ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1701–1720 of 2,807 studies

E2 ModerateCohortPEM not requiredLongitudinal

Adolescent chronic fatigue syndrome: a follow-up study.

van Geelen, Stefan M, Bakker, Rob J, Kuis, Wietse et al.·Archives of pediatrics & adolescent medicine·2010

This study followed 54 teenagers with ME/CFS (chronic fatigue syndrome) for about 2 years to see how they were doing. About half of the teens improved significantly, but the other half remained severely fatigued and physically limited. Teens who were older when they first got sick, had pain, struggled with mental health, or felt poorly about themselves were less likely to recover.

E2 ModerateCohortPEM not requiredCase-Control

Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26.

Fletcher, Mary A, Zeng, Xiao R, Maher, Kevin et al.·PloS one·2010

This study tested whether two immune system markers could reliably identify ME/CFS patients. Researchers measured natural killer (NK) cell function—a type of immune cell that fights infections—and CD26, a protein found on immune cells. They found that ME/CFS patients had lower NK cell function and different patterns of CD26 compared to healthy people, suggesting these markers could potentially help diagnose the condition.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Latent class analysis of functional somatic symptoms in a population-based sample of twins.

Kato, Kenji, Sullivan, Patrick F, Pedersen, Nancy L·Journal of psychosomatic research·2010

This study looked at how people with chronic fatigue and multiple physical symptoms cluster into different groups. Researchers studied over 28,000 twins and found five distinct groups: those with no symptoms, those mainly tired, those with stomach problems, those with pain, and those with many symptoms across all areas. The study suggests that while genes play a small role, environmental factors (like stress, infections, or lifestyle) are much more important in determining who develops these symptoms.

Pain and Sensitization

E2 ModerateBehavioralPEM not requiredCross-Sectional

Interpersonal problems in alexithymia: A study in three primary care groups.

Vanheule, Stijn, Vandenbergen, Jan, Verhaeghe, Paul et al.·Psychology and psychotherapy·2010

This study looked at whether people with ME/CFS have difficulty recognizing and talking about their emotions (a condition called alexithymia), and whether this connects to how they interact with others. Researchers compared 52 ME/CFS patients with two other groups: 52 people with heart or autoimmune diseases, and 51 people with minor health problems. They found that ME/CFS patients and those with chronic diseases struggled more with identifying emotions and tended to have more distant or self-centered relationships compared to those with minor illnesses.

E2 ModerateCohortPEM not requiredCase-Control

Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study.

Limonard, G J M, Peters, J B, Nabuurs-Franssen, M H et al.·QJM : monthly journal of the Association of Physicians·2010

This study looked at people who had Q fever (a bacterial infection) during an outbreak in the Netherlands and checked how they were doing about a year later. Compared to people who never had Q fever, the infected patients reported significantly more fatigue, symptoms, and problems with daily functioning. About half of the Q fever patients experienced severe fatigue, which is notably higher than in the comparison group.

E2 ModerateCohortPEM not requiredCross-Sectional

The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same.

Newton, J L, Mabillard, H, Scott, A et al.·The journal of the Royal College of Physicians of Edinburgh·2010

This study looked at patients referred to a specialist fatigue clinic in Newcastle, England to see how many actually had ME/CFS versus other conditions causing tiredness. The researchers found that 60% of referred patients were diagnosed with ME/CFS, while the remaining 40% had other causes of fatigue—most commonly tiredness from other chronic illnesses, sleep problems, or mental health conditions. This suggests many people with fatigue don't fit ME/CFS criteria but still need help managing their symptoms.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Postinfectious and chronic fatigue syndromes: clinical experience from a tertiary-referral centre in Norway.

Naess, Halvor, Sundal, Endre, Myhr, Kjell-Morten et al.·In vivo (Athens, Greece)·2010

This study looked at 873 ME/CFS patients in Norway to see whether their illness started after an infection. About 77% of patients reported having an infection before their fatigue began. Patients who had an infection at the start were more likely to have a sudden onset of fatigue and to show some improvement by the time they were seen at the clinic, compared to those without an infection.

