ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2481–2500 of 2,768 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic debilitating fatigue in Irish general practice: a survey of general practitioners' experience.

Fitzgibbon, E J, Murphy, D, O'Shea, K et al.·The British journal of general practice : the journal of the Royal College of General Practitioners·1997

Irish doctors were surveyed about their experience treating patients with chronic, debilitating fatigue. The study found that fatigue is common in general practice—affecting about 1 in 1,000 people—with twice as many women as men affected. However, doctors used very different approaches to treating these patients and many were unhappy with the care they could provide.

E2 ModerateCohortPEM not requiredCross-Sectional

[High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome].

Cuende, J I, Civeira, P, Diez, N et al.·Anales de medicina interna (Madrid, Spain : 1984)·1997

Researchers tested 20 ME/CFS patients for active herpesvirus-6 (HHV-6) infection, a virus that had been suspected as a possible cause of ME/CFS. They found that half the patients had antibodies showing past HHV-6 infection, but sensitive testing detected only small amounts of viral DNA in blood cells and no active viral replication. This suggests that while many ME/CFS patients may have been infected with HHV-6 in the past, the virus is not actively multiplying in their bodies.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Sleep anomalies in the chronic fatigue syndrome. A comorbidity study.

Fischler, B, Le Bon, O, Hoffmann, G et al.·Neuropsychobiology·1997

This study examined sleep patterns in 49 ME/CFS patients compared to 20 healthy people using overnight sleep monitoring. Patients with ME/CFS had difficulty falling asleep and staying asleep, and spent less time in deep, restorative stage 4 sleep. These sleep problems were distinctive enough that researchers could correctly identify who had ME/CFS based on sleep patterns alone.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

The quality of life of persons with chronic fatigue syndrome.

Anderson, J S, Ferrans, C E·The Journal of nervous and mental disease·1997

This study asked 110 people with ME/CFS to rate their quality of life and interviewed 22 of them in depth about their daily experiences. The researchers found that people with ME/CFS reported significantly lower quality of life compared to people with other chronic illnesses, with the biggest problems in health and physical functioning. The detailed interviews helped explain why the numbers were so low and showed that ME/CFS uniquely disrupts many aspects of a person's life.

E2 ModerateCohortPEM not requiredCross-Sectional

[Prevalence of chronic fatigue syndrome in 4 family practices in Leiden].

Versluis, R G, de Waal, M W, Opmeer, C et al.·Nederlands tijdschrift voor geneeskunde·1997

Researchers in the Netherlands looked at how many people in general medical practices had chronic fatigue syndrome (CFS). They reviewed medical records from about 23,000 patients and found that at least 1-2 out of every 1,000 patients had CFS. Interestingly, they noticed that women were diagnosed with CFS about five times more often than men.

E2 ModerateCohortPEM not requiredCase-Control

Electron microscopic immunocytological profiles in chronic fatigue syndrome.

Holmes, M J, Diack, D S, Easingwood, R A et al.·Journal of psychiatric research·1997

Researchers used a special microscope to examine immune cells from ME/CFS patients and found structures that resembled a type of virus in 10 out of 17 patients, but not in healthy control subjects. However, when they tried to confirm this finding using additional testing methods, the results were unclear. This suggests something might be different in the cells of some ME/CFS patients, but more research is needed to understand what it means.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Fatiguing illness among employees in three large state office buildings, California, 1993: was there an outbreak?

Shefer, A, Dobbins, J G, Fukuda, K et al.·Journal of psychiatric research·1997

Researchers surveyed over 3,300 state office workers in California to see if there was an unusual outbreak of long-lasting fatigue or ME/CFS-like illness. They found that about 18% of workers reported fatigue lasting at least a month, but this rate was similar in buildings thought to have clusters and in a comparison building, suggesting there was no outbreak. The study identified that certain groups—including women, Hispanic workers, Native American workers, and those with lower income or education—were more likely to report fatigue.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease.

