ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2808 studies

2741–2760 of 2,808 studies

E2 ModerateCohortPEM unclearObservational

Does chronic fatigue syndrome predispose to non-Hodgkin's lymphoma?

Levine, P H, Peterson, D, McNamee, F L et al.·Cancer research·1992

Some people with ME/CFS have reported concerns about developing lymphoma (a type of blood cancer). This study looked at cancer rates in Nevada before and after documented ME/CFS outbreaks in the mid-1980s to see if there was an increase in non-Hodgkin's lymphoma cases. The researchers found that cancer rates followed the same patterns as the rest of the country, with no unusual spike linked to ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Fluctuations in perceived energy and mood among patients with chronic fatigue syndrome.

Wood, C, Magnello, M E, Sharpe, M C·Journal of the Royal Society of Medicine·1992

This study looked at how energy and mood change throughout the day in people with ME/CFS compared to healthy people. Patients with active ME/CFS had lower energy levels overall, though their energy peaked mid-morning (10 AM-12 PM) similar to healthy controls. People who had recovered from ME/CFS showed energy levels between the sick and healthy groups, and depression scores were higher in those still ill.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome criteria. A critique of the requirement for multiple physical complaints.

Katon, W, Russo, J·Archives of internal medicine·1992

This study looked at 285 people with chronic fatigue to understand whether having many physical symptoms was linked to psychiatric conditions like depression and anxiety. Researchers found that patients reporting more unexplained physical symptoms were significantly more likely to have current or past psychiatric diagnoses. The authors suggest that ME/CFS diagnostic criteria should be changed to include people with fatigue and few physical symptoms, and potentially exclude those with many physical complaints.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Attention and short-term memory in chronic fatigue syndrome patients: an event-related potential analysis.

Scheffers, M K, Johnson, R, Grafman, J et al.·Neurology·1992

This study compared brain activity and reaction times between 13 people with ME/CFS and 13 healthy volunteers using brain scans while they performed attention and memory tasks. The ME/CFS patients showed much slower and more variable reaction times, but their memory and thinking abilities appeared normal. The researchers found that the brain's basic attention and memory processes were working similarly in both groups, suggesting the slowness came from problems with how the brain signals muscles to respond.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Cell-mediated immunity in patients with chronic fatigue syndrome, healthy control subjects and patients with major depression.

Lloyd, A, Hickie, I, Hickie, C et al.·Clinical and experimental immunology·1992

This study compared immune system function in patients with ME/CFS, people with depression, and healthy individuals. Researchers found that ME/CFS patients had weaker immune responses than both groups, suggesting their immune problems are distinct from depression-related immune changes. This indicates that ME/CFS involves direct immune system dysfunction rather than these problems simply being caused by depression.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Monospot and VP1 tests in chronic fatigue syndrome and major depression.

Lynch, S P, Seth, R V, Main, J·Journal of the Royal Society of Medicine·1992

This study tested whether two blood tests (Monospot and VP1) could help identify ME/CFS by comparing 34 ME/CFS patients with 34 people who had depression. While some patients tested positive for VP1 virus markers, the tests could not reliably tell the two groups apart, and results were inconsistent when patients were retested six months later.

E2 ModerateCohortPEM not requiredCross-Sectional

Human spumavirus antibodies in sera from African patients.

Mahnke, C, Kashaiya, P, Rössler, J et al.·Archives of virology·1992

Researchers tested blood samples from over 3,000 people in Africa and Europe to look for antibodies to a virus called human spumavirus. They found that about 3% of people worldwide had signs of this virus in their blood, but in African patients the rate was much higher at 6.3%. Notably, patients with ME/CFS, multiple sclerosis, and Graves' disease showed very low or no evidence of this virus.

Immune System

E2 ModerateCohortPEM not requiredObservational

Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome.

