ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

2381–2400 of 2,807 studies

E2 ModerateCohortPEM not requiredCase-Control

Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study.

Reeves, W C, Stamey, F R, Black, J B et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2000

Researchers tested whether three common viruses (HHV-6A, HHV-6B, and HHV-7) might be linked to ME/CFS. They compared blood samples from 26 ME/CFS patients with 52 healthy people and looked for signs of active or dormant virus infection. The study found no meaningful differences between the two groups, suggesting these particular viruses are not associated with ME/CFS.

E2 ModerateCohortPEM unclearCross-Sectional

Antibodies to squalene in Gulf War syndrome.

Asa, P B, Cao, Y, Garry, R F·Experimental and molecular pathology·2000

Researchers tested whether Gulf War veterans with illness had antibodies (immune proteins) against a substance called squalene in their blood. They found that 95% of sick Gulf War veterans had these antibodies, while veterans who served but stayed healthy had none. Interestingly, even military personnel who were vaccinated for the Gulf War but never deployed also had these antibodies if they developed the same symptoms.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome.

Evengård, B, Briese, T, Lindh, G et al.·Journal of neurovirology·1999

Researchers tested whether a virus called Borna disease virus (BDV) might be causing ME/CFS in Swedish patients. They examined blood samples from 169 patients and 62 healthy controls using two different detection methods—one looking for antibodies (immune system markers) and another looking for viral genetic material. They found no evidence of BDV in any of the patient samples, suggesting this particular virus is not responsible for ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Orthostatic intolerance in the chronic fatigue syndrome.

Schondorf, R, Benoit, J, Wein, T et al.·Journal of the autonomic nervous system·1999

This study looked at whether ME/CFS patients experience problems with blood pressure and heart rate when standing up quickly, a condition called orthostatic intolerance. Researchers tested 75 ME/CFS patients and 48 healthy controls using a tilt table test and other physical challenges. They found that 40% of ME/CFS patients had orthostatic intolerance compared to fewer healthy controls, suggesting this may be an important symptom in some patients that could be treated.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

TNF-alpha and chronic fatigue syndrome.

Moss, R B, Mercandetti, A, Vojdani, A·Journal of clinical immunology·1999

This study looked at whether a molecule called TNF-alpha, which helps control inflammation in the body, is elevated in people with ME/CFS. Researchers compared blood levels of TNF-alpha in patients with ME/CFS to healthy people without the condition. They found that people with ME/CFS had significantly higher levels of TNF-alpha, suggesting that inflammation may play a role in the disease.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality and social attitudes in chronic fatigue syndrome.

Wood, B, Wessely, S·Journal of psychosomatic research·1999

This study compared personality traits and attitudes between people with ME/CFS and people with rheumatoid arthritis (RA) to see if ME/CFS patients have distinctive personality characteristics. Researchers found that ME/CFS patients and RA patients were actually quite similar in most personality measures, and the common stereotype that ME/CFS patients are perfectionists with negative views about psychiatry was not supported.

E2 ModerateCohortPEM not requiredCase-Control

Mercury and nickel allergy: risk factors in fatigue and autoimmunity.

Sterzl, Ivan, Procházková, Jarmila, Hrdá, Pavlína et al.·Neuro endocrinology letters·1999

This study tested whether allergies to metals like mercury (found in old dental fillings) and nickel might trigger fatigue and autoimmune problems in people with ME/CFS. Researchers compared three groups of tired patients with healthy controls and found that people with fatigue were more sensitive to these metals. When some patients had their mercury-containing fillings removed and replaced, their fatigue improved significantly.

Immune System

E2 ModerateBehavioralPEM unclearCross-Sectional

Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis.

Christodoulou, C, Deluca, J, Johnson, S K et al.·Journal of psychosomatic research·1999

This study looked at personality traits in people with ME/CFS compared to healthy people and those with multiple sclerosis (MS). The researchers used a personality framework that measures how people respond to harm, seek rewards, and persist with goals. Both ME/CFS and MS patients showed similar patterns: they were more cautious about potential harm and less focused on social rewards than healthy controls.

