ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2808 studies

2501–2520 of 2,808 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Serum neopterin and somatization in women with chemical intolerance, depressives, and normals.

Bell, I R, Patarca, R, Baldwin, C M et al.·Neuropsychobiology·1998

This study looked at a marker in the blood called neopterin, which may indicate immune system activation, in women with chemical sensitivity (difficulty tolerating everyday chemicals at low levels), women with depression, and healthy women. The researchers found that neopterin levels themselves were similar across groups, but in women with chemical sensitivity, higher neopterin levels were linked with more physical symptoms—a connection not seen in the other groups.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Core body temperature is normal in chronic fatigue syndrome.

Hamilos, D L, Nutter, D, Gershtenson, J et al.·Biological psychiatry·1998

Many people with ME/CFS report feeling like they have a low body temperature or mild fever, but this study found that their actual core body temperature is normal. Researchers continuously measured body temperature every 5 minutes for 24 hours in people with ME/CFS and compared them to healthy people, those with allergies, and those with depression. All groups had similar normal temperatures and similar daily temperature patterns.

E2 ModerateCohortPEM unclearObservational

Physical activity before and after exercise in women with chronic fatigue syndrome.

Sisto, S A, Tapp, W N, LaManca, J J et al.·QJM : monthly journal of the Association of Physicians·1998

This study tracked the physical activity of 20 women with ME/CFS and 20 healthy volunteers for two weeks using a movement monitor worn at the waist. After all participants did a strenuous treadmill exercise test, researchers measured how their activity changed. Women with ME/CFS showed a noticeable drop in activity levels after the exercise, with the biggest decrease happening around days 12-14, and they took more rest breaks during the day.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Effects of exercise on cognitive and motor function in chronic fatigue syndrome and depression.

Blackwood, S K, MacHale, S M, Power, M J et al.·Journal of neurology, neurosurgery, and psychiatry·1998

This study compared how people with ME/CFS, people with depression, and healthy people performed on thinking and strength tests before and after exercise on a treadmill. People with ME/CFS reported feeling much more tired and struggling harder during the exercise than the other groups. After exercising, people with ME/CFS had bigger drops in their ability to focus and pay attention compared to healthy people, suggesting that exercise affects their thinking ability in a specific way.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive deficits in patients suffering from chronic fatigue syndrome, acute infective illness or depression.

Vollmer-Conna, U, Wakefield, D, Lloyd, A et al.·The British journal of psychiatry : the journal of mental science·1997

This study tested how well people with ME/CFS could think and concentrate compared to people with depression, acute infections, and healthy people. All three patient groups performed worse on attention and memory tests and reported feeling more tired than healthy controls. Importantly, people with ME/CFS and acute infection had less severe mood problems than those with depression, suggesting their cognitive difficulties aren't simply caused by depression.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Does the chronic fatigue syndrome involve the autonomic nervous system?

Freeman, R, Komaroff, A L·The American journal of medicine·1997

This study tested whether ME/CFS patients have problems with their autonomic nervous system—the part of the nervous system that controls automatic functions like heart rate and blood pressure. Researchers found that ME/CFS patients had abnormal heart rate and blood pressure responses during standing and tilting tests, and their nervous system wasn't regulating these responses properly. The findings suggest that either deconditioning from reduced activity, a viral infection damaging the nervous system, or both could explain why many ME/CFS patients feel dizzy or faint when standing up.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

The chronic fatigue syndrome and hyperventilation.

Bazelmans, E, Bleijenberg, G, Vercoulen, J H et al.·Journal of psychosomatic research·1997

This study looked at whether rapid, shallow breathing (hyperventilation) causes ME/CFS or makes it worse. Researchers compared ME/CFS patients with people who hyperventilate but don't have ME/CFS, and healthy people. While ME/CFS patients did show signs of hyperventilation more often than healthy controls, having hyperventilation didn't actually make their fatigue or other symptoms worse.

E2 ModerateCohortPEM not requiredCross-Sectional

Post-Lyme syndrome and chronic fatigue syndrome. Neuropsychiatric similarities and differences.

