ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1681–1700 of 2,768 studies

E2 ModerateCohortPEM not requiredObservational

Sleep is not disrupted by exercise in patients with chronic fatigue syndromes.

Togo, Fumiharu, Natelson, Benjamin H, Cherniack, Neil S et al.·Medicine and science in sports and exercise·2010

Researchers studied whether exercise makes sleep worse in ME/CFS patients, since many report feeling much sicker after activity. They measured sleep quality using overnight sleep monitoring in ME/CFS patients and healthy controls, both before and after an exercise test. The main finding: exercise did not make sleep worse for ME/CFS patients, and about half actually slept better after exercising.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Physical and functional impact of chronic fatigue syndrome/myalgic encephalomyelitis in childhood.

Kennedy, Gwen, Underwood, Christine, Belch, Jill Janette Freda·Pediatrics·2010

This study compared the quality of life of 25 children with ME/CFS to 23 healthy children of similar age and gender. Children with ME/CFS reported much lower quality of life across nearly all areas measured, including physical health, daily activities, and overall well-being. Most children with ME/CFS attended school part-time or received home tutoring only, showing how significantly the illness affects their ability to participate in normal daily life.

E2 ModerateCohortPEM not requiredCase-Control

A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome.

Fukuda, Sanae, Hashimoto, Ryota, Ohi, Kazutaka et al.·Life sciences·2010

This study looked at a genetic variant (a small difference in DNA) in a gene called DISC1 to see if it might be linked to ME/CFS. Researchers compared blood samples from people with ME/CFS and healthy controls, and found that people carrying a particular version of this genetic variant (called Cys704) had a higher risk of developing ME/CFS. This suggests that DISC1 might play a role in how ME/CFS develops, though more research is needed to understand exactly how.

E2 ModerateCohortPEM unclearObservational

Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate.

Spitzer, A Robert, Broadman, Melissa·Pain practice : the official journal of World Institute of Pain·2010

Researchers looked at 118 patients with ME/CFS or fibromyalgia who had sleep problems similar to narcolepsy. When these patients were treated with a medication called sodium oxybate, 75% reported significant improvement in fatigue and 60% reported significant improvement in pain. This suggests that fixing the underlying sleep disorder might help relieve both conditions.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

A national cross-sectional survey of diagnosed sufferers of myalgic encephalomyelitis/chronic fatigue syndrome: pathways to diagnosis, changes in quality of life and service priorities.

Comiskey, C, Larkan, F·Irish journal of medical science·2010

This study surveyed 211 people in Ireland with a diagnosed ME/CFS to understand their journey to diagnosis and how the illness affected their lives. On average, people visited 4-5 different healthcare services before being diagnosed, and it took nearly 4 years to get a diagnosis (though some waited much longer). Patients reported that their quality of life got significantly worse after developing ME/CFS, and they strongly asked for doctors to have better training and understanding of the condition.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Orthostatic symptoms predict functional capacity in chronic fatigue syndrome: implications for management.

Costigan, A, Elliott, C, McDonald, C et al.·QJM : monthly journal of the Association of Physicians·2010

This study found that ME/CFS patients have much greater difficulty with daily activities compared to healthy people. Among ME/CFS patients, those who experience dizziness or lightheadedness when standing up (orthostatic symptoms) had the most trouble with physical functioning. The researchers suggest that treating these standing-related symptoms might help patients do more in their daily lives.

Autonomic Nervous SystemCognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Interpersonal problems in alexithymia: A study in three primary care groups.

Vanheule, Stijn, Vandenbergen, Jan, Verhaeghe, Paul et al.·Psychology and psychotherapy·2010

This study looked at whether people with ME/CFS have difficulty recognizing and talking about their emotions (a condition called alexithymia), and whether this connects to how they interact with others. Researchers compared 52 ME/CFS patients with two other groups: 52 people with heart or autoimmune diseases, and 51 people with minor health problems. They found that ME/CFS patients and those with chronic diseases struggled more with identifying emotions and tended to have more distant or self-centered relationships compared to those with minor illnesses.

E2 ModerateCohortPEM not requiredCase-Control

Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study.

