ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

641–660 of 2,784 studies

E2 ModerateCohortPEM requiredCross-Sectional

A preliminary investigation of nutritional intake and supplement use in Australians with myalgic encephalomyelitis/chronic fatigue syndrome and the implications on health-related quality of life.

Weigel, Breanna, Eaton-Fitch, Natalie, Passmore, Rachel et al.·Food & nutrition research·2021

This study looked at what Australian ME/CFS patients eat and what supplements they take, and whether these choices affect their quality of life. Researchers surveyed 24 ME/CFS patients online and compared their diets to the general Australian population. They found that ME/CFS patients use supplements much more often than the general public, but couldn't find a clear link between specific nutrients or supplements and how patients felt.

E2 ModerateCohortPEM unclearCross-Sectional

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.

Davis, Hannah E, Assaf, Gina S, McCorkell, Lisa et al.·EClinicalMedicine·2021

This study surveyed nearly 3,800 people from around the world who had long-lasting COVID-19 symptoms lasting more than 28 days. By seven months after illness onset, most participants had not fully recovered and experienced an average of 56 symptoms affecting multiple body systems. The three most persistent symptoms were fatigue, post-exertional malaise (feeling worse after activity), and cognitive problems, with nearly 86% experiencing relapses triggered by exercise, physical activity, mental stress, or other exertion.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCase-Control

Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Van Oosterwijck, Jessica, Marusic, Uros, De Wandele, Inge et al.·Journal of clinical medicine·2021

This study examined how the nervous system controls heart rate and other body functions in ME/CFS patients compared to healthy people, both at rest and after exercise. Researchers found that while ME/CFS patients had normal nerve function at rest, their bodies had difficulty recovering after exercise—specifically, their parasympathetic nervous system (the 'rest and digest' system) didn't reactivate properly. This delayed recovery is concerning because similar patterns in other diseases are linked to worse health outcomes.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

A Comparison of Patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis from the United States and Japan.

Wiedbusch, Elzbieta, Cotler, Joseph, Jason, Leonard A·Journal of preventive medicine & healthcare·2021

This study compared how ME/CFS affects people in the United States and Japan by surveying 124 Japanese patients and 210 U.S. patients. The research found that U.S. patients reported more severe brain fog, stomach problems, and exhaustion after activity compared to Japanese patients. Interestingly, Japanese women experienced similar levels of disability as American patients despite being less likely to receive official disability support.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

Metselaar, Paula I, Mendoza-Maldonado, Lucero, Li Yim, Andrew Yung Fong et al.·Scientific reports·2021

Researchers found a set of 23 genes in blood cells that could reliably identify people with ME/CFS. By looking at both gene activity and chemical markers on genes, they developed a test that correctly identified ME/CFS patients about 92-97% of the time. This is important because there's currently no reliable blood test to diagnose ME/CFS.

BiomarkersImmune System

E2 ModerateCohortPEM unclearCross-Sectional

Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Krumina, Angelika, Vecvagare, Katrine, Svirskis, Simons et al.·Medicina (Kaunas, Lithuania)·2021

This study looked at 65 people with ME/CFS in Latvia to understand their main symptoms and how the condition differs from simple tiredness. Researchers found that people with ME/CFS commonly experience fatigue, muscle pain, joint pain, and sleep problems—more often than people without ME/CFS. When patients had other health conditions alongside ME/CFS, their symptoms tended to be more severe.

Pain and SensitizationSleepDiagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Major Impact on Lives of Both Patients and Family Members.

Brittain, Esme, Muirhead, Nina, Finlay, Andrew Y et al.·Medicina (Kaunas, Lithuania)·2021

This study looked at how ME/CFS affects the quality of life of patients and their family members using two surveys. The researchers found that ME/CFS seriously damages patients' quality of life, particularly in physical health, and also significantly impacts the wellbeing of partners and family members who care for them. The study shows that family members experience worry, sadness, and difficulty maintaining normal family activities because of their loved one's illness.

