ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1921–1940 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychological, medical, and pharmacological correlates of persistent genital arousal disorder.

Leiblum, Sandra, Seehuus, Martin, Goldmeier, David et al.·The journal of sexual medicine·2007

This study surveyed 156 women about persistent genital arousal disorder (PGAD), a condition involving unwanted arousal sensations. Women with full PGAD were more likely to experience depression, anxiety, panic attacks, and chronic fatigue compared to women with milder symptoms or no condition. The researchers suggest that anxiety and worry about these sensations may play a role in making PGAD worse.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia.

Reeves, William C, Jones, James F, Maloney, Elizabeth et al.·Population health metrics·2007

This study surveyed over 5,600 people in Georgia to find out how many have ME/CFS. Researchers found that about 2.5% of adults aged 18-59 have the condition, which is higher than estimates from other parts of the United States. Interestingly, the disease affected men and women very differently depending on whether they lived in cities or rural areas.

E2 ModerateCohortPEM unclearObservational

A real-time assessment of the effect of exercise in chronic fatigue syndrome.

Yoshiuchi, Kazuhiro, Cook, Dane B, Ohashi, Kyoko et al.·Physiology & behavior·2007

This study looked at what happens to people with ME/CFS after they exercise, tracking their symptoms in real-time using a watch-like computer for a week before and two weeks after exercise. The main finding was that physical symptoms like pain and fatigue got worse in ME/CFS patients, but this didn't happen right away—it took about five days to appear. Interestingly, mental symptoms and thinking abilities didn't show the same delayed worsening pattern that physical symptoms did.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Reduced levels of oestrogen receptor beta mRNA in Swedish patients with chronic fatigue syndrome.

Gräns, Hanna, Nilsson, Maria, Dahlman-Wright, Karin et al.·Journal of clinical pathology·2007

This study looked at a protein called estrogen receptor beta in immune cells from ME/CFS patients and healthy people. Researchers found that ME/CFS patients had lower levels of this protein compared to healthy controls. Since estrogen plays a role in immune function and ME/CFS affects more women than men, this finding suggests hormone-related immune problems might be involved in the disease.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome.

Rajeevan, M S, Smith, A K, Dimulescu, I et al.·Genes, brain, and behavior·2007

This study looked at whether differences in a specific gene (the glucocorticoid receptor gene) might affect who develops ME/CFS. Researchers compared 40 people with ME/CFS to people without the illness and found that certain genetic variations were more common in those with ME/CFS. This gene is involved in how the body manages stress through a system called the HPA axis, which may be disrupted in ME/CFS.

Endocrine Disruption

E2 ModerateBehavioralPEM unclearCross-Sectional

Alexithymia in chronic fatigue syndrome: associations with momentary, recall, and retrospective measures of somatic complaints and emotions.

Friedberg, Fred, Quick, Joyce·Psychosomatic medicine·2007

This study looked at whether difficulty identifying and expressing emotions (a trait called alexithymia) is linked to fatigue and pain in ME/CFS patients. Researchers asked 111 people with ME/CFS to report their symptoms three ways: in real-time through daily diaries, in weekly recall, and in overall retrospective ratings over 6 months. The results showed that day-to-day emotional difficulty was not connected to how patients experienced symptoms moment-to-moment, but there was a weak connection to how they remembered pain over longer periods.

E2 ModerateCohortPEM not requiredCross-Sectional

The prevalence of chronic fatigue syndrome in Nigeria.

Njoku, Mary Gloriac C, Jason, Leonard A, Torres-Harding, Susan R·Journal of health psychology·2007

This study measured how common ME/CFS is in Nigeria and found it occurs more often there than in similar studies done in the United States. The researchers suggest that illnesses like malaria and typhoid, combined with limited access to healthcare and poverty, may make people more likely to develop chronic fatigue. This highlights that ME/CFS may affect different populations around the world in different ways.

E2 ModerateCohortPEM not requiredLongitudinal

Cortisol and severe fatigue: a longitudinal study in adolescent girls.