Gaudino, E A, Coyle, P K, Krupp, L B·Archives of neurology·1997

This study compared people with ME/CFS and people with post-Lyme syndrome (ongoing fatigue after Lyme disease treatment) to understand how their symptoms differ. Both groups had severe fatigue and trouble thinking clearly, but people with post-Lyme syndrome showed more significant problems with memory, attention, and processing speed than people with ME/CFS. The findings suggest these two conditions may involve different types of brain function problems despite feeling similar to patients.

Cognitive Impairment

E2 ModerateCohortPEM unclearCase-Control

A common genetic variant affecting folate metabolism is not over-represented in chronic fatigue syndrome.

Harmon, D L, McMaster, D, McCluskey, D R et al.·Annals of clinical biochemistry·1997

This study looked at whether a specific genetic variant related to how the body processes folate (a B vitamin) is more common in people with ME/CFS compared to healthy controls. The researchers found that this particular genetic variation was not significantly more frequent in ME/CFS patients, suggesting this specific genetic factor is unlikely to be a major cause of the condition.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

[High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome].

Cuende, J I, Civeira, P, Diez, N et al.·Anales de medicina interna (Madrid, Spain : 1984)·1997

Researchers tested 20 ME/CFS patients for active herpesvirus-6 (HHV-6) infection, a virus that had been suspected as a possible cause of ME/CFS. They found that half the patients had antibodies showing past HHV-6 infection, but sensitive testing detected only small amounts of viral DNA in blood cells and no active viral replication. This suggests that while many ME/CFS patients may have been infected with HHV-6 in the past, the virus is not actively multiplying in their bodies.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients.

Kubo, K, Fujiyoshi, T, Yokoyama, M M et al.·Clinical and diagnostic laboratory immunology·1997

Researchers tested whether two viruses—Borna disease virus (BDV) and HTLV-1—might be linked to psychiatric disorders like schizophrenia and depression in Japanese patients. After testing blood samples from 346 patients with psychiatric conditions and 70 healthy people, they found almost no evidence that either virus was associated with these mental health conditions.

E2 ModerateCohortPEM unclearCase-Control

Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome.

Bennett, A L, Chao, C C, Hu, S et al.·Journal of clinical immunology·1997

Researchers measured a protein called TGF-beta in the blood of ME/CFS patients and compared it to healthy people and patients with other diseases like lupus and multiple sclerosis. They found that ME/CFS patients had significantly higher levels of this protein than all the other groups studied. This suggests that TGF-beta might play a role in ME/CFS, though more research is needed to understand exactly how.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Electron microscopic immunocytological profiles in chronic fatigue syndrome.

Holmes, M J, Diack, D S, Easingwood, R A et al.·Journal of psychiatric research·1997

Researchers used a special microscope to examine immune cells from ME/CFS patients and found structures that resembled a type of virus in 10 out of 17 patients, but not in healthy control subjects. However, when they tried to confirm this finding using additional testing methods, the results were unclear. This suggests something might be different in the cells of some ME/CFS patients, but more research is needed to understand what it means.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The relationship between fibromyalgia and interstitial cystitis.

Clauw, D J, Schmidt, M, Radulovic, D et al.·Journal of psychiatric research·1997

This study compared symptom patterns in people with fibromyalgia, interstitial cystitis (a bladder pain condition), and healthy people. Researchers found that fibromyalgia and IC patients reported very similar types of symptoms beyond their primary complaints, and both groups showed increased pain sensitivity throughout their bodies—not just in the areas they typically experienced pain.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

An investigation of sympathetic hypersensitivity in chronic fatigue syndrome.

Sendrowski, D P, Buker, E A, Gee, S S·Optometry and vision science : official publication of the American Academy of Optometry·1997

Researchers tested whether ME/CFS patients have unusually sensitive nerves that control pupil size, similar to what is seen in fibromyalgia. They applied eye drops to 29 ME/CFS patients and 33 healthy controls and measured how much the pupils dilated. The results showed no significant difference between the two groups, suggesting that ME/CFS patients do not have this type of nerve sensitivity.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Physical fatigability and exercise capacity in chronic fatigue syndrome: association with disability, somatization and psychopathology.

