ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2785 studies

1941–1960 of 2,785 studies

E2 ModerateCohortPEM not requiredCross-Sectional

How fatigue is related to other somatic symptoms.

van de Putte, E M, Engelbert, R H H, Kuis, W et al.·Archives of disease in childhood·2006

This study compared how fatigue and other body symptoms are connected in healthy teens versus teens with ME/CFS. Researchers found that both groups experience the same types of symptoms—like headaches, muscle pain, and dizziness—but teens with ME/CFS report them as more severe. The study suggests fatigue and these other symptoms are related and exist on a spectrum, rather than being completely separate problems.

E2 ModerateCohortPEM not requiredCase-Control

Probing the working memory system in chronic fatigue syndrome: a functional magnetic resonance imaging study using the n-back task.

Caseras, Xavier, Mataix-Cols, David, Giampietro, Vincent et al.·Psychosomatic medicine·2006

Researchers used brain imaging to study how people with ME/CFS perform memory tasks. Although patients and healthy people did equally well on the tasks, their brains used different patterns of activity—patients showed unusual activation in certain brain regions during easier tasks and reduced activity in key memory areas during harder tasks. This suggests that people with ME/CFS may need to work harder mentally to achieve the same results.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome.

Chapenko, S, Krumina, A, Kozireva, S et al.·Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2006

This study looked at whether two common viruses (HHV-6 and HHV-7) that usually stay dormant in the body might be reactivating in people with ME/CFS. Researchers found that people with ME/CFS were more likely to have both viruses active at the same time, and when both were active, their immune cells showed signs of stress. This suggests these viruses might play a role in ME/CFS, though the study cannot prove they cause the disease.

Immune System

E2 ModerateBehavioralPEM not requiredLongitudinal

Mortality in a cohort of chronically fatigued patients.

Smith, Wayne R, Noonan, Carolyn, Buchwald, Dedra·Psychological medicine·2006

Researchers tracked 1,201 patients with chronic fatigue for up to 14 years to see if the condition was linked to higher death rates. They found that overall death rates were normal, but suicide rates were much higher than expected in the general population—especially among patients with chronic fatigue who did NOT meet the full criteria for ME/CFS, and particularly those with a history of depression.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Screening for psychological distress using internet administration of the Hospital Anxiety and Depression Scale (HADS) in individuals with chronic fatigue syndrome.

McCue, Patricia, Buchanan, Tom, Martin, Colin R·The British journal of clinical psychology·2006

This study tested whether an online questionnaire called the HADS (Hospital Anxiety and Depression Scale) accurately measures anxiety and depression in people with ME/CFS. Researchers found that people with ME/CFS did have higher anxiety and depression scores than healthy controls, but the online format may have artificially inflated these scores. The questionnaire appears useful for screening but measures three different aspects of emotional distress rather than just two as previously thought.

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.

Mommersteeg, Paula M C, Heijnen, Cobi J, Verbraak, Marc J P M et al.·Psychoneuroendocrinology·2006

This study tested whether burnout affects the body's stress hormone system (cortisol levels) in the same way that chronic stress does. Researchers measured cortisol levels in 74 people with burnout and 35 healthy people using saliva samples and a hormone suppression test. They found no differences between the two groups, suggesting that burnout may not change cortisol patterns the way researchers expected.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredLongitudinal

How relevant are exercise capacity measures for evaluating treatment effects in chronic fatigue syndrome? Results from a prospective, multidisciplinary outcome study.

Pardaens, K, Haagdorens, L, Van Wambeke, P et al.·Clinical rehabilitation·2006

This study tested whether a 6-month rehabilitation program combining cognitive therapy and graded exercise improved ME/CFS patients' quality of life and physical fitness. Patients reported significant improvements in how they felt and functioned in daily life, but their measured physical capacity (like strength and endurance on a bike test) only improved modestly. Importantly, feeling better didn't require becoming noticeably fitter—especially for patients who started out less fit.

Interventions

E2 ModerateBehavioralPEM not requiredCross-Sectional

Mirrored symptoms in mother and child with chronic fatigue syndrome.

van de Putte, Elise M, van Doornen, Lorenz J P, Engelbert, Raoul H H et al.·Pediatrics·2006

This study looked at whether parents of teenagers with ME/CFS also have ME/CFS or similar fatigue symptoms. Researchers compared 40 adolescents with ME/CFS to 36 healthy teens and surveyed both children and parents about fatigue and mood. They found that mothers of teens with ME/CFS were significantly more likely to have fatigue and psychological distress similar to their child, while fathers showed no such pattern.