DeLuca, J, Johnson, S K, Ellis, S P et al.·Journal of neurology, neurosurgery, and psychiatry·1997

This study tested thinking and memory skills in people with ME/CFS and found they performed worse than healthy people, even among those without depression or anxiety. The cognitive problems—like difficulty concentrating, remembering things, and processing information—appear to be a direct part of ME/CFS itself, not caused by mental health conditions. This suggests the 'brain fog' many ME/CFS patients experience is a real biological feature of the illness.

Cognitive Impairment

E2 ModerateCohortPEM unclearCase-Control

A common genetic variant affecting folate metabolism is not over-represented in chronic fatigue syndrome.

Harmon, D L, McMaster, D, McCluskey, D R et al.·Annals of clinical biochemistry·1997

This study looked at whether a specific genetic variant related to how the body processes folate (a B vitamin) is more common in people with ME/CFS compared to healthy controls. The researchers found that this particular genetic variation was not significantly more frequent in ME/CFS patients, suggesting this specific genetic factor is unlikely to be a major cause of the condition.

Energy Metabolism

E2 ModerateBehavioralPEM not requiredCross-Sectional

A population-based incidence study of chronic fatigue.

Lawrie, S M, Manders, D N, Geddes, J R et al.·Psychological medicine·1997

This study looked at how many people develop chronic fatigue in the general population (rather than just in doctor's offices), and what factors might increase the risk. Researchers found that people who were already somewhat fatigued before the study began were more likely to develop chronic fatigue later on. Interestingly, emotional difficulties and psychiatric conditions appeared less common in ME/CFS patients when researchers carefully adjusted for fatigue itself.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The chronic fatigue syndrome and hyperventilation.

Bazelmans, E, Bleijenberg, G, Vercoulen, J H et al.·Journal of psychosomatic research·1997

This study looked at whether rapid, shallow breathing (hyperventilation) causes ME/CFS or makes it worse. Researchers compared ME/CFS patients with people who hyperventilate but don't have ME/CFS, and healthy people. While ME/CFS patients did show signs of hyperventilation more often than healthy controls, having hyperventilation didn't actually make their fatigue or other symptoms worse.

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome.

Mawle, A C·Immunological investigations·1997

This study examined whether ME/CFS might be caused by an infection or involve immune system problems. While researchers didn't find a specific virus or bacteria responsible for the illness, they discovered that when they grouped patients based on whether their symptoms started suddenly or gradually, some differences in immune markers appeared between patients and healthy people.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome.

von Mikecz, A, Konstantinov, K, Buchwald, D S et al.·Arthritis and rheumatism·1997

Researchers tested blood samples from 60 ME/CFS patients and found that 83% had unusual antibodies (immune proteins) attacking their own cells—specifically targeting proteins that form the structural framework inside and around cell nuclei. These antibodies were rarely seen in healthy people (only 17%), suggesting this autoimmune pattern might be unique to ME/CFS and could potentially help doctors identify the disease.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Brain MR in chronic fatigue syndrome.

Greco, A, Tannock, C, Brostoff, J et al.·AJNR. American journal of neuroradiology·1997

Researchers used brain MRI scans to look for white matter abnormalities (areas of damage in the brain's connecting tissue) in 43 ME/CFS patients and compared them to 43 healthy control subjects. While some abnormalities were found in both groups, there was no pattern of brain changes that was unique to ME/CFS, suggesting that MRI scans alone cannot diagnose the condition.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS).

Wearden, A, Appleby, L·Psychological medicine·1997

This study asked people with ME/CFS about memory and concentration problems and then tested them in the lab. While ME/CFS patients reported more trouble concentrating and remembering when reading compared to healthy people, standard lab tests didn't always show measurable differences—except in those with depression. This suggests that cognitive difficulties in ME/CFS may be real but show up more in everyday activities than in controlled lab settings.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Generalized anxiety disorder in chronic fatigue syndrome.

