Meeus, Mira, Nijs, Jo, Huybrechts, Sven et al. · Clinical rheumatology · 2010 · DOI
This study tested whether people with ME/CFS feel pain more intensely than healthy people, even in areas where they don't typically experience pain. Researchers measured how much pressure patients and healthy volunteers could tolerate before feeling pain. They found that ME/CFS patients with chronic pain had significantly lower pain thresholds everywhere on their body, suggesting their nervous system may be in a heightened state of sensitivity.
This study provides objective physiological evidence that ME/CFS-related pain involves central nervous system sensitization rather than merely reflecting patients' psychological state or local tissue damage. Understanding the neurobiological basis of ME/CFS pain may guide development of targeted treatments and validate patient experiences of widespread pain sensitivity.
This study demonstrates association between ME/CFS and generalized hyperalgesia but does not establish causation or the mechanism by which central sensitization develops. The study cannot determine whether hyperalgesia predates ME/CFS onset, emerges as a consequence of the disease, or results from shared underlying factors. Results apply specifically to ME/CFS patients with chronic pain and may not generalize to all ME/CFS presentations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Meeus, Mira, Nijs, Jo, Huybrechts, Sven, & Truijen, Steven (2010). Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study.. Clinical rheumatology. https://doi.org/10.1007/s10067-009-1339-0
BibTeX
@article{mecfsatlas-meeus-2010-evidence-generalized,
author = {Meeus, Mira and Nijs, Jo and Huybrechts, Sven and Truijen, Steven},
title = {Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study.},
journal = {Clinical rheumatology},
year = {2010},
doi = {10.1007/s10067-009-1339-0},
note = {PubMed: 20077123},
url = {https://www.mecfsatlas.com/evidence/meeus-2010-evidence-generalized},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/meeus-2010-evidence-generalized
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