Clauw, D J, Schmidt, M, Radulovic, D et al. · Journal of psychiatric research · 1997 · DOI
This study compared symptom patterns in people with fibromyalgia, interstitial cystitis (a bladder pain condition), and healthy people. Researchers found that fibromyalgia and IC patients reported very similar types of symptoms beyond their primary complaints, and both groups showed increased pain sensitivity throughout their bodies—not just in the areas they typically experienced pain.
This study is relevant to ME/CFS because fibromyalgia and CFS are clinically overlapping conditions, and the evidence that seemingly different disorders (IC and fibromyalgia) share common pain mechanisms supports the hypothesis that ME/CFS may involve central sensitization and widespread nociceptive changes rather than isolated organ dysfunction. Understanding these overlaps helps explain why ME/CFS patients often experience multiple seemingly unrelated symptoms.
This study does not prove that IC causes fibromyalgia or vice versa, nor does it establish whether the shared symptoms reflect a single underlying disease process or separate conditions with coincidental overlap. The cross-sectional design cannot determine causality or the temporal relationship between conditions. It also does not directly examine ME/CFS patients or establish how these findings apply to ME/CFS specifically.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Clauw, D J, Schmidt, M, Radulovic, D, Singer, A, Katz, P, & Bresette, J (1997). The relationship between fibromyalgia and interstitial cystitis.. Journal of psychiatric research. https://doi.org/10.1016/s0022-3956(96)00051-9
BibTeX
@article{mecfsatlas-clauw-1997-relationship-between,
author = {Clauw, D J and Schmidt, M and Radulovic, D and Singer, A and Katz, P and Bresette, J},
title = {The relationship between fibromyalgia and interstitial cystitis.},
journal = {Journal of psychiatric research},
year = {1997},
doi = {10.1016/s0022-3956(96)00051-9},
note = {PubMed: 9201654},
url = {https://www.mecfsatlas.com/evidence/clauw-1997-relationship-between},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/clauw-1997-relationship-between
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