Linde, A, Andersson, B, Svenson, S B et al.·The Journal of infectious diseases·1992

This study compared immune system markers in the blood of people with acute EBV infection (infectious mononucleosis), people recovering from EBV, and people with ME/CFS who had evidence of EBV reactivation. The researchers found that while acute EBV infection caused strong immune activation markers, people with ME/CFS did not show these same activation patterns, suggesting that active EBV reactivation may not be the primary cause of ME/CFS symptoms.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.

Ichise, M, Salit, I E, Abbey, S E et al.·Nuclear medicine communications·1992

This study used a special brain imaging technique called SPECT to measure blood flow in different regions of the brain in ME/CFS patients and healthy controls. Researchers found that most ME/CFS patients (80%) had reduced blood flow in several brain areas compared to healthy people, particularly in the front, side, and back regions of the brain. This provides the first objective evidence that ME/CFS may involve changes in how blood flows to the brain.

E2 ModerateCohortPEM not requiredCross-Sectional

Studies on the relationship between chronic fatigue syndrome and Epstein-Barr virus in Japan.

Kawai, K, Kawai, A·Internal medicine (Tokyo, Japan)·1992

This study examined whether Epstein-Barr virus (EBV), a common virus that causes infectious mononucleosis, might be connected to chronic fatigue syndrome (CFS). Researchers tested 22 patients with long-lasting fatigue and found that those with definite CFS had higher levels of certain EBV antibodies compared to patients with milder symptoms and healthy controls. The study suggests a possible link between EBV activation and the severity of fatigue experienced.

Immune System

E2 ModerateCohortPEM not requiredObservational

Clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome.

Levine, P H, Jacobson, S, Pocinki, A G et al.·Archives of internal medicine·1992

Researchers studied four different outbreaks of ME/CFS in the Nevada-California region over 3 years, following patients through interviews and blood tests to look for viral causes. They found that almost all patients recovered and returned to their normal activities within the 3-year period. The viruses they tested for—including Epstein-Barr virus and others—were not responsible for the illness, though one outbreak may have been triggered by a parasite called giardia.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Ureaplasma urealyticum and Mycoplasma hominis in women with systemic lupus erythematosus.

Ginsburg, K S, Kundsin, R B, Walter, C W et al.·Arthritis and rheumatism·1992

This study looked for a type of bacteria called mycoplasma in urine samples from women with two different conditions: systemic lupus erythematosus (SLE, an autoimmune disease) and ME/CFS (chronic fatigue syndrome). They found that mycoplasma was much more common in the SLE group (63%) than in the ME/CFS group (4.5%), suggesting these conditions may have different underlying causes.

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbidity of fibromyalgia with medical and psychiatric disorders.

Hudson, J I, Goldenberg, D L, Pope, H G et al.·The American journal of medicine·1992

This study looked at women diagnosed with fibromyalgia to see what other health conditions they commonly experience. The researchers found that fibromyalgia often occurs together with migraines, irritable bowel syndrome, chronic fatigue syndrome, depression, and panic disorder. This pattern suggests these conditions might share a common underlying biological cause.

E2 ModerateCohortPEM not requiredCross-Sectional

Epstein-Barr virus serology in the chronic fatigue syndrome.

Woodward, C G, Cox, R A·The Journal of infection·1992

Researchers tested blood samples from 136 ME/CFS patients to look for signs of past or ongoing Epstein-Barr virus (EBV) infection, comparing them to healthy blood donors. They found that CFS patients had higher levels of certain EBV antibodies than the control group, but these differences weren't consistent enough to be useful for diagnosing individual patients. The study also found that some patients had signs of other viral infections alongside the EBV markers.

Immune System

E2 ModerateCohortPEM unclearObservational

Alleged link between hepatitis B vaccine and chronic fatigue syndrome.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·1992

This 1992 study examined whether the hepatitis B vaccine might be linked to ME/CFS. Researchers looked at cases where people reported developing chronic fatigue symptoms after receiving the vaccine. This early observation-based study raised questions about a possible connection that researchers wanted to investigate further.

