ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2786 studies

2501–2520 of 2,786 studies

E2 ModerateCohortPEM not requiredCross-Sectional

An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome.

Fukuda, K, Dobbins, J G, Wilson, L J et al.·Journal of psychiatric research·1997

Researchers surveyed nearly 1,700 households across four rural Michigan communities to investigate reports of a cluster of chronic fatigue syndrome cases. They found that fatigue was equally common across all communities studied, and the symptoms people with fatigue experienced were similar to generic tiredness rather than distinctly different. The reported cluster of CFS cases could not be confirmed.

E2 ModerateCohortPEM not requiredCross-Sectional

The relationship between fibromyalgia and interstitial cystitis.

Clauw, D J, Schmidt, M, Radulovic, D et al.·Journal of psychiatric research·1997

This study compared symptom patterns in people with fibromyalgia, interstitial cystitis (a bladder pain condition), and healthy people. Researchers found that fibromyalgia and IC patients reported very similar types of symptoms beyond their primary complaints, and both groups showed increased pain sensitivity throughout their bodies—not just in the areas they typically experienced pain.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCase-Control

Electron microscopic immunocytological profiles in chronic fatigue syndrome.

Holmes, M J, Diack, D S, Easingwood, R A et al.·Journal of psychiatric research·1997

Researchers used a special microscope to examine immune cells from ME/CFS patients and found structures that resembled a type of virus in 10 out of 17 patients, but not in healthy control subjects. However, when they tried to confirm this finding using additional testing methods, the results were unclear. This suggests something might be different in the cells of some ME/CFS patients, but more research is needed to understand what it means.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Post-Lyme syndrome and chronic fatigue syndrome. Neuropsychiatric similarities and differences.

Gaudino, E A, Coyle, P K, Krupp, L B·Archives of neurology·1997

This study compared people with ME/CFS and people with post-Lyme syndrome (ongoing fatigue after Lyme disease treatment) to understand how their symptoms differ. Both groups had severe fatigue and trouble thinking clearly, but people with post-Lyme syndrome showed more significant problems with memory, attention, and processing speed than people with ME/CFS. The findings suggest these two conditions may involve different types of brain function problems despite feeling similar to patients.

Cognitive Impairment

E2 ModerateCohortPEM unclearCase-Control

Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome.

Bennett, A L, Chao, C C, Hu, S et al.·Journal of clinical immunology·1997

Researchers measured a protein called TGF-beta in the blood of ME/CFS patients and compared it to healthy people and patients with other diseases like lupus and multiple sclerosis. They found that ME/CFS patients had significantly higher levels of this protein than all the other groups studied. This suggests that TGF-beta might play a role in ME/CFS, though more research is needed to understand exactly how.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The quality of life of persons with chronic fatigue syndrome.

Anderson, J S, Ferrans, C E·The Journal of nervous and mental disease·1997

This study asked 110 people with ME/CFS to rate their quality of life and interviewed 22 of them in depth about their daily experiences. The researchers found that people with ME/CFS reported significantly lower quality of life compared to people with other chronic illnesses, with the biggest problems in health and physical functioning. The detailed interviews helped explain why the numbers were so low and showed that ME/CFS uniquely disrupts many aspects of a person's life.

E2 ModerateCohortPEM not requiredObservational

[Demonstration on Borna disease virus in patients with chronic fatigue syndrome].

Nakaya, T, Kuratsune, H, Kitani, T et al.·Nihon rinsho. Japanese journal of clinical medicine·1997

Researchers tested whether a virus called Borna disease virus (BDV) might be connected to ME/CFS. They found that some patients with ME/CFS had signs of BDV infection, and the virus was also detected in one family where multiple members had ME/CFS. While these findings suggest BDV could play a role, the study shows it's likely not the sole cause of ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients.