Limonard, G J M, Peters, J B, Nabuurs-Franssen, M H et al.·QJM : monthly journal of the Association of Physicians·2010

This study looked at people who had Q fever (a bacterial infection) during an outbreak in the Netherlands and checked how they were doing about a year later. Compared to people who never had Q fever, the infected patients reported significantly more fatigue, symptoms, and problems with daily functioning. About half of the Q fever patients experienced severe fatigue, which is notably higher than in the comparison group.

E2 ModerateBehavioralPEM not requiredObservational

Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

Roberts, A D L, Charler, M-L, Papadopoulos, A et al.·Psychological medicine·2010

This study looked at whether a hormone called cortisol, which helps regulate stress and energy, affects how well cognitive behavioural therapy (CBT) works for ME/CFS patients. The researchers measured cortisol levels in 84 ME/CFS patients and tracked how many improved after receiving CBT. They found that patients with lower cortisol levels were less likely to respond well to CBT, suggesting that abnormal cortisol may be one reason why ME/CFS persists in some people.

Interventions

E2 ModerateCohortPEM not requiredCase-Control

Adolescent offspring of mothers with chronic fatigue syndrome.

Smith, Mark S, Buchwald, Dedra S, Bogart, Andy et al.·The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2010

This study looked at whether teenagers whose mothers have ME/CFS are more likely to develop ME/CFS themselves or experience fatigue and other related symptoms. Researchers compared 26 teenagers with mothers who had ME/CFS to 45 teenagers whose mothers were healthy. While teenagers with affected mothers showed higher rates of prolonged fatigue and ME/CFS diagnosis, the differences were small and not statistically proven.

Pain and SensitizationSleep

E2 ModerateCohortPEM requiredObservational

Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta.

Nijs, J, Van Oosterwijck, J, Meeus, M et al.·Journal of internal medicine·2010

This study looked at what happens in the blood after people with ME/CFS exercise. Researchers compared 22 women with ME/CFS to 22 healthy women and measured specific immune markers (elastase, IL-1beta, and complement C4a) before and after two different types of exercise. Both types of exercise triggered postexertional malaise (a worsening of symptoms after activity) in the ME/CFS group, but surprisingly, the immune markers they measured didn't show significant changes in either group.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

EEG source analysis of chronic fatigue syndrome.

Flor-Henry, Pierre, Lind, John C, Koles, Zoltan J·Psychiatry research·2010

Researchers used a specialized brain-wave test (EEG) to compare 61 women with ME/CFS to 80 healthy women. The brain activity patterns were different between the two groups, especially when the women were doing mental tasks. The computer could correctly identify who had ME/CFS based on these brain patterns about 72-83% of the time.

E2 ModerateCohortPEM not requiredCase-Control

Postinfectious fatigue in adolescents and physical activity.

Huang, Yue, Katz, Ben Z, Mears, Cynthia et al.·Archives of pediatrics & adolescent medicine·2010

This study followed 301 teenagers with infectious mononucleosis (mono) for 2 years, comparing those who developed chronic fatigue syndrome (CFS) with those who recovered normally. Adolescents with post-infection CFS reported much more severe fatigue and needed more daytime sleep than their peers, even though their overall activity levels looked similar on paper. The key finding suggests that teenagers with CFS after mono may be forcing themselves to stay active like their friends, but at a significant physical cost in terms of exhaustion and sleep needs.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearLongitudinal

The occupational and quality of life consequences of chronic fatigue syndrome/myalgic encephalomyelitis in young people.

Taylor, Renee R, O'Brien, Jane, Kielhofner, Gary et al.·The British journal of occupational therapy·2010

This study followed young people aged 12-18 who had glandular fever to see what happened after infection. Most recovered normally, but 39 developed ME/CFS. Compared to those who recovered, young people with ME/CFS reported feeling less confident in their abilities, had more difficulty with physical activities, and experienced worse overall health—affecting school, friendships, and emotional wellbeing.

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbid health conditions in women with syncope.

