ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1941–1960 of 2,768 studies

E2 ModerateBehavioralPEM not requiredLongitudinal

How relevant are exercise capacity measures for evaluating treatment effects in chronic fatigue syndrome? Results from a prospective, multidisciplinary outcome study.

Pardaens, K, Haagdorens, L, Van Wambeke, P et al.·Clinical rehabilitation·2006

This study tested whether a 6-month rehabilitation program combining cognitive therapy and graded exercise improved ME/CFS patients' quality of life and physical fitness. Patients reported significant improvements in how they felt and functioned in daily life, but their measured physical capacity (like strength and endurance on a bike test) only improved modestly. Importantly, feeling better didn't require becoming noticeably fitter—especially for patients who started out less fit.

Interventions

E2 ModerateBehavioralPEM not requiredCross-Sectional

Mirrored symptoms in mother and child with chronic fatigue syndrome.

van de Putte, Elise M, van Doornen, Lorenz J P, Engelbert, Raoul H H et al.·Pediatrics·2006

This study looked at whether parents of teenagers with ME/CFS also have ME/CFS or similar fatigue symptoms. Researchers compared 40 adolescents with ME/CFS to 36 healthy teens and surveyed both children and parents about fatigue and mood. They found that mothers of teens with ME/CFS were significantly more likely to have fatigue and psychological distress similar to their child, while fathers showed no such pattern.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Severe fatigue in adolescents: a common phenomenon?

ter Wolbeek, Maike, van Doornen, Lorenz J P, Kavelaars, Annemieke et al.·Pediatrics·2006

This study looked at how common severe tiredness is in teenagers and whether it's connected to depression, anxiety, and other symptoms seen in ME/CFS patients. Researchers surveyed over 3,400 teenagers about their fatigue, mood, sleep, and daily habits. They found that severe fatigue is quite common in adolescents—especially in girls—and that it often clusters with depression, anxiety, and ME/CFS-like symptoms.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour?

Heesen, C, Nawrath, L, Reich, C et al.·Journal of neurology, neurosurgery, and psychiatry·2006

This study looked at whether immune system chemicals called cytokines might cause fatigue in multiple sclerosis patients, similar to how infection makes you feel tired and sick. Researchers compared blood samples from 15 MS patients with severe fatigue to 15 MS patients without fatigue, and found that those with fatigue had significantly higher levels of inflammatory molecules. This suggests that immune system activation may be a key driver of MS-related fatigue.

E2 ModerateBehavioralPEM not requiredCase-Control

A case-control study of risk factors for arm pain presenting to primary care services.

Ryall, Claire, Coggon, David, Peveler, Robert et al.·Occupational medicine (Oxford, England)·2006

This study looked at why some people develop arm pain and sought medical help for it. Researchers compared 132 people with arm pain to 127 people without arm pain and found that anxiety, depression, health worry, and having other conditions like chronic fatigue syndrome were all strongly linked to arm pain. Some physical activities like repetitive wrist movements and carrying heavy items were also associated with arm pain, especially when there was a specific diagnosis.

Pain and Sensitization

E2 ModerateCohortPEM not requiredObservational

The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes.

Weir, Peter T, Harlan, Gregory A, Nkoy, Flo L et al.·Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2006

This study looked at how often fibromyalgia is diagnosed in a large group of insured people over a 6-year period. The researchers found that fibromyalgia is diagnosed more often in women than men, though not as dramatically as previous studies suggested. People with fibromyalgia were much more likely to also have other conditions like depression, anxiety, headaches, irritable bowel syndrome, chronic fatigue syndrome, lupus, and rheumatoid arthritis.

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.

Mommersteeg, Paula M C, Heijnen, Cobi J, Verbraak, Marc J P M et al.·Psychoneuroendocrinology·2006

This study tested whether burnout affects the body's stress hormone system (cortisol levels) in the same way that chronic stress does. Researchers measured cortisol levels in 74 people with burnout and 35 healthy people using saliva samples and a hormone suppression test. They found no differences between the two groups, suggesting that burnout may not change cortisol patterns the way researchers expected.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome.