Ter Wolbeek, Maike, van Doornen, Lorenz J P, Coffeng, Luc E et al.·Psychoneuroendocrinology·2007

This study looked at whether girls with severe, ongoing fatigue have different stress hormone (cortisol) levels than girls without fatigue. Researchers tested cortisol levels at different times over a year and found that while fatigued girls reported much worse symptoms overall, their cortisol levels were actually normal and similar to non-fatigued girls. This suggests that severe fatigue in adolescents may not be caused by problems with how the body manages stress hormones.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Symptoms of autonomic dysfunction in chronic fatigue syndrome.

Newton, J L, Okonkwo, O, Sutcliffe, K et al.·QJM : monthly journal of the Association of Physicians·2007

This study looked at whether people with ME/CFS have problems with their autonomic nervous system (the part that controls automatic body functions like heart rate and blood pressure). Researchers used a questionnaire called COMPASS to measure autonomic symptoms in ME/CFS patients and healthy controls. They found that autonomic dysfunction symptoms were significantly more common in ME/CFS patients and were linked to how severe their fatigue was.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Hypocapnia is a biological marker for orthostatic intolerance in some patients with chronic fatigue syndrome.

Natelson, Benjamin H, Intriligator, Roxann, Cherniack, Neil S et al.·Dynamic medicine : DM·2007

This study compared how ME/CFS patients and healthy volunteers responded to standing up for 8 minutes. Researchers measured blood pressure, heart rate, breathing rate, and carbon dioxide levels in the blood. ME/CFS patients were more likely than healthy people to have abnormal responses, particularly low carbon dioxide levels (hypocapnia), which was linked to feeling more ill and short of breath.

Biomarkers

E2 ModerateCohortPEM unclearCase-Control

Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome.

Maes, Michael, Mihaylova, Ivana, Kubera, Marta et al.·Neuro endocrinology letters·2007

This study found that people with ME/CFS have higher levels of two inflammatory molecules (COX-2 and iNOS) in their white blood cells compared to healthy people. The levels of these inflammatory markers were directly linked to how severe their symptoms were, including fatigue, pain, brain fog, and feeling like they have an infection. This suggests ME/CFS involves real inflammation in the body, not just psychological factors.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Assessment of vulvodynia symptoms in a sample of US women: a prevalence survey with a nested case control study.

Arnold, Lauren D, Bachmann, Gloria A, Rosen, Raymond et al.·American journal of obstetrics and gynecology·2007

This study looked at how common vulvodynia (chronic pain in the vulva) is among American women and found that about 4% currently experience it. Women with vulvodynia were more likely to also have other conditions like chronic fatigue syndrome, fibromyalgia, depression, and irritable bowel syndrome. Many women reported that the pain significantly affected their sexual life and daily activities.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Health status and health care utilization of multiple sclerosis in Canada.

Pohar, Sheri L, Jones, C Allyson, Warren, Sharon et al.·The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2007

This Canadian study compared people living with multiple sclerosis (MS) to people without MS to understand how the disease affects their daily lives and health care needs. People with MS reported much worse overall health, were far more likely to experience fatigue and urinary problems, and had greater health care utilization. The study found that MS significantly burdens patients' quality of life and that their health care needs were often not being met.

E2 ModerateCohortPEM not requiredCase-Control

Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.

Sherlin, Leslie, Budzynski, Thomas, Kogan Budzynski, Helen et al.·NeuroImage·2007

Researchers used a special brain scanning technique called LORETA to measure electrical activity in the brains of identical twins—one with ME/CFS and one without. They found that twins with ME/CFS had different patterns of brain activity in specific regions, particularly in areas related to mood, energy management, and the nervous system's stress response. This suggests that ME/CFS may involve measurable differences in how certain parts of the brain function.

E2 ModerateCohortPEM unclearCross-Sectional

The experience of cancer-related fatigue and chronic fatigue syndrome: a qualitative and comparative study.

Bennett, Barbara, Goldstein, David, Friedlander, Michael et al.·Journal of pain and symptom management·2007

This study compared how fatigue affects women with cancer-related fatigue (after breast cancer treatment) versus women with ME/CFS. Both groups described very similar experiences: exhaustion, problems with thinking and memory, and mood changes. Women with ME/CFS also reported muscle pain and flu-like symptoms more often. The researchers found that these two conditions share a common set of disabling symptoms, suggesting they may involve similar underlying causes despite different triggers.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of clinically significant functional fatigue or weakness in specialty outpatient clinics of Pune, India.

