether a virus called XMRV is present in children with autism, particularly those born to mothers with ME/CFS. Researchers used blood tests and antibody checks on over 400 participants and found no evidence that XMRV is linked to autism. This helps clarify that despite earlier media suggestions, this particular virus does not appear to contribute to autism development.

E2 ModerateCohortPEM unclearCross-Sectional

Biochemical and vascular aspects of pediatric chronic fatigue syndrome.

Kennedy, Gwen, Khan, Faisel, Hill, Alexander et al.·Archives of pediatrics & adolescent medicine·2010

This study compared 25 children with ME/CFS to 23 healthy children to understand what happens in their bodies at a chemical and blood vessel level. The researchers found that children with ME/CFS had signs of increased oxidative stress (cellular damage from harmful molecules) and more dying white blood cells, similar to what has been seen in adults with ME/CFS. However, unlike adults, the children's blood vessel stiffness appeared normal.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder.

Murrough, James W, Mao, Xiangling, Collins, Katherine A et al.·NMR in biomedicine·2010

This study used a special type of brain imaging called MRI to measure a substance called lactate in the fluid around the brain of people with ME/CFS. The researchers found that people with ME/CFS had significantly higher lactate levels compared to healthy people and people with depression. Interestingly, people with depression had normal lactate levels, suggesting this finding may be specific to ME/CFS and not just a symptom of mental illness.

Biomarkers

E2 ModerateBehavioralPEM not requiredCross-Sectional

Illness duration and coping style in chronic fatigue syndrome.

Brown, Molly M, Brown, Abigail A, Jason, Leonard A·Psychological reports·2010

This study looked at how people with ME/CFS cope with their illness depending on how long they've had it. Researchers found that people who had been sick for longer tended to use more helpful coping strategies—like planning, acceptance, and looking for positive aspects—compared to those who were more recently diagnosed. Interestingly, the severity of symptoms and physical limitations were similar in both groups, but people with longer illness duration were less likely to be working.

E2 ModerateCohortPEM unclearObservational

Sex differences in plasma prolactin response to tryptophan in chronic fatigue syndrome patients with and without comorbid fibromyalgia.

Weaver, Shelley A, Janal, Malvin N, Aktan, Nadine et al.·Journal of women's health (2002)·2010

Researchers gave patients with ME/CFS a tryptophan infusion (a building block for serotonin, a brain chemical) to see how their bodies would respond. They found that women with ME/CFS alone had a stronger response in a hormone called prolactin compared to healthy women, but women with ME/CFS plus fibromyalgia did not show this difference. Men in all groups showed similar responses, suggesting ME/CFS may work differently in women than in men.

E2 ModerateCohortPEM not requiredLongitudinal

The effects of repeated thermal therapy on quality of life in patients with type II diabetes mellitus.

Beever, Richard·Journal of alternative and complementary medicine (New York, N.Y.)·2010

This study tested whether far-infrared sauna sessions (3 times per week for 3 months) could improve quality of life in people with type II diabetes. Researchers found that participants reported improvements in physical health, general health, stress, and fatigue. The study suggests that saunas might help people with diabetes feel better, and interestingly, more people seemed willing to try saunas compared to other lifestyle changes.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of rheumatologic manifestations of chronic hepatitis C virus infection among Egyptians.

Mohammed, Reem Hamdy Abdellatif, ElMakhzangy, Hesham Ibrahim, Gamal, Amira et al.·Clinical rheumatology·2010

This study looked at 306 people in Egypt with chronic hepatitis C virus (HCV) infection to see how often they experienced joint pain, fatigue, dry eyes, and other autoimmune-related symptoms. Researchers found that about 16% of people with HCV had these types of rheumatologic symptoms, with fatigue and dry eyes being most common. The study suggests that HCV infection can trigger these kinds of whole-body symptoms through autoimmune mechanisms.

E2 ModerateCohortPEM not requiredCross-Sectional

Phenotypes of chronic fatigue syndrome in children and young people.

