ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

661–680 of 2,784 studies

E2 ModerateCohortPEM unclearLongitudinal

Impact of Life Stressors on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symptoms: An Australian Longitudinal Study.

Balinas, Cassandra, Eaton-Fitch, Natalie, Maksoud, Rebekah et al.·International journal of environmental research and public health·2021

This Australian study followed 36 ME/CFS patients over five months to see how life stressors affected their symptoms. The researchers found that major life changes like work disruptions or money problems were linked to worsening symptoms like brain fog, stomach issues, pain, and sleep problems. Interestingly, patients who had better access to healthcare and support services experienced fewer severe symptoms.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM unclearCross-Sectional

How common are depression and anxiety in adolescents with chronic fatigue syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study.

Loades, Maria E, Read, Rebecca, Smith, Lucie et al.·European child & adolescent psychiatry·2021

This study looked at how common depression and anxiety are in teenagers with ME/CFS. Researchers interviewed 164 young people with ME/CFS and their parents using detailed diagnostic interviews and questionnaires. They found that about 1 in 3 teenagers had depression or anxiety, which is higher than expected. However, the questionnaires commonly used to screen for these conditions were not always accurate at detecting problems in this group, so doctors need to be careful and do thorough assessments rather than relying on questionnaires alone.

E2 ModerateCohortPEM not requiredObservational

Infections in temporal proximity to HPV vaccination and adverse effects following vaccination in Denmark: A nationwide register-based cohort study and case-crossover analysis.

Krogsgaard, Lene Wulff, Petersen, Irene, Plana-Ripoll, Oleguer et al.·PLoS medicine·2021

This study examined whether having an infection around the time of HPV vaccination increases the risk of developing illness symptoms afterward in Danish women. Researchers found that women who had a treated infection within one month before or after their first HPV vaccine dose were more likely to later seek care at specialized centers for suspected vaccine side effects. The symptoms reported were similar to those seen in chronic fatigue syndrome.

E2 ModerateCohortPEM not requiredCross-Sectional

The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

Murga, Iñigo, Aranburu, Larraitz, Gargiulo, Pascual A et al.·Journal of translational medicine·2021

This study looked at attention problems in ME/CFS patients by giving them a simple attention test (the Toulouse-Piéron test) and comparing their results to healthy people. Most ME/CFS patients had normal overall thinking skills, but 70% showed very low attention scores and complained of mental fatigue. Women with ME/CFS reported feeling more effort during the test than men did, even though their attention scores were similar.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

A retrospective cross-sectional study on tinnitus prevalence and disease associations in the Dutch population-based cohort Lifelines.

Schubert, Nick M A, Rosmalen, Judith G M, van Dijk, Pim et al.·Hearing research·2021

This study looked at how common tinnitus (ringing in the ears) is in a large group of Dutch adults and found that about one-third experience it at some point. The researchers discovered that tinnitus is linked to various conditions including hearing problems, heart issues, depression, and notably, chronic fatigue syndrome (ME/CFS). Understanding these connections may help doctors better treat tinnitus and related conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

Postural orthostatic tachycardia syndrome in patients of orthostatic intolerance symptoms: an ambispective study.

Chouksey, Dinesh, Rathi, Pankaj, Sodani, Ajoy et al.·AIMS neuroscience·2021

This study looked at patients who experience dizziness, fainting, or heart racing when standing up—symptoms of a condition called POTS (Postural Orthostatic Tachycardia Syndrome). Researchers tested 246 patients with these symptoms and confirmed POTS in 40 of them using a special tilt-table test. Most POTS patients experienced fainting, lightheadedness, and heart palpitations, and nearly half also had a related condition causing fainting.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women.

Shafrir, Amy L, Palmor, Marissa C, Fourquet, Jessica et al.·American journal of reproductive immunology (New York, N.Y. : 1989)·2021

This study looked at whether young women and adolescents with endometriosis (a painful condition where tissue grows outside the uterus) are more likely to have immune system problems like allergies, asthma, or chronic fatigue. Researchers compared 551 women with surgically confirmed endometriosis to 652 women without it and found that those with endometriosis were significantly more likely to have chronic fatigue syndrome, fibromyalgia, or a history of mononucleosis. The more immune-related conditions a woman had, the higher her chances of also having endometriosis.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID.

