ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2786 studies

2701–2720 of 2,786 studies

E2 ModerateCohortPEM not requiredObservational

Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment.

Langsjoen, P H, Langsjoen, P H, Folkers, K·The Clinical investigator·1993

This study looked at heart function in patients with chronic fatigue syndrome (ME/CFS) and compared them to patients with other heart conditions. Researchers found that many of these patients had a specific type of heart problem called diastolic dysfunction—where the heart doesn't relax properly between beats. When patients were given a supplement called CoQ10, their heart function improved and their symptoms got better.

E2 ModerateCohortPEM not requiredCross-Sectional

Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

Centers for Disease Control and Prevention (CDC)·MMWR. Morbidity and mortality weekly report·1993

In the early 1990s, some laboratories were offering blood tests to check if people with ME/CFS had been infected with certain viruses called retroviruses. This CDC study tested whether three of these commercial tests could actually tell the difference between people with ME/CFS and healthy people. The researchers found that these tests could not reliably distinguish between the two groups, meaning the tests were not accurate for identifying ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Repetitively negative changing T waves at 24-h electrocardiographic monitors in patients with the chronic fatigue syndrome. Left ventricular dysfunction in a cohort.

Lerner, A M, Lawrie, C, Dworkin, H S·Chest·1993

This study looked at heart activity recorded over 24 hours in ME/CFS patients compared to others. All 24 ME/CFS patients showed unusual patterns on their heart monitors (abnormal T waves), compared to only 22% of people without ME/CFS. Further testing found that 8 out of 60 ME/CFS patients had mild heart pumping problems that only showed up during exercise, even though their resting heart function appeared normal. The researchers suggest ME/CFS fatigue might be related to the heart not working well during normal daily activities.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep disturbance in chronic fatigue syndrome.

Krupp, L B, Jandorf, L, Coyle, P K et al.·Journal of psychosomatic research·1993

This study looked at sleep problems in 72 people with ME/CFS, comparing them to people with multiple sclerosis and healthy volunteers. People with ME/CFS reported much worse sleep and fatigue than the other groups. When researchers used sleep monitoring equipment on some ME/CFS patients, they found that over half had treatable sleep disorders like sleep apnea or periodic leg movements during sleep.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Human herpesvirus 6 and chronic fatigue syndrome.

Eymard, D, Lebel, F, Miller, M et al.·The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·1993

This study compared antibody levels against human herpesvirus 6 (HHV-6) in two groups: people with ME/CFS and people with chronic fatigue who didn't meet the official ME/CFS diagnosis. Researchers found that people with ME/CFS had significantly higher antibody levels against HHV-6, suggesting the virus might play a role in the condition. The study also found that sore throat, headache, and recurrent fatigue were more common in the ME/CFS group.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue, depression, and social adjustment in chronic fatigue syndrome.

Walford, G A, Nelson, W M, McCluskey, D R·Archives of disease in childhood·1993

This study looked at 12 children with ME/CFS and compared them to children with cystic fibrosis and healthy children. Children with ME/CFS reported much higher levels of tiredness affecting both body and mind, and many showed signs of depression. Their schooling and social lives were seriously disrupted by the illness.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Japanese patients with chronic fatigue syndrome are negative for known retrovirus infections.

Honda, M, Kitamura, K, Nakasone, T et al.·Microbiology and immunology·1993

This study tested 30 Japanese patients with ME/CFS to see if they had been infected with certain viruses called retroviruses, which some researchers thought might cause the illness. Using multiple testing methods, the researchers found that none of the patients had these viral infections. This suggests that these particular known viruses are not responsible for causing ME/CFS in this Japanese patient population.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of chronic fatigue syndrome-related symptoms among nurses.

Jason, L A, Taylor, S L, Johnson, S et al.·Evaluation & the health professions·1993

This study looked at how common ME/CFS-related symptoms are among nurses. Researchers surveyed a group of nurses and found that when using different definitions of the illness, more nurses showed signs of ME/CFS than had been found in previous studies of the general population. This was the first study to specifically examine ME/CFS in healthcare workers.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

A comparison of neuropsychiatric characteristics in chronic fatigue syndrome, multiple sclerosis, and major depression.

Pepper, C M, Krupp, L B, Friedberg, F et al.·The Journal of neuropsychiatry and clinical neurosciences·1993

This study compared the emotional and psychological characteristics of people with ME/CFS to those with multiple sclerosis and major depression. The researchers found that people with ME/CFS experienced depression, but overall had fewer psychiatric and personality-related issues compared to those with major depression alone. Interestingly, ME/CFS patients were more likely to develop depression after their illness began, compared to MS patients.

E2 ModerateCohortPEM not requiredCross-Sectional

Behavioural problems associated with the chronic fatigue syndrome.

Smith, A P, Behan, P O, Bell, W et al.·British journal of psychology (London, England : 1953)·1993

This study tested whether people with ME/CFS actually experience the memory, concentration, and coordination problems they report. Researchers gave 57 ME/CFS patients and 19 healthy controls a series of computerized tests measuring thinking speed, memory, attention, and motor skills. ME/CFS patients performed worse on many tests—they were slower at tasks requiring coordination, had trouble focusing, and struggled with complex reasoning—even though their depression and anxiety levels didn't fully explain these differences.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Investigation of retroviral involvement in chronic fatigue syndrome.

Folks, T M, Heneine, W, Khan, A et al.·Ciba Foundation symposium·1993

Researchers tested whether certain viruses called retroviruses might be a biological marker that could help diagnose ME/CFS. They looked for five different retroviruses in people with ME/CFS and compared them to healthy controls. None of these viruses were found in either group, meaning they cannot be used to identify who has ME/CFS.