Capuron, Lucile, Welberg, Leonie, Heim, Christine et al.·Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2006

People with ME/CFS often report trouble thinking clearly, but researchers haven't always found proof of this on tests. This study found that cognitive problems are real, but mainly in patients who experience significant mental fatigue. When researchers gave cognitive tests to ME/CFS patients, those with high mental fatigue showed genuine difficulties with memory and attention, while those with low mental fatigue performed normally.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles.

Carlo-Stella, N, Badulli, C, De Silvestri, A et al.·Clinical and experimental rheumatology·2006

This study looked at genetic variations in immune system genes among Italian ME/CFS patients to see if certain genetic patterns might make some people more prone to developing the condition. Researchers found that patients with ME/CFS were more likely to carry specific genetic variants in two genes (TNF and IFNgamma) that are involved in controlling inflammation. These findings suggest that genetic differences might influence how a person's immune system responds and could play a role in ME/CFS development.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Is chronic fatigue syndrome associated with platelet activation?

Kennedy, Gwen, Norris, Gillian, Spence, Vance et al.·Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2006

This study looked at whether people with ME/CFS have problems with blood clotting and platelet activation (small cells in blood that help form clots). Researchers tested 17 patients with CFS and 16 healthy control participants using standard blood tests. They found no evidence that CFS patients have increased clotting problems or overactive platelets.

E2 ModerateCohortPEM not requiredCross-Sectional

Impaired natural immunity, cognitive dysfunction, and physical symptoms in patients with chronic fatigue syndrome: preliminary evidence for a subgroup?

Siegel, Scott D, Antoni, Michael H, Fletcher, Mary Ann et al.·Journal of psychosomatic research·2006

This study looked at whether a specific immune system measure called natural killer cell activity (NKCA) could help identify different subgroups of ME/CFS patients. Researchers compared 41 women with ME/CFS who had low NKCA levels to those with normal levels, measuring their cognitive ability and symptoms. They found that patients with low NKCA reported worse cognitive problems, more daytime dysfunction, and performed worse on thinking tests compared to those with normal NKCA levels.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Spectroscopic diagnosis of chronic fatigue syndrome by visible and near-infrared spectroscopy in serum samples.

Sakudo, Akikazu, Kuratsune, Hirohiko, Kobayashi, Takanori et al.·Biochemical and biophysical research communications·2006

Researchers used a special light-based scanning technique to analyze blood samples from ME/CFS patients and healthy people. The scans could correctly identify which samples came from ME/CFS patients about 93% of the time. This suggests that a simple blood test using this technology might one day help doctors diagnose ME/CFS objectively, rather than relying only on symptoms and other tests.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

The management of children with chronic fatigue syndrome-like illness in primary care: a cross-sectional study.

Saidi, Guitta, Haines, Linda·The British journal of general practice : the journal of the Royal College of General Practitioners·2006

This study looked at how family doctors (GPs) in the UK identify and care for children and teenagers with ME/CFS-like illness in their regular clinics. Researchers reviewed medical records and patient experiences from 116 young people with severe fatigue lasting over 3 months. Most were girls around age 13, and their illness had lasted several years. The study found that GPs diagnosed about half of them with CFS/ME, often within 6 months, and referred most patients to specialists or suggested strategies like pacing and graded exercise.

Diagnostics

E2 ModerateBehavioralPEM not requiredLongitudinal

Long-term outcomes of an integrative rehabilitation program on quality of life: a follow-up study.

Taylor, Renee R, Thanawala, Sachi G, Shiraishi, Yukiko et al.·Journal of psychosomatic research·2006

This study tested whether a counseling program could improve quality of life for people with ME/CFS. Twenty-three participants attended 8 group sessions about managing their illness, followed by 7 months of one-on-one counseling. When researchers checked in at multiple points over a year, they found that people reported better quality of life for up to 12 months after completing the program.

E2 ModerateCohortPEM not requiredCross-Sectional

Shortened QT interval: a distinctive feature of the dysautonomia of chronic fatigue syndrome.

Naschitz, Jochanan, Fields, Madeline, Isseroff, Hillel et al.·Journal of electrocardiology·2006

This study examined heart rhythm patterns in ME/CFS patients by measuring a specific electrical timing interval on EKGs (called the QT interval). Researchers found that people with ME/CFS had shorter QT intervals than healthy controls, both when lying down and during a head-up tilt test. This shortened interval appears to be linked to the autonomic nervous system problems common in ME/CFS.

