ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

661–680 of 2,795 studies

E2 ModerateCohortPEM unclearCross-Sectional

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.

Davis, Hannah E, Assaf, Gina S, McCorkell, Lisa et al.·EClinicalMedicine·2021

This study surveyed nearly 3,800 people from around the world who had long-lasting COVID-19 symptoms lasting more than 28 days. By seven months after illness onset, most participants had not fully recovered and experienced an average of 56 symptoms affecting multiple body systems. The three most persistent symptoms were fatigue, post-exertional malaise (feeling worse after activity), and cognitive problems, with nearly 86% experiencing relapses triggered by exercise, physical activity, mental stress, or other exertion.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

Beyond bones: The relevance of variants of connective tissue (hypermobility) to fibromyalgia, ME/CFS and controversies surrounding diagnostic classification: an observational study.

Eccles, Jessica A, Thompson, Beth, Themelis, Kristy et al.·Clinical medicine (London, England)·2021

This study looked at whether joint hypermobility (unusual flexibility and loose joints) is connected to fibromyalgia and ME/CFS. Researchers found that most patients with these conditions also had signs of hypermobility, and that higher hypermobility scores matched with worse symptoms. The results suggest that hypermobility is often missed in diagnosis, even though it significantly affects how sick people feel.

Diagnostics

E2 ModerateCohortPEM not requiredLongitudinal

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID.

Haran, John P, Bradley, Evan, Zeamer, Abigail L et al.·JCI insight·2021

This study looked at bacteria in the mouth of people with COVID-19 to understand why some people develop long COVID. Researchers found that people with long COVID had higher levels of inflammation-causing bacteria, particularly types called Prevotella and Veillonella. Interestingly, the oral bacteria patterns in long COVID patients resembled those seen in chronic fatigue syndrome patients, suggesting the microbiome may play a role in prolonged illness.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight.

Kuo, Chien-Feng, Shi, Leiyu, Lin, Cheng-Li et al.·Scientific reports·2021

This study looked at whether people who have had peptic ulcers (stomach ulcers often caused by H. pylori bacteria) are at higher risk of developing ME/CFS. Researchers compared hospital records from Taiwan for people with and without peptic ulcers over many years. They found that people with a history of peptic ulcers were about twice as likely to develop ME/CFS, with higher risk in women and older adults.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Krumina, Angelika, Vecvagare, Katrine, Svirskis, Simons et al.·Medicina (Kaunas, Lithuania)·2021

This study looked at 65 people with ME/CFS in Latvia to understand their main symptoms and how the condition differs from simple tiredness. Researchers found that people with ME/CFS commonly experience fatigue, muscle pain, joint pain, and sleep problems—more often than people without ME/CFS. When patients had other health conditions alongside ME/CFS, their symptoms tended to be more severe.

Pain and SensitizationSleepDiagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Major Impact on Lives of Both Patients and Family Members.

Brittain, Esme, Muirhead, Nina, Finlay, Andrew Y et al.·Medicina (Kaunas, Lithuania)·2021

This study looked at how ME/CFS affects the quality of life of patients and their family members using two surveys. The researchers found that ME/CFS seriously damages patients' quality of life, particularly in physical health, and also significantly impacts the wellbeing of partners and family members who care for them. The study shows that family members experience worry, sadness, and difficulty maintaining normal family activities because of their loved one's illness.

E2 ModerateCohortPEM unclearCross-Sectional

Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Zinn, Mark A, Jason, Leonard A·International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2021

This study looked at how the brain controls the autonomic nervous system (the part that manages heart rate, breathing, and other automatic functions) in people with ME/CFS. Researchers used special brain recordings to measure electrical activity in 34 ME/CFS patients and 34 healthy people at rest, then looked for differences in how different brain regions communicate with each other. They found that people with ME/CFS had different patterns of brain communication, and these differences were connected to specific symptoms like fatigue, thinking problems, and pain.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE).

Cullinan, John, Pheby, Derek F H, Araja, Diana et al.·Medicina (Kaunas, Lithuania)·2021

ME/CFS experts across Europe were asked what they think family doctors know about ME/CFS and how to help them understand it better. The experts reported serious concerns: about 60% of ME/CFS patients go undiagnosed because family doctors lack knowledge about the condition, don't believe it's real, or don't know how to manage it. Most experts agreed that better training for doctors at all levels would help.