Haran, John P, Bradley, Evan, Zeamer, Abigail L et al.·JCI insight·2021

This study looked at bacteria in the mouth of people with COVID-19 to understand why some people develop long COVID. Researchers found that people with long COVID had higher levels of inflammation-causing bacteria, particularly types called Prevotella and Veillonella. Interestingly, the oral bacteria patterns in long COVID patients resembled those seen in chronic fatigue syndrome patients, suggesting the microbiome may play a role in prolonged illness.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue of nurses in view of the challenges of contemporary psychiatric care. Do temperament and work environment matter?

Sygit-Kowalkowska, Ewa·Psychiatria polska·2021

This study looked at fatigue in psychiatric nurses and found that most experienced moderate to high levels of chronic fatigue. The research suggests that workplace communication problems—like unclear instructions and poor teamwork—may contribute to this fatigue, and that some people's personality traits may make them more resilient to fatigue than others.

E2 ModerateCohortPEM not requiredCross-Sectional

Potential of Activin B as a Clinical Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Gravelsina, Sabine, Nora-Krukle, Zaiga, Vilmane, Anda et al.·Biomolecules·2021

Researchers tested whether a protein called activin B could be used as a simple blood test to diagnose ME/CFS. They compared activin B levels in 134 people with ME/CFS and 54 healthy people, but found no meaningful difference between the two groups. Based on these results, activin B does not appear to be a useful diagnostic tool for ME/CFS.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments.

Almulla, Abbas F, Moustafa, Shatha R, Al-Dujaili, Arafat H et al.·Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)·2021

This study looked at a mineral called cesium in the blood of people with schizophrenia and compared it to healthy people. They found that people with schizophrenia had lower cesium levels, and this was connected to cognitive problems (like memory and thinking difficulties), fatigue symptoms, and signs of immune system activity. The researchers suggest that low cesium might contribute to some of the symptoms seen in schizophrenia.

Immune System

E2 ModerateCohortPEM requiredCase-Control

Female Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome or Idiopathic Chronic Fatigue: Comparison of Responses to a Two-Day Cardiopulmonary Exercise Testing Protocol.

van Campen, C Linda M C, Visser, Frans C·Healthcare (Basel, Switzerland)·2021

This study tested whether people with ME/CFS and people with chronic fatigue (but not ME/CFS) respond differently to exercise on two consecutive days. Researchers had 50 women with ME/CFS and 51 women with chronic fatigue perform exercise tests while measuring oxygen use and heart rate. Women with ME/CFS performed worse on day 2, while women with chronic fatigue actually performed slightly better, suggesting ME/CFS creates a unique pattern of exercise intolerance.

Post-Exertional Malaise

E2 ModerateCohortPEM requiredObservational

Markers of Cardiac Autonomic Function During Consecutive Day Peak Exercise Tests in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Nelson, Maximillian J, Buckley, Jonathan D, Thomson, Rebecca L et al.·Frontiers in physiology·2021

This study looked at how the hearts of ME/CFS patients respond to exercise on two consecutive days, comparing them to healthy people. Researchers measured heart rate patterns and recovery after exercise, finding that ME/CFS patients had slower heart rate recovery after working out. However, these measurements alone were not reliable enough to diagnose ME/CFS, suggesting that a single heart rate test may not be a useful diagnostic tool on its own.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Chronotropic Incompetence in Non-Hospitalized Patients with Post-COVID-19 Syndrome.

Jimeno-Almazán, Amaya, Pallarés, Jesús G, Buendía-Romero, Ángel et al.·Journal of clinical medicine·2021

Some people who recover from COVID-19 experience persistent fatigue and difficulty exercising for months afterward. This study tested 32 people with long-lasting COVID symptoms and found that about 12% had a specific heart problem called chronotropic incompetence—their heart rate doesn't increase normally during exercise. This heart rhythm problem may explain why some patients struggle with exercise intolerance after COVID-19.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt.

Aly, Menna A E G, Saber, Heba G·International journal of clinical practice·2021

This study looked at 115 elderly women in Egypt who had recovered from COVID-19 to see if their lingering symptoms might lead to chronic fatigue syndrome (ME/CFS). Most women reported problems like fatigue, muscle pain, and sleep trouble after COVID, and the study found that stress, sadness, and poor sleep were most strongly linked to developing CFS-like symptoms. Only one person in the study actually met full criteria for probable CFS, but the researchers suggest doctors should watch for these warning signs in long COVID patients.

SleepCognitive Impairment

E2 ModerateCohortPEM requiredCase-Control

Hypothalamic-Pituitary Autoimmunity and Related Impairment of Hormone Secretions in Chronic Fatigue Syndrome.