E2 ModerateCohortPEM unclearCross-Sectional

Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Zinn, Mark A, Jason, Leonard A·International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2021

This study looked at how the brain controls the autonomic nervous system (the part that manages heart rate, breathing, and other automatic functions) in people with ME/CFS. Researchers used special brain recordings to measure electrical activity in 34 ME/CFS patients and 34 healthy people at rest, then looked for differences in how different brain regions communicate with each other. They found that people with ME/CFS had different patterns of brain communication, and these differences were connected to specific symptoms like fatigue, thinking problems, and pain.

Autonomic Nervous System

E2 ModerateCohortPEM requiredCross-Sectional

Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort.

González-Hermosillo, J Antonio, Martínez-López, Jhanea Patricia, Carrillo-Lampón, Sofía Antonieta et al.·Brain sciences·2021

This study followed 130 people recovering from COVID-19 for 6 months to see how many developed symptoms similar to ME/CFS. Nearly half the patients experienced ongoing fatigue, and those with fatigue tended to be older and had spent more time in the hospital. Only 13% of the patients met the strict diagnostic criteria for ME/CFS, suggesting that while some people have overlapping symptoms, post-COVID fatigue and ME/CFS may be distinct conditions.

E2 ModerateCohortPEM unclearCross-Sectional

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE).

Cullinan, John, Pheby, Derek F H, Araja, Diana et al.·Medicina (Kaunas, Lithuania)·2021

ME/CFS experts across Europe were asked what they think family doctors know about ME/CFS and how to help them understand it better. The experts reported serious concerns: about 60% of ME/CFS patients go undiagnosed because family doctors lack knowledge about the condition, don't believe it's real, or don't know how to manage it. Most experts agreed that better training for doctors at all levels would help.

Diagnostics

E2 ModerateCohortPEM requiredCross-Sectional

Diffusion tensor imaging reveals neuronal microstructural changes in myalgic encephalomyelitis/chronic fatigue syndrome.

Thapaliya, Kiran, Marshall-Gradisnik, Sonya, Staines, Donald et al.·The European journal of neuroscience·2021

This study used a specialized brain imaging technique called diffusion tensor imaging (DTI) to look for structural changes in the brains of ME/CFS patients compared to healthy people. The researchers found subtle differences in how water moves through certain nerve fiber pathways in the brains of patients who met strict diagnostic criteria for ME/CFS, particularly in areas controlling movement, coordination, and breathing. These brain changes were linked to patient symptoms like difficulty processing information, fatigue, and sleep problems.

E2 ModerateCohortPEM unclearCross-Sectional

Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Simonato, Manuela, Dall'Acqua, Stefano, Zilli, Caterina et al.·Biomedicines·2021

This study compared blood samples from 40 people with ME/CFS to 40 healthy people to look for biological differences. Researchers found that ME/CFS patients had different levels of certain molecules related to immune function, gut health, and how the body uses the amino acid tryptophan. These differences were independent of each other, suggesting multiple biological pathways may be disrupted in ME/CFS.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Parent-child discrepancies in health-related quality of life of children and adolescents with myalgic encephalomyelitis/chronic fatigue syndrome.

Ekberg, Krista M, Torres, Chelsea, Jason, Leonard A·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2021

This study looked at whether parents and their children with ME/CFS report symptoms and quality of life differently. Researchers compared 75 families where children had ME/CFS and 72 families without the condition, asking both parents and children to describe the child's health and symptoms. They found that parents and children often gave different answers, suggesting that both perspectives are important for understanding how ME/CFS affects young people.

E2 ModerateCohortPEM unclearObservational

Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Greatly Improved Fatigue Symptoms When Treated with Oxygen-Ozone Autohemotherapy.

Tirelli, Umberto, Franzini, Marianno, Valdenassi, Luigi et al.·Journal of clinical medicine·2021

This study tested whether a treatment called oxygen-ozone autohemotherapy (a procedure where blood is drawn, treated with ozone gas, and returned to the body) could help ME/CFS patients with fatigue. Among 200 patients treated, most experienced significant improvements in their fatigue levels within 30 days, with nearly half reporting the best possible improvement on a fatigue scale. No serious side effects were reported.

