ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2808 studies

2701–2720 of 2,808 studies

E2 ModerateBehavioralPEM not requiredLongitudinal

Chronic fatigue syndrome: a follow up study.

Bonner, D, Ron, M, Chalder, T et al.·Journal of neurology, neurosurgery, and psychiatry·1994

Researchers followed up with 46 ME/CFS patients four years after their initial diagnosis to see how they were doing. Patients who had improved with treatment generally stayed better, while those who didn't benefit from treatment were unlikely to recover on their own. Patients who still had ME/CFS symptoms four years later tended to have had more physical health problems, greater fatigue levels, and a history of mental health conditions when first diagnosed.

Interventions

E2 ModerateBehavioralPEM not requiredCross-Sectional

Neuropsychology and psychology of MCS.

Fiedler, N, Kipen, H, Deluca, J et al.·Toxicology and industrial health·1994

This study looked at whether people with multiple chemical sensitivities (MCS) and chronic fatigue syndrome (CFS) have psychiatric issues or thinking problems. Researchers found that both groups reported more psychiatric diagnoses than healthy people, and both groups tended to report physical symptoms rather than emotional ones. Surprisingly, the study did not find significant cognitive impairment in MCS patients, except for a small difference in visual memory.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression.

Schwartz, R B, Komaroff, A L, Garada, B M et al.·AJR. American journal of roentgenology·1994

Researchers used a type of brain imaging called SPECT scans to compare brain blood flow patterns in people with ME/CFS, AIDS-related dementia, depression, and healthy people. People with ME/CFS and AIDS dementia showed similar patterns of reduced blood flow in certain brain areas, while people with depression showed different patterns. These findings suggest ME/CFS may involve brain inflammation similar to a chronic viral infection rather than being purely psychological.

E2 ModerateCohortPEM not requiredObservational

Concurrent sick building syndrome and chronic fatigue syndrome: epidemic neuromyasthenia revisited.

Chester, A C, Levine, P H·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study looked at three groups of people in different buildings who reported feeling sick, and found that some developed symptoms beyond what's typically expected from poor indoor air quality. While many had the usual complaints like respiratory irritation and headaches from their building environments, others developed more serious symptoms like extreme fatigue and neurological problems that match ME/CFS. The researchers concluded that ME/CFS may often occur alongside or be connected to sick building syndrome.

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of intracranial abnormalities in patients with chronic fatigue syndrome: comparison of MR imaging and SPECT.

Schwartz, R B, Garada, B M, Komaroff, A L et al.·AJR. American journal of roentgenology·1994

Researchers used two different brain imaging techniques—MRI and SPECT—to look for abnormalities in the brains of ME/CFS patients. They found that SPECT scans detected significantly more brain abnormalities in ME/CFS patients compared to healthy controls, while MRI scans showed fewer differences. Importantly, SPECT abnormalities appeared to change with clinical status, suggesting they might be useful for tracking disease progression.

E2 ModerateCohortPEM not requiredCross-Sectional

A comparison of case definitions of chronic fatigue syndrome.

Bates, D W, Buchwald, D, Lee, J et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study tested whether three different sets of diagnostic criteria for ME/CFS identified the same patients. Researchers looked at 805 patients at two clinics and found that about 55-61% met each of the three definitions, though different patients sometimes qualified under different criteria. The study suggests that using broader, more flexible definitions might better capture people with ME/CFS.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

[Chronic fatigue syndrome--a controlled cross-sectional study].

Rasmussen, A K, Nielsen, H, Andersen, V et al.·Ugeskrift for laeger·1994

This study compared immune system markers in 21 people with ME/CFS to 21 healthy people matched by age and sex. Researchers found that certain immune cells in ME/CFS patients produced higher levels of specific immune signaling molecules, while antibody levels were slightly lower than normal. Overall, the study did not find clear evidence that ME/CFS is caused by a persistent viral infection or a severely damaged immune system.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Quality of attention in chronic fatigue syndrome: subjective reports of everyday attention and cognitive difficulty, and performance on tasks of focused attention.

