ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

641–660 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Prevalence and correlates of chronic fatigue syndrome and post-traumatic stress disorder after the outbreak of the COVID-19.

Simani, Leila, Ramezani, Mahtab, Darazam, Ilad Alavi et al.·Journal of neurovirology·2021

This study looked at whether people who survived COVID-19 developed chronic fatigue syndrome (ME/CFS) or PTSD within 6 months of infection. Among 120 COVID-19 survivors in Iran, about 2.5% met the criteria for ME/CFS and 5.8% showed signs of PTSD. Interestingly, the researchers found that having PTSD was not linked to developing ME/CFS in these patients.

Long COVID Overlap

E2 ModerateCohortPEM unclearObservational

Oral Minocycline Therapy Improves Symptoms of Myalgic Encephalomyelitis, Especially in the Initial Disease Stage.

Miwa, Kunihisa·Internal medicine (Tokyo, Japan)·2021

Researchers tested whether minocycline, an antibiotic that may reduce brain inflammation, could help ME/CFS patients. About 27% of 100 patients taking minocycline for 6 weeks experienced meaningful symptom improvement, particularly those who had been sick for less than 3 years. However, 38% of patients had to stop taking it early due to side effects like nausea and dizziness.

Neuroinflammation

E2 ModerateCohortPEM unclearCross-Sectional

Cerebral blood flow remains reduced after tilt testing in myalgic encephalomyelitis/chronic fatigue syndrome patients.

van Campen, C Linda M C, Rowe, Peter C, Visser, Frans C·Clinical neurophysiology practice·2021

This study looked at blood flow to the brain in ME/CFS patients during and after a tilt test (where people are tilted upright). Researchers found that when ME/CFS patients were tilted, blood flow to their brain decreased abnormally, and importantly, it did not fully recover even after returning to lying down—unlike their heart's ability to recover. The severity of this delayed blood flow recovery was directly related to how sick the patient was, with the most severely ill patients showing the slowest recovery.

Autonomic Nervous System

E2 ModerateCohortPEM requiredCross-Sectional

Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort.

González-Hermosillo, J Antonio, Martínez-López, Jhanea Patricia, Carrillo-Lampón, Sofía Antonieta et al.·Brain sciences·2021

This study followed 130 people recovering from COVID-19 for 6 months to see how many developed symptoms similar to ME/CFS. Nearly half the patients experienced ongoing fatigue, and those with fatigue tended to be older and had spent more time in the hospital. Only 13% of the patients met the strict diagnostic criteria for ME/CFS, suggesting that while some people have overlapping symptoms, post-COVID fatigue and ME/CFS may be distinct conditions.

E2 ModerateCohortPEM unclearCross-Sectional

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.

Davis, Hannah E, Assaf, Gina S, McCorkell, Lisa et al.·EClinicalMedicine·2021

This study surveyed nearly 3,800 people from around the world who had long-lasting COVID-19 symptoms lasting more than 28 days. By seven months after illness onset, most participants had not fully recovered and experienced an average of 56 symptoms affecting multiple body systems. The three most persistent symptoms were fatigue, post-exertional malaise (feeling worse after activity), and cognitive problems, with nearly 86% experiencing relapses triggered by exercise, physical activity, mental stress, or other exertion.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearLongitudinal

Risks for Developing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in College Students Following Infectious Mononucleosis: A Prospective Cohort Study.

Jason, Leonard A, Cotler, Joseph, Islam, Mohammed F et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2021

This study followed college students to see who developed ME/CFS after getting infectious mononucleosis (mono). Researchers found that about 23% of students who got mono later met criteria for ME/CFS within 6 months. Before getting mono, students who later developed ME/CFS had more physical symptoms and certain immune markers that were different from those who recovered, but they didn't have more stress, anxiety, or depression.

Immune System

E2 ModerateCohortPEM unclearCase-Control

Saliva Fatigue Biomarker Index As a Marker for Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a Community Based Sample.

Jason, Leonard A, Kalns, John, Richarte, Alicia et al.·Fatigue : biomedicine, health & behavior·2021

Researchers tested whether a simple saliva test could help diagnose severe ME/CFS in children and teens. They measured two protein fragments in saliva from young people with ME/CFS and compared them to healthy controls. The study found that this 'Fatigue Biomarker Index' showed significant differences between those with severe ME/CFS and healthy youth, suggesting it might one day be a useful objective test to help doctors diagnose the condition.

Diagnostics

E2 ModerateCohortPEM unclearObservational

Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.

