ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2785 studies

2381–2400 of 2,785 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Idiopathic chronic fatigue and chronic fatigue syndrome: a comparison of two case-definitions.

Arpino, C, Carrieri, M P, Valesini, G et al.·Annali dell'Istituto superiore di sanita·1999

This study compared how many patients were diagnosed with ME/CFS using two different diagnostic definitions from 1988 and 1994. The researchers found that the 1994 definition diagnosed more patients as having CFS, but these additional patients were less likely to have had a sudden onset of illness or signs suggesting an infectious trigger like fever or sore throat. This suggests the two definitions captured somewhat different groups of people.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

[The chronic fatigue and neurasthenia in the student population].

Mojarro Práxedes MD, Benjumea Pino P·Actas espanolas de psiquiatria·1999

This study looked at fatigue in 277 medical students to see how common chronic fatigue syndrome (CFS) and a related condition called neurasthenia actually are. The researchers found that while over one-third of students reported fatigue, very few met the strict criteria for CFS (less than 1%), and a small number met criteria for neurasthenia (about 3%). The study also found that students with fatigue were more likely to have depression symptoms, though it's unclear whether depression causes fatigue or results from it.

Cognitive Impairment

E2 ModerateCohortPEM not requiredLongitudinal

Natural history of severe chronic fatigue syndrome.

Hill, N F, Tiersky, L A, Scavalla, V R et al.·Archives of physical medicine and rehabilitation·1999

This study followed 23 people with severe ME/CFS over approximately 4 years to see how their illness changed over time. The researchers found that most patients stayed severely ill or showed only modest improvement, with just one person (4%) fully recovering. The study suggests that severe ME/CFS has a very poor outlook for recovery in most patients.

Severe ME

E2 ModerateCohortPEM not requiredCross-Sectional

[Patients with fatigue in family practice: prevalence and treatment].

Kenter, E G, Okkes, I M·Nederlands tijdschrift voor geneeskunde·1999

This study looked at how often people visit their doctor complaining of fatigue and what doctors do about it. Researchers tracked visits from general practitioners across the Netherlands over 10 years, involving over 93,000 patient visits. They found that about 92 out of every 1,000 patients saw their doctor each year because of fatigue, but only about 4% had fatigue lasting 6 months or longer.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome, chronic fatigue, and psychiatric disorders: predictors of functional status in a national nursing sample.

Wagner-Raphael, Lynne I, Jason, Leonard A, Ferrari, Joseph R·Journal of occupational health psychology·1999

This study looked at nurses with severe tiredness to understand how fatigue affects their daily lives and well-being. Researchers found that as fatigue got worse, people had more trouble with physical activities, work tasks, social interactions, and overall quality of life. Nurses who had ME/CFS experienced greater difficulties than those with fatigue from other causes.

E2 ModerateCohortPEM not requiredObservational

Approaches to coping with chronic fatigue syndrome (CFS).

Stark, F M, Sobetzko, H M·Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine·1999

This study looked at how people with ME/CFS can better manage their condition by following long-term care and support. The researchers observed a support group over time to understand what helps patients cope with this serious illness that causes extreme fatigue and reduces ability to work, study, and maintain social activities. They found that a personalized approach combining medical care from a regular doctor and participation in a support group was helpful for disease management.

E2 ModerateCohortPEM not requiredCross-Sectional

Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.

Scott, L V, Salahuddin, F, Cooney, J et al.·Journal of affective disorders·1999

This study measured several hormones related to stress in people with ME/CFS, depression, and healthy individuals. Researchers found that people with ME/CFS had significantly lower levels of DHEA and DHEA-S (hormones produced by the adrenal glands) compared to healthy people, while cortisol levels were similar across all groups. This suggests ME/CFS may involve a different hormone pattern than depression, and DHEA could potentially help diagnose or treat ME/CFS.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCase-Control

Is depression associated with immune activation?