De Bellis, Annamaria, Bellastella, Giuseppe, Pernice, Vlenia et al.·The Journal of clinical endocrinology and metabolism·2021

This study looked for specific immune system antibodies that attack the pituitary and hypothalamus—two small brain structures that control hormone production—in people with ME/CFS. Researchers found these antibodies in more than half of ME/CFS patients but none in healthy controls. Patients with these antibodies had lower levels of important hormones (like cortisol and growth hormone), and those with the highest antibody levels had the most severe ME/CFS symptoms.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Association between chronic fatigue syndrome and suicidality among survivors of Middle East respiratory syndrome over a 2-year follow-up period.

Ahn, So-Hyun, Kim, Jeong Lan, Kim, Jang Rae et al.·Journal of psychiatric research·2021

This study followed people who recovered from MERS (a serious respiratory illness) for 2 years to see if chronic fatigue increased their risk of suicidal thoughts. Researchers found that people who had chronic fatigue were about 7.5 times more likely to experience suicidal thoughts than those without fatigue. This connection remained strong even when accounting for other factors that might affect mental health.

E2 ModerateCohortPEM unclearCross-Sectional

Comparative Survey of People with ME/CFS in Italy, Latvia, and the UK: A Report on Behalf of the Socioeconomics Working Group of the European ME/CFS Research Network (EUROMENE).

Brenna, Elenka, Araja, Diana, Pheby, Derek F H·Medicina (Kaunas, Lithuania)·2021

Researchers surveyed people with ME/CFS in Italy, Latvia, and the UK to understand how the disease affects their lives and finances. They found that ME/CFS has a serious impact on income and quality of life across all three countries, and that graded exercise therapy (a treatment commonly used in the UK) did not work for patients. The study also revealed differences in how doctors diagnose and treat ME/CFS depending on which country people live in.

E2 ModerateCohortPEM unclearCross-Sectional

Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping.

Castro-Marrero, Jesús, Zacares, Mario, Almenar-Pérez, Eloy et al.·Journal of clinical medicine·2021

Researchers analyzed blood samples from 250 women with ME/CFS to see if specific blood markers could help identify different types of the disease. They found that about 43% of participants had high levels of a protein called C1q, which was particularly associated with those experiencing more pain symptoms. This discovery suggests that blood tests might one day help doctors identify which ME/CFS patients belong to which subgroup, potentially leading to better tailored treatments.

Immune System

E2 ModerateCohortPEM requiredCross-Sectional

Homebound versus Bedridden Status among Those with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Conroy, Karl, Bhatia, Shaun, Islam, Mohammed et al.·Healthcare (Basel, Switzerland)·2021

This study looked at over 2,100 people with ME/CFS to understand different levels of severity, focusing on those who are homebound (unable to leave home) and bedridden (unable to leave bed). The researchers found that people who are bedridden experience post-exertional malaise (PEM)—a worsening of symptoms after physical or mental activity—differently or more severely than those who are only homebound. This research helps doctors and patients better understand how severe ME/CFS can become.

Post-Exertional Malaise

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Impact of Life Stressors on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Symptoms: An Australian Longitudinal Study.

How common are depression and anxiety in adolescents with chronic fatigue syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study.

Infections in temporal proximity to HPV vaccination and adverse effects following vaccination in Denmark: A nationwide register-based cohort study and case-crossover analysis.

The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

A retrospective cross-sectional study on tinnitus prevalence and disease associations in the Dutch population-based cohort Lifelines.

Postural orthostatic tachycardia syndrome in patients of orthostatic intolerance symptoms: an ambispective study.

Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women.

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID.

Chronic fatigue of nurses in view of the challenges of contemporary psychiatric care. Do temperament and work environment matter?

Potential of Activin B as a Clinical Biomarker in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments.

Female Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome or Idiopathic Chronic Fatigue: Comparison of Responses to a Two-Day Cardiopulmonary Exercise Testing Protocol.

Markers of Cardiac Autonomic Function During Consecutive Day Peak Exercise Tests in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Chronotropic Incompetence in Non-Hospitalized Patients with Post-COVID-19 Syndrome.

Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt.

Hypothalamic-Pituitary Autoimmunity and Related Impairment of Hormone Secretions in Chronic Fatigue Syndrome.

Association between chronic fatigue syndrome and suicidality among survivors of Middle East respiratory syndrome over a 2-year follow-up period.

Comparative Survey of People with ME/CFS in Italy, Latvia, and the UK: A Report on Behalf of the Socioeconomics Working Group of the European ME/CFS Research Network (EUROMENE).

Complement Component C1q as a Potential Diagnostic Tool for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Subtyping.

Homebound versus Bedridden Status among Those with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

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