Paralikar, Vasudeo, Agashe, Mohan, Oke, Meera et al.·Journal of the Indian Medical Association·2007

This study looked at how common significant fatigue and weakness are in hospital outpatient clinics in Pune, India. Researchers surveyed nearly 1,900 patients across four different specialty clinics and found that about 5% experienced clinically significant fatigue or weakness. Women were more likely to have this condition than men, and it was more common in dermatology and traditional medicine clinics than in psychiatry or general medicine clinics.

E2 ModerateCohortPEM not requiredCross-Sectional

[Estimation of fatigue state in patient with CFS using actigraph and R-R interval power spectrum analysis].

Tajima, Seiki, Kuratsune, Hirohiko, Yamaguti, Kouzi et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

This study measured activity levels and sleep patterns in people with ME/CFS using wearable devices and heart rate analysis. Researchers found that ME/CFS patients had lower activity during waking hours, slept longer, experienced more frequent sleep disruptions, and showed abnormal nervous system activity during sleep compared to healthy people.

SleepAutonomic Nervous System

E2 ModerateCohortPEM not requiredCase-Control

Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.

Niblett, Suzanne H, King, Katrina E, Dunstan, R Hugh et al.·Experimental biology and medicine (Maywood, N.J.)·2007

Researchers compared blood and urine samples from 100 people with ME/CFS and 82 healthy controls to look for abnormalities. While standard blood tests appeared normal, closer examination found subtle differences in blood cell counts and patterns in how patients' bodies were processing and excreting amino acids (building blocks of protein) and other compounds in their urine.

Energy MetabolismImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Exercise testing in children and adolescents with chronic fatigue syndrome.

Takken, T, Henneken, T, van de Putte, E et al.·International journal of sports medicine·2007

This study tested how well 20 young people with ME/CFS could exercise on a stationary bike and measured their oxygen use. The researchers found that most of these young people had similar exercise capacity to healthy peers their age, though a smaller group showed reduced fitness. The amount of fatigue they experienced was related to how active they were in daily life.

E2 ModerateCohortPEM not requiredCross-Sectional

Sympathetic predominance of cardiovascular regulation during mild orthostatic stress in adolescents with chronic fatigue.

Wyller, Vegard B, Saul, J P, Amlie, Jan P et al.·Clinical physiology and functional imaging·2007

This study looked at how the nervous system controls the heart and blood vessels in teenagers with ME/CFS when their bodies experience mild stress (tilting on a bed). Researchers found that adolescents with ME/CFS showed an exaggerated sympathetic nervous system response—meaning their "fight or flight" system kicked in too strongly compared to healthy teenagers. This suggests the body's automatic control of heart rate and blood pressure may not work normally in ME/CFS.

Autonomic Nervous System

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Psychological, medical, and pharmacological correlates of persistent genital arousal disorder.

Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia.

A real-time assessment of the effect of exercise in chronic fatigue syndrome.

Reduced levels of oestrogen receptor beta mRNA in Swedish patients with chronic fatigue syndrome.

Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome.

Alexithymia in chronic fatigue syndrome: associations with momentary, recall, and retrospective measures of somatic complaints and emotions.

The prevalence of chronic fatigue syndrome in Nigeria.

Cortisol and severe fatigue: a longitudinal study in adolescent girls.

Symptoms of autonomic dysfunction in chronic fatigue syndrome.

Hypocapnia is a biological marker for orthostatic intolerance in some patients with chronic fatigue syndrome.

Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome.

Assessment of vulvodynia symptoms in a sample of US women: a prevalence survey with a nested case control study.

Health status and health care utilization of multiple sclerosis in Canada.

Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.

The experience of cancer-related fatigue and chronic fatigue syndrome: a qualitative and comparative study.

Prevalence of clinically significant functional fatigue or weakness in specialty outpatient clinics of Pune, India.

[Estimation of fatigue state in patient with CFS using actigraph and R-R interval power spectrum analysis].

Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.

Exercise testing in children and adolescents with chronic fatigue syndrome.

Sympathetic predominance of cardiovascular regulation during mild orthostatic stress in adolescents with chronic fatigue.

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Neuroinflammation Evidence

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