E2 ModerateCohortPEM not requiredLongitudinal

Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion.

van Heukelom, R O, Prins, J B, Smits, M G et al.·European journal of neurology·2006

This study tested whether melatonin could help reduce fatigue in ME/CFS patients who have a delayed internal body clock. Twenty-nine patients took 5 mg of melatonin for 3 months timed to their natural sleep-wake rhythm, and researchers measured changes in their fatigue using a validated questionnaire. The treatment improved fatigue, concentration, motivation, and activity levels, with the biggest improvements seen in patients whose body clocks were most delayed.

E2 ModerateCohortPEM not requiredCross-Sectional

Is chronic fatigue syndrome associated with platelet activation?

Kennedy, Gwen, Norris, Gillian, Spence, Vance et al.·Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2006

This study looked at whether people with ME/CFS have problems with blood clotting and platelet activation (small cells in blood that help form clots). Researchers tested 17 patients with CFS and 16 healthy control participants using standard blood tests. They found no evidence that CFS patients have increased clotting problems or overactive platelets.

E2 ModerateCohortPEM not requiredLongitudinal

Chronic fatigue syndrome-like caseness as a predictor of work status in fatigued employees on sick leave: four year follow up study.

Huibers, M J H, Leone, S S, Kant, I J et al.·Occupational and environmental medicine·2006

This study followed people on sick leave due to fatigue for four years to see whether those who met the clinical criteria for ME/CFS were more likely to remain unable to work. Researchers found that employees meeting CFS criteria at the start were about three times more likely to still be unable to work four years later compared to those with fatigue who didn't meet CFS criteria. This suggests that CFS-like illness is associated with longer-term work disability.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Evaluation of maximal exercise performance, fatigue, and depression in athletes with acquired chronic training intolerance.

St Clair Gibson, A, Grobler, L A, Collins, M et al.·Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine·2006

This study looked at athletes who reported unusual tiredness and couldn't train like they normally could, even though their bodies seemed to work normally during fitness tests. Researchers found that these athletes' muscles and heart/lung capacity were just as strong as athletes without fatigue problems, but they had higher scores for depression and mood problems. The study suggests that the excessive tiredness these athletes felt might be connected to depression rather than a physical problem with their muscles or fitness.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

An empirical delineation of the heterogeneity of chronic unexplained fatigue in women.

Vollmer-Conna, Uté, Aslakson, Eric, White, Peter D·Pharmacogenomics·2006

This study looked at 159 women to understand why chronic fatigue affects people differently. Researchers used statistical analysis to group the women into distinct clusters based on their symptoms, sleep patterns, hormone levels, and stress responses. They found that chronic fatigue is not one single condition, but rather several different conditions with different underlying causes—some linked to sleep problems, others to depression, obesity, or hormonal changes.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles.

Carlo-Stella, N, Badulli, C, De Silvestri, A et al.·Clinical and experimental rheumatology·2006

This study looked at genetic variations in immune system genes among Italian ME/CFS patients to see if certain genetic patterns might make some people more prone to developing the condition. Researchers found that patients with ME/CFS were more likely to carry specific genetic variants in two genes (TNF and IFNgamma) that are involved in controlling inflammation. These findings suggest that genetic differences might influence how a person's immune system responds and could play a role in ME/CFS development.

Immune System

E2 ModerateBehavioralPEM unclearCross-Sectional

Depression, attribution style and self-esteem in chronic fatigue syndrome and fibromyalgia patients: is there a link?

Michielsen, H J, Van Houdenhove, B, Leirs, I et al.·Clinical rheumatology·2006

This study looked at whether people with ME/CFS and fibromyalgia who blame external factors (rather than themselves) for problems are protected from depression. Researchers surveyed 85 patients and found that depression was common in both single diagnosis (ME/CFS only) and dual diagnosis (ME/CFS + fibromyalgia) groups. Blaming external factors did not prevent depression in patients with low self-esteem, suggesting that how we think about our situation may not be a key factor in whether we develop depression.