E2 ModerateCohortPEM not requiredObservational

Human herpesviruses in chronic fatigue syndrome.

Wallace, H L, Natelson, B, Gause, W et al.·Clinical and diagnostic laboratory immunology·1999

Researchers tested whether common viruses (HHV6, HHV7, Epstein-Barr virus, and cytomegalovirus) are more active or present in people with ME/CFS compared to healthy people. They examined blood samples from ME/CFS patients and matched healthy controls, looking for both the viruses themselves and antibodies (immune markers) against these viruses. They found no significant differences between the two groups, suggesting these particular viruses may not be a primary driver of ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredObservational

Metal-specific lymphocytes: biomarkers of sensitivity in man.

Stejskal, Vera DM, Danersund, Antero, Lindvall, Anders et al.·Neuro endocrinology letters·1999

This study tested whether people with ME/CFS-like symptoms had immune reactions to metals in their dental fillings and other restorations. Researchers found that many patients had immune cells that reacted to metals like mercury, nickel, and gold, and that 76% of patients who replaced their metal restorations with non-metal alternatives reported feeling better. The study suggests that metal sensitivity might trigger inflammatory responses that contribute to chronic fatigue and related conditions.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Melatonin levels in women with fibromyalgia and chronic fatigue syndrome.

Korszun, A, Sackett-Lundeen, L, Papadopoulos, E et al.·The Journal of rheumatology·1999

This study looked at melatonin—a hormone that helps control sleep and daily rhythms—in women with fibromyalgia and chronic fatigue syndrome. Researchers collected blood samples every 10 minutes over 24 hours and found that women with fibromyalgia had higher melatonin levels at night compared to healthy controls, but women with chronic fatigue syndrome did not. The authors concluded there is no evidence that taking melatonin supplements would help these patients.

Sleep

E2 ModerateCohortPEM not requiredObservational

Approaches to coping with chronic fatigue syndrome (CFS).

Stark, F M, Sobetzko, H M·Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine·1999

This study looked at how people with ME/CFS can better manage their condition by following long-term care and support. The researchers observed a support group over time to understand what helps patients cope with this serious illness that causes extreme fatigue and reduces ability to work, study, and maintain social activities. They found that a personalized approach combining medical care from a regular doctor and participation in a support group was helpful for disease management.

E2 ModerateBehavioralPEM not requiredCase-Control

Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis.

Theorell, T, Blomkvist, V, Lindh, G et al.·Psychosomatic medicine·1999

This study looked at whether stressful life events and infections in the months before ME/CFS develops might play a role in triggering the illness. Researchers interviewed 46 people with ME/CFS and 46 matched control subjects without the illness, asking them to recall what happened and how they felt month-by-month for a year. They found that people who developed ME/CFS experienced more infections and stressful events—especially in the 3 months right before onset—and their fatigue, pain, and fever symptoms stayed very high even after diagnosis, unlike the control group who recovered.

E2 ModerateCohortPEM not requiredCross-Sectional

Vitamin B status in patients with chronic fatigue syndrome.

Heap, L C, Peters, T J, Wessely, S·Journal of the Royal Society of Medicine·1999

This study tested whether people with ME/CFS have lower levels of three B vitamins (B6, B2, and B1) compared to healthy people. Researchers measured how well these vitamins work in red blood cells from 12 ME/CFS patients and 18 healthy controls. They found that all three B vitamins appeared to be functioning less effectively in ME/CFS patients, suggesting a possible vitamin deficiency that might contribute to symptoms.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Increased postwar symptoms and psychological morbidity among U.S. Navy Gulf War veterans.

Gray, G C, Kaiser, K S, Hawksworth, A W et al.·The American journal of tropical medicine and hygiene·1999

This study compared Navy veterans who served in the Gulf War to those who did not, looking for differences in health symptoms and physical condition. Gulf War veterans reported significantly more health problems, psychological difficulties, and lower physical strength than non-deployed veterans. The researchers found higher levels of certain inflammatory markers in blood tests, but couldn't pinpoint exactly what caused these differences.

E2 ModerateCohortPEM not requiredCross-Sectional

Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.