Crosby, L D, Kalanidhi, S, Bonilla, A et al.·Journal of translational medicine·2021

This study looked back at medical records of 101 ME/CFS patients who were prescribed a low dose of aripiprazole, a medication typically used for other conditions. The researchers found that some patients reported improvements in their symptoms. While these results are encouraging, the study design means we need to be cautious about how much weight to give these findings.

Interventions

E2 ModerateCohortPEM unclearObservational

Sex-specific plasma lipid profiles of ME/CFS patients and their association with pain, fatigue, and cognitive symptoms.

Nkiliza, Aurore, Parks, Megan, Cseresznye, Adam et al.·Journal of translational medicine·2021

This study analyzed fatty substances in the blood of ME/CFS patients and healthy controls to see if they differ in ways that might explain symptoms. Researchers found that men and women with ME/CFS had different patterns of these blood fats compared to healthy people. Importantly, certain blood fats were connected to the severity of fatigue, headaches, and thinking difficulties, suggesting that problems with how the body processes fats may play a role in ME/CFS symptoms.

BiomarkersEnergy MetabolismImmune System

E2 ModeratePEM not requiredRegistry-Resource

Sarcoidosis among US Hispanics in a Nationwide Registry.

Innabi, Ayoub, Alzghoul, Bashar N, Kalra, Saminder et al.·Respiratory medicine·2021

This study looked at how sarcoidosis (a disease that causes inflammation in the body) affects Hispanic patients in the United States compared to non-Hispanic patients. Researchers surveyed nearly 3,835 people and found that Hispanic patients with sarcoidosis experience more depression, chronic pain, sleep problems, and job loss than non-Hispanic patients. The findings suggest that doctors may need to approach treatment differently for Hispanic patients with this condition.

Pain and SensitizationSleep

E2 ModerateCohortPEM requiredCase-Control

Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci.

Hajdarevic, Riad, Lande, Asgeir, Rekeland, Ingrid et al.·Brain, behavior, and immunity·2021

This study looked at genes related to the immune system in people with ME/CFS to understand why some people develop the condition. Researchers compared genetic markers in 427 Norwegian ME/CFS patients with 480 healthy controls and found two specific genetic regions associated with ME/CFS—one involving immune system genes that present antigens to cells, and another in a different immune region. These findings suggest the immune system's ability to recognize and respond to threats may play a role in ME/CFS.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Experiential avoidance is associated with medical and mental health diagnoses in a national sample of deployed Gulf War veterans.

Blakey, Shannon M, Halverson, Tate F, Evans, Mariah K et al.·Journal of psychiatric research·2021

This study looked at whether avoiding uncomfortable thoughts and feelings is connected to health problems in Gulf War veterans. Researchers surveyed over 450 veterans and found that those who tend to avoid dealing with difficult emotions were more likely to have PTSD, depression, chronic fatigue syndrome, fibromyalgia, and digestive problems—even after accounting for combat exposure and chemical exposure during the war.

E2 ModerateCohortPEM unclearCross-Sectional

Subcortical brain segment volumes in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Addiego, Florencia Martinez, Zajur, Kristina, Knack, Sarah et al.·Life sciences·2021

Researchers used brain imaging to measure the size of deep brain structures in people with ME/CFS, Gulf War Illness, and healthy controls. They found that men and women with these conditions had different patterns of brain volume changes, suggesting that sex differences play an important role in how these illnesses affect the brain. The findings suggest that previous brain imaging studies may need to be reconsidered to account for whether participants were male or female.

E2 ModerateCohortPEM not requiredCross-Sectional

Potential of Activin B as a Clinical Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Gravelsina, Sabine, Nora-Krukle, Zaiga, Vilmane, Anda et al.·Biomolecules·2021

Researchers tested whether a protein called activin B could be used as a simple blood test to diagnose ME/CFS. They compared activin B levels in 134 people with ME/CFS and 54 healthy people, but found no meaningful difference between the two groups. Based on these results, activin B does not appear to be a useful diagnostic tool for ME/CFS.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Associations between the gut microbiome and fatigue in cancer patients.

Hajjar, Joud, Mendoza, Tito, Zhang, Liangliang et al.·Scientific reports·2021

Researchers studied 88 cancer patients to see if the bacteria living in their gut were connected to cancer-related fatigue. They found that certain beneficial bacteria (Eubacterium hallii) were linked to lower fatigue levels, while other bacteria (Cosenzaea) were linked to higher fatigue. This suggests that the mix of gut bacteria might play a role in how tired cancer patients feel, opening the door to new treatments.

