ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

2141–2160 of 2,807 studies

E2 ModerateReviewPEM unclearReview-Narrative

Chronic fatigue syndrome: matching exercise to symptom fluctuations.

Skinner, James S·The Physician and sportsmedicine·2004

People with ME/CFS often feel extremely tired and experience worsening fatigue after physical activity, leading many to stop exercising altogether and become weaker. This review suggests that gentle, intermittent exercise at low to moderate intensity may actually help improve how much activity patients can do and reduce their fatigue and other symptoms. The good news is that standard exercise testing doesn't make ME/CFS symptoms worse, and matching exercise type to daily symptom changes appears to be a practical approach.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCase-Control

Physiological responses during a submaximal cycle test in chronic fatigue syndrome.

Wallman, Karen E, Morton, Alan R, Goodman, Carmel et al.·Medicine and science in sports and exercise·2004

This study compared how people with ME/CFS and healthy people without the condition respond to exercise on a stationary bike. The main finding was that people with ME/CFS felt much more exhausted during the same amount of exercise, and they couldn't exercise as hard before becoming tired. Both groups were matched carefully so they had similar activity levels before the study, which makes the comparison more fair.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Post-traumatic stress disorder among patients with chronic pain and chronic fatigue.

Roy-Byrne, P, Smith, W R, Goldberg, J et al.·Psychological medicine·2004

This study examined whether trauma and PTSD are more common in people with fibromyalgia and chronic fatigue syndrome. Researchers found that among 571 patients, about 20% had experienced PTSD and 42% had depression. The link between fibromyalgia symptoms (pain and tender points) and PTSD was strongest in patients who also had depression, suggesting that depression may play an important role in how trauma and chronic pain conditions are connected.

E2 ModerateCohortPEM unclearCase-Control

Prevalence of abnormal cardiac wall motion in the cardiomyopathy associated with incomplete multiplication of Epstein-barr Virus and/or cytomegalovirus in patients with chronic fatigue syndrome.

Lerner, A Martin, Dworkin, Howard J, Sayyed, Tawfeeq et al.·In vivo (Athens, Greece)·2004

This study examined whether certain ME/CFS patients have heart problems caused by incomplete viral infections with Epstein-Barr virus or cytomegalovirus. Researchers found that ME/CFS patients with specific viral antibodies in their blood were more likely to show abnormal heart wall movement compared to control patients without ME/CFS. Some ME/CFS patients even showed heart tissue damage (cardiomyopathy) on biopsy.

E2 ModerateCohortPEM unclearLongitudinal

Childhood predictors of self reported chronic fatigue syndrome/myalgic encephalomyelitis in adults: national birth cohort study.

Viner, Russell, Hotopf, Matthew·BMJ (Clinical research ed.)·2004

This study followed over 11,000 children born in 1970 into adulthood to understand what childhood factors might lead to developing ME/CFS later in life. Researchers found that people who were less active as children, had long-term health conditions in childhood, or were female had higher chances of developing ME/CFS by age 30. Importantly, childhood stress or psychological problems were not found to be risk factors, contrary to some earlier beliefs.

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue and organophosphate pesticides in sheep farming: a retrospective study amongst people reporting to a UK pharmacovigilance scheme.

Tahmaz, N, Soutar, A, Cherrie, J W·The Annals of occupational hygiene·2003

This study looked at sheep farmers in the UK who reported health problems they believed were caused by pesticides used in sheep dipping. Researchers wanted to know if repeated exposure to these pesticides was linked to chronic fatigue. They found that fatigue was very common among farmers who thought pesticides affected their health, and there was some association between higher pesticide exposure and higher fatigue scores, though the evidence was limited.

E2 ModerateCohortPEM not requiredCross-Sectional

Functional status of persons with chronic fatigue syndrome in the Wichita, Kansas, population.

Solomon, Laura, Nisenbaum, Rosane, Reyes, Michele et al.·Health and quality of life outcomes·2003

This study surveyed people in Wichita, Kansas to understand how ME/CFS affects daily life and work. Researchers found that people with ME/CFS were just as impaired in their ability to work and do activities as people whose fatigue came from other medical or psychiatric conditions, and all of them had much less energy than people without fatigue.

E2 ModerateCohortPEM unclearCross-Sectional

Epidemiology of chronic fatigue syndrome and self reported myalgic encephalomyelitis in 5-15 year olds: cross sectional study.

Chalder, T, Goodman, R, Wessely, S et al.·BMJ (Clinical research ed.)·2003

This study looked at how common ME/CFS is in children aged 5-15 years old in the United Kingdom. Researchers surveyed thousands of families to find out how many children experienced long-lasting tiredness and muscle pain similar to ME/CFS. The findings help doctors understand how widespread this condition is in young people.

