ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2785 studies

1701–1720 of 2,785 studies

E2 ModerateCohortPEM not requiredCase-Control

Adolescent offspring of mothers with chronic fatigue syndrome.

Smith, Mark S, Buchwald, Dedra S, Bogart, Andy et al.·The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2010

This study looked at whether teenagers whose mothers have ME/CFS are more likely to develop ME/CFS themselves or experience fatigue and other related symptoms. Researchers compared 26 teenagers with mothers who had ME/CFS to 45 teenagers whose mothers were healthy. While teenagers with affected mothers showed higher rates of prolonged fatigue and ME/CFS diagnosis, the differences were small and not statistically proven.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.

van Hoogmoed, Dewy, Fransen, Jaap, Bleijenberg, Gijs et al.·Rheumatology (Oxford, England)·2010

This study looked at severe fatigue in people with rheumatoid arthritis (RA), a condition that causes joint inflammation. Researchers found that 42% of RA patients experienced severe fatigue that felt frustrating and exhausting. Importantly, this severe fatigue was more closely linked to pain, mood, sleep quality, and how patients thought about their fatigue—rather than to inflammation markers alone.

Pain and SensitizationSleep

E2 ModerateCohortPEM unclearCross-Sectional

No evidence for XMRV association in pediatric idiopathic diseases in France.

Jeziorski, Eric, Foulongne, Vincent, Ludwig, Catherine et al.·Retrovirology·2010

Researchers tested whether a virus called XMRV might be causing various childhood illnesses and respiratory diseases. They checked samples from 151 children and adults with different conditions, but found no evidence that XMRV was present in any of them. This suggests that XMRV is likely not responsible for these particular diseases.

E2 ModerateCohortPEM not requiredObservational

Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV.

Kunstman, Kevin J, Bhattacharya, Tanmoy, Flaherty, John et al.·AIDS (London, England)·2010

Researchers tested nearly 1,000 men for a virus called XMRV that had been found in some ME/CFS patients. They found no evidence of this virus in any of the men tested, even though the virus had been detected in a small percentage of healthy people from similar geographic areas. This suggests that if XMRV is linked to ME/CFS, it may only occur in certain populations.

E2 ModerateCohortPEM not requiredCase-Control

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

Hong, Ping, Li, Jinming, Li, Yongzhe·Virology journal·2010

Researchers tested 65 people with ME/CFS and 85 healthy controls to see if a virus called XMRV might cause ME/CFS. Using sensitive laboratory tests, they found no evidence of XMRV in any of the study participants' blood cells. This study suggests XMRV is not associated with ME/CFS in Chinese patients.

E2 ModerateBehavioralPEM unclearLongitudinal

An investigation of victimization and the clinical course of chronic fatigue syndrome.

Johnson, Susan K, Schmaling, Karen B, Dmochowski, Jacek et al.·Journal of health psychology·2010

This study looked at whether people with ME/CFS who experienced trauma or abuse—either as children or adults—had worse symptoms or outcomes. Researchers followed 93 patients over time and found that childhood abuse and neglect were more strongly connected to illness severity than adult experiences. However, the connections were modest, and past trauma did not predict whether the illness would get worse over time.

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia.

Maloney, Elizabeth M, Boneva, Roumiana S, Lin, Jin-Mann S et al.·Metabolism: clinical and experimental·2010

This study found that people with ME/CFS are twice as likely to have metabolic syndrome—a cluster of conditions including high blood pressure, high blood sugar, excess belly fat, and abnormal cholesterol levels—compared to healthy people. The more metabolic factors someone had, the worse their fatigue tended to be. This suggests that metabolic problems may be connected to ME/CFS severity.

Energy Metabolism

E2 ModerateCohortPEM unclearCross-Sectional

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Satterfield, Brent C, Garcia, Rebecca A, Gurrieri, Fiorella et al.·Molecular autism·2010

This study tested whether a virus called XMRV is present in children with autism, particularly those born to mothers with ME/CFS. Researchers used blood tests and antibody checks on over 400 participants and found no evidence that XMRV is linked to autism. This helps clarify that despite earlier media suggestions, this particular virus does not appear to contribute to autism development.