Autonomic Nervous System

E2 ModeratePEM not requiredRegistry-Resource

Update on the NAS-NRC Twin Registry.

Page, William F·Twin research and human genetics : the official journal of the International Society for Twin Studies·2006

This article describes an ongoing study of twin brothers who served in World War II, tracking their health over many decades. Researchers have collected detailed health information on over 15,900 pairs of twins and are studying various diseases including chronic fatigue syndrome, as well as how people age and stay healthy. The study is now organizing and combining all their collected data to better understand what factors influence disease risk.

E2 ModerateBehavioralPEM not requiredObservational

Linkages between goal attainment and quality of life for individuals with chronic fatigue syndrome.

Query, Michelle, Taylor, Renée R·Occupational therapy in health care·2006

This study looked at whether setting and achieving personal goals could improve quality of life for people with ME/CFS. Forty-seven participants attended eight group sessions where they set goals and tracked their progress. The researchers found that people who made progress toward their goals reported better quality of life, regardless of how severe their fatigue or other symptoms were.

E2 ModerateBehavioralPEM not requiredLongitudinal

Mortality in a cohort of chronically fatigued patients.

Smith, Wayne R, Noonan, Carolyn, Buchwald, Dedra·Psychological medicine·2006

Researchers tracked 1,201 patients with chronic fatigue for up to 14 years to see if the condition was linked to higher death rates. They found that overall death rates were normal, but suicide rates were much higher than expected in the general population—especially among patients with chronic fatigue who did NOT meet the full criteria for ME/CFS, and particularly those with a history of depression.

E2 ModerateGuidelinePEM unclearGuideline

Management of patients presenting with Sjogren's syndrome.

Venables, P J·Best practice & research. Clinical rheumatology·2006

Sjögren's syndrome is an autoimmune disease where the body attacks its own glands that produce tears and saliva, causing dry eyes and mouth. This article explains how doctors diagnose and treat Sjögren's syndrome, emphasizing that most patients do well with local treatments (like eye drops) and a medication called hydroxychloroquine, while stronger drugs are reserved for patients with more serious complications.

E2 ModerateCohortPEM not requiredCross-Sectional

Differential diagnosis of chronic fatigue syndrome and major depressive disorder.

Hawk, Caroline, Jason, Leonard A, Torres-Harding, Susan·International journal of behavioral medicine·2006

This study compared people with ME/CFS, people with depression, and healthy controls to find which symptoms best tell these conditions apart. Researchers found that post-exertional malaise (worsening after activity), unrefreshing sleep, and memory problems were the strongest differences. When they used a combination of symptoms including fatigue duration and severity of various symptoms, they could correctly identify which group each person belonged to nearly 100% of the time.

Post-Exertional Malaise

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

How relevant are exercise capacity measures for evaluating treatment effects in chronic fatigue syndrome? Results from a prospective, multidisciplinary outcome study.

Mirrored symptoms in mother and child with chronic fatigue syndrome.

Severe fatigue in adolescents: a common phenomenon?

Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour?

A case-control study of risk factors for arm pain presenting to primary care services.

The incidence of fibromyalgia and its associated comorbidities: a population-based retrospective cohort study based on International Classification of Diseases, 9th Revision codes.

Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test.

Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome.

A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles.

Is chronic fatigue syndrome associated with platelet activation?

Impaired natural immunity, cognitive dysfunction, and physical symptoms in patients with chronic fatigue syndrome: preliminary evidence for a subgroup?

Spectroscopic diagnosis of chronic fatigue syndrome by visible and near-infrared spectroscopy in serum samples.

The management of children with chronic fatigue syndrome-like illness in primary care: a cross-sectional study.

Long-term outcomes of an integrative rehabilitation program on quality of life: a follow-up study.

Shortened QT interval: a distinctive feature of the dysautonomia of chronic fatigue syndrome.

Update on the NAS-NRC Twin Registry.

Linkages between goal attainment and quality of life for individuals with chronic fatigue syndrome.

Mortality in a cohort of chronically fatigued patients.

Management of patients presenting with Sjogren's syndrome.

Differential diagnosis of chronic fatigue syndrome and major depressive disorder.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research