Diagnostics

E2 ModerateCohortPEM requiredCross-Sectional

Diffusion tensor imaging reveals neuronal microstructural changes in myalgic encephalomyelitis/chronic fatigue syndrome.

Thapaliya, Kiran, Marshall-Gradisnik, Sonya, Staines, Donald et al.·The European journal of neuroscience·2021

This study used a specialized brain imaging technique called diffusion tensor imaging (DTI) to look for structural changes in the brains of ME/CFS patients compared to healthy people. The researchers found subtle differences in how water moves through certain nerve fiber pathways in the brains of patients who met strict diagnostic criteria for ME/CFS, particularly in areas controlling movement, coordination, and breathing. These brain changes were linked to patient symptoms like difficulty processing information, fatigue, and sleep problems.

E2 ModerateCohortPEM unclearCross-Sectional

Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Simonato, Manuela, Dall'Acqua, Stefano, Zilli, Caterina et al.·Biomedicines·2021

This study compared blood samples from 40 people with ME/CFS to 40 healthy people to look for biological differences. Researchers found that ME/CFS patients had different levels of certain molecules related to immune function, gut health, and how the body uses the amino acid tryptophan. These differences were independent of each other, suggesting multiple biological pathways may be disrupted in ME/CFS.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Parent-child discrepancies in health-related quality of life of children and adolescents with myalgic encephalomyelitis/chronic fatigue syndrome.

Ekberg, Krista M, Torres, Chelsea, Jason, Leonard A·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2021

This study looked at whether parents and their children with ME/CFS report symptoms and quality of life differently. Researchers compared 75 families where children had ME/CFS and 72 families without the condition, asking both parents and children to describe the child's health and symptoms. They found that parents and children often gave different answers, suggesting that both perspectives are important for understanding how ME/CFS affects young people.

E2 ModerateCohortPEM unclearCross-Sectional

Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Li, Xia, Julin, Per, Li, Tie-Qiang·Tomography (Ann Arbor, Mich.)·2021

Researchers used a specialized brain imaging technique to measure blood flow in the brains of ME/CFS patients and compared it to healthy people. They found that patients with ME/CFS have reduced blood flow in several areas of the limbic system—the part of the brain that helps control emotions, automatic body functions, and memory. The amount of reduced blood flow was also linked to how severe patients' symptoms were.

Autonomic Nervous System

E2 ModerateCohortPEM requiredLongitudinal

COVID-19 Symptoms Over Time: Comparing Long-Haulers to ME/CFS.

Jason, Leonard A, Islam, Mohammed, Conroy, Karl et al.·Fatigue : biomedicine, health & behavior·2021

This study compared how symptoms change over time in people with long COVID versus people with ME/CFS. Researchers asked 278 long-haulers to describe their current symptoms and symptoms from about 5 months earlier, and compared them to 502 ME/CFS patients. They found that long-haulers generally improved over time, with better sleep and less post-exertional malaise, but their brain fog and memory problems actually got worse. Long-haulers started off more symptomatic than ME/CFS patients but became less symptomatic over time, though orthostatic symptoms (dizziness when standing) remained similar in both groups.

Post-Exertional Malaise

E2 ModerateBehavioralPEM unclearCross-Sectional

How common are depression and anxiety in adolescents with chronic fatigue syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study.

Loades, Maria E, Read, Rebecca, Smith, Lucie et al.·European child & adolescent psychiatry·2021

This study looked at how common depression and anxiety are in teenagers with ME/CFS. Researchers interviewed 164 young people with ME/CFS and their parents using detailed diagnostic interviews and questionnaires. They found that about 1 in 3 teenagers had depression or anxiety, which is higher than expected. However, the questionnaires commonly used to screen for these conditions were not always accurate at detecting problems in this group, so doctors need to be careful and do thorough assessments rather than relying on questionnaires alone.

E2 ModerateCohortPEM not requiredObservational

Infections in temporal proximity to HPV vaccination and adverse effects following vaccination in Denmark: A nationwide register-based cohort study and case-crossover analysis.

Krogsgaard, Lene Wulff, Petersen, Irene, Plana-Ripoll, Oleguer et al.·PLoS medicine·2021

This study examined whether having an infection around the time of HPV vaccination increases the risk of developing illness symptoms afterward in Danish women. Researchers found that women who had a treated infection within one month before or after their first HPV vaccine dose were more likely to later seek care at specialized centers for suspected vaccine side effects. The symptoms reported were similar to those seen in chronic fatigue syndrome.