E2 ModerateCohortPEM not requiredCross-Sectional

A measure of heart rate variability is sensitive to orthostatic challenge in women with chronic fatigue syndrome.

Yamamoto, Yoshiharu, LaManca, John J, Natelson, Benjamin H·Experimental biology and medicine (Maywood, N.J.)·2003

This study tested whether a simple heart rhythm measurement during a tilt test could help diagnose ME/CFS. Researchers compared heart rate patterns in 24 women with ME/CFS and 22 healthy women while they lay down and then tilted upright for 10 minutes. They found that women with ME/CFS showed a distinctive abnormal change in their heart rhythm pattern during tilting that could identify about 9 out of 10 ME/CFS patients correctly.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Diagnostic evaluation of 2', 5'-oligoadenylate synthetase activities and antibodies against Epstein-Barr virus and Coxiella burnetii in patients with chronic fatigue syndrome in Japan.

Ikuta, Kazufumi, Yamada, Takeshi, Shimomura, Tokio et al.·Microbes and infection·2003

This study tested whether certain viral infections and immune system markers are linked to ME/CFS. Researchers measured a protein called 2-5AS in blood cells from ME/CFS patients in Japan and compared it to healthy people. They found that ME/CFS patients had higher levels of this immune marker than healthy controls, and some patients showed signs of past infections with Epstein-Barr virus or another bacteria.

BiomarkersImmune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Functional status, neuropsychological functioning, and mood in chronic fatigue syndrome (CFS): relationship to psychiatric disorder.

Tiersky, Lana A, Matheis, Robert J, Deluca, John et al.·The Journal of nervous and mental disease·2003

This study looked at how depression and anxiety affect people with ME/CFS. Researchers compared four groups: people with ME/CFS alone, people with ME/CFS plus mental health symptoms that started after CFS, people with ME/CFS plus mental health symptoms that started before CFS, and healthy controls. The main finding was that while mental health problems don't make the physical fatigue and weakness worse, they do make people feel more emotionally distressed—especially if those mental health issues came before the CFS diagnosis.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Unexplained fatigue syndromes in a multinational primary care sample: specificity of definition and prevalence and distinctiveness from depression and generalized anxiety.

Skapinakis, Petros, Lewis, Glyn, Mavreas, Venetsanos·The American journal of psychiatry·2003

This study looked at how different definitions of unexplained fatigue affect how many people are diagnosed and whether they also have depression or anxiety. Researchers interviewed over 5,400 primary care patients from 14 countries and found that when they required more physical symptoms in addition to fatigue, fewer people were diagnosed, but those diagnosed were more likely to also have depression or anxiety.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Detection of enterovirus in human skeletal muscle from patients with chronic inflammatory muscle disease or fibromyalgia and healthy subjects.

Douche-Aourik, Fatima, Berlier, Willy, Féasson, Léonard et al.·Journal of medical virology·2003

Researchers tested muscle tissue samples from patients with fibromyalgia/ME/CFS and inflammatory muscle diseases to see if they contained enterovirus (a type of virus). They found viral genetic material in some patient samples but not in healthy people, though they did not find evidence of active viral proteins. This suggests that if a virus is present, it may be dormant or not fully active in muscle tissue.

E2 ModerateCohortPEM not requiredCross-Sectional

Aerobic capacity of Gulf War veterans with chronic fatigue syndrome.

Nagelkirk, Paul R, Cook, Dane B, Peckerman, Arnold et al.·Military medicine·2003

This study tested whether Gulf War veterans with ME/CFS had reduced exercise capacity compared to healthy Gulf War veterans. Researchers measured how well the heart and lungs worked during maximum exercise on a stationary bike. Surprisingly, the two groups performed similarly—those with ME/CFS were able to exercise just as hard and achieve similar fitness levels as the healthy veterans.

E2 ModerateCohortPEM unclearCross-Sectional

The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome.

Naschitz, J E, Rosner, I, Rozenbaum, M et al.·QJM : monthly journal of the Association of Physicians·2003

Researchers developed a simple test using a tilting table to measure how well the body controls blood pressure and heart rate in ME/CFS patients. By tilting people upright and measuring these vital signs, they found a pattern (called a haemodynamic instability score) that appeared in ME/CFS patients but not in healthy people or those with other conditions. This test could help doctors confirm an ME/CFS diagnosis with objective measurements rather than relying only on symptoms.

Autonomic Nervous SystemDiagnostics

E2 ModerateCohortPEM not requiredLongitudinal

A population-based study of the clinical course of chronic fatigue syndrome.