E2 ModerateCohortPEM not requiredCross-Sectional

Medical comorbidity in bipolar disorder: implications for functional outcomes and health service utilization.

McIntyre, Roger S, Konarski, Jakub Z, Soczynska, Joanna K et al.·Psychiatric services (Washington, D.C.)·2006

This study looked at how common medical conditions like chronic fatigue syndrome, migraines, and asthma are in people with bipolar disorder, and how these extra health problems affect their daily lives. Researchers found that people with bipolar disorder who also had other medical conditions struggled more with work, needed more help from doctors, and were less likely to be employed than those with bipolar disorder alone.

E2 ModerateBehavioralPEM not requiredLongitudinal

In search of a new balance. Can high "action-proneness" in patients with chronic fatigue syndrome be changed by a multidisciplinary group treatment?

Van Houdenhove, Boudewijn, Bruyninckx, Karolien, Luyten, Patrick·Journal of psychosomatic research·2006

This study looked at whether people with ME/CFS who tend to be very action-oriented or driven can change this trait through treatment. Researchers asked 62 patients to recall how active and driven they were before getting sick, when they started treatment, and after completing a multidisciplinary program (which included cognitive behavioral therapy and graded exercise). The treatment did help increase action-proneness, though patients didn't return to their pre-illness levels.

E2 ModerateBehavioralPEM not requiredCase-Control

A case-control study of risk factors for arm pain presenting to primary care services.

Ryall, Claire, Coggon, David, Peveler, Robert et al.·Occupational medicine (Oxford, England)·2006

This study looked at why some people develop arm pain and sought medical help for it. Researchers compared 132 people with arm pain to 127 people without arm pain and found that anxiety, depression, health worry, and having other conditions like chronic fatigue syndrome were all strongly linked to arm pain. Some physical activities like repetitive wrist movements and carrying heavy items were also associated with arm pain, especially when there was a specific diagnosis.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Sub-typing CFS patients on the basis of 'minor' symptoms.

Janal, Malvin N, Ciccone, Donald S, Natelson, Benjamin H·Biological psychology·2006

This study looked at 161 women with ME/CFS to see if different symptom patterns might point to different types of the illness. Researchers found three possible subtypes: one involving muscle and joint pain, one resembling infectious illness, and one affecting the brain and thinking. People with the brain-related subtype had more trouble with memory and attention, while those with the muscle/joint subtype were more likely to also have fibromyalgia.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome.

Jerjes, Walid K, Peters, Timothy J, Taylor, Norman F et al.·Journal of psychosomatic research·2006

This study measured stress hormone levels in urine samples from ME/CFS patients and healthy people throughout the day. Researchers found that ME/CFS patients had lower levels of certain stress hormones (cortisol and cortisone) compared to healthy controls, though the daily pattern of these hormones was normal. Interestingly, when they looked at other related hormone measurements, they didn't see the same difference, which suggests the stress response system may not be working as hard in ME/CFS.

Endocrine Disruption

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

How fatigue is related to other somatic symptoms.

Probing the working memory system in chronic fatigue syndrome: a functional magnetic resonance imaging study using the n-back task.

Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome.

Mortality in a cohort of chronically fatigued patients.

Screening for psychological distress using internet administration of the Hospital Anxiety and Depression Scale (HADS) in individuals with chronic fatigue syndrome.

Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.

How relevant are exercise capacity measures for evaluating treatment effects in chronic fatigue syndrome? Results from a prospective, multidisciplinary outcome study.

Mirrored symptoms in mother and child with chronic fatigue syndrome.

Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion.

Is chronic fatigue syndrome associated with platelet activation?

Chronic fatigue syndrome-like caseness as a predictor of work status in fatigued employees on sick leave: four year follow up study.

Evaluation of maximal exercise performance, fatigue, and depression in athletes with acquired chronic training intolerance.

An empirical delineation of the heterogeneity of chronic unexplained fatigue in women.

A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles.

Depression, attribution style and self-esteem in chronic fatigue syndrome and fibromyalgia patients: is there a link?

Medical comorbidity in bipolar disorder: implications for functional outcomes and health service utilization.

In search of a new balance. Can high "action-proneness" in patients with chronic fatigue syndrome be changed by a multidisciplinary group treatment?

A case-control study of risk factors for arm pain presenting to primary care services.

Sub-typing CFS patients on the basis of 'minor' symptoms.

Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research