ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1701–1720 of 2,768 studies

E2 ModerateCohortPEM not requiredObservational

Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.

Robinson, M, Gray, S R, Watson, M S et al.·Scandinavian journal of medicine & science in sports·2010

This study looked at specific markers of inflammation and oxidative stress (cellular damage) in people with ME/CFS compared to healthy individuals, both at rest and after exercise. Researchers found that a marker called F2-isoprostanes—which indicates oxidative stress—was consistently higher in ME/CFS patients. However, they did not find differences in inflammation markers like IL-6 between the two groups.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Adolescent offspring of mothers with chronic fatigue syndrome.

Smith, Mark S, Buchwald, Dedra S, Bogart, Andy et al.·The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2010

This study looked at whether teenagers whose mothers have ME/CFS are more likely to develop ME/CFS themselves or experience fatigue and other related symptoms. Researchers compared 26 teenagers with mothers who had ME/CFS to 45 teenagers whose mothers were healthy. While teenagers with affected mothers showed higher rates of prolonged fatigue and ME/CFS diagnosis, the differences were small and not statistically proven.

Pain and SensitizationSleep

E2 ModerateCohortPEM not requiredObservational

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Cameron, Barbara, Flamand, Louis, Juwana, Hedy et al.·Journal of medical virology·2010

Researchers tested blood samples from ME/CFS patients and healthy controls to see whether three common herpesviruses (EBV, CMV, and HHV-6) were actively reactivating or causing ongoing infection. They found no evidence that these viruses were actively infected or reactivating in ME/CFS patients compared to controls who recovered normally from infection.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

U.S. healthcare providers' knowledge, attitudes, beliefs, and perceptions concerning Chronic Fatigue Syndrome.

Brimmer, Dana J, Fridinger, Frederick, Lin, Jin-Mann S et al.·BMC family practice·2010

Researchers surveyed over 4,000 U.S. doctors and nurses to find out how much they know about ME/CFS and what they think about diagnosing and treating it. Most healthcare providers had heard of ME/CFS and knew its basic symptoms, but many said they rarely diagnose it. The study found that doctors got their information mainly from medical journals, the internet, and continuing education courses.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study.

Limonard, G J M, Peters, J B, Nabuurs-Franssen, M H et al.·QJM : monthly journal of the Association of Physicians·2010

This study looked at people who had Q fever (a bacterial infection) during an outbreak in the Netherlands and checked how they were doing about a year later. Compared to people who never had Q fever, the infected patients reported significantly more fatigue, symptoms, and problems with daily functioning. About half of the Q fever patients experienced severe fatigue, which is notably higher than in the comparison group.

E2 ModerateBehavioralPEM not requiredCross-Sectional

New dimensions of abnormal illness behaviour derived from the Illness Behaviour Questionnaire.

Prior, Kirsty N, Bond, Malcolm J·Psychology & health·2010

Researchers tested a questionnaire that measures how people respond to and think about illness. They gave the questionnaire to 675 people, including 77 with ME/CFS, to see if it could identify different patterns of illness-related thoughts and behaviors. They found three main patterns: how much people affirm their illness, how concerned they are about their health, and their overall emotional state.

E2 ModerateCohortPEM unclearCross-Sectional

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Satterfield, Brent C, Garcia, Rebecca A, Gurrieri, Fiorella et al.·Molecular autism·2010

This study tested whether a virus called XMRV is present in children with autism, particularly those born to mothers with ME/CFS. Researchers used blood tests and antibody checks on over 400 participants and found no evidence that XMRV is linked to autism. This helps clarify that despite earlier media suggestions, this particular virus does not appear to contribute to autism development.

E2 ModerateCohortPEM unclearObservational

Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract.