E2 ModerateCohortPEM not requiredCase-Control

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

Hong, Ping, Li, Jinming, Li, Yongzhe·Virology journal·2010

Researchers tested 65 people with ME/CFS and 85 healthy controls to see if a virus called XMRV might cause ME/CFS. Using sensitive laboratory tests, they found no evidence of XMRV in any of the study participants' blood cells. This study suggests XMRV is not associated with ME/CFS in Chinese patients.

E2 ModerateCohortPEM not requiredObservational

Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV.

Kunstman, Kevin J, Bhattacharya, Tanmoy, Flaherty, John et al.·AIDS (London, England)·2010

Researchers tested nearly 1,000 men for a virus called XMRV that had been found in some ME/CFS patients. They found no evidence of this virus in any of the men tested, even though the virus had been detected in a small percentage of healthy people from similar geographic areas. This suggests that if XMRV is linked to ME/CFS, it may only occur in certain populations.

E2 ModerateCohortPEM not requiredObservational

Exercise tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.

Katz, Ben Z, Boas, Steven, Shiraishi, Yukiko et al.·The Journal of pediatrics·2010

After infectious mononucleosis, some teenagers develop ME/CFS. Researchers compared how well teenagers with ME/CFS could exercise compared to teenagers who recovered normally from mono. Teenagers with ME/CFS showed lower oxygen use and heart efficiency during exercise tests, even though they looked the same as healthy teens in other ways.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Fibromyalgia and related conditions: electromyogram profile during isometric muscle contraction.

Maquet, Didier, Croisier, Jean-Louis, Dupont, Catherine et al.·Joint bone spine·2010

This study measured how muscles work during sustained effort by recording electrical signals from shoulder muscles in people with fibromyalgia, ME/CFS, depression, and healthy controls. People with fibromyalgia stopped their muscle contraction much earlier than others and showed a distinctive electrical pattern suggesting their muscles gave up prematurely. Importantly, ME/CFS patients showed muscle patterns very similar to healthy people, not the abnormal pattern seen in fibromyalgia.

E2 ModerateCohortPEM unclearLongitudinal

The occupational and quality of life consequences of chronic fatigue syndrome/myalgic encephalomyelitis in young people.

Taylor, Renee R, O'Brien, Jane, Kielhofner, Gary et al.·The British journal of occupational therapy·2010

This study followed young people aged 12-18 who had glandular fever to see what happened after infection. Most recovered normally, but 39 developed ME/CFS. Compared to those who recovered, young people with ME/CFS reported feeling less confident in their abilities, had more difficulty with physical activities, and experienced worse overall health—affecting school, friendships, and emotional wellbeing.

E2 ModerateCohortPEM requiredObservational

Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta.

Nijs, J, Van Oosterwijck, J, Meeus, M et al.·Journal of internal medicine·2010

This study looked at what happens in the blood after people with ME/CFS exercise. Researchers compared 22 women with ME/CFS to 22 healthy women and measured specific immune markers (elastase, IL-1beta, and complement C4a) before and after two different types of exercise. Both types of exercise triggered postexertional malaise (a worsening of symptoms after activity) in the ME/CFS group, but surprisingly, the immune markers they measured didn't show significant changes in either group.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate.

Spitzer, A Robert, Broadman, Melissa·Pain practice : the official journal of World Institute of Pain·2010

Researchers looked at 118 patients with ME/CFS or fibromyalgia who had sleep problems similar to narcolepsy. When these patients were treated with a medication called sodium oxybate, 75% reported significant improvement in fatigue and 60% reported significant improvement in pain. This suggests that fixing the underlying sleep disorder might help relieve both conditions.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

EEG source analysis of chronic fatigue syndrome.

Flor-Henry, Pierre, Lind, John C, Koles, Zoltan J·Psychiatry research·2010

Researchers used a specialized brain-wave test (EEG) to compare 61 women with ME/CFS to 80 healthy women. The brain activity patterns were different between the two groups, especially when the women were doing mental tasks. The computer could correctly identify who had ME/CFS based on these brain patterns about 72-83% of the time.