Gut Microbiome

E2 ModerateCohortPEM unclearCross-Sectional

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

Metselaar, Paula I, Mendoza-Maldonado, Lucero, Li Yim, Andrew Yung Fong et al.·Scientific reports·2021

Researchers found a set of 23 genes in blood cells that could reliably identify people with ME/CFS. By looking at both gene activity and chemical markers on genes, they developed a test that correctly identified ME/CFS patients about 92-97% of the time. This is important because there's currently no reliable blood test to diagnose ME/CFS.

BiomarkersImmune System

E2 ModerateCohortPEM unclearCross-Sectional

Medical School Education on Myalgic Encephalomyelitis.

Muirhead, Nina, Muirhead, John, Lavery, Grace et al.·Medicina (Kaunas, Lithuania)·2021

This study looked at how much medical schools in the UK teach doctors-in-training about ME/CFS. Researchers sent questionnaires to all 34 UK medical schools and found that only about half actually teach ME/CFS, and the teaching varies widely between schools. Most schools said they would welcome better teaching materials and resources about ME/CFS, suggesting doctors need more education on how to recognize and diagnose this condition.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Infections in temporal proximity to HPV vaccination and adverse effects following vaccination in Denmark: A nationwide register-based cohort study and case-crossover analysis.

Krogsgaard, Lene Wulff, Petersen, Irene, Plana-Ripoll, Oleguer et al.·PLoS medicine·2021

This study examined whether having an infection around the time of HPV vaccination increases the risk of developing illness symptoms afterward in Danish women. Researchers found that women who had a treated infection within one month before or after their first HPV vaccine dose were more likely to later seek care at specialized centers for suspected vaccine side effects. The symptoms reported were similar to those seen in chronic fatigue syndrome.

E2 ModerateCohortPEM unclearCross-Sectional

Who should we ask about mental health symptoms in adolescents with CFS/ME? Parent-child agreement on the revised children's anxiety and depression scale.

Serafimova, Teona, Loades, Maria, Gaunt, Daisy et al.·Clinical child psychology and psychiatry·2021

This study looked at how well parents and teenagers with ME/CFS agreed when reporting on anxiety and depression symptoms. Researchers compared what 93 teenagers said about their mental health with what their parents said, using a standard questionnaire. Both teenagers and parents were reasonably accurate at spotting mental health problems, though teenagers more often reported reaching diagnostic thresholds. The findings suggest that doctors should listen to both the young person and their parent, since severe fatigue might make it harder for teenagers to fully report their symptoms on their own.

E2 ModerateCohortPEM unclearCross-Sectional

Exercise modifies glutamate and other metabolic biomarkers in cerebrospinal fluid from Gulf War Illness and Myalgic encephalomyelitis / Chronic Fatigue Syndrome.

Baraniuk, James N, Kern, Grant, Narayan, Vaishnavi et al.·PloS one·2021

Researchers studied the fluid around the brain and spinal cord in people with ME/CFS and Gulf War Illness to see how exercise affects certain chemicals in the body. They found that glutamate (a brain chemical) levels changed differently depending on whether someone had exercised and how their body responded, and that some fat-related molecules were different between the two conditions. This suggests that ME/CFS and Gulf War Illness may involve different problems with how the body uses energy and processes fats.

NeuroinflammationBiomarkersPost-Exertional Malaise

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Evidence browser

Prevalence and correlates of chronic fatigue syndrome and post-traumatic stress disorder after the outbreak of the COVID-19.

Oral Minocycline Therapy Improves Symptoms of Myalgic Encephalomyelitis, Especially in the Initial Disease Stage.

Cerebral blood flow remains reduced after tilt testing in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort.

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.

Risks for Developing Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in College Students Following Infectious Mononucleosis: A Prospective Cohort Study.

Saliva Fatigue Biomarker Index As a Marker for Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a Community Based Sample.

Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.

Sex-specific plasma lipid profiles of ME/CFS patients and their association with pain, fatigue, and cognitive symptoms.

Sarcoidosis among US Hispanics in a Nationwide Registry.

Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci.

Experiential avoidance is associated with medical and mental health diagnoses in a national sample of deployed Gulf War veterans.

Subcortical brain segment volumes in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Potential of Activin B as a Clinical Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Associations between the gut microbiome and fatigue in cancer patients.

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

Medical School Education on Myalgic Encephalomyelitis.

Infections in temporal proximity to HPV vaccination and adverse effects following vaccination in Denmark: A nationwide register-based cohort study and case-crossover analysis.

Who should we ask about mental health symptoms in adolescents with CFS/ME? Parent-child agreement on the revised children's anxiety and depression scale.

Exercise modifies glutamate and other metabolic biomarkers in cerebrospinal fluid from Gulf War Illness and Myalgic encephalomyelitis / Chronic Fatigue Syndrome.

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