E2 ModerateCohortPEM not requiredCross-Sectional

The economic impact of chronic fatigue syndrome.

Lloyd, A R, Pender, H·The Medical journal of Australia·1992

This study looked at how much money ME/CFS costs—not just for patients themselves, but for the healthcare system and society overall. Researchers surveyed 42 patients in one Australian region about their medical expenses and lost income, then used those numbers to estimate what ME/CFS might cost across all of Australia. They found the disease creates a huge financial burden that had been largely overlooked by policymakers.

E2 ModerateCohortPEM not requiredCross-Sectional

[Overview of our patients with chronic fatigue syndrome (CFS) from the pathoetiological aspects].

Matsuda, J, Gohchi, K·Nihon rinsho. Japanese journal of clinical medicine·1992

Researchers studied 285 people who reported severe fatigue, and confirmed that 55 of them actually had chronic fatigue syndrome (CFS) using official diagnostic criteria. They tested patients' blood for signs of viral infections and measured certain immune cell markers to understand what might be causing CFS. This study looked at various biological factors that could explain why people develop this condition.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

[Chronic fatigue syndrome--study of 51 cases treated at the Second Tokyo National Hospital].

Nishikai, M·Nihon rinsho. Japanese journal of clinical medicine·1992

This study examined 51 patients with ME/CFS to look for physical and immune system clues about the illness. Researchers found that most patients had tender points similar to those seen in fibromyalgia, elevated antibodies to Epstein-Barr virus (a common virus), and lower numbers of certain immune cells called NK cells. These findings suggest that viral infections and immune system problems may play a role in ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: clinical condition associated with immune activation.

Landay, A L, Jessop, C, Lennette, E T et al.·Lancet (London, England)·1991

Researchers used specialized tests to examine immune cells from 147 people with ME/CFS and compared them to healthy people. They found that people with ME/CFS had lower levels of certain immune cells (CD8 suppressor cells) and higher levels of immune activation markers on other immune cells. These differences were not seen in healthy people, contacts of patients, or people with other illnesses, suggesting that immune system activation may be involved in ME/CFS.

Immune System

E2 ModerateCohortPEM unclearObservational

Search for an association between Epstein-Barr virus infection and the chronic fatigue syndrome.

Joncas, J H·Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada·1991

This study looked at whether Epstein-Barr virus (EBV), a common virus that causes mononucleosis, might be connected to ME/CFS. Researchers compared people with ME/CFS to other groups to see if they had different levels of EBV infection or antibodies. This was one of the early investigations into potential viral causes of ME/CFS.

Immune System

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Evidence browser

Does chronic fatigue syndrome predispose to non-Hodgkin's lymphoma?

Fluctuations in perceived energy and mood among patients with chronic fatigue syndrome.

Chronic fatigue syndrome criteria. A critique of the requirement for multiple physical complaints.

Attention and short-term memory in chronic fatigue syndrome patients: an event-related potential analysis.

Cell-mediated immunity in patients with chronic fatigue syndrome, healthy control subjects and patients with major depression.

Monospot and VP1 tests in chronic fatigue syndrome and major depression.

Human spumavirus antibodies in sera from African patients.

Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome.

Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome.

Studies on the relationship between chronic fatigue syndrome and Epstein-Barr virus in Japan.

Clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome.

Ureaplasma urealyticum and Mycoplasma hominis in women with systemic lupus erythematosus.

Comorbidity of fibromyalgia with medical and psychiatric disorders.

Epstein-Barr virus serology in the chronic fatigue syndrome.

Alleged link between hepatitis B vaccine and chronic fatigue syndrome.

The economic impact of chronic fatigue syndrome.

[Overview of our patients with chronic fatigue syndrome (CFS) from the pathoetiological aspects].

[Chronic fatigue syndrome--study of 51 cases treated at the Second Tokyo National Hospital].

Chronic fatigue syndrome: clinical condition associated with immune activation.

Search for an association between Epstein-Barr virus infection and the chronic fatigue syndrome.

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