May, Margaret, Emond, Alan, Crawley, Esther·Archives of disease in childhood·2010

Researchers studied 333 children and young people with ME/CFS to see if the illness presents differently in different people. They found three main patterns: one involving muscle and joint pain, another involving migraine-like symptoms with sensitivity to light and sound, and a third involving sore throat and swollen lymph nodes. These different patterns were linked to varying levels of severity, suggesting that ME/CFS affects children in different ways.

Pain and Sensitization

E2 ModerateCohortPEM unclearObservational

Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract.

Fischer, Nicole, Schulz, Claudia, Stieler, Kristin et al.·Emerging infectious diseases·2010

Researchers looked for a virus called XMRV in respiratory samples (like saliva or mucus) from healthy and immunocompromised people. They found viral traces in a small percentage of healthy people (2-3%) and a higher percentage of immunocompromised people (10%). This study was one of several investigating whether XMRV might be linked to ME/CFS, though the findings were modest.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Impaired cardiovascular response to standing in chronic fatigue syndrome.

Hollingsworth, Kieren G, Jones, David E J, Taylor, Roy et al.·European journal of clinical investigation·2010

This study found that people with ME/CFS have abnormal heart function when standing up, and their heart and muscle cells struggle to produce energy efficiently. Researchers used specialized scans to measure energy metabolism in the heart and muscles, and found that about one-third of ME/CFS patients showed significant heart energy problems. When standing, ME/CFS patients had stronger heart contractions and more symptoms compared to healthy controls, suggesting their bodies are working much harder to maintain blood flow.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCase-Control

Mood volatility with rumination but neither attentional nor interpretation biases in chronic fatigue syndrome.

Martin, Maryanne, Alexeeva, Iana·British journal of health psychology·2010

This study looked at whether people with ME/CFS have a tendency to automatically focus their attention on illness-related information, and whether they interpret ambiguous words in an illness-focused way. The researchers found that people with ME/CFS did not show these automatic biases. However, they did find that people with ME/CFS experienced greater mood swings when they spent time thinking repetitively about their condition (rumination) compared to when they were distracted.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Reduced heart rate variability predicts poor sleep quality in a case-control study of chronic fatigue syndrome.

Burton, A R, Rahman, K, Kadota, Y et al.·Experimental brain research·2010

People with ME/CFS often report poor sleep quality. This study measured heart rate patterns during sleep in 20 patients with ME/CFS and 20 healthy controls, finding that ME/CFS patients had much lower heart rate variability (natural changes in heart rate) during sleep. The researchers concluded that this reduced variability—suggesting the nervous system stays "on high alert" even at night—is closely linked to their sleep problems.

Autonomic Nervous System

E2 ModerateCohortPEM unclearLongitudinal

The occupational and quality of life consequences of chronic fatigue syndrome/myalgic encephalomyelitis in young people.

Taylor, Renee R, O'Brien, Jane, Kielhofner, Gary et al.·The British journal of occupational therapy·2010

This study followed young people aged 12-18 who had glandular fever to see what happened after infection. Most recovered normally, but 39 developed ME/CFS. Compared to those who recovered, young people with ME/CFS reported feeling less confident in their abilities, had more difficulty with physical activities, and experienced worse overall health—affecting school, friendships, and emotional wellbeing.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.

van Hoogmoed, Dewy, Fransen, Jaap, Bleijenberg, Gijs et al.·Rheumatology (Oxford, England)·2010

This study looked at severe fatigue in people with rheumatoid arthritis (RA), a condition that causes joint inflammation. Researchers found that 42% of RA patients experienced severe fatigue that felt frustrating and exhausting. Importantly, this severe fatigue was more closely linked to pain, mood, sleep quality, and how patients thought about their fatigue—rather than to inflammation markers alone.