Ray, C, Phillips, L, Weir, W R·The British journal of clinical psychology·1993

Many people with ME/CFS report problems with attention and concentration in daily life. This study compared ME/CFS patients with healthy people using questionnaires about attention problems and computer-based attention tests. Patients reported significantly more attention difficulties than controls, though standard attention tests didn't show clear differences. Interestingly, patients were slower at processing tasks like reading words and naming colors, suggesting their thinking speed may be affected rather than their ability to focus.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

A controlled study of brain magnetic resonance imaging in patients with the chronic fatigue syndrome.

Natelson, B H, Cohen, J M, Brassloff, I et al.·Journal of the neurological sciences·1993

Researchers compared brain scans (MRIs) of 52 people with ME/CFS to 52 similar healthy people. They found that ME/CFS patients were much more likely to have abnormal brain scans—27% compared to only 2% in the control group. The abnormalities included areas of white matter changes and some brain tissue enlargement, though the researchers noted that some of these findings might actually indicate other medical conditions rather than ME/CFS itself.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue in primary care attenders.

McDonald, E, David, A S, Pelosi, A J et al.·Psychological medicine·1993

Researchers studied 77 primary care patients with chronic fatigue and found that 26% met criteria for chronic fatigue syndrome (CFS). Most patients received other diagnoses, including depression and a condition called neurasthenia. Interestingly, patients seen in general practice were more likely to recognize that stress and emotional factors played a role in their fatigue, unlike hospital patients who often blamed purely physical causes like viruses.

E2 ModerateCohortPEM not requiredCross-Sectional

General practitioners acceptance of the validity of chronic fatigue syndrome as a diagnosis.

Denz-Penhey, H, Murdoch, J C·The New Zealand medical journal·1993

Researchers surveyed 83 general practitioners in New Zealand to see if they believed ME/CFS was a real medical condition. The vast majority (90%) said yes, they accepted it as a valid diagnosis. Most doctors said they had treated patients with this condition, suggesting ME/CFS was being recognized and diagnosed in primary care.

E2 ModerateCohortPEM not requiredCross-Sectional

A brief mental fatigue questionnaire.

Bentall, R P, Wood, G C, Marrinan, T et al.·The British journal of clinical psychology·1993

Researchers created a short questionnaire to measure mental tiredness and tested it in people with ME/CFS, depression, recovered ME/CFS, muscle disease, and healthy people. The questionnaire worked well at identifying mental fatigue, but it could not tell the difference between people with ME/CFS and people with depression—both groups reported similar types and amounts of mental tiredness.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Assessment of a retrovirus sequence and other possible risk factors for the chronic fatigue syndrome in adults.

Khan, A S, Heneine, W M, Chapman, L E et al.·Annals of internal medicine·1993

Researchers tested whether a virus called HTLV-II might be a cause of ME/CFS by comparing blood samples from 21 people with CFS to 21 healthy controls. They found no trace of the HTLV-II virus in any of the participants, and found no differences between the two groups in exposure to activities that spread viruses. This study argues against the idea that HTLV-II is linked to ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Serum folate and chronic fatigue syndrome.

Jacobson, W, Saich, T, Borysiewicz, L K et al.·Neurology·1993

Researchers measured folic acid levels in the blood of 60 ME/CFS patients and found that about half had lower-than-normal amounts. This suggests that some people with ME/CFS may not have enough folic acid in their body, which is a B vitamin important for many body functions.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue and chronic fatigue syndrome: clinical epidemiology and aetiological classification.

Manu, P, Lane, T J, Matthews, D A·Ciba Foundation symposium·1993

This study looked at 405 patients who came to a hospital complaining of chronic fatigue and tried to figure out what was causing it. Doctors found that most patients had psychiatric conditions like depression or anxiety rather than physical diseases. About 30% of patients met the definition for ME/CFS, and these patients were more likely to attribute their illness to a viral infection than other fatigued patients.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Investigation of retroviral involvement in chronic fatigue syndrome.