Fischer, Nicole, Schulz, Claudia, Stieler, Kristin et al.·Emerging infectious diseases·2010

Researchers looked for a virus called XMRV in respiratory samples (like saliva or mucus) from healthy and immunocompromised people. They found viral traces in a small percentage of healthy people (2-3%) and a higher percentage of immunocompromised people (10%). This study was one of several investigating whether XMRV might be linked to ME/CFS, though the findings were modest.

Immune System

E2 ModerateBehavioralPEM not requiredCase-Control

Mood volatility with rumination but neither attentional nor interpretation biases in chronic fatigue syndrome.

Martin, Maryanne, Alexeeva, Iana·British journal of health psychology·2010

This study looked at whether people with ME/CFS have a tendency to automatically focus their attention on illness-related information, and whether they interpret ambiguous words in an illness-focused way. The researchers found that people with ME/CFS did not show these automatic biases. However, they did find that people with ME/CFS experienced greater mood swings when they spent time thinking repetitively about their condition (rumination) compared to when they were distracted.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome.

Fukuda, Sanae, Hashimoto, Ryota, Ohi, Kazutaka et al.·Life sciences·2010

This study looked at a genetic variant (a small difference in DNA) in a gene called DISC1 to see if it might be linked to ME/CFS. Researchers compared blood samples from people with ME/CFS and healthy controls, and found that people carrying a particular version of this genetic variant (called Cys704) had a higher risk of developing ME/CFS. This suggests that DISC1 might play a role in how ME/CFS develops, though more research is needed to understand exactly how.

E2 ModerateCohortPEM not requiredCross-Sectional

No differences in cardiovascular autonomic responses to mental stress in chronic fatigue syndrome adolescents as compared to healthy controls.

Egge, Caroline, Wyller, Vegard Bruun·BioPsychoSocial medicine·2010

This study tested how the hearts and blood vessels of teenagers with ME/CFS respond to mental stress (doing math problems) compared to healthy teens. While ME/CFS patients had faster resting heart rates, their cardiovascular response during the mental stress test was similar to healthy controls, suggesting that simple mental stress doesn't cause the same abnormal autonomic nervous system responses that physical stress does in this condition.

E2 ModerateBehavioralPEM not requiredObservational

Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

Roberts, A D L, Charler, M-L, Papadopoulos, A et al.·Psychological medicine·2010

This study looked at whether a hormone called cortisol, which helps regulate stress and energy, affects how well cognitive behavioural therapy (CBT) works for ME/CFS patients. The researchers measured cortisol levels in 84 ME/CFS patients and tracked how many improved after receiving CBT. They found that patients with lower cortisol levels were less likely to respond well to CBT, suggesting that abnormal cortisol may be one reason why ME/CFS persists in some people.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder.

Murrough, James W, Mao, Xiangling, Collins, Katherine A et al.·NMR in biomedicine·2010

This study used a special type of brain imaging called MRI to measure a substance called lactate in the fluid around the brain of people with ME/CFS. The researchers found that people with ME/CFS had significantly higher lactate levels compared to healthy people and people with depression. Interestingly, people with depression had normal lactate levels, suggesting this finding may be specific to ME/CFS and not just a symptom of mental illness.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.

Scully, Paul, McKernan, Declan P, Keohane, John et al.·The American journal of gastroenterology·2010

This study looked at inflammation markers in the blood of women with irritable bowel syndrome (IBS), particularly those who also had fibromyalgia, premenstrual symptoms, or chronic fatigue syndrome. Researchers found that women with IBS plus these extra conditions had higher levels of four inflammation-related substances (IL-1β, IL-6, IL-8, and TNFα) compared to healthy women, while those with IBS alone had elevated levels of two of these markers.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

Hong, Ping, Li, Jinming, Li, Yongzhe·Virology journal·2010

Researchers tested 65 people with ME/CFS and 85 healthy controls to see if a virus called XMRV might cause ME/CFS. Using sensitive laboratory tests, they found no evidence of XMRV in any of the study participants' blood cells. This study suggests XMRV is not associated with ME/CFS in Chinese patients.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Interpersonal problems in alexithymia: A study in three primary care groups.