Kubo, K, Fujiyoshi, T, Yokoyama, M M et al.·Clinical and diagnostic laboratory immunology·1997

Researchers tested whether two viruses—Borna disease virus (BDV) and HTLV-1—might be linked to psychiatric disorders like schizophrenia and depression in Japanese patients. After testing blood samples from 346 patients with psychiatric conditions and 70 healthy people, they found almost no evidence that either virus was associated with these mental health conditions.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Outcomes of occupational stressors on nurses: chronic fatigue syndrome--related symptoms.

Wagner, L I, Jason, L A·NursingConnections·1997

This study looked at whether job stress in nurses is connected to ME/CFS-like symptoms. Researchers followed 202 nurses with prolonged exhaustion for one year, asking about their symptoms and work conditions. They found that specific workplace hazards—like fear of accidents and poor working environments—were linked to ME/CFS-related symptoms, though not all stressed nurses developed these symptoms.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Neuropsychological and psychological functioning in chronic fatigue syndrome.

Kane, R L, Gantz, N M, DiPino, R K·Neuropsychiatry, neuropsychology, and behavioral neurology·1997

This study compared 17 people with ME/CFS to 17 healthy controls on thinking and memory tests, as well as psychological well-being. While ME/CFS patients reported feeling cognitively foggy, most formal test scores were similar between groups. However, ME/CFS patients showed significantly higher levels of psychological distress, anxiety, and depression compared to controls.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

An investigation of sympathetic hypersensitivity in chronic fatigue syndrome.

Sendrowski, D P, Buker, E A, Gee, S S·Optometry and vision science : official publication of the American Academy of Optometry·1997

Researchers tested whether ME/CFS patients have unusually sensitive nerves that control pupil size, similar to what is seen in fibromyalgia. They applied eye drops to 29 ME/CFS patients and 33 healthy controls and measured how much the pupils dilated. The results showed no significant difference between the two groups, suggesting that ME/CFS patients do not have this type of nerve sensitivity.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease.

DeLuca, J, Johnson, S K, Ellis, S P et al.·Journal of neurology, neurosurgery, and psychiatry·1997

This study tested thinking and memory skills in people with ME/CFS and found they performed worse than healthy people, even among those without depression or anxiety. The cognitive problems—like difficulty concentrating, remembering things, and processing information—appear to be a direct part of ME/CFS itself, not caused by mental health conditions. This suggests the 'brain fog' many ME/CFS patients experience is a real biological feature of the illness.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Patterns of utilization of medical care and perceptions of the relationship between doctor and patient with chronic illness including chronic fatigue syndrome.

Twemlow, S W, Bradshaw, S L, Coyne, L et al.·Psychological reports·1997

This study surveyed 609 people with ME/CFS to understand how their relationships with doctors differ from those of other patients with medical conditions. People with ME/CFS reported missing about 65 days of work per year due to illness, experienced more side effects from medical treatments, spent more money on healthcare, and visited more specialists than patients with typical medical conditions. The researchers found that doctors may need to pay more attention to how ME/CFS patients perceive their illness and their doctor-patient relationship, as these beliefs can affect how well treatments work.

E2 ModerateCohortPEM not requiredCross-Sectional

High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome.

von Mikecz, A, Konstantinov, K, Buchwald, D S et al.·Arthritis and rheumatism·1997

Researchers tested blood samples from 60 ME/CFS patients and found that 83% had unusual antibodies (immune proteins) attacking their own cells—specifically targeting proteins that form the structural framework inside and around cell nuclei. These antibodies were rarely seen in healthy people (only 17%), suggesting this autoimmune pattern might be unique to ME/CFS and could potentially help doctors identify the disease.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Fatiguing illness among employees in three large state office buildings, California, 1993: was there an outbreak?

Shefer, A, Dobbins, J G, Fukuda, K et al.·Journal of psychiatric research·1997

Researchers surveyed over 3,300 state office workers in California to see if there was an unusual outbreak of long-lasting fatigue or ME/CFS-like illness. They found that about 18% of workers reported fatigue lasting at least a month, but this rate was similar in buildings thought to have clusters and in a comparison building, suggesting there was no outbreak. The study identified that certain groups—including women, Hispanic workers, Native American workers, and those with lower income or education—were more likely to report fatigue.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic debilitating fatigue in Irish general practice: a survey of general practitioners' experience.