Natelson, B H, Denny, T, Zhou, X D et al.·Journal of affective disorders·1999

Researchers tested whether depression and ME/CFS are caused by an overactive immune system. They compared immune cell counts and immune signaling molecules in people with depression, people with ME/CFS who later developed depression, and healthy controls. Surprisingly, they found no signs of immune activation in either patient group—instead, the data suggested the immune system was actually downregulated (less active) in people with depression.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome and nickel allergy.

Marcusson, J A, Lindh, G, Evengård, B·Contact dermatitis·1999

This study tested 50 patients with ME/CFS and 73 healthy people for allergic reactions to eight different metals. Researchers found that people with ME/CFS were more likely to be allergic to nickel—36% of ME/CFS patients had nickel allergies compared to only 19% of healthy people. This difference was especially pronounced in women with ME/CFS, where over half (52%) showed nickel allergy. The researchers suggest that nickel exposure might somehow trigger or contribute to ME/CFS in some people.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome.

Nasralla, M, Haier, J, Nicolson, G L·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1999

Researchers tested blood samples from 91 patients with ME/CFS and/or fibromyalgia who already tested positive for mycoplasma bacteria. They found that most patients carried multiple types of mycoplasma—particularly Mycoplasma pneumoniae and Mycoplasma fermentans—and some patients had two or even three different mycoplasma species at the same time. Patients with multiple infections tended to have been sick longer, suggesting they may have picked up additional infections over time.

E2 ModerateCohortPEM not requiredCross-Sectional

Autonomic function in patients with chronic fatigue syndrome.

Soetekouw, P M, Lenders, J W, Bleijenberg, G et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1999

Researchers tested whether ME/CFS patients have problems with the part of the nervous system that automatically controls heart rate and blood pressure. They compared 37 ME/CFS patients to 38 healthy people using several tests (like standing up quickly, holding their breath, and doing mental math). The study found only minor differences, suggesting that major autonomic problems may not be the primary issue in ME/CFS, though some specific responses to stress were reduced.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Associations between perfectionism, mood, and fatigue in chronic fatigue syndrome: a pilot study.

Blenkiron, P, Edwards, R, Lynch, S·The Journal of nervous and mental disease·1999

This study looked at whether people with ME/CFS who tend to be perfectionists experience different levels of fatigue, anxiety, or depression compared to healthy people. Researchers found that people with ME/CFS actually had lower perfectionism scores than healthy controls, and were less likely to set high standards for others. Interestingly, this lower expectation of others was linked to less physical fatigue.

E2 ModerateCohortPEM not requiredCase-Control

Mercury and nickel allergy: risk factors in fatigue and autoimmunity.

Sterzl, Ivan, Procházková, Jarmila, Hrdá, Pavlína et al.·Neuro endocrinology letters·1999

This study tested whether allergies to metals like mercury (found in old dental fillings) and nickel might trigger fatigue and autoimmune problems in people with ME/CFS. Researchers compared three groups of tired patients with healthy controls and found that people with fatigue were more sensitive to these metals. When some patients had their mercury-containing fillings removed and replaced, their fatigue improved significantly.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: gender differences in the search for legitimacy.

Clarke, J N·The Australian and New Zealand journal of mental health nursing·1999

This study interviewed 59 people with ME/CFS (18 men and 41 women) about their experiences with the illness and how doctors treated them. While men and women described similar symptoms and the disease itself affected them in comparable ways, they experienced very different treatment from healthcare providers. The study suggests that gender plays an important role in how seriously doctors take ME/CFS patients and how they are believed.

E2 ModerateCohortPEM not requiredCross-Sectional

TNF-alpha and chronic fatigue syndrome.

Moss, R B, Mercandetti, A, Vojdani, A·Journal of clinical immunology·1999

This study looked at whether a molecule called TNF-alpha, which helps control inflammation in the body, is elevated in people with ME/CFS. Researchers compared blood levels of TNF-alpha in patients with ME/CFS to healthy people without the condition. They found that people with ME/CFS had significantly higher levels of TNF-alpha, suggesting that inflammation may play a role in the disease.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Absence of Borrelia burgdorferi-specific immune complexes in chronic fatigue syndrome.