E2 ModerateCohortPEM unclearCase-Control

Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study.

Meeus, Mira, Nijs, Jo, Huybrechts, Sven et al.·Clinical rheumatology·2010

This study tested whether people with ME/CFS feel pain more intensely than healthy people, even in areas where they don't typically experience pain. Researchers measured how much pressure patients and healthy volunteers could tolerate before feeling pain. They found that ME/CFS patients with chronic pain had significantly lower pain thresholds everywhere on their body, suggesting their nervous system may be in a heightened state of sensitivity.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Impaired sleep in chronic fatigue syndrome: how is it best measured?

Creti, Laura, Libman, Eva, Baltzan, Marcel et al.·Journal of health psychology·2010

This study compared three different ways of measuring sleep in people with ME/CFS: overnight hospital testing (polysomnography), wrist-worn activity monitors (actigraphy), and patients reporting on their own sleep. Researchers found that while objective measurements matched what patients reported about total sleep time, the objective tests didn't capture daytime symptoms like non-refreshing sleep, fatigue, or sleepiness that patients actually experience.

E2 ModerateCohortPEM not requiredCross-Sectional

Fibromyalgia and related conditions: electromyogram profile during isometric muscle contraction.

Maquet, Didier, Croisier, Jean-Louis, Dupont, Catherine et al.·Joint bone spine·2010

This study measured how muscles work during sustained effort by recording electrical signals from shoulder muscles in people with fibromyalgia, ME/CFS, depression, and healthy controls. People with fibromyalgia stopped their muscle contraction much earlier than others and showed a distinctive electrical pattern suggesting their muscles gave up prematurely. Importantly, ME/CFS patients showed muscle patterns very similar to healthy people, not the abnormal pattern seen in fibromyalgia.

E2 ModerateCohortPEM unclearCross-Sectional

Physical and functional impact of chronic fatigue syndrome/myalgic encephalomyelitis in childhood.

Kennedy, Gwen, Underwood, Christine, Belch, Jill Janette Freda·Pediatrics·2010

This study compared the quality of life of 25 children with ME/CFS to 23 healthy children of similar age and gender. Children with ME/CFS reported much lower quality of life across nearly all areas measured, including physical health, daily activities, and overall well-being. Most children with ME/CFS attended school part-time or received home tutoring only, showing how significantly the illness affects their ability to participate in normal daily life.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Interpersonal problems in alexithymia: A study in three primary care groups.

Vanheule, Stijn, Vandenbergen, Jan, Verhaeghe, Paul et al.·Psychology and psychotherapy·2010

This study looked at whether people with ME/CFS have difficulty recognizing and talking about their emotions (a condition called alexithymia), and whether this connects to how they interact with others. Researchers compared 52 ME/CFS patients with two other groups: 52 people with heart or autoimmune diseases, and 51 people with minor health problems. They found that ME/CFS patients and those with chronic diseases struggled more with identifying emotions and tended to have more distant or self-centered relationships compared to those with minor illnesses.

E2 ModerateCohortPEM not requiredCross-Sectional

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.

Groom, Harriet C T, Boucherit, Virginie C, Makinson, Kerry et al.·Retrovirology·2010

This study looked for a virus called XMRV in 170 ME/CFS patients and 395 healthy controls to see if the virus was linked to the disease. Researchers used two methods: direct detection of viral material and blood tests looking for immune responses. They found no evidence that XMRV was associated with ME/CFS, contradicting an earlier study that had reported finding the virus in most CFS patients.

E2 ModerateBehavioralPEM not requiredCross-Sectional

New dimensions of abnormal illness behaviour derived from the Illness Behaviour Questionnaire.