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbid health conditions in women with syncope.

Ulas, Umit H, Chelimsky, Thomas C, Chelimsky, Gisela et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2010

This study looked at hospital records of over 305,000 patients admitted for fainting (syncope) to see which health conditions were more common in women versus men. Researchers found that women were more likely to have several conditions related to nervous system problems that control blood pressure and heart rate, including chronic fatigue syndrome, migraines, and postural tachycardia syndrome (a condition where heart rate increases abnormally when standing). These autonomic conditions were especially common in women of reproductive age.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue status in relation to lifestyle in healthy Japanese adolescents.

Zou, Ning, Kubota, Masaru, Kuruma, Eriko et al.·International journal of pediatrics·2010

This study looked at fatigue in over 1,200 healthy Japanese teenagers aged 11–16 to see how common different types of fatigue were and whether lifestyle habits made a difference. Researchers found that girls reported higher fatigue scores related to ME/CFS-type symptoms than boys, and fatigue increased as teenagers got older. Sleep, exercise, diet quality, and sugary drinks were all linked to how tired teenagers felt.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome.

Fletcher, Mary A, Rosenthal, Martin, Antoni, Michael et al.·Behavioral and brain functions : BBF·2010

This study measured a stress-related substance called neuropeptide Y (NPY) in the blood of ME/CFS patients and compared it to healthy people and people with Gulf War Illness. The researchers found that ME/CFS patients had significantly higher NPY levels, and these levels correlated with how severe their symptoms were—including stress, depression, fatigue, and cognitive problems. This suggests NPY could be a useful blood test to help identify ME/CFS and track symptom severity.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Psychiatric misdiagnoses in patients with chronic fatigue syndrome.

Lawn, Tara, Kumar, Praveen, Knight, Bernice et al.·JRSM short reports·2010

This study looked at whether doctors in ME/CFS clinics were accurately diagnosing psychiatric conditions like depression and anxiety in their ME/CFS patients. Researchers compared diagnoses made by clinic doctors with diagnoses made using a standardized psychiatric interview on 135 patients. They found that doctors missed psychiatric diagnoses in about 22% of patients, but incorrectly diagnosed them in only 10%—meaning missed diagnoses were more than twice as common as false diagnoses.

E2 ModerateCohortPEM not requiredCross-Sectional

Functional impairment in chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivity.

Lavergne, M Ruth, Cole, Donald C, Kerr, Kathleen et al.·Canadian family physician Medecin de famille canadien·2010

This study looked at 128 patients with ME/CFS, fibromyalgia, or multiple chemical sensitivity seen at a Toronto clinic to understand how much these illnesses affect daily life. Compared to healthy Canadians, these patients had significantly lower ability to work, care for themselves, and function in their homes—with 69% having stopped working an average of 3 years after becoming ill. The study found that having fibromyalgia, becoming ill at a younger age, and lower income were linked to worse functional outcomes.

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Adolescent chronic fatigue syndrome: a follow-up study.

Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26.

Latent class analysis of functional somatic symptoms in a population-based sample of twins.

Interpersonal problems in alexithymia: A study in three primary care groups.

Detailed analysis of health status of Q fever patients 1 year after the first Dutch outbreak: a case-control study.

The Newcastle NHS Chronic Fatigue Syndrome Service: not all fatigue is the same.

Postinfectious and chronic fatigue syndromes: clinical experience from a tertiary-referral centre in Norway.

Failure to detect Xenotropic murine leukaemia virus-related virus in Chinese patients with chronic fatigue syndrome.

Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV.

Exercise tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.

Fibromyalgia and related conditions: electromyogram profile during isometric muscle contraction.

The occupational and quality of life consequences of chronic fatigue syndrome/myalgic encephalomyelitis in young people.

Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta.

Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate.

EEG source analysis of chronic fatigue syndrome.

Comorbid health conditions in women with syncope.

Fatigue status in relation to lifestyle in healthy Japanese adolescents.

Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome.

Psychiatric misdiagnoses in patients with chronic fatigue syndrome.

Functional impairment in chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivity.

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