Vanheule, Stijn, Vandenbergen, Jan, Verhaeghe, Paul et al.·Psychology and psychotherapy·2010

This study looked at whether people with ME/CFS have difficulty recognizing and talking about their emotions (a condition called alexithymia), and whether this connects to how they interact with others. Researchers compared 52 ME/CFS patients with two other groups: 52 people with heart or autoimmune diseases, and 51 people with minor health problems. They found that ME/CFS patients and those with chronic diseases struggled more with identifying emotions and tended to have more distant or self-centered relationships compared to those with minor illnesses.

E2 ModerateCohortPEM not requiredCross-Sectional

Phenotypes of chronic fatigue syndrome in children and young people.

May, Margaret, Emond, Alan, Crawley, Esther·Archives of disease in childhood·2010

Researchers studied 333 children and young people with ME/CFS to see if the illness presents differently in different people. They found three main patterns: one involving muscle and joint pain, another involving migraine-like symptoms with sensitivity to light and sound, and a third involving sore throat and swollen lymph nodes. These different patterns were linked to varying levels of severity, suggesting that ME/CFS affects children in different ways.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCase-Control

Reduced complexity of activity patterns in patients with chronic fatigue syndrome: a case control study.

Burton, Christopher, Knoop, Hans, Popovic, Nikola et al.·BioPsychoSocial medicine·2009

This study measured how people with ME/CFS move and rest over a 12-day period compared to healthy people. Researchers found that people with ME/CFS have activity patterns that are more repetitive and predictable—like a broken record—whereas healthy people's activity patterns are more varied and flexible. This difference held true even when accounting for the fact that ME/CFS patients were less active overall.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Clinical assessment of the physical activity pattern of chronic fatigue syndrome patients: a validation of three methods.

Scheeres, Korine, Knoop, Hans, Meer, van der Jos et al.·Health and quality of life outcomes·2009

This study tested three different ways to measure physical activity patterns in ME/CFS patients to see which method works best. Researchers compared a clinical interview, two questionnaires, and an objective activity monitor (actometer) in 226 patients. All three methods were reasonably accurate but had significant errors, and the questionnaire called IPAQ was best at identifying patients with low activity levels, which is important for treatment planning.

E2 ModerateCohortPEM unclearCross-Sectional

Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome.

Maes, Michael, Mihaylova, Ivanka, Kubera, Marta et al.·Neuro endocrinology letters·2009

This study measured a marker of DNA damage in the urine of people with ME/CFS, depression, both conditions together, and healthy controls. Researchers found that people with both ME/CFS and depression had the highest levels of this DNA damage marker, and the damage correlated with fatigue severity and flu-like symptoms. This suggests that oxidative stress—a type of cellular damage from harmful molecules—may play a role in both conditions.

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Plasma IL-6, its soluble receptors and F2-isoprostanes at rest and during exercise in chronic fatigue syndrome.

Adolescent offspring of mothers with chronic fatigue syndrome.

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

U.S. healthcare providers' knowledge, attitudes, beliefs, and perceptions concerning Chronic Fatigue Syndrome.

Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study.

New dimensions of abnormal illness behaviour derived from the Illness Behaviour Questionnaire.

PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism.

Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract.

Mood volatility with rumination but neither attentional nor interpretation biases in chronic fatigue syndrome.

A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome.

No differences in cardiovascular autonomic responses to mental stress in chronic fatigue syndrome adolescents as compared to healthy controls.

Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder.

Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity.

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

Interpersonal problems in alexithymia: A study in three primary care groups.

Phenotypes of chronic fatigue syndrome in children and young people.

Reduced complexity of activity patterns in patients with chronic fatigue syndrome: a case control study.

Clinical assessment of the physical activity pattern of chronic fatigue syndrome patients: a validation of three methods.

Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome.

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