Fischler, B, Dendale, P, Michiels, V et al.·Journal of psychosomatic research·1997

This study looked at how people with ME/CFS respond to exercise by measuring whether they can reach their target heart rate during activity. Researchers found that many patients don't reach expected heart rates and that this relates to how disabled they feel in daily life. Interestingly, anxiety and depression didn't explain why people avoided strenuous exercise, suggesting that avoidance behavior in ME/CFS may have different causes than in other conditions.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Outcomes of occupational stressors on nurses: chronic fatigue syndrome--related symptoms.

Wagner, L I, Jason, L A·NursingConnections·1997

This study looked at whether job stress in nurses is connected to ME/CFS-like symptoms. Researchers followed 202 nurses with prolonged exhaustion for one year, asking about their symptoms and work conditions. They found that specific workplace hazards—like fear of accidents and poor working environments—were linked to ME/CFS-related symptoms, though not all stressed nurses developed these symptoms.

E2 ModerateCohortPEM unclearObservational

Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue.

Moorkens, G, Manuel y Keenoy, B, Vertommen, J et al.·Magnesium research·1997

This study tested whether people with chronic fatigue have low magnesium levels. Researchers gave 97 patients a special magnesium test and found that 44 had magnesium deficiency. After magnesium supplements, their bodies retained less magnesium, suggesting the treatment may have helped. However, the researchers did not find a clear link between low magnesium and chronic fatigue syndrome itself.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS).

Wearden, A, Appleby, L·Psychological medicine·1997

This study asked people with ME/CFS about memory and concentration problems and then tested them in the lab. While ME/CFS patients reported more trouble concentrating and remembering when reading compared to healthy people, standard lab tests didn't always show measurable differences—except in those with depression. This suggests that cognitive difficulties in ME/CFS may be real but show up more in everyday activities than in controlled lab settings.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

[Prevalence of chronic fatigue syndrome and primary fibromyalgia syndrome in The Netherlands].

Bazelmans, E, Vercoulen, J H, Galama, J M et al.·Nederlands tijdschrift voor geneeskunde·1997

This study asked general doctors across the Netherlands how many ME/CFS and fibromyalgia patients they saw in their practices. Based on their responses, researchers estimated that about 112 out of every 100,000 people in the Netherlands have ME/CFS, and 157 out of every 100,000 have fibromyalgia. The study found that both conditions affect mostly women and tend to develop in early-to-middle adulthood.

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Serum neopterin and somatization in women with chemical intolerance, depressives, and normals.

Core body temperature is normal in chronic fatigue syndrome.

Physical activity before and after exercise in women with chronic fatigue syndrome.

Effects of exercise on cognitive and motor function in chronic fatigue syndrome and depression.

Cognitive deficits in patients suffering from chronic fatigue syndrome, acute infective illness or depression.

Does the chronic fatigue syndrome involve the autonomic nervous system?

The chronic fatigue syndrome and hyperventilation.

Post-Lyme syndrome and chronic fatigue syndrome. Neuropsychiatric similarities and differences.

A common genetic variant affecting folate metabolism is not over-represented in chronic fatigue syndrome.

[High prevalence without reactivation of herpes virus 6 in subjects with chronic fatigue syndrome].

Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients.

Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome.

Electron microscopic immunocytological profiles in chronic fatigue syndrome.

The relationship between fibromyalgia and interstitial cystitis.

An investigation of sympathetic hypersensitivity in chronic fatigue syndrome.

Physical fatigability and exercise capacity in chronic fatigue syndrome: association with disability, somatization and psychopathology.

Outcomes of occupational stressors on nurses: chronic fatigue syndrome--related symptoms.

Magnesium deficit in a sample of the Belgian population presenting with chronic fatigue.

Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS).

[Prevalence of chronic fatigue syndrome and primary fibromyalgia syndrome in The Netherlands].

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