Fitzgibbon, E J, Murphy, D, O'Shea, K et al.·The British journal of general practice : the journal of the Royal College of General Practitioners·1997

Irish doctors were surveyed about their experience treating patients with chronic, debilitating fatigue. The study found that fatigue is common in general practice—affecting about 1 in 1,000 people—with twice as many women as men affected. However, doctors used very different approaches to treating these patients and many were unhappy with the care they could provide.

E2 ModerateBehavioralPEM unclearCross-Sectional

Physical activity in chronic fatigue syndrome: assessment and its role in fatigue.

Vercoulen, J H, Bazelmans, E, Swanink, C M et al.·Journal of psychiatric research·1997

This study looked at how active people with ME/CFS actually are compared to healthy people and patients with multiple sclerosis (MS). Researchers used three different methods to measure activity: questionnaires, daily logs, and a wearable device. They found that ME/CFS patients were less active than healthy people, similar to MS patients, but ME/CFS patients were more likely to avoid activities they feared would make their fatigue worse.

E2 ModerateCohortPEM unclearCase-Control

Somatomedin C (insulin-like growth factor I) levels in patients with chronic fatigue syndrome.

Bennett, A L, Mayes, D M, Fagioli, L R et al.·Journal of psychiatric research·1997

Researchers measured levels of somatomedin C (a growth-related hormone) in 49 ME/CFS patients and compared them to 30 healthy people. They found that ME/CFS patients had higher levels of this hormone than healthy controls. This is interesting because a similar condition called fibromyalgia shows the opposite pattern—lower levels of this hormone.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Precipitating factors for the chronic fatigue syndrome.

Salit, I E·Journal of psychiatric research·1997

This study looked at what triggered ME/CFS in 134 patients by asking them about their medical history, infections, and life events. While many patients reported an illness before ME/CFS started, actual proof of a specific infection was rare. Importantly, the researchers found that stressful life events in the year before ME/CFS onset were very common in patients but uncommon in healthy people, suggesting multiple different factors may trigger the illness rather than one single cause.

E2 ModerateCohortPEM not requiredLongitudinal

The natural history of concurrent sick building syndrome and chronic fatigue syndrome.

Chester, A C, Levine, P H·Journal of psychiatric research·1997

This study followed 23 people who developed fatigue and other symptoms during an outbreak linked to a problem building environment. Four years later, about two-thirds of the group had improved significantly or felt much better, while about one-third remained quite ill and unable to work. People who improved tended to also see their respiratory symptoms, sore throats, and headaches get better over time.

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An epidemiologic study of fatigue with relevance for the chronic fatigue syndrome.

The relationship between fibromyalgia and interstitial cystitis.

Electron microscopic immunocytological profiles in chronic fatigue syndrome.

Post-Lyme syndrome and chronic fatigue syndrome. Neuropsychiatric similarities and differences.

Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome.

The quality of life of persons with chronic fatigue syndrome.

[Demonstration on Borna disease virus in patients with chronic fatigue syndrome].

Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients.

Outcomes of occupational stressors on nurses: chronic fatigue syndrome--related symptoms.

Neuropsychological and psychological functioning in chronic fatigue syndrome.

An investigation of sympathetic hypersensitivity in chronic fatigue syndrome.

Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease.

Patterns of utilization of medical care and perceptions of the relationship between doctor and patient with chronic illness including chronic fatigue syndrome.

High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome.

Fatiguing illness among employees in three large state office buildings, California, 1993: was there an outbreak?

Chronic debilitating fatigue in Irish general practice: a survey of general practitioners' experience.

Physical activity in chronic fatigue syndrome: assessment and its role in fatigue.

Somatomedin C (insulin-like growth factor I) levels in patients with chronic fatigue syndrome.

Precipitating factors for the chronic fatigue syndrome.

The natural history of concurrent sick building syndrome and chronic fatigue syndrome.

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