Fischler, B, Cluydts, R, De Gucht, Y et al.·Acta psychiatrica Scandinavica·1997

This study found that people with ME/CFS have much higher rates of anxiety disorders—particularly generalized anxiety disorder (GAD)—compared to people without ME/CFS. The anxiety often started early and frequently occurred alongside other mental health conditions. The researchers suggest that anxiety may be a risk factor that makes someone more vulnerable to developing ME/CFS, rather than simply being caused by the illness itself.

E2 ModerateCohortPEM unclearCross-Sectional

An investigation of sympathetic hypersensitivity in chronic fatigue syndrome.

Sendrowski, D P, Buker, E A, Gee, S S·Optometry and vision science : official publication of the American Academy of Optometry·1997

Researchers tested whether ME/CFS patients have unusually sensitive nerves that control pupil size, similar to what is seen in fibromyalgia. They applied eye drops to 29 ME/CFS patients and 33 healthy controls and measured how much the pupils dilated. The results showed no significant difference between the two groups, suggesting that ME/CFS patients do not have this type of nerve sensitivity.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

[Demonstration on Borna disease virus in patients with chronic fatigue syndrome].

Nakaya, T, Kuratsune, H, Kitani, T et al.·Nihon rinsho. Japanese journal of clinical medicine·1997

Researchers tested whether a virus called Borna disease virus (BDV) might be connected to ME/CFS. They found that some patients with ME/CFS had signs of BDV infection, and the virus was also detected in one family where multiple members had ME/CFS. While these findings suggest BDV could play a role, the study shows it's likely not the sole cause of ME/CFS.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Outcomes of occupational stressors on nurses: chronic fatigue syndrome--related symptoms.

Wagner, L I, Jason, L A·NursingConnections·1997

This study looked at whether job stress in nurses is connected to ME/CFS-like symptoms. Researchers followed 202 nurses with prolonged exhaustion for one year, asking about their symptoms and work conditions. They found that specific workplace hazards—like fear of accidents and poor working environments—were linked to ME/CFS-related symptoms, though not all stressed nurses developed these symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Do patients with "pure" chronic fatigue syndrome (neurasthenia) have abnormal sleep?

Sharpley, A, Clements, A, Hawton, K et al.·Psychosomatic medicine·1997

This study compared sleep in 20 people with ME/CFS (who did not have depression, anxiety, or other sleep disorders) to 20 healthy people. Although ME/CFS patients reported feeling like they had poor, unrefreshing sleep and took daytime naps, objective sleep measurements showed surprisingly few differences—most patients actually slept a normal amount of time at night, though they spent longer lying awake after first falling asleep.

Sleep

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Chronic debilitating fatigue in Irish general practice: a survey of general practitioners' experience.

[High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome].

Sleep anomalies in the chronic fatigue syndrome. A comorbidity study.

The quality of life of persons with chronic fatigue syndrome.

[Prevalence of chronic fatigue syndrome in 4 family practices in Leiden].

Electron microscopic immunocytological profiles in chronic fatigue syndrome.

Fatiguing illness among employees in three large state office buildings, California, 1993: was there an outbreak?

Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease.

A common genetic variant affecting folate metabolism is not over-represented in chronic fatigue syndrome.

A population-based incidence study of chronic fatigue.

The chronic fatigue syndrome and hyperventilation.

Chronic fatigue syndrome.

High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome.

Brain MR in chronic fatigue syndrome.

Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS).

Generalized anxiety disorder in chronic fatigue syndrome.

An investigation of sympathetic hypersensitivity in chronic fatigue syndrome.

[Demonstration on Borna disease virus in patients with chronic fatigue syndrome].

Outcomes of occupational stressors on nurses: chronic fatigue syndrome--related symptoms.

Do patients with "pure" chronic fatigue syndrome (neurasthenia) have abnormal sleep?

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