ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2761–2768 of 2,768 studies

E2 ModerateCohortPEM unclearCase-Control

Chronic fatigue syndrome and the diagnostic utility of antibody to Epstein-Barr virus early antigen.

Hellinger, W C, Smith, T F, Van Scoy, R E et al.·JAMA·1988

Researchers tested whether a specific blood marker for Epstein-Barr virus (EBV) could help diagnose chronic fatigue. They compared 30 people with chronic fatigue who had very high levels of this EBV marker to 30 healthy people without the marker. They found no meaningful differences between the two groups in their symptoms, physical exams, or other lab results, and this held true at follow-up visits. The study concluded that this particular EBV blood test is not useful for diagnosing or evaluating chronic fatigue.

E2 ModerateBehavioralPEM not requiredObservational

The frequency of the chronic fatigue syndrome in patients with symptoms of persistent fatigue.

Manu, P, Lane, T J, Matthews, D A·Annals of internal medicine·1988

This study looked at 135 people with severe fatigue lasting at least 6 months to see how many actually had ME/CFS. The researchers found that only 6 patients (about 4%) met the criteria for ME/CFS, while most of the others had psychiatric conditions like depression or anxiety that were causing their fatigue. This suggests that ME/CFS is quite rare among people presenting with fatigue symptoms.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Frequency of 'chronic active Epstein-Barr virus infection' in a general medical practice.

Buchwald, D, Sullivan, J L, Komaroff, A L·JAMA·1987

Researchers studied 500 patients visiting a general doctor's office and found that about 21% experienced severe, ongoing fatigue similar to ME/CFS, often with symptoms like sore throat, muscle pain, and headaches lasting months or years. While some blood tests showed higher levels of Epstein-Barr virus (EBV) antibodies in these patients compared to healthy people, the differences were not strong enough to prove EBV caused their fatigue. The study warns that current EBV blood tests should be interpreted carefully and may not reliably diagnose the cause of chronic fatigue.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Depression in patients with neuromyasthenia (benign myalgic encephalomyelitis).

Taerk, G S, Toner, B B, Salit, I E et al.·International journal of psychiatry in medicine·1987

This study looked at depression in people with ME/CFS (then called neuromyasthenia) using structured interviews and psychological tests. Researchers found that 67% of ME/CFS patients met criteria for major depression, and notably, half of these patients had depression before they developed ME/CFS. The study suggests that some people with ME/CFS may be psychologically vulnerable to developing the condition after a viral illness.

E2 ModerateCohortPEM unclearCross-Sectional

Blood rheology and myalgic encephalomyelitis: a pilot study.

Simpson, L O, Shand, B I, Olds, R J·Pathology·1986

This study examined whether blood flows differently in people with ME/CFS compared to healthy people. Researchers tested blood samples and found that in the early stages of ME/CFS, blood may not flow as easily through tiny blood vessels, which could reduce oxygen delivery to tissues. However, in long-term ME/CFS, these blood flow problems were not observed.

E2 ModerateCohortPEM unclearObservational

A study of Coxsackie B virus infections, 1972-1983.

Bell, E J, McCartney, R A·The Journal of hygiene·1984

Over 12 years, researchers tested blood samples from patients with various illnesses to see if they had been infected with Coxsackie B virus. They found that people with ME/CFS were more likely to have evidence of this virus infection (41% of well-documented ME patients) compared to healthy people (4%). This suggests Coxsackie B virus might play a role in some ME/CFS cases, though the study cannot prove the virus causes the illness.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality and medical perception in benign myalgic encephalomyelitis.

May, P G, Donnan, S P, Ashton, J R et al.·Lancet (London, England)·1980

This 1980 study looked at girls at a school where some developed ME/CFS-like illness during an outbreak. Researchers tested all the girls—both sick and healthy—and found that the sick girls tended to be more emotionally sensitive or anxious than the healthy ones. However, viruses weren't consistently found, and the study suggested that doctors may have sometimes labeled different conditions with the same name, making it harder to understand what was really happening.

E2 ModerateCohortPEM unclearObservational

[Epidemic myalgic encephalomyelitis].

Walther, H·Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis·1972

This 1972 case study describes an outbreak of myalgic encephalomyelitis (ME), a serious illness causing muscle pain, brain inflammation, and extreme fatigue. The author documented patients who experienced this epidemic, helping early medical professionals recognize and understand the disease pattern.

Diagnostics

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