Scott, L V, Salahuddin, F, Cooney, J et al.·Journal of affective disorders·1999

This study measured several hormones related to stress in people with ME/CFS, depression, and healthy individuals. Researchers found that people with ME/CFS had significantly lower levels of DHEA and DHEA-S (hormones produced by the adrenal glands) compared to healthy people, while cortisol levels were similar across all groups. This suggests ME/CFS may involve a different hormone pattern than depression, and DHEA could potentially help diagnose or treat ME/CFS.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Brain MRI abnormalities exist in a subset of patients with chronic fatigue syndrome.

Lange, G, DeLuca, J, Maldjian, J A et al.·Journal of the neurological sciences·1999

Researchers used brain MRI scans to look for abnormalities in people with ME/CFS and compared them to healthy controls. They found that some ME/CFS patients—specifically those without a separate psychiatric diagnosis—had small spots of unusual tissue in the white matter of their brains, mostly in the frontal lobes (the front part of the brain). These brain changes were not found in healthy people or in ME/CFS patients who also had psychiatric diagnoses.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Attention and information processing efficiency in patients with Chronic Fatigue Syndrome.

Michiels, V, de Gucht, V, Cluydts, R et al.·Journal of clinical and experimental neuropsychology·1999

This study tested thinking and memory skills in 29 people with ME/CFS and compared them to 22 healthy people of similar age and education. The results showed that people with ME/CFS had slower thinking speed and difficulty processing information efficiently, but their ability to shift attention or focus on specific visual tasks was not notably impaired. Interestingly, memory problems appeared to stem from difficulty storing new information initially, rather than trouble recalling it later.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychological states and neuropsychological performances in chronic Lyme disease.

Elkins, L E, Pollina, D A, Scheffer, S R et al.·Applied neuropsychology·1999

This study looked at mood and thinking abilities in 30 people with post-Lyme syndrome (a condition that can develop after Lyme disease). Researchers found that these patients had lower levels of positive feelings (like happiness or hopefulness) compared to the general population, but their actual thinking and memory skills tested normally. The study suggests that reduced positive mood, rather than depression or other psychiatric conditions, may be the most important psychological marker of this illness.

Cognitive Impairment

E2 ModerateBehavioralPEM unclearCross-Sectional

Psychiatric diagnoses in Gulf War veterans with fatiguing illness.

Lange, G, Tiersky, L, DeLuca, J et al.·Psychiatry research·1999

Researchers studied Gulf War veterans with severe fatigue to see whether psychiatric disorders could explain their illness. About half of the veterans with Gulf War Illness had similar rates of psychiatric diagnoses as healthy veterans, while the other half had more psychiatric problems. The study found that psychiatric conditions alone cannot account for the fatiguing illness these veterans experience.

Diagnostics

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Human herpesviruses 6 and 7 in chronic fatigue syndrome: a case-control study.

Antibodies to squalene in Gulf War syndrome.

Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome.

Orthostatic intolerance in the chronic fatigue syndrome.

TNF-alpha and chronic fatigue syndrome.

Personality and social attitudes in chronic fatigue syndrome.

Mercury and nickel allergy: risk factors in fatigue and autoimmunity.

Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis.

Human herpesviruses in chronic fatigue syndrome.

Metal-specific lymphocytes: biomarkers of sensitivity in man.

Melatonin levels in women with fibromyalgia and chronic fatigue syndrome.

Approaches to coping with chronic fatigue syndrome (CFS).

Critical life events, infections, and symptoms during the year preceding chronic fatigue syndrome (CFS): an examination of CFS patients and subjects with a nonspecific life crisis.

Vitamin B status in patients with chronic fatigue syndrome.

Increased postwar symptoms and psychological morbidity among U.S. Navy Gulf War veterans.

Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.

Brain MRI abnormalities exist in a subset of patients with chronic fatigue syndrome.

Attention and information processing efficiency in patients with Chronic Fatigue Syndrome.

Psychological states and neuropsychological performances in chronic Lyme disease.

Psychiatric diagnoses in Gulf War veterans with fatiguing illness.

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