E2 ModerateCohortPEM unclearCross-Sectional

Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Li, Xia, Julin, Per, Li, Tie-Qiang·Tomography (Ann Arbor, Mich.)·2021

Researchers used a specialized brain imaging technique to measure blood flow in the brains of ME/CFS patients and compared it to healthy people. They found that patients with ME/CFS have reduced blood flow in several areas of the limbic system—the part of the brain that helps control emotions, automatic body functions, and memory. The amount of reduced blood flow was also linked to how severe patients' symptoms were.

Autonomic Nervous System

E2 ModerateBehavioralPEM unclearCross-Sectional

How common are depression and anxiety in adolescents with chronic fatigue syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study.

Loades, Maria E, Read, Rebecca, Smith, Lucie et al.·European child & adolescent psychiatry·2021

This study looked at how common depression and anxiety are in teenagers with ME/CFS. Researchers interviewed 164 young people with ME/CFS and their parents using detailed diagnostic interviews and questionnaires. They found that about 1 in 3 teenagers had depression or anxiety, which is higher than expected. However, the questionnaires commonly used to screen for these conditions were not always accurate at detecting problems in this group, so doctors need to be careful and do thorough assessments rather than relying on questionnaires alone.

E2 ModerateCohortPEM not requiredCross-Sectional

The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

Murga, Iñigo, Aranburu, Larraitz, Gargiulo, Pascual A et al.·Journal of translational medicine·2021

This study looked at attention problems in ME/CFS patients by giving them a simple attention test (the Toulouse-Piéron test) and comparing their results to healthy people. Most ME/CFS patients had normal overall thinking skills, but 70% showed very low attention scores and complained of mental fatigue. Women with ME/CFS reported feeling more effort during the test than men did, even though their attention scores were similar.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome.

Laden, Bethany F, Bresee, Catherine, De Hoedt, Amanda et al.·Urology·2021

This study looked at how often people with bladder pain syndrome (IC/BPS) also have other health conditions, using data from a large group of veterans. Researchers found that people with IC/BPS are much more likely to have multiple overlapping conditions—including chronic fatigue syndrome, fibromyalgia, IBS, and migraines—as well as mental health challenges like depression and trauma. These patterns were especially strong in women.

E2 ModerateCohortPEM unclearObservational

Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.

Crosby, L D, Kalanidhi, S, Bonilla, A et al.·Journal of translational medicine·2021

This study looked back at medical records of 101 ME/CFS patients who were prescribed a low dose of aripiprazole, a medication typically used for other conditions. The researchers found that some patients reported improvements in their symptoms. While these results are encouraging, the study design means we need to be cautious about how much weight to give these findings.

Interventions

E2 ModerateCohortPEM unclearCase-Control

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study.

Josev, Elisha K, Cole, Rebecca C, Scheinberg, Adam et al.·Journal of clinical medicine·2021

This study followed Australian teenagers with ME/CFS for about two years after diagnosis to see how they were doing. While many young people improved in mood and some symptoms, fatigue, pain, and overall quality of life stayed significantly worse compared to healthy teenagers. About two-thirds of the teens still had ME/CFS at follow-up, suggesting the condition often persists in the early years after diagnosis.

Pain and Sensitization

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

A preliminary investigation of nutritional intake and supplement use in Australians with myalgic encephalomyelitis/chronic fatigue syndrome and the implications on health-related quality of life.

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.

Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

A Comparison of Patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis from the United States and Japan.

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Major Impact on Lives of Both Patients and Family Members.

Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort.

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE).

Diffusion tensor imaging reveals neuronal microstructural changes in myalgic encephalomyelitis/chronic fatigue syndrome.

Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Parent-child discrepancies in health-related quality of life of children and adolescents with myalgic encephalomyelitis/chronic fatigue syndrome.

Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Greatly Improved Fatigue Symptoms When Treated with Oxygen-Ozone Autohemotherapy.

Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

How common are depression and anxiety in adolescents with chronic fatigue syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study.

The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome.

Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripiprazole.

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research