Folks, T M, Heneine, W, Khan, A et al.·Ciba Foundation symposium·1993

Researchers tested whether certain viruses called retroviruses might be a biological marker that could help diagnose ME/CFS. They looked for five different retroviruses in people with ME/CFS and compared them to healthy controls. None of these viruses were found in either group, meaning they cannot be used to identify who has ME/CFS.

Biomarkers

E2 ModerateCohortPEM not requiredObservational

Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment.

Langsjoen, P H, Langsjoen, P H, Folkers, K·The Clinical investigator·1993

This study looked at heart function in patients with chronic fatigue syndrome (ME/CFS) and compared them to patients with other heart conditions. Researchers found that many of these patients had a specific type of heart problem called diastolic dysfunction—where the heart doesn't relax properly between beats. When patients were given a supplement called CoQ10, their heart function improved and their symptoms got better.

E2 ModerateBehavioralPEM not requiredCross-Sectional

A comparison of neuropsychiatric characteristics in chronic fatigue syndrome, multiple sclerosis, and major depression.

Pepper, C M, Krupp, L B, Friedberg, F et al.·The Journal of neuropsychiatry and clinical neurosciences·1993

This study compared the emotional and psychological characteristics of people with ME/CFS to those with multiple sclerosis and major depression. The researchers found that people with ME/CFS experienced depression, but overall had fewer psychiatric and personality-related issues compared to those with major depression alone. Interestingly, ME/CFS patients were more likely to develop depression after their illness began, compared to MS patients.

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep disturbance in chronic fatigue syndrome.

Krupp, L B, Jandorf, L, Coyle, P K et al.·Journal of psychosomatic research·1993

This study looked at sleep problems in 72 people with ME/CFS, comparing them to people with multiple sclerosis and healthy volunteers. People with ME/CFS reported much worse sleep and fatigue than the other groups. When researchers used sleep monitoring equipment on some ME/CFS patients, they found that over half had treatable sleep disorders like sleep apnea or periodic leg movements during sleep.

Sleep

E2 ModerateCohortPEM unclearLongitudinal

[Chronic fatigue syndrome].

Fucíková, T, Petanová, J·Vnitrni lekarstvi·1993

Researchers followed 52 ME/CFS patients for 1 to 14 years to see how they progressed over time. About 20% recovered completely, about 32% improved significantly, and about 15% developed thyroiditis (thyroid inflammation). The treatments used were mainly immune-modulating drugs chosen based on each patient's individual immune test results, though the benefits were only partial.

Immune System

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Evidence browser

Chronic fatigue syndrome: a follow up study.

Neuropsychology and psychology of MCS.

SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression.

Concurrent sick building syndrome and chronic fatigue syndrome: epidemic neuromyasthenia revisited.

Detection of intracranial abnormalities in patients with chronic fatigue syndrome: comparison of MR imaging and SPECT.

A comparison of case definitions of chronic fatigue syndrome.

[Chronic fatigue syndrome--a controlled cross-sectional study].

Quality of attention in chronic fatigue syndrome: subjective reports of everyday attention and cognitive difficulty, and performance on tasks of focused attention.

A controlled study of brain magnetic resonance imaging in patients with the chronic fatigue syndrome.

Chronic fatigue in primary care attenders.

General practitioners acceptance of the validity of chronic fatigue syndrome as a diagnosis.

A brief mental fatigue questionnaire.

Assessment of a retrovirus sequence and other possible risk factors for the chronic fatigue syndrome in adults.

Serum folate and chronic fatigue syndrome.

Chronic fatigue and chronic fatigue syndrome: clinical epidemiology and aetiological classification.

Investigation of retroviral involvement in chronic fatigue syndrome.

Isolated diastolic dysfunction of the myocardium and its response to CoQ10 treatment.

A comparison of neuropsychiatric characteristics in chronic fatigue syndrome, multiple sclerosis, and major depression.

Sleep disturbance in chronic fatigue syndrome.

[Chronic fatigue syndrome].

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