Schutzer, S E, Natelson, B H·Neurology·1999

This study tested whether people with ME/CFS have signs of Lyme disease infection in their blood. Researchers compared 39 ME/CFS patients to 40 healthy people using a specialized test that looks for Borrelia burgdorferi, the bacterium that causes Lyme disease. None of the patients or controls showed signs of this infection, suggesting that Lyme disease is not the hidden cause of ME/CFS in people without typical Lyme disease symptoms like the characteristic rash or joint problems.

Diagnostics

E2 ModerateBehavioralPEM unclearCross-Sectional

Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis.

Christodoulou, C, Deluca, J, Johnson, S K et al.·Journal of psychosomatic research·1999

This study looked at personality traits in people with ME/CFS compared to healthy people and those with multiple sclerosis (MS). The researchers used a personality framework that measures how people respond to harm, seek rewards, and persist with goals. Both ME/CFS and MS patients showed similar patterns: they were more cautious about potential harm and less focused on social rewards than healthy controls.

E2 ModerateCohortPEM not requiredObservational

Metal-specific lymphocytes: biomarkers of sensitivity in man.

Stejskal, Vera DM, Danersund, Antero, Lindvall, Anders et al.·Neuro endocrinology letters·1999

This study tested whether people with ME/CFS-like symptoms had immune reactions to metals in their dental fillings and other restorations. Researchers found that many patients had immune cells that reacted to metals like mercury, nickel, and gold, and that 76% of patients who replaced their metal restorations with non-metal alternatives reported feeling better. The study suggests that metal sensitivity might trigger inflammatory responses that contribute to chronic fatigue and related conditions.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Attention and information processing efficiency in patients with Chronic Fatigue Syndrome.

Michiels, V, de Gucht, V, Cluydts, R et al.·Journal of clinical and experimental neuropsychology·1999

This study tested thinking and memory skills in 29 people with ME/CFS and compared them to 22 healthy people of similar age and education. The results showed that people with ME/CFS had slower thinking speed and difficulty processing information efficiently, but their ability to shift attention or focus on specific visual tasks was not notably impaired. Interestingly, memory problems appeared to stem from difficulty storing new information initially, rather than trouble recalling it later.

Cognitive Impairment

E2 ModerateCohortPEM not requiredLongitudinal

Can we predict recovery in chronic fatigue syndrome?

Pheley, A M, Melby, D, Schenck, C et al.·Minnesota medicine·1999

Researchers followed up with people who had ME/CFS for many years to see who recovered and what factors might predict recovery. Only 12% of patients reported recovery. Patients who had better physical and social functioning and lower anxiety at the start were more likely to recover, but there was so much overlap between those who recovered and those who didn't that doctors cannot reliably predict who will recover.

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Idiopathic chronic fatigue and chronic fatigue syndrome: a comparison of two case-definitions.

[The chronic fatigue and neurasthenia in the student population].

Natural history of severe chronic fatigue syndrome.

[Patients with fatigue in family practice: prevalence and treatment].

Chronic fatigue syndrome, chronic fatigue, and psychiatric disorders: predictors of functional status in a national nursing sample.

Approaches to coping with chronic fatigue syndrome (CFS).

Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.

Is depression associated with immune activation?

Chronic fatigue syndrome and nickel allergy.

Multiple mycoplasmal infections detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia syndrome.

Autonomic function in patients with chronic fatigue syndrome.

Associations between perfectionism, mood, and fatigue in chronic fatigue syndrome: a pilot study.

Mercury and nickel allergy: risk factors in fatigue and autoimmunity.

Chronic fatigue syndrome: gender differences in the search for legitimacy.

TNF-alpha and chronic fatigue syndrome.

Absence of Borrelia burgdorferi-specific immune complexes in chronic fatigue syndrome.

Examination of Cloninger's basic dimensions of personality in fatiguing illness: chronic fatigue syndrome and multiple sclerosis.

Metal-specific lymphocytes: biomarkers of sensitivity in man.

Attention and information processing efficiency in patients with Chronic Fatigue Syndrome.

Can we predict recovery in chronic fatigue syndrome?

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