Nisenbaum, Rosane, Jones, James F, Unger, Elizabeth R et al.·Health and quality of life outcomes·2003

This study followed 65 people with ME/CFS for up to 3 years to understand how the illness changes over time. Most people experienced periods where symptoms improved (called remission), though only 10% had complete and lasting improvement. The study found that people who had been sick for 2 years or less were more likely to recover, and that sleep problems remained a major issue even when other symptoms improved.

E2 ModerateCohortPEM not requiredCross-Sectional

Perceived exertion in fatiguing illness: civilians with chronic fatigue syndrome.

Cook, Dane B, Nagelkirk, Paul R, Peckerman, Arnold et al.·Medicine and science in sports and exercise·2003

This study looked at how hard exercise feels to people with ME/CFS compared to healthy people. Researchers had both groups exercise on a treadmill and rate their effort. While people with ME/CFS said exercise felt harder at moderate intensities, when researchers compared effort levels to each person's maximum oxygen capacity, there was no real difference—suggesting the difference in how hard it felt might be explained by their lower fitness level rather than a problem with how their body perceives effort.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychiatric adjustment in chronic fatigue syndrome of childhood and in juvenile idiopathic arthritis.

Rangel, L, Garralda, M E, Hall, A et al.·Psychological medicine·2003

This study compared psychiatric and emotional problems in children with ME/CFS versus children with juvenile arthritis, another serious chronic illness. Children with ME/CFS had significantly more depression, anxiety, and personality difficulties than the arthritis group, even though both groups faced similar challenges from living with chronic illness. This suggests that ME/CFS may involve specific factors that increase psychiatric risk beyond what chronic illness alone would explain.

E2 ModerateCohortPEM not requiredCross-Sectional

Comparing symptoms of chronic fatigue syndrome in a community-based versus tertiary care sample.

Jason, Leonard A, Plioplys, Audrius V, Torres-Harding, Susan et al.·Journal of health psychology·2003

This study compared ME/CFS symptoms between two groups of patients: those who sought care at major medical centers and those found in the general community. Researchers found that people being treated at tertiary care hospitals reported experiencing more symptoms than community members with ME/CFS. This suggests that the people typically studied in research may not represent all people living with ME/CFS.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.

Tiev, Kiet Phong, Demettre, Edith, Ercolano, Philippe et al.·Clinical and diagnostic laboratory immunology·2003

This study looked at a protein called RNase L in the immune cells of ME/CFS patients and healthy people. Researchers found that ME/CFS patients had a different pattern of RNase L forms compared to healthy volunteers, and this pattern could potentially be used as a simple blood test to help diagnose ME/CFS. The test showed promise in distinguishing ME/CFS patients from healthy people in this small group.

Immune System

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Chronic fatigue syndrome: matching exercise to symptom fluctuations.

Physiological responses during a submaximal cycle test in chronic fatigue syndrome.

Post-traumatic stress disorder among patients with chronic pain and chronic fatigue.

Prevalence of abnormal cardiac wall motion in the cardiomyopathy associated with incomplete multiplication of Epstein-barr Virus and/or cytomegalovirus in patients with chronic fatigue syndrome.

Childhood predictors of self reported chronic fatigue syndrome/myalgic encephalomyelitis in adults: national birth cohort study.

Chronic fatigue and organophosphate pesticides in sheep farming: a retrospective study amongst people reporting to a UK pharmacovigilance scheme.

Functional status of persons with chronic fatigue syndrome in the Wichita, Kansas, population.

Epidemiology of chronic fatigue syndrome and self reported myalgic encephalomyelitis in 5-15 year olds: cross sectional study.

A measure of heart rate variability is sensitive to orthostatic challenge in women with chronic fatigue syndrome.

Diagnostic evaluation of 2', 5'-oligoadenylate synthetase activities and antibodies against Epstein-Barr virus and Coxiella burnetii in patients with chronic fatigue syndrome in Japan.

Functional status, neuropsychological functioning, and mood in chronic fatigue syndrome (CFS): relationship to psychiatric disorder.

Unexplained fatigue syndromes in a multinational primary care sample: specificity of definition and prevalence and distinctiveness from depression and generalized anxiety.

Detection of enterovirus in human skeletal muscle from patients with chronic inflammatory muscle disease or fibromyalgia and healthy subjects.

Aerobic capacity of Gulf War veterans with chronic fatigue syndrome.

The head-up tilt test with haemodynamic instability score in diagnosing chronic fatigue syndrome.

A population-based study of the clinical course of chronic fatigue syndrome.

Perceived exertion in fatiguing illness: civilians with chronic fatigue syndrome.

Psychiatric adjustment in chronic fatigue syndrome of childhood and in juvenile idiopathic arthritis.

Comparing symptoms of chronic fatigue syndrome in a community-based versus tertiary care sample.

RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.

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