Ulas, Umit H, Chelimsky, Thomas C, Chelimsky, Gisela et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2010

This study looked at hospital records of over 305,000 patients admitted for fainting (syncope) to see which health conditions were more common in women versus men. Researchers found that women were more likely to have several conditions related to nervous system problems that control blood pressure and heart rate, including chronic fatigue syndrome, migraines, and postural tachycardia syndrome (a condition where heart rate increases abnormally when standing). These autonomic conditions were especially common in women of reproductive age.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Fibromyalgia and related conditions: electromyogram profile during isometric muscle contraction.

Maquet, Didier, Croisier, Jean-Louis, Dupont, Catherine et al.·Joint bone spine·2010

This study measured how muscles work during sustained effort by recording electrical signals from shoulder muscles in people with fibromyalgia, ME/CFS, depression, and healthy controls. People with fibromyalgia stopped their muscle contraction much earlier than others and showed a distinctive electrical pattern suggesting their muscles gave up prematurely. Importantly, ME/CFS patients showed muscle patterns very similar to healthy people, not the abnormal pattern seen in fibromyalgia.

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue status in relation to lifestyle in healthy Japanese adolescents.

Zou, Ning, Kubota, Masaru, Kuruma, Eriko et al.·International journal of pediatrics·2010

This study looked at fatigue in over 1,200 healthy Japanese teenagers aged 11–16 to see how common different types of fatigue were and whether lifestyle habits made a difference. Researchers found that girls reported higher fatigue scores related to ME/CFS-type symptoms than boys, and fatigue increased as teenagers got older. Sleep, exercise, diet quality, and sugary drinks were all linked to how tired teenagers felt.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome.

Fletcher, Mary A, Rosenthal, Martin, Antoni, Michael et al.·Behavioral and brain functions : BBF·2010

This study measured a stress-related substance called neuropeptide Y (NPY) in the blood of ME/CFS patients and compared it to healthy people and people with Gulf War Illness. The researchers found that ME/CFS patients had significantly higher NPY levels, and these levels correlated with how severe their symptoms were—including stress, depression, fatigue, and cognitive problems. This suggests NPY could be a useful blood test to help identify ME/CFS and track symptom severity.

Biomarkers

E2 ModerateBehavioralPEM not requiredCross-Sectional

One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders.

Fink, Per, Schröder, Andreas·Journal of psychosomatic research·2010

This study looked at whether a new diagnosis called 'bodily distress syndrome' could capture several different conditions that cause physical symptoms not explained by standard medical tests—including ME/CFS, fibromyalgia, and irritable bowel syndrome. Researchers tested nearly 1,000 patients and found that bodily distress syndrome successfully identified 95% of patients across all these different diagnoses, suggesting these conditions might be better understood as variations of one underlying problem rather than completely separate diseases.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Phenotypes of chronic fatigue syndrome in children and young people.

May, Margaret, Emond, Alan, Crawley, Esther·Archives of disease in childhood·2010

Researchers studied 333 children and young people with ME/CFS to see if the illness presents differently in different people. They found three main patterns: one involving muscle and joint pain, another involving migraine-like symptoms with sensitivity to light and sound, and a third involving sore throat and swollen lymph nodes. These different patterns were linked to varying levels of severity, suggesting that ME/CFS affects children in different ways.

Pain and Sensitization

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Sleep is not disrupted by exercise in patients with chronic fatigue syndromes.

Physical and functional impact of chronic fatigue syndrome/myalgic encephalomyelitis in childhood.

A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome.

Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate.

A national cross-sectional survey of diagnosed sufferers of myalgic encephalomyelitis/chronic fatigue syndrome: pathways to diagnosis, changes in quality of life and service priorities.

Orthostatic symptoms predict functional capacity in chronic fatigue syndrome: implications for management.

Interpersonal problems in alexithymia: A study in three primary care groups.

Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study.

Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

Adolescent offspring of mothers with chronic fatigue syndrome.

Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta.

EEG source analysis of chronic fatigue syndrome.

Postinfectious fatigue in adolescents and physical activity.

The occupational and quality of life consequences of chronic fatigue syndrome/myalgic encephalomyelitis in young people.

Comorbid health conditions in women with syncope.

Fibromyalgia and related conditions: electromyogram profile during isometric muscle contraction.

Fatigue status in relation to lifestyle in healthy Japanese adolescents.

Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome.

One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders.

Phenotypes of chronic fatigue syndrome in children and young people.

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