Biomarkers

E2 ModerateCohortPEM not requiredCase-Control

Abnormalities of sleep in patients with the chronic fatigue syndrome.

Morriss, R, Sharpe, M, Sharpley, A L et al.·BMJ (Clinical research ed.)·1993

This study compared sleep patterns between 12 people with ME/CFS and 12 healthy volunteers using both sleep diaries and objective monitoring devices. People with ME/CFS spent more time in bed but slept less efficiently, woke up more after falling asleep, and were more likely to have sleep disorders. The researchers concluded that sleep problems are common in ME/CFS and may contribute to daytime fatigue.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Positive and negative social support in a chronic illness.

Ray, C·Psychological reports·1992

This study looked at how social support affects the emotional well-being of people with ME/CFS. Researchers surveyed 207 patients and found that positive support from others (like encouragement and practical help) was connected to lower anxiety, while negative support (like criticism or dismissal) was linked to both increased anxiety and depression. This suggests that the quality of relationships and social interactions may play a role in how ME/CFS patients experience mental health symptoms.

E2 ModerateCohortPEM not requiredObservational

[Allergy among Japanese patients with chronic fatigue syndrome].

Matsumoto, Y, Ninomiya, S·Arerugi = [Allergy]·1992

This study looked at allergies in 18 Japanese patients with ME/CFS and found that 78% had allergies either before or after developing ME/CFS. Most allergies involved skin reactions or drug allergies. Interestingly, allergies that existed before ME/CFS often improved once the illness developed, but ME/CFS symptoms got worse when allergies were present.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Human spumavirus antibodies in sera from African patients.

Mahnke, C, Kashaiya, P, Rössler, J et al.·Archives of virology·1992

Researchers tested blood samples from over 3,000 people in Africa and Europe to look for antibodies to a virus called human spumavirus. They found that about 3% of people worldwide had signs of this virus in their blood, but in African patients the rate was much higher at 6.3%. Notably, patients with ME/CFS, multiple sclerosis, and Graves' disease showed very low or no evidence of this virus.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Illness perception and symptom components in chronic fatigue syndrome.

Ray, C, Weir, W R, Cullen, S et al.·Journal of psychosomatic research·1992

This study asked 208 people with ME/CFS about their symptoms and how they experience their illness. Researchers found that ME/CFS involves four main types of problems: emotional distress, fatigue, physical symptoms, and difficulty thinking clearly. Emotional distress did not directly determine how sick people felt overall, but negative emotions did make the other symptoms worse.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Monospot and VP1 tests in chronic fatigue syndrome and major depression.

Lynch, S P, Seth, R V, Main, J·Journal of the Royal Society of Medicine·1992

This study tested whether two blood tests (Monospot and VP1) could help identify ME/CFS by comparing 34 ME/CFS patients with 34 people who had depression. While some patients tested positive for VP1 virus markers, the tests could not reliably tell the two groups apart, and results were inconsistent when patients were retested six months later.

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbidity of fibromyalgia with medical and psychiatric disorders.

Hudson, J I, Goldenberg, D L, Pope, H G et al.·The American journal of medicine·1992

This study looked at women diagnosed with fibromyalgia to see what other health conditions they commonly experience. The researchers found that fibromyalgia often occurs together with migraines, irritable bowel syndrome, chronic fatigue syndrome, depression, and panic disorder. This pattern suggests these conditions might share a common underlying biological cause.

E2 ModerateCohortPEM not requiredCross-Sectional

The economic impact of chronic fatigue syndrome.

Lloyd, A R, Pender, H·The Medical journal of Australia·1992

This study looked at how much money ME/CFS costs—not just for patients themselves, but for the healthcare system and society overall. Researchers surveyed 42 patients in one Australian region about their medical expenses and lost income, then used those numbers to estimate what ME/CFS might cost across all of Australia. They found the disease creates a huge financial burden that had been largely overlooked by policymakers.

E2 ModerateCohortPEM not requiredCross-Sectional

Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.

Ichise, M, Salit, I E, Abbey, S E et al.·Nuclear medicine communications·1992

This study used a special brain imaging technique called SPECT to measure blood flow in different regions of the brain in ME/CFS patients and healthy controls. Researchers found that most ME/CFS patients (80%) had reduced blood flow in several brain areas compared to healthy people, particularly in the front, side, and back regions of the brain. This provides the first objective evidence that ME/CFS may involve changes in how blood flows to the brain.

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Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment.

Inability of retroviral tests to identify persons with chronic fatigue syndrome, 1992.

Repetitively negative changing T waves at 24-h electrocardiographic monitors in patients with the chronic fatigue syndrome. Left ventricular dysfunction in a cohort.

Sleep disturbance in chronic fatigue syndrome.

Human herpesvirus 6 and chronic fatigue syndrome.

Fatigue, depression, and social adjustment in chronic fatigue syndrome.

Japanese patients with chronic fatigue syndrome are negative for known retrovirus infections.

Prevalence of chronic fatigue syndrome-related symptoms among nurses.

A comparison of neuropsychiatric characteristics in chronic fatigue syndrome, multiple sclerosis, and major depression.

Behavioural problems associated with the chronic fatigue syndrome.

Investigation of retroviral involvement in chronic fatigue syndrome.

Abnormalities of sleep in patients with the chronic fatigue syndrome.

Positive and negative social support in a chronic illness.

[Allergy among Japanese patients with chronic fatigue syndrome].

Human spumavirus antibodies in sera from African patients.

Illness perception and symptom components in chronic fatigue syndrome.

Monospot and VP1 tests in chronic fatigue syndrome and major depression.

Comorbidity of fibromyalgia with medical and psychiatric disorders.

The economic impact of chronic fatigue syndrome.

Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.

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