E2 ModerateCohortPEM not requiredCross-Sectional

The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

Murga, Iñigo, Aranburu, Larraitz, Gargiulo, Pascual A et al.·Journal of translational medicine·2021

This study looked at attention problems in ME/CFS patients by giving them a simple attention test (the Toulouse-Piéron test) and comparing their results to healthy people. Most ME/CFS patients had normal overall thinking skills, but 70% showed very low attention scores and complained of mental fatigue. Women with ME/CFS reported feeling more effort during the test than men did, even though their attention scores were similar.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Postural orthostatic tachycardia syndrome in patients of orthostatic intolerance symptoms: an ambispective study.

Chouksey, Dinesh, Rathi, Pankaj, Sodani, Ajoy et al.·AIMS neuroscience·2021

This study looked at patients who experience dizziness, fainting, or heart racing when standing up—symptoms of a condition called POTS (Postural Orthostatic Tachycardia Syndrome). Researchers tested 246 patients with these symptoms and confirmed POTS in 40 of them using a special tilt-table test. Most POTS patients experienced fainting, lightheadedness, and heart palpitations, and nearly half also had a related condition causing fainting.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt.

Aly, Menna A E G, Saber, Heba G·International journal of clinical practice·2021

This study looked at 115 elderly women in Egypt who had recovered from COVID-19 to see if their lingering symptoms might lead to chronic fatigue syndrome (ME/CFS). Most women reported problems like fatigue, muscle pain, and sleep trouble after COVID, and the study found that stress, sadness, and poor sleep were most strongly linked to developing CFS-like symptoms. Only one person in the study actually met full criteria for probable CFS, but the researchers suggest doctors should watch for these warning signs in long COVID patients.

SleepCognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post-Coronavirus Disease.

Mancini, Donna M, Brunjes, Danielle L, Lala, Anuradha et al.·JACC. Heart failure·2021

This study looked at 41 people who had long-lasting breathing problems after COVID-19, even though their standard lung and heart tests appeared normal. Researchers used a special exercise test to measure how well their bodies could use oxygen and how they breathed during activity. They found that most patients had unusual breathing patterns or reduced exercise capacity, and about half met the criteria for ME/CFS.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

Metselaar, Paula I, Mendoza-Maldonado, Lucero, Li Yim, Andrew Yung Fong et al.·Scientific reports·2021

Researchers found a set of 23 genes in blood cells that could reliably identify people with ME/CFS. By looking at both gene activity and chemical markers on genes, they developed a test that correctly identified ME/CFS patients about 92-97% of the time. This is important because there's currently no reliable blood test to diagnose ME/CFS.

BiomarkersImmune System

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Evidence browser

Characterizing long COVID in an international cohort: 7 months of symptoms and their impact.

Beyond bones: The relevance of variants of connective tissue (hypermobility) to fibromyalgia, ME/CFS and controversies surrounding diagnostic classification: an observational study.

Inflammation-type dysbiosis of the oral microbiome associates with the duration of COVID-19 symptoms and long COVID.

How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight.

Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Major Impact on Lives of Both Patients and Family Members.

Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE).

Diffusion tensor imaging reveals neuronal microstructural changes in myalgic encephalomyelitis/chronic fatigue syndrome.

Tryptophan Metabolites, Cytokines, and Fatty Acid Binding Protein 2 in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Parent-child discrepancies in health-related quality of life of children and adolescents with myalgic encephalomyelitis/chronic fatigue syndrome.

Limbic Perfusion Is Reduced in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

COVID-19 Symptoms Over Time: Comparing Long-Haulers to ME/CFS.

How common are depression and anxiety in adolescents with chronic fatigue syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study.

Infections in temporal proximity to HPV vaccination and adverse effects following vaccination in Denmark: A nationwide register-based cohort study and case-crossover analysis.

The maintained attention assessment in patients affected by Myalgic encephalomyelitis/chronic fatigue syndrome: a reliable biomarker?

Postural orthostatic tachycardia syndrome in patients of orthostatic intolerance symptoms: an ambispective study.

Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt.

Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post-Coronavirus Disease.

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

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