Prior, Kirsty N, Bond, Malcolm J·Psychology & health·2010

Researchers tested a questionnaire that measures how people respond to and think about illness. They gave the questionnaire to 675 people, including 77 with ME/CFS, to see if it could identify different patterns of illness-related thoughts and behaviors. They found three main patterns: how much people affirm their illness, how concerned they are about their health, and their overall emotional state.

E2 ModerateCohortPEM unclearCross-Sectional

A national cross-sectional survey of diagnosed sufferers of myalgic encephalomyelitis/chronic fatigue syndrome: pathways to diagnosis, changes in quality of life and service priorities.

Comiskey, C, Larkan, F·Irish journal of medical science·2010

This study surveyed 211 people in Ireland with a diagnosed ME/CFS to understand their journey to diagnosis and how the illness affected their lives. On average, people visited 4-5 different healthcare services before being diagnosed, and it took nearly 4 years to get a diagnosis (though some waited much longer). Patients reported that their quality of life got significantly worse after developing ME/CFS, and they strongly asked for doctors to have better training and understanding of the condition.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Cameron, Barbara, Flamand, Louis, Juwana, Hedy et al.·Journal of medical virology·2010

Researchers tested blood samples from ME/CFS patients and healthy controls to see whether three common herpesviruses (EBV, CMV, and HHV-6) were actively reactivating or causing ongoing infection. They found no evidence that these viruses were actively infected or reactivating in ME/CFS patients compared to controls who recovered normally from infection.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

A formal analysis of cytokine networks in chronic fatigue syndrome.

Broderick, Gordon, Fuite, Jim, Kreitz, Andrea et al.·Brain, behavior, and immunity·2010

Researchers studied immune system chemicals called cytokines in people with ME/CFS and healthy controls to understand how their immune systems differ. Instead of looking at single markers, they examined how 16 different cytokines work together as networks. They found that people with ME/CFS have a very different immune system pattern—like a hub with one central point—compared to the more balanced network in healthy people.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality and perfectionism in chronic fatigue syndrome: a closer look.

Deary, Vincent, Chalder, Trudie·Psychology & health·2010

This study compared personality traits in 27 women with ME/CFS to 30 healthy women. People with ME/CFS scored higher on neuroticism (tendency to experience negative emotions) and unhealthy perfectionism (setting unrealistic standards and being self-critical). Interestingly, the combination of these traits appeared to be particularly problematic in the fatigued group, suggesting that personality patterns that might seem positive in healthy people can sometimes be harmful when someone has ME/CFS.

E2 ModerateCohortPEM not requiredObservational

Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.

Robinson, M, Gray, S R, Watson, M S et al.·Scandinavian journal of medicine & science in sports·2010

This study looked at specific markers of inflammation and oxidative stress (cellular damage) in people with ME/CFS compared to healthy individuals, both at rest and after exercise. Researchers found that a marker called F2-isoprostanes—which indicates oxidative stress—was consistently higher in ME/CFS patients. However, they did not find differences in inflammation markers like IL-6 between the two groups.

Immune SystemPost-Exertional Malaise

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Adolescent offspring of mothers with chronic fatigue syndrome.

Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis.

No evidence for XMRV association in pediatric idiopathic diseases in France.

Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV.

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

An investigation of victimization and the clinical course of chronic fatigue syndrome.

Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in Georgia.

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study.

Impaired sleep in chronic fatigue syndrome: how is it best measured?

Fibromyalgia and related conditions: electromyogram profile during isometric muscle contraction.

Physical and functional impact of chronic fatigue syndrome/myalgic encephalomyelitis in childhood.

Interpersonal problems in alexithymia: A study in three primary care groups.

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.

New dimensions of abnormal illness behaviour derived from the Illness Behaviour Questionnaire.

A national cross-sectional survey of diagnosed sufferers of myalgic encephalomyelitis/chronic fatigue syndrome: pathways to diagnosis, changes in quality of life and service priorities.

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

A formal analysis of cytokine networks in chronic fatigue syndrome.

Personality and perfectionism in chronic fatigue syndrome: a closer look.

Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.

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