Pain and SensitizationSleep

E2 ModerateCohortPEM not requiredObservational

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Cameron, Barbara, Flamand, Louis, Juwana, Hedy et al.·Journal of medical virology·2010

Researchers tested blood samples from ME/CFS patients and healthy controls to see whether three common herpesviruses (EBV, CMV, and HHV-6) were actively reactivating or causing ongoing infection. They found no evidence that these viruses were actively infected or reactivating in ME/CFS patients compared to controls who recovered normally from infection.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Postinfectious fatigue in adolescents and physical activity.

Huang, Yue, Katz, Ben Z, Mears, Cynthia et al.·Archives of pediatrics & adolescent medicine·2010

This study followed 301 teenagers with infectious mononucleosis (mono) for 2 years, comparing those who developed chronic fatigue syndrome (CFS) with those who recovered normally. Adolescents with post-infection CFS reported much more severe fatigue and needed more daytime sleep than their peers, even though their overall activity levels looked similar on paper. The key finding suggests that teenagers with CFS after mono may be forcing themselves to stay active like their friends, but at a significant physical cost in terms of exhaustion and sleep needs.

Post-Exertional Malaise

E2 ModerateBehavioralPEM unclearLongitudinal

An investigation of victimization and the clinical course of chronic fatigue syndrome.

Johnson, Susan K, Schmaling, Karen B, Dmochowski, Jacek et al.·Journal of health psychology·2010

This study looked at whether people with ME/CFS who experienced trauma or abuse—either as children or adults—had worse symptoms or outcomes. Researchers followed 93 patients over time and found that childhood abuse and neglect were more strongly connected to illness severity than adult experiences. However, the connections were modest, and past trauma did not predict whether the illness would get worse over time.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality features and personality disorders in chronic fatigue syndrome: a population-based study.

Nater, Urs M, Jones, James F, Lin, Jin-Mann S et al.·Psychotherapy and psychosomatics·2010

This study looked at whether certain personality traits are more common in people with ME/CFS. Researchers compared 113 people with ME/CFS to people without it and found that those with ME/CFS had higher rates of certain personality patterns (like being more anxious or withdrawn) and personality disorders. However, these personality differences were not unique to ME/CFS—they also appeared in other chronically ill groups.

E2 ModerateCohortPEM not requiredObservational

[Multiple chemical sensitivity: epidemiological, clinical and prognostic differences between occupational and non-occupational cases].

Nogué Xarau, Santiago, Alarcón Romay, María, Martínez Martínez, José-Miguel et al.·Medicina clinica·2010

This study looked at 165 people with multiple chemical sensitivity (MCS)—a condition where people react badly to everyday chemicals—to see if it made a difference whether their condition started from workplace exposure or other sources. People whose MCS began at work had fewer related conditions like chronic fatigue and fibromyalgia, and were less likely to become permanently disabled, compared to those whose MCS developed from non-work exposures.

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Longitudinal MRI shows no cerebral abnormality in chronic fatigue syndrome.

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Biochemical and vascular aspects of pediatric chronic fatigue syndrome.

Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder.

Illness duration and coping style in chronic fatigue syndrome.

Sex differences in plasma prolactin response to tryptophan in chronic fatigue syndrome patients with and without comorbid fibromyalgia.

The effects of repeated thermal therapy on quality of life in patients with type II diabetes mellitus.

Prevalence of rheumatologic manifestations of chronic hepatitis C virus infection among Egyptians.

Phenotypes of chronic fatigue syndrome in children and young people.

Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract.

Impaired cardiovascular response to standing in chronic fatigue syndrome.

Mood volatility with rumination but neither attentional nor interpretation biases in chronic fatigue syndrome.

Reduced heart rate variability predicts poor sleep quality in a case-control study of chronic fatigue syndrome.

The occupational and quality of life consequences of chronic fatigue syndrome/myalgic encephalomyelitis in young people.

Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Postinfectious fatigue in adolescents and physical activity.

An investigation of victimization and the clinical course of chronic fatigue syndrome.

Personality features and personality disorders in chronic fatigue syndrome: a population-based study.

[Multiple chemical sensitivity: epidemiological, clinical and prognostic differences between occupational and non-occupational cases].

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